Estrogen stimulates Th2 cytokine production and regulates the compartmentalisation of eosinophils during allergen challenge in a mouse model of asthma

International Archives of Allergy and Immunology

Volumn 158, Issue 3, 2012, Pages 252-260

  Cai, Yeping ^a   Zhou, Jiansheng ^a   Webb, Dianne C ^a  

^a Australian National University   (Australia)

Author keywords

Asthma; Eosinophils; Estrogen; IL 13; IL 5; Mucus

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ALLERGEN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; INTERLEUKIN 13; INTERLEUKIN 5; METHACHOLINE; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BLOOD; BONE MARROW; CD4+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; CELL HYPERPLASIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; EOSINOPHILIA; FEMALE; GOBLET CELL; LUNG FUNCTION; LUNG RESISTANCE; LYMPH NODE CELL; MALE; MEDIASTINUM LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH2 CELL;

ALLERGENS; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CYTOKINES; DISEASE MODELS, ANIMAL; EOSINOPHILS; ESTROGENS; FEMALE; HUMANS; HYPERSENSITIVITY; INTERLEUKIN-13; INTERLEUKIN-5; LUNG; MALE; MICE; MICE, INBRED BALB C; TH2 CELLS;

EID: 84862803178     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000331437     Document Type: Article

References (31)

