Direct detection of tetrahydrobiopterin (BH4) and dopamine in rat brain using liquid chromatography coupled electrospray tandem mass spectrometry

Biochemical and Biophysical Research Communications

Volumn 419, Issue 4, 2012, Pages 632-637

  Kim, Hak Rim ^a   Kim, Tae Hyun ^a   Hong, Sung Hyun ^a   Kim, Hyung Gun ^a  

^a Dankook University   (South Korea)

Author keywords

Dopamine; Rat brain; Tandem mass spectrometry; Tetrahydrobiopterin

Indexed keywords

ACETONITRILE; ACEXAMIC ACID; AMMONIUM FORMATE; DOPAMINE; EPSILON CRYSTALLIN; TETRAHYDROBIOPTERIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CALIBRATION; CEREBELLUM; CORPUS STRIATUM; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; FRONTAL CORTEX; HIPPOCAMPUS; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MESENCEPHALON; NONHUMAN; OCCIPITAL LOBE; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SUBSTANTIA NIGRA; SUPERNATANT;

ANIMALS; BIOPTERIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, LIQUID; DOPAMINE; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

RATTUS;

EID: 84862809771     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.02.064     Document Type: Article

References (22)

1. Duch D.S., Smith G.K. Biosynthesis and function of tetrahydrobiopterin. Journal of Nutritional Biochemistry 1991, 2:411-423.
2. Schmidt T.S., Alp N.J. Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clinical Science 2007, 113:47-63.
3. Scriver C.R., Eisensmith R.C., Woo S.L.C., Kaufman S. The hyperphenylalaninemias of man and mouse. Annual Review of Genetics 1994, 28:141-165.
4. Scriver C.R. The PAH gene, phenylketonuria, and a paradigm shift. Human Mutation 2007, 28:831-845.
5. Werner E.R., Blau N., Thony B. Tetrahydrobiopterin: biochemistry and pathophysiology. Biochemical Journal 2011, 438:397-414.
6. Marletta M.A. Nitric oxide synthase structure and mechanism. Journal of Biological Chemistry 1993, 268:12231-12234.
7. Moens A.L., Kass D.A. Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease. Journal of Cardiovascular Pharmacology 2007, 50:238-246.
8. Katusic Z.S., d'Uscio L.V., Nath K.A. Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects. Trends in Pharmacological Sciences 2008, 30:48-54.
9. Antoniades C., Bakogiannis C., Leeson P., Guzik T.J., Zhang M.H., Tousoulis D., Antonopoluos A.S., Demosthenous M., Marinou K., Hale A., Paschalis A., Psarros C., Triantafyllou C., Bendall J., Casadei B., Stefanadis C., Channon K.M. Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling. Circulation 2011, 124:335-345.
10. Annuk M., Zilmer M., Fellstrom B. Endothelium-dependent vasodilation and oxidative stress in chronic renal failure: impact on cardiovascular disease. Kidney International 2003, 63:S50-S53.
11. Ryu M.Y., Lee M.A., Ahn Y.H., Kim K.S., Yoon S.H., Snyder E.Y., Cho K.G., Kim S.U. Brain transplantation of neural stem cells cotransduced with tyrosine hydroxylase and GTP cyclohydrolase 1 in parkinsonian rats. Cell Transplantation 2005, 14:193-202.
12. Choi H.J., Lee S.Y., Cho Y., No H., Kim S.W., Hwang O. Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease. Neurochemistry International 2006, 48:255-262.
13. Blau N., Hennermann J.B., Langenbeck U., Lichter-Konecki U. Diagnosis, classification, and genetics of phenylketonuria and tetrahydrobiopterin (BH4) deficiencies. Molecular Genetics and Metabolism 2011, 10.1016/j.ymgme.2011.08.017.
14. Lukacs Z., Santer R. Evaluation of electrospray-tandem mass spectrometry for the detection of phenylketonuria and other rare disorders. Molecular Nutrition and Food Research 2006, 50:443-450.
15. Cañada-Cañada F., Espinosa-Mansilla A., Muñoz de la Peña A., Mancha de Llanos A. Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method. Analytica Chimica Acta 2009, 648:113-122.
16. Fukushima T., Nixon J.C. Chromatographic analysis of pteridines. Methods in Enzymology 1980, 66:429-436.
17. Fukushima T., Nixon J.C. Analysis of reduced forms of biopterin in biological tissues and fluids. Analytical Biochemistry 1980, 102:176-188.
18. Zhao Y., Cao J., Chen Y.-S., Zhu Y., Patrick C., Chien B., Cheng A., Foehr E.D. Detection of tetrahydrobiopterin by LC-MS/MS in plasma from multiple species. Bioanalysis 2009, 1:895-903.
19. Milstien S., Kaufman S. The biosynthesis of tetrahydrobiopterin in rat brain. Journal of Biological Chemistry 1989, 264:8066-8073.
20. Hefti F., Melamed E., Wurtman R.J. Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization. Brain Research 1980, 195:123-137.
21. Versteeg D.H.G., der Gugten J.V., De Jong W., Palkovits M.S. Regional concentration of noradrenaline and dopamine in rat brain. Brain Research 1976, 113:563-574.
22. Brownstein M., Saavedra J.M., Palkovits M. Norepinephrine and dopamine in the limbic system of the rat. Brain Research 1974, 79:431-436.