-
1
-
-
0020596551
-
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
-
F. Barré-Sinoussi, J.C. Chermann, F. Rey, M.T. Nugeyre, S. Chamaret, J. Gruest, C. Dauguet, C. Axler-Blin, F. Vézinet-Brun, C. Rouzioux, W. Rozenbaum, and L. Montagnier Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) Science 220 1983 868 871
-
(1983)
Science
, vol.220
, pp. 868-871
-
-
Barré-Sinoussi, F.1
Chermann, J.C.2
Rey, F.3
Nugeyre, M.T.4
Chamaret, S.5
Gruest, J.6
Dauguet, C.7
Axler-Blin, C.8
Vézinet-Brun, F.9
Rouzioux, C.10
Rozenbaum, W.11
Montagnier, L.12
-
2
-
-
0020532060
-
Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)
-
R.C. Gallo, P.S. Sarin, E.P. Gelmann, M. Robert-Guroff, E. Richardson, V.S. Kalyanaraman, D. Mann, G.D. Sidhu, R.E. Stahl, S. Zolla-Pazner, J. Leibowitch, and M. Popovic Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS) Science 220 1983 865 867 (Pubitemid 13080156)
-
(1983)
Science
, vol.220
, Issue.4599
, pp. 865-867
-
-
Gallo, R.C.1
Sarin, P.S.2
Gelmann, E.P.3
-
3
-
-
0037249691
-
Long-term HIV/AIDS survival estimation in the highly active antiretroviral therapy era
-
DOI 10.1177/0272989X02239652
-
J.T. King Jr., A.C. Justice, M.S. Roberts, C.C. Chang, and J.S. Fusco Collaboration in HIV outcomes research - U.S. Program Team. Long-term HIV-AIDS survival estimation in the highly active antiretroviral therapy era Med. Decis. Making 23 2003 9 20 (Pubitemid 36133356)
-
(2003)
Medical Decision Making
, vol.23
, Issue.1
, pp. 9-20
-
-
King Jr., J.T.1
Justice, A.C.2
Roberts, M.S.3
Chang, C.-C.H.4
Fusco, J.S.5
-
4
-
-
0035882308
-
Initial virological and immunologic response to highly active antiretroviral therapy predicts long-term clinical outcome
-
DOI 10.1086/321900
-
C.M. Kitchen, S.G. Kitchen, J.A. Dubin, and M.S. Gottieb Initial virological and immunologic response to highly active antiretroviral therapy predicts long-term clinical outcome Clin. Infect. Dis. 33 2001 466 472 (Pubitemid 32709577)
-
(2001)
Clinical Infectious Diseases
, vol.33
, Issue.4
, pp. 466-472
-
-
Kitchen, C.M.1
Kitchen, S.G.2
Dubin, J.A.3
Gottlieb, M.S.4
-
5
-
-
0034977285
-
HAART is a cost-effective and improves outcomes
-
W.M. Valenti HAART is a cost-effective and improves outcomes AIDS Reader 11 2001 260 262
-
(2001)
AIDS Reader
, vol.11
, pp. 260-262
-
-
Valenti, W.M.1
-
6
-
-
0043069555
-
Toxicity of antiretroviral therapy and implications for drug development
-
A. Carr Toxicity of antiretroviral therapy and implications for drug development Nat. Rev. Drug Discov. 2 2003 624 634 (Pubitemid 37361766)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.8
, pp. 624-634
-
-
Carr, A.1
-
7
-
-
12944335238
-
Antiretroviral resistance during successful therapy of HIV type 1 infection
-
J. Martinez-Picado, M.P. De Pasquale, N. Kartsonis, G.J. Hanna, J. Wong, D. Finzi, E. Rosenberg, H.F. Gunthard, L. Sutton, A. Savara, C.J. Petropoulos, N. Hellmann, B.D. Walker, D.D. Richman, R. Siliciano, and R.T. D'Aquila Antiretroviral resistance during successful therapy of HIV type 1 infection Proc. Natl. Acad. Sci. U.S.A.U. S. A. 97 2000 10948 10953
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.U. S. A.
, vol.97
, pp. 10948-10953
-
-
Martinez-Picado, J.1
De Pasquale, M.P.2
Kartsonis, N.3
Hanna, G.J.4
Wong, J.5
Finzi, D.6
Rosenberg, E.7
Gunthard, H.F.8
Sutton, L.9
Savara, A.10
Petropoulos, C.J.11
Hellmann, N.12
Walker, B.D.13
Richman, D.D.14
Siliciano, R.15
D'Aquila, R.T.16
-
8
-
-
0037043652
-
Antiretroviral-drug resistance among patients recently infected with HIV
-
DOI 10.1056/NEJMoa013552
-
S.J. Little, S. Holte, J.P. Routy, E.S. Daar, M. Markowitz, A.C. Collier, R.A. Koup, J.W. Mellors, E. Connick, B. Conway, M. Kilby, L. Wang, J.M. Whitcomb, N.S. Hellmann, and D.D. Richman Antiretroviral-drug resistance among patients recently infected with HIV N. Engl. J. Med. 347 2002 385 394 (Pubitemid 34851830)
-
(2002)
New England Journal of Medicine
, vol.347
, Issue.6
, pp. 385-394
-
-
Little, S.J.1
Holte, S.2
Routy, J.-P.3
Daar, E.S.4
Markowitz, M.5
Collier, A.C.6
Koup, R.A.7
Mellors, J.W.8
Connick, E.9
Conway, B.10
Kilby, M.11
Wang, L.12
Whitcomb, J.M.13
Hellmann, N.S.14
Richman, D.D.15
-
9
-
-
0021237243
-
Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
-
M. Popovic, M.G. Sarngadharan, E. Read, and R.C. Gallo Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS Science 224 1984 497 500 (Pubitemid 14134740)
-
(1984)
Science
, vol.224
, Issue.4648
, pp. 497-500
-
-
Popovic, M.1
Sarngadharan, M.G.2
Read, E.3
Gallo, R.C.4
-
10
-
-
73549103358
-
The development of antiretroviral therapy and its impact on the global HIV-1/AIDS pandemic
-
S. Broder The development of antiretroviral therapy and its impact on the global HIV-1/AIDS pandemic Antiviral Res. 85 2010 1 18
-
(2010)
Antiviral Res.