1. Almqvist C, Worm M, Leynaert B: Impact of gender on asthma in childhood and adolescence: a GA2LEN review. Allergy 2008; 63: 47-57. (Pubitemid 350198234)
2. McCallister JW, Mastronarde JG: Sex differences in asthma. J Asthma 2008; 45: 853-861.
3. Jensen-Jarolim E, Untersmayr E: Gendermedicine aspects in allergology. Allergy 2008; 63: 610-615.
4. Ligeiro de Oliveira AP, Oliveira-Filho RM, da Silva ZL, Borelli P, Tavares de Lima W: Regulation of allergic lung inflammation in rats: Interaction between estradiol and corticosterone. Neuroimmunomodulation 2004; 11: 20-27. (Pubitemid 37256092)
5. Riffo-vasquez Y, Ligeiro de Oliveira AP, Page CP, Spina D, Tavares-de-Lima W: Role of sex hormones in allergic inflammation in mice. Clin Exp Allergy 2007; 37: 459-470. (Pubitemid 46393246)
6. Dimitropoulou C, Drakopanagiotakis F, Chatterjee A, Snead C, Catravas JD: Estrogen replacement therapy prevents airway dysfunction in a murine model of allergen-induced asthma. Lung 2009; 187: 116-127.
7. Ligeiro de Oliveira AP, Domingos Hv, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho RM, vargaftig BB, de Lima WT: Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol. Am J Physiol Cell Physiol 2007; 293:C1120-C1128. (Pubitemid 47437389)
8. Jensen Ev, Khan SA: A two-site model for antiestrogen action. Mech Ageing Dev 2004; 125: 679-682. (Pubitemid 39482398)
9. Robertson JF: Faslodex (ICI 182, 780), a novel estrogen receptor downregulator - future possibilities in breast cancer. J Steroid Biochem Mol Biol 2001; 79: 209-212. (Pubitemid 34158797)
10. Webb DC, Cai Y, Matthaei KI, Foster PS: Comparative roles of IL-4, IL-13, and IL4Rα in dendritic cell maturation and CD4+ Th2 cell function. J Immunol 2007; 178: 219-227. (Pubitemid 46033604)
11. Siegle JS, Hansbro N, Herbert C, Yang M, Foster PS, Kumar RK: Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation. Am J Respir Cell Mol Biol 2006; 35: 565-570. (Pubitemid 44706429)
12. Lu B, Dotzlaw H, Leygue E, Murphy LJ, Watson PH, Murphy LC: Estrogen receptor - mRNA variants in murine and human tissues. Mol Cell Endocrinol 1999; 158: 153-161.
13. Cai Y, Kumar RK, Zhou J, Foster PS, Webb DC: Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation. J Immunol 2009; 182: 5393-5399.
14. Travlos GS: Normal structure, function, and histology of the bone marrow. Toxicol Pathol 2006; 34: 548-565. (Pubitemid 44652217)
15. Martin LA, Pancholi S, Chan CM, Farmer I, Kimberley C, Dowsett M, Johnston SR: The anti-oestrogen ICI 182,780, but not tamoxifen, inhibits the growth of MCF-7 breast cancer cells refractory to long-term oestrogen deprivation through down-regulation of oestrogen receptor and IGF signalling. Endocr Relat Cancer 2005; 12: 1017-1036.
16. Stygar D, Masironi B, Eriksson H, Sahlin L: Studies on estrogen receptor (ER) alpha and beta responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists. J Endocrinol 2007; 194: 101-119. (Pubitemid 47162891)
17. Matsubara S, Swasey CH, Loader JE, Dakhama A, Joetham A, Ohnishi H, Balhorn A, Miyahara N, Takeda K, Gelfand EW: Estrogen determines sex differences in airway responsiveness after allergen exposure. Am J Respir Cell Mol Biol 2008; 38: 501-508. (Pubitemid 351758667)
18. Paharkova-vatchkova v, Maldonado R, Kovats S: Estrogen preferentially promotes the differentiation of CD11c+ CD11b (intermediate) dendritic cells from bone marrow precursors. J Immunol 2004; 172: 1426-1436.
19. varga T, Nagy L: Nuclear receptors, transcription factors linking lipid metabolism and immunity: the case of peroxisome proliferator- activated receptor gamma. Eur J Clin Invest 2008; 38: 695-707.
20. Pernis AB: Estrogen and CD4+ T cells. Curr Opin Rheumatol 2007; 19: 414-420. (Pubitemid 47344231)
21. Lambert KC, Curran EM, Judy BM, Milligan GN, Lubahn DB, Estes DM: Estrogen receptor - (ER - ) deficiency in macrophages results in increased stimulation of CD4+ T cells while 17 - -estradiol acts through ER - to increase IL-4 and GATA-3 expression in CD4+ T cells independent of antigen presentation. J Immunol 2005; 175: 5716-5723. (Pubitemid 41508054)
22. Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C, Witztum JL, Funk CD, Conrad D, Glass CK: Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature 1999; 400: 378-382. (Pubitemid 29344205)
23. Li Q, Cheon YP, Kannan A, Shanker S, Bagchi IC, Bagchi MK: A novel pathway involving progesterone receptor, 12/15-lipoxygenase- derived eicosanoids, and peroxisome proliferator-activated receptor gamma regulates implantation in mice. J Biol Chem 2004; 279: 11570-11581. (Pubitemid 38401658)
24. Yamaguchi Y, Suda T, Suda J, Eguchi M, Miura Y, Harada N, Tominaga A, Takatsu K: Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J Exp Med 1988; 167: 43-56. (Pubitemid 18093692)
25. Tomaki M, Zhao L-L, lundahl J, Sjöstrand M, Jordana M, Lindén A, OByrne PM, Lötvall J: Eosinophilopoiesis in a murine model of allergic airway eosinophilia: involvement of bone marrow IL-5 and IL-5 receptor - 1 . J Immnuol 2000; 165: 4040-4050. (Pubitemid 32057316)
26. Palframan RT, Collins PD, Severs NJ, Rothery S, Williams TJ, Rankin SM: Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med 1998; 188: 1621-1632. (Pubitemid 28516107)
27. Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS: Eosinophils role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003; 167: 199-204. (Pubitemid 36076080)
28. Erjefalt JS, Uller L, Malm-Erjefalt M, Persson CG: Rapid and efficient clearance of airway tissue granulocytes through transepithelial migration. Thorax 2004; 59: 136-143. (Pubitemid 38223485)
29. Persson C, Uller L: Transepithelial exit of leucocytes: inflicting, reflecting or resolving airway inflammation? Thorax 2011; 65: 1111-1115.
30. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999; 103: 779-788. (Pubitemid 29152623)
31. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ: Direct effects of interleukin- 13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002; 8: 885-889.