Hibiscus sabdariffa L. extracts reduce serum uric acid levels in oxonate-induced rats

Journal of Functional Foods

Volumn 4, Issue 1, 2012, Pages 375-381

  Kuo, Chih Yi ^a,b   Kao, Erl Shyh ^d   Chan, Kuei Chuan ^b,c   Lee, Huei Jane ^b   Huang, Tsai Feng ^b   Wang, Chau Jong ^b,c  

^a Tai An Hospital   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHIENKUO TECHNOLOGY UNIVERSITY   (Taiwan)

Author keywords

Hibiscus sabdariffa extract; Hyperuricemia; Oxonic acid; Uricase; Xanthine oxidase

Indexed keywords

HIBISCUS SABDARIFFA; RATTUS;

EID: 84862799056     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2012.01.007     Document Type: Article

References (38)

1. Ali B.H., Mousa H.M., El-Mougy S. The effect of a water extract and anthocyanins of hibiscus sabdariffa L on paracetamol-induced hepatoxicity in rats. Phytotherapy Research 2003, 17:56-59.
2. Battelli M.G., Abbondanza A., Musiani S., Buonamici L., Strocchi P., Tazzari P.L., Gramantieri L., Stirpe F. Determination of xanthine oxidase in human serum by a competitive enzyme-linked immunosorbent assay (ELISA). Clinica Chimica Acta 1999, 281:147-158.
3. Christopher M.B., Robert L.W. Gout therapeutics: New drugs for an old disease. New Drug Class 2011, 377:165-177.
4. Choi H.K., Ford E.S. Prevalence of the metabolic syndrome in individuals with hyperuricemia. American Journal of Medicine 2007, 120:442-447.
5. Cleland L.G., Hill C.L., James M.J. Diet and arthritis. Bailliere's Clinical Rheumatology 1995, 9:771-785.
6. Dafallah A.A., al-Mustafa Z. Investigation of the anti-inflammatory activity of Acacia nilotica and Hibiscus sabdariffa. American Journal of Chinese Medicine 1996, 24:263-269.
7. Fuleki T., Francis F.J. Quantitative methods for anthocyanins: Extraction and determination of total anthocyanin in cranberries. Journal of Food Science 1968, 33:72-77.
8. Huang J., Wang S., Zhu M., Chen J., Zhu X. Effects of Genistein, Apigenin, Quercetin, Rutin and Astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. Food and Chemical Toxicology 2011, 49:1943-1947.
9. Haidari F., Mohammad Shahi M., Keshavarz S.A., Rashidi M.R. Inhibitory effects of Tart Cherry (Prunus cerasus) juice on xanthine oxidoreductase activity and its hypouricemic and antioxidant effects on rats. Malaysian Journal of Nutrition 2009, 15. Effects 0.
10. Haji Faraji M., Haji Tarkhani A. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. Journal of Ethnopharmacology 1999, 65:231-236.
11. Hall I.H., Scoville J.P., Reynolds D.J., Simlot R., Duncan P. Substituted cyclic imides as potential anti-gout agents. Life Science 1990, 46:1923-1927.
12. Johnson R.J., Titte S., Cade J.R., Rideout B.A., Oliver W.J. Uric acid, evolution and primitive cultures. Seminars in Nephrology 2005, 25:3-8.
13. Jia Z.S., Tang M.C., Wu J.M. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chemistry 1999, 64:555-559.
14. Kong L.D., Cai Y., Huang W.W., Cheng C.H., Tan R.X. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. Journal of Ethnopharmacology 2000, 73:199-207.
15. Lee W.C., Wang C.J., Chen Y.H., Hsu J.D., Cheng S.Y., Chen H.C., Lee H.J. Polyphenol extracts from Hibiscus sabdariffa Linnaeus attenuate nephropathy in experimental type 1 diabetes. Journal of Agricultural Food Chemistry 2009, 57:2206-2210.
16. Lin H.H., Huang H.P., Huang C.C., Chen J.H., Wang C.J. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Molecular Carcinogenesis 2005, 43:86-99.
17. Lin C.M., Chen C.S., Chen C.T., Liang Y.C., Lin J.K. Molecular modeling of flavonoids that inhibits xanthine oxidase. Biochemical Biophysical Research Communications 2002, 294:167-172.