, vol.85
, pp. 1-18
-
-
Broder, S.1
-
11
-
-
0001707601
-
3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
-
DOI 10.1073/pnas.82.20.7096
-
H. Mitsuya, K.J. Weinhold, P.A. Furman, St. M.H. Clair, S.N. Lehrman, R.C. Gallo, D. Bolognesi, D.W. Barry, and S. Broder 3′-Azido-3′- deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy- associated virus in vitro Proc. Natl. Acad. Sci. U.S.A.U. S. A. 82 1985 7096 7100 (Pubitemid 16209699)
-
(1985)
Proceedings of the National Academy of Sciences of the United States of America
, vol.82
, Issue.20
, pp. 7096-7100
-
-
Mitsuya, H.1
Weinhold, K.J.2
Furman, P.A.3
-
12
-
-
0030979361
-
Antiretroviral therapy for HIV infection in 1997: Updated recommendations of the International AIDS Society-USA panel
-
C.C. Carpenter, M.A. Fischl, S.M. Hammer, M.S. Hirsch, D.M. Jacobsen, D.A. Katzenstein, J.S. Montaner, D.D. Richman, M.S. Saag, R.T. Schooley, M.A. Thompson, S. Vella, P.G. Yeni, and P.A. Volberding Antiretroviral therapy for HIV infection in 1997. Updated recommendations of the International AIDS Society-USA panel JAMA 277 1997 1962 1969 (Pubitemid 27272775)
-
(1997)
Journal of the American Medical Association
, vol.277
, Issue.24
, pp. 1962-1969
-
-
Carpenter, C.C.J.1
Fischl, M.A.2
Hammer, S.M.3
Hirsch, M.S.4
Jacobsen, D.M.5
Katzenstein, D.A.6
Montaner, J.S.G.7
Richman, D.D.8
Saag, M.S.9
Schooley, R.T.10
Thompson, M.A.11
Vella, S.12
Yeni, P.G.13
Volberding, P.A.14
-
13
-
-
0023265911
-
The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: A comparison with their parental 2',3'-dideoxyribonucleosides
-
J. Balzarini, G.J. Kang, M. Dalal, P. Herdewijn, E. De Clercq, S. Broder, and D.G. Johns The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2′,3′-didehydro-2′,3′-dideoxyribonucleosides: a comparison with their parental 2′,3′-dideoxyribonucleosides Mol. Pharmacol. 32 1987 162 167 (Pubitemid 17112329)
-
(1987)
Molecular Pharmacology
, vol.32
, Issue.1
, pp. 162-167
-
-
Balzarini, J.1
Kang, G.-J.2
Dalal, M.3
-
14
-
-
0030982931
-
1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity
-
S.M. Daluge, S.S. Good, M.B. Faletto, W.H. Miller, St.M.H. Clair, L.R. Boone, M. Tisdale, N.R. Parry, J.E. Reardon, R.E. Dornsife, D.R. Averett, and T.A. Krenitsky 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity Antimicrob. Agents Chemother. 41 1997 1082 1093 (Pubitemid 27194190)
-
(1997)
Antimicrobial Agents and Chemotherapy
, vol.41
, Issue.5
, pp. 1082-1093
-
-
Daluge, S.M.1
Good, S.S.2
Faletto, M.B.3
Miller, W.H.4
St. Clair, M.H.5
Boone, L.R.6
Tisdale, M.7
Parry, N.R.8
Reardon, J.E.9
Dornsife, R.E.10
Averett, D.R.11
Krenitsky, T.A.12
-
15
-
-
0028230923
-
Anti-human immunodeficiency virus activities of the β-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro
-
G. Gosselin, R.F. Schinazi, J.P. Sommadossi, C. Mathe, M.C. Bergogne, A.M. Aubertin, A. Kirn, and J.L. Imbach Antihuman immunodeficiency virus activities of the beta-L enantiomer of 2′,3′-dideoxycytidine and its 5-fluoro derivative in vitro Antimicrob. Agents Chemother. 38 1994 1292 1297 (Pubitemid 24170709)
-
(1994)
Antimicrobial Agents and Chemotherapy
, vol.38
, Issue.6
, pp. 1292-1297
-
-
Gosselin, G.1
Schinazi, R.F.2
Sommadossi, J.-P.3
Mathe, C.4
Bergogne -, M.C.5
Aubertin, A.-M.6
Kirn, A.7
Imbach, J.-L.8
-
16
-
-
0026480950
-
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]cytosine
-
R.F. Schinazi, A. McMillan, D. Cannon, R. Mathis, R.M. Lloyd, A. Peck, J.P. Sommadossi, St M.J. Clair, J. Wilson, P.A. Furman, G. Painter, W.-B. Choi, and D.C. Liotta Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]cytosine Antimicrob. Agents Chemother. 36 1992 2423 2431
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 2423-2431
-
-
Schinazi, R.F.1
McMillan, A.2
Cannon, D.3
Mathis, R.4
Lloyd, R.M.5
Peck, A.6
Sommadossi, J.P.7
Clair, S.M.J.8
Wilson, J.9
Furman, P.A.10
Painter, G.11
Choi, W.-B.12
Liotta, D.C.13
-
17
-
-
0028205185
-
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives
-
J. Balzarini Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives Pharm. World Soc. 16 1994 113 126 (Pubitemid 24142453)
-
(1994)
Pharmacy World and Science
, vol.16
, Issue.2
, pp. 113-126
-
-
Balzarini, J.1
-
18
-
-
0025122369
-
Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2', 3'-dideoxyuridine-5'- triphosphate
-
Z. Hao, D.A. Cooney, D. Farquhar, C.F. Perno, K. Zhang, R. Masood, Y. Wilson, N.R. Hartman, J. Balzarini, and D.G. Johns DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2′,3′-dideoxyuridine-5′-triphosphate Mol. Pharmacol. 37 1990 157 163 (Pubitemid 20082978)
-
(1990)
Molecular Pharmacology
, vol.37
, Issue.2
, pp. 157-163
-
-
Hao, Z.1
Cooney, D.A.2
Farquhar, D.3
Perno, C.F.4
Zhang, K.5
Masood, R.6
Wilson, Y.7
Hartman, N.R.8
Balzarini, J.9
Johns, D.G.10
-
19
-
-
0032819048
-
Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2'-deoxy-3'-oxa-4'-thiocytidine
