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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2613-2619

Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity

(17) Dudkin, Vadim Y a Wang, Cheng a Arrington, Kenneth L a Fraley, Mark E a Hartman, George D a Stirdivant, Steven M a Drakas, Robert A a Rickert, Keith a Walsh, Eileen S a Hamilton, Kelly a Buser, Carolyn A a Hardwick, James a Tao, Weikang a Beck, Stephen C a Mao, Xianzhi a Lobell, Robert B a Sepp Lorenzino, Laura a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIPYRIDINE DERIVATIVE; BROMINE DERIVATIVE; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 7; MORPHOLINE; PIPERAZINE; PIPERIDINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDYL AMINOTHIAZOLE; QUINOLINE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CELL ACTIVITY; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; MOLECULAR WEIGHT; PROCESS OPTIMIZATION; PROTEIN FUNCTION;

ANTINEOPLASTIC AGENTS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CYCLIN-DEPENDENT KINASES; DRUG DESIGN; HALOGENATION; HUMANS; KINETICS; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84862812412 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.01.120 Document Type: Article

Times cited : (8)

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