Immune reconstitution inflammatory syndrome: Incidence and implications for mortality

AIDS

Volumn 26, Issue 6, 2012, Pages 721-730

  Novak, Richard M ^a   Richardson, James T ^b   Buchacz, Kate ^c,g   Chmiel, Joan S ^d   Durham, Marcus D ^c,g   Palella, Frank J ^d   Wendrow, Andrea ^a   Wood, Kathy ^b   Young, Benjamin ^e,f,i   Brooks, John T ^c,g   Baker, Rose K ^b   Hankerson, Darlene ^b   Armon, Carl ^b   Studney, Carolyn ^d   Enyia, Onyinye ^d   Lichtenstein, Kenneth A ^h   Stewart, Cheryl ^h   Hammer, John ⁱ   Greenberg, Kenneth S ⁱ   Widick, Barbara ⁱ   Axinn, Joslyn D ⁱ   Yangco, Bienvenido G ^j   Halkias, Kalliope ^j   Ward, Douglas J ^k   Miller, Jay ^k   Fuhrer, Jack ^l   Ording Bauer, Linda ^l   Kelly, Rita ^l   Esteves, Jane ^l   Tedaldi, Ellen M ^m   Christian, Ramona A ^m   Ruley, Faye ^m   Beadle, Dania ^m   more..

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b CERNER CORPORATION   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e Rocky Mountain CARES/DIDC   (United States)

^f Health Connections International   (Netherlands)

^g CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^h NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

ⁱ ROSE MEDICAL CENTER   (United States)

^j INFECTIOUS DISEASE RESEARCH INSTITUTE   (United States)

^k Dupont Circle Physician's Group   (United States)

^l STONY BROOK UNIVERSITY   (United States)

^m TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

HAART; HIV; immune reconstitution inflammatory syndrome; mortality; opportunistic infections; risk factors; United States

Indexed keywords

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RISK FACTOR; UNITED STATES; VIRUS LOAD;

ADOLESCENT; ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BACTERIAL INFECTIONS; CD4 LYMPHOCYTE COUNT; FEMALE; HIV INFECTIONS; HUMANS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INCIDENCE; MALE; MIDDLE AGED; RISK FACTORS; RNA, VIRAL; UNITED STATES; VIRAL LOAD; YOUNG ADULT;

EID: 84862811555     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e3283511e91     Document Type: Article

References (45)