-
J.M. De Muys, H. Gourdeau, N. Nguyen-Ba, D.L. Taylor, P.S. Ahmed, T. Mansour, C. Locas, N. Richard, M.A. Wainberg, and R.F. Rando Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2′-deoxy-3′-oxa-4′-thiocytidine Antimicrob. Agents Chemother. 43 1999 1835 1844 (Pubitemid 29395173)
-
(1999)
Antimicrobial Agents and Chemotherapy
, vol.43
, Issue.8
, pp. 1835-1844
-
-
De Muys, J.-M.1
Gourdeau, H.2
Nguyen-Ba, N.3
Taylor, D.L.4
Ahmed, P.S.5
Mansour, T.6
Locas, C.7
Richard, N.8
Wainberg, M.A.9
Rando, R.F.10
-
20
-
-
0026480950
-
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]cytosine
-
R.F. Schinazi, A. McMillan, D. Cannon, R. Mathis, R.M. Lloyd, A. Peck, J.P. Sommadossi, St.M. Clair, J. Wilson, P.A. Furman, G. Painter, W.-B. Choi, and D.C. Liotta Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]cytosine Antimicrob. Agents Chemother. 36 1992 2423 2431
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 2423-2431
-
-
Schinazi, R.F.1
McMillan, A.2
Cannon, D.3
Mathis, R.4
Lloyd, R.M.5
Peck, A.6
Sommadossi, J.P.7
Clair, St.M.8
Wilson, J.9
Furman, P.A.10
Painter, G.11
Choi, W.-B.12
Liotta, D.C.13
-
21
-
-
0027534937
-
L-β-(2S,4S)- and L-α-(2S,4R)-dioxolanyl nucleosides as potential anti- HIV agents: Asymmetric synthesis and structure-activity relationships
-
H.O. Kim, R.F. Schinazi, K. Shanmuganathan, L.S. Jeong, J.W. Beach, S. Nampalli, D.L. Cannon, and C.K. Chu L-β-(2S, 4S)- and L-α-(2S,4R)- Dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships J. Med. Chem. 36 1993 519 528 (Pubitemid 23097416)
-
(1993)
Journal of Medicinal Chemistry
, vol.36
, Issue.5
, pp. 519-528
-
-
Kim, H.O.1
Schinazi, R.F.2
Shanmuganathan, K.3
Jeong, L.S.4
Beach, J.W.5
Nampalli, S.6
Cannon, D.L.7
Chu, C.K.8
-
22
-
-
0028047132
-
Antiviral activity of β-L(-)-2′,3′-dideoxy-5-fluoro- cytidine (L(-)ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro
-
T.S. Lin, M.Z. Luo, M.C. Liu, S.B. Pai, G.E. Dutschman, and Y.C. Cheng Antiviral activity of β-L(-)-2′,3′-dideoxy-5-fluoro-cytidine (L(-)ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro Biochem. Pharmacol. 47 1994 171 174
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 171-174
-
-
Lin, T.S.1
Luo, M.Z.2
Liu, M.C.3
Pai, S.B.4
Dutschman, G.E.5
Cheng, Y.C.6
-
23
-
-
26044432728
-
In vitro activity of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor (NRTI), against 215 HIV-1 isolates resistant to other NRTIs
-
R.C. Bethell, Y.S. Lie, and N.T. Parkin In vitro activity of SPD754, a new deoxycitidine nucleoside reverse transcriptase inhibitor (NRTI), against 215 HIV-1 isolates resistant to other NRTIs, Antiviral Chem. Chemother. 16 2005 295 302 (Pubitemid 41405996)
-
(2005)
Antiviral Chemistry and Chemotherapy
, vol.16
, Issue.5
, pp. 295-302
-
-
Bethell, R.C.1
Lie, Y.S.2
Parkin, N.T.3
-
24
-
-
31944441500
-
In vitro antiretroviral activity and in vitro toxicity profile of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus infection
-
DOI 10.1128/AAC.50.2.625-631.2006
-
Z. Gu, B. Allard, J.M. de Muys, J. Lippens, R.F. Rando, N. Nguyen-Ba, C. Ren, P. McKenna, D.L. Taylor, and R.C. Bethell In vitro antiretroviral activity and in vitro toxicity profile of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus infection Antimicrob. Agents Chemother. 50 2006 625 631 (Pubitemid 43190975)
-
(2006)
Antimicrobial Agents and Chemotherapy
, vol.50
, Issue.2
, pp. 625-631
-
-
Gu, Z.1
Allard, B.2
De Muys, J.M.3
Lippens, J.4
Rando, R.F.5
Nguyen-Ba, N.6
Ren, C.7
McKenna, P.8
Taylor, D.L.9
Bethell, R.C.10
-
25
-
-
33745869106
-
Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients
-
DOI 10.1097/01.aids.0000232233.41877.63, PII 0000203020060612000006
-
P. Cahn, I. Cassetti, R. Wood, P. Phanuphak, L. Shiveley, R.C. Bethell, and J. Sawyer Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naïve, HIV-infected patients AIDS 20 2006 1261 1268 (Pubitemid 44030374)
-
(2006)
AIDS
, vol.20
, Issue.9
, pp. 1261-1268
-
-
Cahn, P.1
Cassetti, I.2
Wood, R.3
Phanuphak, P.4
Shiveley, L.5
Bethell, R.C.6
Sawyer, J.7
-
26
-
-
65149105330
-
Safety profile of apricitabine, a novel NRTI, during 24-week dosing in experienced HIV-1 infected patients
-
Mexico City, Mexico, August 3-8 abstract no. TUAB0106
-
S. Cox, S. Moore, J. Southby, and A. Alsumbe Safety profile of apricitabine, a novel NRTI, during 24-week dosing in experienced HIV-1 infected patients XVII International AIDS Conference Mexico City, Mexico, August 3-8 2008 abstract no. TUAB0106
-
(2008)
XVII International AIDS Conference
-
-
Cox, S.1
Moore, S.2
Southby, J.3
Alsumbe, A.4
-
27
-
-
34547229756
-
The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naïve HIV-1-infected patients
-
DOI 10.1310/hct0803-164
-
