Expression of GSK-3β in renal allograft tissue and its significance in pathogenesis of chronic allograft dysfunction

Diagnostic Pathology

Volumn 7, Issue 1, 2012, Pages

  Yan, Qiang ^a   Wang, Baoyao ^b   Sui, Weiguo ^a   Zou, Guimian ^a   Chen, Huaizhou ^a   Xie, Shenping ^a   Zou, Hequn ^c  

^a Clinical College of Southern Medical University   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c THE THIRD AFFILIATED HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

GSK 3 ; Inflammatory cell infiltration; Kidney transplantation

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ADULT; ALLOTRANSPLANTATION; ARTICLE; ATROPHY; BIOSYNTHESIS; DELAYED GRAFT FUNCTION; FEMALE; FIBROSIS; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY TRANSPLANTATION; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; ATROPHY; DELAYED GRAFT FUNCTION; FEMALE; FIBROSIS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; TRANSPLANTATION, HOMOLOGOUS;

EID: 84862815631     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-7-5     Document Type: Article

References (8)

1. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008, 8(4):753-760. 10.1111/j.1600-6143.2008.02159.x, 18294345.
2. Giannopoulou M, Dai C, Tan X, et al. Hepatocyte growth factor exerts its anti- inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol 2008, 173(1):30-41. 10.2353/ajpath.2008.070583, 2438283, 18502824.
3. Martin M, Rehani K, Jope RS, et al. Toll- like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 2005, 6(8):777-784. 10.1038/ni1221, 1933525, 16007092.
4. Gong R, Ge Y, Chen S, et al. Glycogen synthase kinase 3beta: a novel marker and modulator of inflammatory injury in chronic renal allograft disease. Am J Transplant 2008, 8(9):1852-1863. 10.1111/j.1600-6143.2008.02319.x, 18786229.
5. Lee YJ, Han HJ. Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3{beta}, Snail1, and {beta}-catenin in renal proximal tubule cells. Am J Physiol Renal Physiol 2009,
6. Pippin JW, Qu Q, Meijer L, et al. Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. J Clin Invest 1997, 100(10):2512-2520. 10.1172/JCI119793, 508451, 9366565.
7. Obligado SH, Ibraghimov-Beskrovnaya O, Zuk A, et al. CDK/GSK-3 inhibitors as therapeutic agents for parenchymal renal diseases. Kidney Int 2008, 73(6):684-690. 10.1038/sj.ki.5002731, 18094678.
8. Sinha D, Wang Z, Ruchalski KL, et al. Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. Am J Physiol Renal Physiol 2005, 288(4):F703-713.