Randomized, double-blind pilot study of transendocardial injection of autologous aldehyde dehydrogenase-bright stem cells in patients with ischemic heart failure

American Heart Journal

Volumn 163, Issue 3, 2012, Pages

  Perin, Emerson C ^a   Silva, Guilherme V ^a   Zheng, Yi ^a   Gahremanpour, Amir ^a   Canales, John ^a   Patel, Dipsu ^a   Fernandes, Marlos R ^a   Keller, Laurence H ^b   Quan, Xin ^a   Coulter, Stephanie A ^a   Moore, Warren H ^a   Herlihy, J Patrick ^a   Willerson, James T ^a  

^a ST LUKE S EPISCOPAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE;

ALDEHYDE DEHYDROGENASE BRIGHT STEM CELL; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CELL ISOLATION; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HEART FAILURE; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HEMATOPOIETIC STEM CELL; HUMAN; INJECTION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SAFETY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TRANSENDOCARDIAL INJECTION;

EID: 84862810905     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2011.11.020     Document Type: Article

References (27)

1. A. Abdel-Latif, R. Bolli, and I.M. Tleyjeh Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis Arch Intern Med 167 2007 989 997
2. S.L. Beeres, J.J. Bax, and P. Dibbets-Schneider Sustained effect of autologous bone marrow mononuclear cell injection in patients with refractory angina pectoris and chronic myocardial ischemia: twelve-month follow-up results Am Heart J 152 2006 684.e11 684.e16
3. C. Briguori, B. Reimers, and C. Sarais Direct intramyocardial percutaneous delivery of autologous bone marrow in patients with refractory myocardial angina Am Heart J 151 2006 674 680
4. R.K. Burt, Y. Loh, and W. Pearce Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases JAMA 299 2008 925 936
5. S. Fuchs, R. Kornowski, and G. Weisz Safety and feasibility of transendocardial autologous bone marrow cell transplantation in patients with advanced heart disease Am J Cardiol 97 2006 823 829
6. C. Heeschen, R. Lehmann, and J. Honold Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease Circulation 109 2004 1615 1622
7. M.J. Lipinski, G.G. Biondi-Zoccai, and A. Abbate Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials J Am Coll Cardiol 50 2007 1761 1767
8. D.W. Losordo, R.A. Schatz, and C.J. White Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial Circulation 115 2007 3165 3172
9. E. Martin-Rendon, S.J. Brunskill, and C.J. Hyde Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review Eur Heart J 29 2008 1807 1818
10. E.C. Perin, H.F. Dohmann, and R. Borojevic Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure Circulation 107 2003 2294 2302
11. E.C. Perin, H.F. Dohmann, and R. Borojevic Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy Circulation 110 2004 II213 II218
12. H.F. Tse, S. Thambar, and Y.L. Kwong Safety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis Am J Cardiol 98 2006 60 62
13. H.F. Tse, S. Thambar, and Y.L. Kwong Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial) Eur Heart J 28 2007 2998 3005
14. R.W. Storms, A.P. Trujillo, and J.B. Springer Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity Proc Natl Acad Sci U S A 96 1999 9118 9123
15. T. Gentry, E. Deibert, and S.J. Foster Isolation of early hematopoietic cells, including megakaryocyte progenitors, in the ALDH-bright cell population of cryopreserved, banked UC blood Cytotherapy 9 2007 569 576
16. T. Gentry, S. Foster, and L. Winstead Simultaneous isolation of human BM hematopoietic, endothelial and mesenchymal progenitor cells by flow sorting based on aldehyde dehydrogenase activity: implications for cell therapy Cytotherapy 9 2007 259 274
17. B.J. Capoccia, D.L. Robson, and K.D. Levac Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity Blood 113 2009 5340 5351
18. G.S. Lin, H.H. Hines, and G. Grant Automated quantification of myocardial ischemia and wall motion defects by use of cardiac SPECT polar mapping and 4-dimensional surface rendering J Nucl Med Technol 34 2006 3 17
19. K. Krause, C. Schneider, and C. Lange Endocardial electrogram analysis after intramyocardial injection of mesenchymal stem cells in the chronic ischemic myocardium Pacing Clin Electrophysiol 32 2009 1319 1328
20. G.V. Silva, E.C. Perin, and H.F. Dohmann Catheter-based transendocardial delivery of autologous bone-marrow-derived mononuclear cells in patients listed for heart transplantation Tex Heart Inst J 31 2004 214 219
21. J.O. Beitnes, E. Hopp, and K. Lunde Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study Heart 95 2009 1983 1989
22. S. Pasquet, H. Sovalat, and P. Henon Long-term benefit of intracardiac delivery of autologous granulocyte-colony-stimulating factor-mobilized blood CD34+ cells containing cardiac progenitors on regional heart structure and function after myocardial infarct Cytotherapy 11 2009 1002 1015
23. C.S. Sondergaard, D.A. Hess, and D.J. Maxwell Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction J Transl Med 8 2010 24
24. J. van Ramshorst, J.J. Bax, and S.L. Beeres Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial JAMA 301 2009 1997 2004
25. D.W. Losordo, T.D. Henry, and C. Davidson Intramyocardial, autologous CD34+ cell therapy for refractory angina Circ Res 109 2011 428 436
26. D.M. Mancini, H. Eisen, and W. Kussmaul Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure Circulation 83 1991 778 786
27. V.G. Florea, M.Y. Henein, and S.D. Anker Prognostic value of changes over time in exercise capacity and echocardiographic measurements in patients with chronic heart failure Eur Heart J 21 2000 146 153