I. Cassetti, J.V.R. Madruga, J.M.A.H. Suleiman, A. Etzel, L.J. Zhong, A.K. Cheng, and J. Enejosa The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naïve HIV-1-infected patients HIV Clin. Trials 8 2007 164 172 (Pubitemid 47121761)
-
(2007)
HIV Clinical Trials
, vol.8
, Issue.3
, pp. 164-172
-
-
Cassetti, I.1
Madruga, J.V.R.2
Suleiman, J.M.A.H.3
Etzel, A.4
Zhong, L.5
Cheng, A.K.6
Enejosa, J.7
-
28
-
-
3042848853
-
Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: A 3-year randomized trial
-
DOI 10.1001/jama.292.2.191
-
J.E. Gallant, S. Straszewski, A.L. Pozniak, E. DeJesus, J.M.A.H. Suleiman, M.D. Miller, D.F. Coakley, B. Lu, J.J. Toole, and A.K. Cheng Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naïve patients. A 3-year randomized trial JAMA 292 2004 191 201 (Pubitemid 38917996)
-
(2004)
Journal of the American Medical Association
, vol.292
, Issue.2
, pp. 191-201
-
-
Gallant, J.E.1
Staszewski, S.2
Pozniak, A.L.3
DeJesus, E.4
Suleiman, J.M.A.H.5
Miller, M.D.6
Coakley, D.F.7
Lu, B.8
Toole, J.J.9
Cheng, A.K.10
-
29
-
-
39049101609
-
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-Week analysis
-
DOI 10.1097/QAI.0b013e31815acab8, PII 0012633420080101000009
-
J.R. Arribas, A.L. Pozniak, J.E. Gallant, E. Dejesus, B. Gazzard, R.E. Campo, S.S. Chen, D. McColl, C.B. Holmes, J. Enejosa, J.J. Toole, and A.K. Cheng Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naïve patients: 144-week analysis J. Acquir. Defic. Syndr. 47 2008 74 78 (Pubitemid 351619372)
-
(2008)
Journal of Acquired Immune Deficiency Syndromes
, vol.47
, Issue.1
, pp. 74-78
-
-
Arribas, J.R.1
Pozniak, A.L.2
Gallant, J.E.3
DeJesus, E.4
Gazzard, B.5
Campo, R.E.6
Chen, S.-S.7
McColl, D.8
Holmes, C.B.9
Enejosa, J.10
Toole, J.J.11
Cheng, A.K.12
-
30
-
-
33846697977
-
GS9148: A novel nucleotide active against HIV-1 variants with drug resistance mutations in reverse transcriptase
-
Denver, CO, February 5-8 abstract no. 45
-
T. Cihlar, A. Ray, D. Boojamra, L. Zhang, H. Hui, D. Grant, K. White, M. Desai, N. Parkin, and R. Mackman GS9148: a novel nucleotide active against HIV-1 variants with drug resistance mutations in reverse transcriptase 13th Conference on Retroviruses and Opportunistic Infections Denver, CO, February 5-8 2006 abstract no. 45
-
(2006)
13th Conference on Retroviruses and Opportunistic Infections
-
-
Cihlar, T.1
Ray, A.2
Boojamra, D.3
Zhang, L.4
Hui, H.5
Grant, D.6
White, K.7
Desai, M.8
Parkin, N.9
MacKman, R.10
-
31
-
-
12144265244
-
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): Past, present and future
-
E. De Clercq Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present and future Chem. Biodivers. 1 2004 44 64
-
(2004)
Chem. Biodivers.
, vol.1
, pp. 44-64
-
-
De Clercq, E.1
-
32
-
-
0024832408
-
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative
-
DOI 10.1016/0006-291X(89)92756-3
-
M. Baba, H. Tanaka, E. De Clercq, R. Pauwels, J. Balzarini, D. Schols, H. Nakashima, C.-F. Perno, R.T. Walker, and T. Miyasaka Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative Biochem. Biophys. Res. Commun. 165 1989 1375 1381 (Pubitemid 20029862)
-
(1989)
Biochemical and Biophysical Research Communications
, vol.165
, Issue.3
, pp. 1375-1381
-
-
Baba, M.1
Tanaka, H.2
De Clercq, E.3
Pauwels, R.4
Balzarini, J.5
Schols, D.6
Nakashima, H.7
Perno, C.-F.8
Walker, R.T.9
Miyasaka, T.10
-
33
-
-
0025679303
-
Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor
-
V.J. Merluzzi, K.D. Hargrave, M. Labadia, K. Grozinger, M. Skoog, J.C. Wu, C.K. Shih, K. Eckner, S. Hattox, J. Adams, A.S. Rosenthal, R. Faanes, R.J. Eckner, R.A. Koup, and J.L. Sullvian Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor Science 250 1990 1411 1413 (Pubitemid 120031860)
-
(1990)
Science
, vol.250
, Issue.4986
, pp. 1411-1413
-
-
Merluzzi, V.J.1
Hargrave, K.D.2
Labadia, M.3
Grozinger, K.4
Skoog, M.5
Wu, J.C.6
Shih, C.-K.7
Eckner, K.8
Hattox, S.9
Adams, J.10
Rosehthal, A.S.11
Faanes, R.12
Eckner, R.J.13
Koup, R.A.14
Sullivan, J.L.15
-
34
-
-
15444370583
-
New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections
-
DOI 10.1016/j.coph.2004.07.005, PII S1471489204001304
-
R. Pauwels New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections Curr. Opin. Pharmacol. 4 2004 437 446 (Pubitemid 40533003)
-
(2004)
Current Opinion in Pharmacology
, vol.4
, Issue.5
, pp. 437-446
-
-
Pauwels, R.1
-
35
-
-
0025014499
-
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
-
R. Pauwels, K. Andries, J. Desmyter, D. Schols, M.J. Kukla, H.J. Breslin, A. Raeymaeckers, J. Van Gelder, R. Woestenborghs, J. Heykants, K. Schellekens, M.A.C. Janssen, E. De Clercq, and P.A. Janssen Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives Nature 343 1990 470 474 (Pubitemid 120028562)
-
(1990)
Nature
, vol.343
, Issue.6257
, pp. 470-474
-
-
Pauwels, R.1
Andries, K.2
Desmyter, J.3
Schols, D.4
Kukla, M.J.5
Breslin, H.J.6
Raeymaeckers, A.7
Van Gelder, J.8
Woestenborghs, R.9
Heykants, J.10