18. Lakenbrink C., Lapczynski S., Maiwald B., Engelhardt U.H. Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages. Journal Agricultural and Food Chemistry 2000, 48:2848-2852.
19. Mo S.F., Zhou F., Lv Y.Z., Hu Q.H., Zhang D.M., Kong L.D. Hypouricemic action of selected flavonoids in mice: Structure-activity relationships. Biological & Pharmaceutical Bulletin 2007, 30:1551-1556.
20. Mazzali M., Hughes J., Kim Y.G., Jefferson J.A., Kang D.H., Gordon K.L., Lan H.Y., Kivlighn S., Johnson R.J. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001, 38:1101-1106.
21. Nagao A., Seki M., Kobayashi H. Inhibition of xanthine oxidase by flavonoids. Bioscience Biotechnology and Biochemistry 1999, 63:1787-1790.
22. Newburger J., Combs A.B., Hsu T.F. Diurnal variation in serum uric acid of rats fed potassium oxonate. Drug and Chemical Toxicology 1978, 1:231-235.
23. Onyenekwe P.C., Ajani E.O., Ameh D.A., Gamaniel K.S. Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell Biochemistry and Function 1999, 17:199-206.
24. Ponce A.M., Blanco S.E., Molina A.S., Garcia-Domenech R., Galvez J. Study of the action of flavonoids on xanthine-oxidase by molecular topology. Journal of Chemical Information and Computer Sciences 2000, 40:1039-1045.
25. Riegersperger M., Covic A., Goldsmith D. Allopurinol, uric acid, and oxidative stress in cardiorenal disease. International Urology and Nephrology 2011, 43:441-449.
26. Ramallo I.A., Zacchino S.A., Furlan R.L. A rapid TLC autographic method for the detection of xanthine oxidase inhibitors and superoxide scavengers. Phytochemical Analysis 2006, 17:15-19.
27. Stamp L.K., Jordan S. The challenges of gout management in the elderly. Drugs & Aging 2011, 28:591-603.
28. Sherman M.R., Saifer M.G., Perez-Ruiz F. PEG-uricase in the management of treatment-resistant gout and hyperuricemia. Advanced Drug Delivery Reviews 2008, 60:59-68.
29. Short R.A., Tuttle K.R. Clinical evidence for the influence of uric acid on hypertension, cardiovascular disease, and kidney disease: A statistical modeling perspective. Seminars in Nephrology 2005, 25:25-31.
30. Sweeney A.P., Wyllie S.G., Shalliker R.A., Markham J.L. Xanthine oxidase inhibitory activity of selected Australian native plants. Journal of Ethnopharmacology 2001, 75:273-277.
31. Selloum L., Reichl S., Muller M., Sebihi L., Arnhold J. Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils. Archives of Biochemistry and Biophysics 2001, 395:49-56.
32. Tung Y.T., Hsu C.A., Chen C.S., Yang S.C., Huang C.C., Chang S.T. Phytochemicals from Acacia confusa heartwood extracts reduce serum uric acid levels in oxonate-induced mice. Their potential use as xanthine oxidase inhibitors. Journal of Agricultural and Food Chemistry 2010, 58:9936-9941.
33. Terkeltaub R.A. Clinical practice. Gout. The New England Journal of Medicine 2003, 349:1647-1655.
34. Van Hoorn D.E., Nijveldt R.J., Van Leeuwen P.A., Hofman Z., M'Rabet L., De Bont D.B., Van Norren K. Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids. European Journal of Pharmacology 2002, 451:111-118.
35. Tseng T.H., Kao T.W., Chu C.Y., Chou F.P., Lin W.L., Wang C.J. Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochemical Pharmacology 2000, 60:307-315.
36. Wallach S.L. The side effects of allopurinol. Hospital Practice (Minneap) 1998, 33:22.
37. Wu X., Wakamiya M., Vaishnav S., Geske R., Montgomery C., Jones P., Bradley A., Caskey C.T. Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:742-746.
38. Yonetani Y., Ishii M., Iwaki K. Hyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats. The Japanese Journal of Pharmacology 1980, 30:829-840.