A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2818-2822

  Graham, Thomas H ^a   Liu, Wensheng ^a   Verras, Andreas ^a   Reibarkh, Mikhail ^a   Bleasby, Kelly ^a   Bhatt, Urmi R ^a   Chen, Qing ^a   Garcia Calvo, Margarita ^a   Geissler, Wayne M ^a   Gorski, Judith N ^a   He, Huaibing ^a   Lassman, Michael E ^a   Lisnock, Jeanmarie ^a   Li, Xiaohua ^a   Shen, Zhu ^a   Tong, Xinchun ^a   Tung, Elaine C ^a   Wiltsie, Judyann ^a   Xie, Dan ^a   Xu, Suoyu ^a   Xiao, Jianying ^a   Hale, Jeffrey J ^a   Pinto, Shirly ^a   Shen, Dong Ming ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aminocyclopentane; Angiotensinase C; Enzyme inhibitor; High throughput screening; Melanocyte stimulating hormone; Metabolic syndrome; Obesity; PrCP; Prolylcarboxypeptidase; Pyrrolidine

Indexed keywords

AMINOCYCLOPENTANE DERIVATIVE; CYCLOPENTANE DERIVATIVE; ENZYME INHIBITOR; PROLINE CARBOXYPEPTIDASE; PROLYLCARBOXYPEPTIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; MALE; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

AMINES; ANIMALS; CARBOXYPEPTIDASES; CYCLIZATION; CYCLOPENTANES; DRUG DISCOVERY; ENZYME ACTIVATION; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; OBESITY;

EID: 84862811621     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.077     Document Type: Article

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