Automated approach for the rapid identification of purification conditions using a unified, walk-up high performance liquid chromatography/supercritical fluid chromatography/mass spectrometry screening system

Journal of Chromatography A

Volumn 1229, Issue , 2012, Pages 260-267

  Aurigemma, Christine M ^a   Farrell, William P ^a   Simpkins, Joseph ^b   Bayliss, Mark ^b   Alimuddin, Muhammad ^a   Wang, Wei ^a  

^a PFIZER INC   (United States)

^b Virscidian Inc   (United States)

Author keywords

Analytical SFC; Data analysis; HPLC MS; Multi column screening; SFC MS; Supercritical fluid chromatography

Indexed keywords

ANALYTICAL SFC; AUTOMATED APPROACH; AUTOMATED METHODS; AUTOMATED SOLUTIONS; CHROMATOGRAPHIC SYSTEMS; DATA EVALUATION; DATA FILES; FLUID CHROMATOGRAPHY; HPLC/MS; MEDICINAL CHEMISTRY; ORTHOGONAL DATA; PEAK SHAPES; RAPID IDENTIFICATION; RETENTION TIME; REVERSED PHASE; SCREENING SYSTEM; SCREENING TECHNIQUES; SEPARATION CONDITION; SFC/MS; SUPERCRITICAL FLUID CHROMATOGRAPHY; USER INTERVENTION;

BATCH DATA PROCESSING; DATA REDUCTION; GAS CHROMATOGRAPHY; LIQUIDS; PURIFICATION; SEPARATION; SPECTROMETRY;

AUTOMATION;

ARTICLE; AUTOMATION; DATA ANALYSIS SOFTWARE; DATA PROCESSING; MASS SPECTROMETRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCALE UP; SCREENING TEST; SEPARATION TECHNIQUE; SUPERCRITICAL FLUID CHROMATOGRAPHY; SYSTEM ANALYSIS; VALIDATION PROCESS;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, SUPERCRITICAL FLUID; EQUIPMENT DESIGN; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; RESEARCH DESIGN; SOFTWARE; USER-COMPUTER INTERFACE;

EID: 84862811892     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.01.048     Document Type: Article

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