Schellekens, K.11
Janssen, M.A.C.12
De Clercq, E.13
Janssen, P.A.J.14
-
36
-
-
0009505878
-
R165335-TMC125, a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) with nanomolar activity against NNRTI resistant HIV strains
-
Toronto, Canada, September 17-20 abstract no. 1840
-
K. Andries, M.-p. de Bethune, M.J. Kukla, H. Azijn, P.J. Lewi, P.A.J. Janssen, and R. Pauwels R165335-TMC125, a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) with nanomolar activity against NNRTI resistant HIV strains 40th Interscience Conference on Antimicrobial Agents and Chemotherapy Toronto, Canada, September 17-20 2000 abstract no. 1840
-
(2000)
40th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Andries, K.1
Bethune2
Kukla, M.J.3
Azijn, H.4
Lewi, P.J.5
Janssen, P.A.J.6
Pauwels, R.7
-
37
-
-
0027178052
-
U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication
-
T.J. Dueweke, S.M. Poppe, D.L. Romero, S.M. Swaney, A.G. So, K.M. Downer, I.W. Althaus, F. Reusser, M. Busso, L. Resnick, D. Mayers, J. Lane, P.A. Aristoff, R.C. Thomas, and W.G. Tarpley U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication Antimicrob. Agents Chemother. 37 1993 1127 1131 (Pubitemid 23141331)
-
(1993)
Antimicrobial Agents and Chemotherapy
, vol.37
, Issue.5
, pp. 1127-1131
-
-
Dueweke, T.J.1
Poppe, S.M.2
Romero, D.L.3
Swaney, S.M.4
So, A.G.5
Downey, K.M.6
Althaus, I.W.7
Reusser, F.8
Busso, M.9
Resnick, L.10
Mayers, D.L.11
Lane, J.12
Aristoff, P.A.13
Thomas, R.C.14
Tarpley, W.G.15
-
38
-
-
2942565660
-
Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors
-
DOI 10.1016/j.biocel.2004.02.026, PII S1357272504000937, Molecular Biology of HIV
-
R.A. Domaoal, and L.M. Demeter Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors Int. J. Biochem. Cell Biol. 36 2004 1735 1751 (Pubitemid 38750243)
-
(2004)
International Journal of Biochemistry and Cell Biology
, vol.36
, Issue.9
, pp. 1735-1751
-
-
Domaoal, R.A.1
Demeter, L.M.2
-
39
-
-
20144372481
-
In search of a novel anti-HIV drug: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine)
-
DOI 10.1021/jm040840e
-
P.A. Janssen, P.J. Lewi, E. Arnold, F. Daeyaert, M. De Jonge, J. Heeres, L. Koymans, M. Vinkers, J. Guillemont, E. Pasquier, M. Kukla, D. Ludovici, K. Andries, and M.P. De Bethune In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[4-[[4-[(1E)-2, 6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine) J. Med. Chem. 48 2005 1901 1909 (Pubitemid 40396320)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.6
, pp. 1901-1909
-
-
Janssen, P.A.J.1
Lewi, P.J.2
Arnold, E.3
Daeyaert, F.4
De Jonge, M.5
Heeres, J.6
Koymans, L.7
Vinkers, M.8
Guillemont, J.9
Pasquier, E.10
Kukla, M.11
Ludovici, D.12
Andries, K.13
De Bethune, M.-P.14
Pauwels, R.15
Das, K.16
Clark Jr., A.D.17
Frenkel, Y.V.18
Hughes, S.H.19
Medaer, B.20
De Knaep, F.21
Bohets, H.22
De Clerck, F.23
Lampo, A.24
Williams, P.25
Stoffels, P.26
more..
-
40
-
-
13344277278
-
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers
-
DOI 10.1021/jm950797i
-
M.T. Flavin, J.D. Rizzo, A. Khilevich, A. Kucherenko, A.K. Shwinkman, V. Vilaychack, L. Lin, W. Chen, E.M. Greenwood, T. Pengsuparp, J.M. Pezzuto, S.H. Hughes, T.M. Flavin, W.A. Boulanger, R.L. Shone, and Z.Q. Xu Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+)-calanolide A and its enantiomers J. Med. Chem. 39 1996 1303 1313 (Pubitemid 26089845)
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, Issue.6
, pp. 1303-1313
-
-
Flavin, M.T.1
Rizzo, J.D.2
Khilevich, A.3
Kucherenko, A.4
Sheinkman, A.K.5
Vilaychack, V.6
Lin, L.7
Chen, W.8
Greenwood, E.M.9
Pengsuparp, T.10
Pezzuto, J.M.11
Hughes, S.H.12
Flavin, T.M.13
Cibulski, M.14
Boulanger, W.A.15
Shone, R.L.16
Xu, Z.-Q.17
-
41
-
-
46749140428
-
IDX12899 and IDX12989, novel NNRTI with potent anti-HIV activity, enhanced barrier to resistance and favorable pharmacokinetic profile
-
Los Angeles, February 25-28 CA abstract 489
-
D.D. Richman, C.B. Dousson, R. Storer, A. Moussa, J. Randall, E. Bridges, M. Liuzzi, J. Jakubik, M. Seifer, and D. Standring IDX12899 and IDX12989, novel NNRTI with potent anti-HIV activity, enhanced barrier to resistance and favorable pharmacokinetic profile 14th Conference on Retroviruses and Opportunistic Infections Los Angeles, February 25-28 2007 CA abstract 489
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
-
-
Richman, D.D.1
Dousson, C.B.2
Storer, R.3
Moussa, A.4
Randall, J.5
Bridges, E.6
Liuzzi, M.7
Jakubik, J.8
Seifer, M.9
Standring, D.10
-
42
-
-
50349090435
-
MIV-150 in a vaginal microbicide with superior anti-HIV activities
-
Bangkok, Thailand, July 12-16 abstract no. TuPeB4667
-
H. Zhang, B. Oberg, D. Bottiger, D. Phillips, J.F. Romeo, M. Thom, and L. Vrang MIV-150 in a vaginal microbicide with superior anti-HIV activities Presented at the XV International AIDS Conference Bangkok, Thailand, July 12-16 2004 abstract no. TuPeB4667