1. Narita M, Ashkin D, Hollender ES, Pitchenik AE. Paradoxical worsening oftuberculosis following antiretroviral therapy in patients with AIDS. Am J Respir Crit Care Med 1998; 158:157-161. (Pubitemid 28337174)
2. Shelburne SA, Visnegarwala F, Darcourt J, Graviss EA, Giordano TP, White AC Jr, et al. Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS 2005; 19:399-406. (Pubitemid 40446186)
3. Posada-Vergara MP, Lindoso JA, Tolezano JE, Pereira-Chioccola VL, Silva MV, Goto H. Tegumentary leishmaniasis as amanifestation of immune reconstitution inflammatory syndrome in 2 patients with AIDS. J Infect Dis 2005; 192:1819-1822. (Pubitemid 41587835)
4. Shelburne SA 3rd, Hamill RJ, Rodriguez-Barradas MC, Greenberg SB, Atmar RL, Musher DW, et al. Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy. Medicine 2002, 81:213-227. (Pubitemid 34507208)
5. Ratnam I, Chiu C, Kandala NB, Easterbrook PJ. Incidence and risk factors for immune reconstitution inflammatory syndrome in an ethnically diverse HIV type 1-infected cohort. Clin Infect Dis 2006; 42:418-427. (Pubitemid 43122323)
6. Martinez JV, Mazziotti JV, Efron ED, Bonardo P, Jordan R, Sevlever G, et al. Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder. Neurology 2006; 67:1692-1694. (Pubitemid 44747950)
7. Patel AK, Patel KK, Shah SD, Desai J. Immune reconstitution syndrome presenting with cerebral varicella zoster vasculitis in HIV-1-infected patient: a case report. J Int Assoc Physicians AIDS Care (Chic Ill) 2006; 5:157-160.
8. Godoy MC, Silva CI, Ellis J, Phillips P, Muller NL. Organizing pneumonia as amanifestation of Pneumocystis jiroveci immune reconstitution syndrome in HIV-positive patients: report of 2 cases. J Thorac Imaging 2008; 23:39-43.
9. Mortimer RB, Libke R, Egbalieh B, Bilello JF. Immune Reconstitution inflammatory syndrome presenting as superior vena cava syndrome secondary to coccidioides lymphadenopathy in an HIV-infected patient. J Int Assoc Physicians AIDS Care (Chic Ill) 2008; 7:283-285.
10. von Both U, Laffer R, Grube C, Bossart W, Gaspert A, Gunthard HF. Acute cytomegalovirus colitis presenting during primary HIV infection: an unusual case of an immune reconstitution inflammatory syndrome. Clin Infect Dis 2008; 46:e38-e40. (Pubitemid 351263516)
11. Shelburne SA 3rd, Hamill RJ. The immune reconstitution inflammatory syndrome. AIDS Rev 2003; 5:67-79.
12. French MA, Price P, Stone SF. Immune restoration disease after antiretroviral therapy. AIDS 2004; 18:1615-1627. (Pubitemid 39095778)
13. Lipman M, Breen R. Immune reconstitution inflammatory syndrome in HIV. Curr Opin Infect Dis 2006; 19:20-25. (Pubitemid 43032435)
14. Murdoch DM, Venter WD, Van Rie A, Feldman C. Immune reconstitution inflammatory syndrome (IRIS): review of common infectious manifestations and treatment options. AIDS Res Ther 2007; 4:9.
15. Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, et al. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis 2008; 8:516-523. (Pubitemid 352005824)
16. Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998; 338:853-860. (Pubitemid 28135961)
17. Centers for Disease Control and Prevention (CDC). 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Rep 1992; 41 (RR-17):1-19.
18. Lehloenya R, Meintjes G. Dermatologic manifestations ofthe immune reconstitution inflammatory syndrome. Dermatol Clin 2006; 24:549-570; vii.
19. Kerob D, Dupuy A, Vignon-Pennamen MD, Bournerias I, Dohin E, Lebbe C. A case ofefflorescence of cutaneous warts as a manifestation of immune reconstitution inflammatory syndrome in an HIV-infected patient. Clin Infect Dis 2007; 45:405-406. (Pubitemid 47101049)
20. Pereira B, Fernandes C, Nachiambo E, Catarino MC, Rodrigues A, Cardoso J. Exuberant molluscum contagiosum asa manifestation of the immune reconstitution inflammatory syndrome. Dermatol Online J 2007; 13:6.
21. Robertson J, Meier M, Wall J, Ying J, Fichtenbaum CJ. Immune reconstitution syndrome inHIV: validating a case definition and identifying clinical predictors in persons initiating antiretroviral therapy. Clin Infect Dis 2006; 42:1639-1646.
22. Murdoch DM, Venter WD, Feldman C, Van Rie A. Incidence and risk factors for the immune reconstitution inflammatory syndrome in HIV patients in South Africa: a prospective study. AIDS 2008; 22:601-610. (Pubitemid 351640593)
23. Huruy K, Mulu A, Mengistu G, Shewa-Amare A, Akalu A, Kassu A, et al. Immune reconstitution inflammatory syndrome among HIV/AIDS patients during highly active antiretroviral therapy in Addis Ababa, Ethiopia. Jpn J Infect Dis 2008; 61:205-209. (Pubitemid 351888591)
24. Tansuphasawadikul S, Saito W, Kim J, Phonrat B, Dhitavat J, Chamnachanan S, et al. Outcomes inHIV-infected patients on antiretroviral therapy with tuberculosis. Southeast Asian J Trop Med Public Health 2007; 38:1053-1060.