-
(2004)
Presented at the XV International AIDS Conference
-
-
Zhang, H.1
Oberg, B.2
Bottiger, D.3
Phillips, D.4
Romeo, J.F.5
Thom, M.6
Vrang, L.7
-
43
-
-
77249102156
-
The discovery of RDEA806, a potent new HIV NNRTI in phase 1 clinical trials
-
Chicago, IL, September 17-20 abstract no. 3285
-
J.-L. Girardet, Y.-H. Koh, M. De La Rosa, E. Gunic, Z. Zhang, R. Hamatake, and L. Yeh The discovery of RDEA806, a potent new HIV NNRTI in phase 1 clinical trials 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago, IL, September 17-20 2007 abstract no. 3285
-
(2007)
47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Girardet, J.-L.1
Koh, Y.-H.2
De La Rosa, M.3
Gunic, E.4
Zhang, Z.5
Hamatake, R.6
Yeh, L.7
-
44
-
-
33646545948
-
Antiviral characterization and human experience with BILR 355 BS, a novel next-generation non-nucleoside reverse transcriptase inhibitor with a broad anti HIV-1 profile
-
Boston, MA, February 22-25 abstract no. 558
-
P. Bonneau, P. Robinson, J. Duan, L. Doyon, B. Simoneau, C. Yoakim, M. Garneau, M. Bos, M. Cordingley, B. Brenner, B. Spira, M. Wainberg, F. Huang, K. Drda, C. Ballow, and D. Mayers Antiviral characterization and human experience with BILR 355 BS, a novel next-generation non-nucleoside reverse transcriptase inhibitor with a broad anti HIV-1 profile 12th Conference on Retroviruses and Opportunistic Infections Boston, MA, February 22-25 2005 abstract no. 558
-
(2005)
12th Conference on Retroviruses and Opportunistic Infections
-
-
Bonneau, P.1
Robinson, P.2
Duan, J.3
Doyon, L.4
Simoneau, B.5
Yoakim, C.6
Garneau, M.7
Bos, M.8
Cordingley, M.9
Brenner, B.10
Spira, B.11
Wainberg, M.12
Huang, F.13
Drda, K.14
Ballow, C.15
Mayers, D.16
-
45
-
-
46749104685
-
Improving non-nucleoside reverse transcriptase inhibitors for first-line treatment of HIV infection: The development pipeline and recent clinical data
-
Z.K. Sweeney, and K. Klumpp Improving non-nucleoside reverse transcriptase inhibitors for first-line treatment of HIV infection: the development pipeline and recent clinical data Curr. Opin. Drug Discov. Devel. 11 2008 458 470 (Pubitemid 351950841)
-
(2008)
Current Opinion in Drug Discovery and Development
, vol.11
, Issue.4
, pp. 458-470
-
-
Sweeney, Z.K.1
Klumpp, K.2
-
46
-
-
0026647540
-
HIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivative from the tropical rain forest tree, Calophyllum lanigerum
-
Y. Kashman, K.R. Gustafson, R.W. Fuller, J.H. Cardellina, J.B. McMohan, M.J. Currens, R.W. Buckheit, S.H. Hughes, G.M. Cragg, and M.R. Boyd HIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivative from the tropical rain forest tree, Calophyllum lanigerum J. Med. Chem. 35 1992 2735 2743
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2735-2743
-
-
Kashman, Y.1
Gustafson, K.R.2
Fuller, R.W.3
Cardellina, J.H.4
McMohan, J.B.5
Currens, M.J.6
Buckheit, R.W.7
Hughes, S.H.8
Cragg, G.M.9
Boyd, M.R.10
-
47
-
-
14944344464
-
New approaches toward anti-HIV chemotherapy
-
DOI 10.1021/jm040158k
-
E. De Clercq New approaches towards anti-HIV chemotherapy J. Med. Chem. 48 2005 1297 1313 (Pubitemid 40364540)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.5
, pp. 1297-1313
-
-
De Clercq, E.1
-
48
-
-
34548239620
-
Darunavir (TMC114): A new HIV-1 protease inhibitor
-
DOI 10.1517/14656566.8.12.1951
-
J.M. Molina, and A. Hill Darunavir (TMC114): a new HIV-1 protease inhibitor Expert Opin. Pharmacother. 8 2007 1951 1964 (Pubitemid 47316150)
-
(2007)
Expert Opinion on Pharmacotherapy
, vol.8
, Issue.12
, pp. 1951-1964
-
-
Molina, J.-M.1
Hill, A.2
-
49
-
-
30444449824
-
Tipranavir
-
DOI 10.1358/dot.2005.41.11.937960
-
Z. Temesgen, F. Cainelli, and S. Vento Tipranavir Drugs Today 41 2005 711 720 (Pubitemid 43074781)
-
(2005)
Drugs of Today
, vol.41
, Issue.11
, pp. 711-720
-
-
Temesgen, Z.1
Cainelli, F.2
Vento, S.3
-
51
-
-
0029840569
-
Ritonavir
-
A.P. Lea, and D. Faulds Ritonavir Drugs 52 1996 541 546
-
(1996)
Drugs
, vol.52
, pp. 541-546
-
-
Lea, A.P.1
Faulds, D.2
-
52
-
-
0033401920
-
Indinavir. A review of its use in the management of HIV infection
-
G.L. Plosker, and S. Noble Indinavir: a review of its use in the management of HIV infection Drugs 58 1999 1165 1203 (Pubitemid 30055050)
-
(1999)
Drugs
, vol.58
, Issue.6
, pp. 1165-1203
-
-
Plosker, G.L.1
Noble, S.2
-
55
-
-
0035160110
-
Lopinavir-ritonavir: A new protease inhibitor
-
E.M. Mangum, and K.K. Graham Lopinavir-ritonavir: a new protease inhibitor Pharmacotherapy 21 2001 1352 1363
-
(2001)
Pharmacotherapy
, vol.21
, pp. 1352-1363
-
-
Mangum, E.M.1
Graham, K.K.2
-
56
-
-
4544227361
-
Fosamprenavir: Advancing HIV protease inhibitor treatment options
-
DOI 10.1517/14656566.5.9.1995
-
S. Becker, and L. Thornton Fosamprenavir: advancing HIV protease inhibitor treatment options Expert Opin. Pharmacother. 5 2004 1995 2005 (Pubitemid 39236600)
-
(2004)
Expert Opinion on Pharmacotherapy
, vol.5
, Issue.9
, pp. 1995-2005
-
-
Becker, S.1
Thornton, L.2
-
58
-
-
1642391068
-
Enfuvirtide: The first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes
-
T. Matthews, M. Salgo, M. Greenberg, J. Chung, R. DeMasi, and D. Bolognesi Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes Nat. Rev. Drug Discov. 3 2004 215 225 (Pubitemid 38379988)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.3
, pp. 215-225
-
-
Matthews, T.1
Salgo, M.2
Greenberg, M.3
Chung, J.4
DeMasi, R.5
Bolognesi, D.6
-
59
-
-
0027692502
-
A synthetic peptide from HIV-1 gp41is a potent inhibitor of virus-mediated cell-cell fusion
-
C. Wild, T. Greenwell, and T. Matthews A synthetic peptide from HIV-1 gp41is a potent inhibitor of virus-mediated cell-cell fusion AIDS Res. Hum. Retroviruses 9 1993 1051 1053
-
(1993)
AIDS Res. Hum. Retroviruses
, vol.9
, pp. 1051-1053
-
-
Wild, C.1
Greenwell, T.2
Matthews, T.3
-
60
-
-
0037126834
-
Design of a protein surface antagonist based on α-helix mimicry: Inhibition of gp41 assembly and viral fusion
-
DOI 10.1002/1521-3773(20020118)41:2<278::AID-ANIE278>3.0.CO;2-A
-
J.T. Ernst, O. Kutzki, A.K. Debnath, S. Jiang, H. Lu, and A.D. Hamilton Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion Angew. Chem. Int. Ed. 41 2002 278 281 (Pubitemid 34118069)
-
(2002)
Angewandte Chemie - International Edition
, vol.41
, Issue.2
, pp. 278-281
-
-
Ernst, J.T.1
Kutzki, O.2
Debnath, A.K.3
Jiang, S.4
Lu, H.5
Hamilton, A.D.6
-
61
-
-
0042376485
-
A new classification for HIV-1
-
E.A. Berger, R.W. Doms, E.M. Fenyo, B.T. Korber, D.R. Littman, J.P. Moore, Q.J. Sattentau, H. Schuitemaker, J. Sodroski, and R.A. Weiss A new classification for HIV-1 Nature 392 1998 240
-
(1998)
Nature
, vol.392
, pp. 240
-
-
Berger, E.A.1
Doms, R.W.2
Fenyo, E.M.3
Korber, B.T.4
Littman, D.R.5
Moore, J.P.6
Sattentau, Q.J.7
Schuitemaker, H.8
Sodroski, J.9
Weiss, R.A.10
-
62
-
-
27644510382
-
Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
-
DOI 10.1128/AAC.49.11.4721-4732.2005
-
P. Dorr, M. Westby, S. Dobbs, P. Griffin, B. Irvine, M. Macartney, J. Mori, G. Rickett, C. Smith-Burchnell, C. Napier, R. Webster, D. Armour, D. Price, B. Stammen, A. Wood, and M. Perros Maraviroc (UK-427, 857), a potent, orally bioavailable and selective small-molecule inhibitor of chemokines receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity Antimicrob. Agents Chemother. 49 2005 4721 4732 (Pubitemid 41552605)
-
(2005)
Antimicrobial Agents and Chemotherapy
, vol.49
, Issue.11
, pp. 4721-4732
-
-
Dorr, P.1
Westby, M.2
Dobbs, S.3
Griffin, P.4
Irvine, B.5
Macartney, M.6
Mori, J.7
Rickett, G.8
Smith-Burchnell, C.9
Napier, C.10
Webster, R.11
Armour, D.12
Price, D.13
Stammen, B.14
Wood, A.15
Perros, M.16
-
63
-
-
28944454412
-
Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1
-
DOI 10.1128/AAC.49.12.4911-4919.2005
-
J.M. Strizki, C. Tremblay, S. Xu, L. Wojcik, N. Wanger, W. Gonsiorek, R.W. Hipkin, C.C. Chou, C. Pugliese-Sivo, Y. Xiao, J.R. Tagat, K. Cox, T. Priestley, S. Sorota, W. Huang, M. Hirsch, G.R. Reyes, and B.M. Baroudy Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1 Antimicrob. Agents Chemother. 49 2005 4911 4919 (Pubitemid 41782160)
-
(2005)
Antimicrobial Agents and Chemotherapy
, vol.49
, Issue.12
, pp. 4911-4919
-
-
Strizki, J.M.1
Tremblay, C.2
Xu, S.3
Wojcik, L.4
Wagner, N.5
Gonsiorek, W.6
Hipkin, R.W.7
Chou, C.-C.8
Pugliese-Sivo, C.9
Xiao, Y.10
Tagat, J.R.11
Cox, K.12
Priestley, T.13
Sorota, S.14
Huang, W.15
Hirsch, M.16
Reyes, G.R.17
Baroudy, B.M.18
-
64
-
-
23044515844
-
Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist
-
DOI 10.1128/AAC.49.8.3474-3482.2005
-
K. Takashima, H. Miyake, N. Kanzaki, Y. Tagawa, X. Wang, Y. Sugihara, Y. Iizawz, and M. Baba Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist Antimicrob. Agents Chemother. 49 2005 3474 3482 (Pubitemid 41060598)
-
(2005)
Antimicrobial Agents and Chemotherapy
, vol.49
, Issue.8
, pp. 3474-3482
-
-
Takashima, K.1
Miyake, H.2
Kanzaki, N.3
Tagawa, Y.4
Wang, X.5
Sugihara, Y.6
Iizawa, Y.7
Baba, M.8
-
65
-
-
56749150826
-
PF-232798, a second generation Pfizer oral CCR5 antagonist
-
Boston, MA, February 3-6 abstract no. 737
-
P. Dorr, M. Westby, L. McFadyen, J. Mori, J. Davis, F. Perruccio, R. Jones, P. Stuppe, and D. Middleton PF-232798, a second generation Pfizer oral CCR5 antagonist 15th Conference on Retroviruses and Opportunistic Infections Boston, MA, February 3-6 2008 abstract no. 737
-
(2008)
15th Conference on Retroviruses and Opportunistic Infections
-
-
Dorr, P.1
Westby, M.2
McFadyen, L.3
Mori, J.4
Davis, J.5
Perruccio, F.6
Jones, R.7
Stuppe, P.8
Middleton, D.9
-
66
-
-
29744465528
-
Human immunodeficiency virus (HIV) entry inhibitors (CCR5 specific blockers) in development: Are they the next novel therapies?