25. Park WB, Choe PG, Jo JH, Kim SH, Bang JH, Kim HB, et al. Tuberculosis manifested byimmune reconstitution inflammatory syndrome during HAART. AIDS 2007; 21:875-877. (Pubitemid 46573163)
26. Ortega KL, Ceballos-Salobrena A, Gaitan-Cepeda LA, Magalhaes MG. Oral manifestations after immune reconstitution in HIV patients on HAART. Int J STD AIDS 2008; 19:305-308. (Pubitemid 351748270)
27. Gaitan Cepeda LA, Ceballos Salobrena A, Lopez Ortega K, Arzate Mora N, Jimenez Soriano Y. Oral lesions and immune reconstitution syndrome in HIV+/AIDS patients receiving highly active antiretroviral therapy. Epidemiological evidence. Med Oral Patol Oral Cir Bucal 2008; 13:E85-E93.
28. O'Leary JG, Zachary K, Misdraji J, Chung RT. De novo autoimmune hepatitis during immune reconstitution in an HIV-infected patient receiving highly active antiretroviral therapy. Clin Infect Dis 2008; 46:e12-e14. (Pubitemid 351263584)
29. Acosta RD, Itzkowitz SL. Immune reconstitution syndrome masquerading as ulcerative colitis in a patient with HIV. Gastrointest Endosc 2008; 68:1197-1198; discussion 1198.
30. Ferrand RA, Cartledge JD, Connolly J, Standish RA, Miller RF. Immune reconstitution sarcoidosis presenting with hypercalcaemia and renal failure in HIV infection. Int J STD AIDS 2007; 18:138-139.
31. Vos F, Pieters G, Keuter M, van der Ven A. Graves' disease during immune reconstitution in HIV-infected patients treated with HAART. Scand J Infect Dis 2006; 38:124-126. (Pubitemid 43203238)
32. Neumann S, Kreth F, Schubert S, Mossner J, Caca K. Reiter's syndrome as amanifestation of an immune reconstitution syndrome in an HIV-infected patient: successful treatment with doxycycline. Clin Infect Dis 2003; 36:1628-1629. (Pubitemid 36783354)
33. Feller L, Wood NH, Lemmer J. Herpes zoster infection asan immune reconstitution inflammatory syndrome in HIV-sero-positive subjects: a review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104:455-460.
34. Couppie P, Sarazin F, Clyti E, El Guedj M, Vaz T, Sainte-Marie D, et al. Increased incidence ofgenital herpes after HAART initiation: a frequent presentation of immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients. AIDS Patient Care STDS 2006; 20:143-145.
35. Kharkar V, Bhor UH, Mahajan S, Khopkar U. Type Ilepra reaction presenting as immune reconstitution inflammatory syndrome. Indian J Dermatol Venereol Leprol 2007; 73:253-256. (Pubitemid 47219996)
36. Kar HK, Sharma P. Does concomitant hiv infection has any epidemiological, clinical, immunopathological and therapeutic relevance in leprosy?. Indian J Lepr 2007; 79: 45-60. (Pubitemid 46864731)
37. Trindade MA, Valente NY, Manini MI, Takahashi MD, Anjos CF, Benard G, et al. Two patients coinfected with Mycobacterium leprae and human immunodeficiency virus type 1 and naive for antiretroviral therapy who exhibited type 1 leprosy reactionsmimicking the immune reconstitution inflammatory syndrome. J Clin Microbiol 2006; 44:4616-4618. (Pubitemid 44937112)
38. Antinori S, Longhi E, Bestetti G, Piolini R, Acquaviva V, Foschi A, et al. Postkala-azar dermal leishmaniasis asan immune reconstitution inflammatory syndrome in a patient with acquired immune deficiency syndrome. Br J Dermatol 2007; 157:1032-1036. (Pubitemid 47583507)
39. Hoyo-Ulloa I, Belaunzaran-Zamudio PF, Crabtree-Ramirez B, Galindo-Fraga A, Perez-Aguinaga ME, Sierra-Madero JG. Impact ofthe immune reconstitution inflammatory syndrome (IRIS) on mortality and morbidity in HIV-infected patients in Mexico. Int J Infect Dis 2011; 15:e408-e414.
40. Park WB, Choe PG, Jo JH, Kim SH, Bang JH, Kim HB, et al. Immune reconstitution inflammatory syndrome in the first year after HAART: influence on long-term clinical outcome. AIDS 2006; 20:2390-2392. (Pubitemid 44789544)
41. Sereti I, Rodger AJ, French MA. Biomarkers inimmune reconstitution inflammatory syndrome: signals from pathogenesis. Curr Opin HIV AIDS 2010; 5:504-510.
42. Porter BO, Ouedraogo GL, Hodge JN, Smith MA, Pau A, Roby G, et al. d-Dimer and CRP levels are elevated prior to antiretroviral treatment in patients who develop IRIS. Clin Immunol 2010; 136:42-50.
43. Cianchetta-Sivori M, Raso S, Fernandez-Guerrero M, Gorgolas M, Garcia R. Do CD8(+)CD25(+) cells predict immune reconstitution syndrome in HIV-positive patients who begin HAART? AIDS 2007; 21:2347-2349. (Pubitemid 350287464)
44. Alatrakchi N, Koziel M. Regulatory Tcells and viral liver disease. J Viral Hepat 2009; 16:223-229.
45. Peng G, Li S, Wu W, Sun Z, Chen Y, Chen Z. Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Immunology 2008; 123:57-65. (Pubitemid 350255997)