-
DOI 10.1310/979L-39QP-NC9G-WFTF
-
V. Idemyor Human immunodeficiency virus (HIV) entry inhibitors (CCR5 specific blockers) in development: are they the next novel therapies? HIV Clin. Trials 6 2005 272 277 (Pubitemid 43025158)
-
(2005)
HIV Clinical Trials
, vol.6
, Issue.5
, pp. 272-277
-
-
Idemyor, V.1
-
68
-
-
0035968306
-
HIV integrase, a brief overview from chemistry to therapeutics
-
R. Craigie HIV integrase, a brief overview from chemistry to therapeutics J. Biol. Chem. 276 2001 23213 23216
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23213-23216
-
-
Craigie, R.1
-
69
-
-
52449097240
-
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
-
V. Summa, A. Petrocchi, F. Bonelli, B. Crescenzi, M. Donghi, M. Ferrara, F. Fiore, C. Gardelli, O.G. Paz, D.J. Hazuda, P. Jones, O. Kinzel, R. Laufer, E. Monteagudo, E. Muraglia, E. Nizi, F. Orvieto, P. Pace, G. Pescatore, R. Scarpelli, K. Stillmock, M.V. Witmer, and M. Rowley Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection J. Med. Chem. 51 2008 5843 5855
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5843-5855
-
-
Summa, V.1
Petrocchi, A.2
Bonelli, F.3
Crescenzi, B.4
Donghi, M.5
Ferrara, M.6
Fiore, F.7
Gardelli, C.8
Paz, O.G.9
Hazuda, D.J.10
Jones, P.11
Kinzel, O.12
Laufer, R.13
Monteagudo, E.14
Muraglia, E.15
Nizi, E.16
Orvieto, F.17
Pace, P.18
Pescatore, G.19
Scarpelli, R.20
Stillmock, K.21
Witmer, M.V.22
Rowley, M.23
more..
-
70
-
-
0033619146
-
The AIDS epidemic - Considerations for the 21st century
-
DOI 10.1056/NEJM199909303411406
-
A.S. Fauci The AIDS epidemic. Considerations for the 21st century N. Engl. J. Med. 341 1999 1046 1050 (Pubitemid 29451801)
-
(1999)
New England Journal of Medicine
, vol.341
, Issue.14
, pp. 1046-1050
-
-
Fauci, A.S.1
-
71
-
-
0032491030
-
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection [1]
-
DOI 10.1056/NEJM199808063390612
-
S.H. Michaels, R. Clark, and P. Kissinger Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection N. Engl. J. Med. 339 1998 405 406 (Pubitemid 28363808)
-
(1998)
New England Journal of Medicine
, vol.339
, Issue.6
, pp. 405-406
-
-
Michaels, S.H.1
Clark, R.2
Kissinger, P.3
-
72
-
-
0033040536
-
Estimating AIDS-free survival in a severely immunosuppressed asymptomatic HIV-infected population in the era of antiretroviral triple combination therapy
-
P.P. Sendi, H.C. Bucher, B.A. Craig, and M. Pfluger Estimating AIDS-free survival in a severely immunosuppressed asymptomatic HIV-infected population in the era of antiretroviral triple combination therapy. Swiss HIV Cohort Study J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 20 1999 376 381 (Pubitemid 29143032)
-
(1999)
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
, vol.20
, Issue.4
, pp. 376-381
-
-
Sendi, P.P.1
Bucher, H.C.2
Craig, B.A.3
Pfluger, D.4
Battegay, M.5
-
73
-
-
73549088708
-
Molecular basis of Human Immunodeficiency Virus drug resistance: An update
-
L. Menendez-Arias Molecular basis of Human Immunodeficiency Virus drug resistance: an update Antiviral Res. 85 2010 210 231
-
(2010)
Antiviral Res.
, vol.85
, pp. 210-231
-
-
Menendez-Arias, L.1
-
75
-
-
0034010539
-
Adherence to HIV combination therapy
-
DOI 10.1016/S0277-9536(99)00468-2, PII S0277953699004682
-
M.A. Chesney, M. Morin, and L. Sherr Adherence to HIV combination therapy Soc. Sci. Med. 50 2000 1599 1605 (Pubitemid 30129133)
-
(2000)
Social Science and Medicine
, vol.50
, Issue.11
, pp. 1599-1605
-
-
Chesney, M.A.1
Morin, M.2
Sherr, L.3
-
76
-
-
0030832598
-
Potential factors affecting adherence with HIV therapy
-
DOI 10.1097/00002030-199714000-00002
-
S. Mehta, R.D. Moore, and N.M. Graham Potential factors affecting adherence with HIV therapy AIDS 11 1997 1665 1670 (Pubitemid 27470267)
-
(1997)
AIDS
, vol.11
, Issue.14
, pp. 1665-1670
-
-
Mehta, S.1
Moore, R.D.2
Graham, N.M.H.3
-
77
-
-
0030889653
-
Compliance with treatment regimens in chronic asymptomatic diseases
-
DOI 10.1016/S0002-9343(97)00467-1, PII S0002934397004676
-
N.H. Miller Compliance with treatment regimens in chronic asymptomatic diseases Am. J. Med. 102 1997 43 49 (Pubitemid 27147947)
-
(1997)
American Journal of Medicine
, vol.102
, Issue.A
, pp. 43-49
-
-
Miller, N.H.1
-
78
-
-
36849058739
-
Metabolic effects of a growth hormone-releasing factor in patients with HIV
-
DOI 10.1056/NEJMoa072375
-
J. Falutz, S. Allas, K. Blot, D. Potvin, D. Kotler, M. Somero, D. Berger, S. Brown, G. Richmond, J. Fessel, R. Turner, and S. Grinspoon Metabolic effects of a growth hormone-releasing factor in patients with HIV N. Engl. J. Med. 357 2007 2359 2370 (Pubitemid 350223390)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.23
, pp. 2359-2370
-
-
Falutz, J.1
Allas, S.2
Blot, K.3
Potvin, D.4
Kotler, D.5
Somero, M.6
Berger, D.7
Brown, S.8
Richmond, G.9
Fessel, J.10
Turner, R.11
Grinspoon, S.12
-
80
-
-
73549105254
-
Sexual transmission of HIV
-
J. Fox, and S. Fidler Sexual transmission of HIV Antivirol Res. 85 2010 276 285
-
(2010)
Antivirol Res.
, vol.85
, pp. 276-285
-
-
Fox, J.1
Fidler, S.2
-
81
-
-
67651096095
-
Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment
-
R.H. Haubrich, S.A. Riddler, A.G. DiRienzo, L. Komarow, W.G. Powderly, K. Klingman, K.W. Garren, D.L. Butcher, J.F. Rooney, D.W. Haas, J.W. Mellors, and D.V. Havlir Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment AIDS 23 2009 1109 1118
-
(2009)
AIDS
, vol.23
, pp. 1109-1118
-
-
Haubrich, R.H.1
Riddler, S.A.2
Dirienzo, A.G.3
Komarow, L.4
Powderly, W.G.5
Klingman, K.6
Garren, K.W.7
Butcher, D.L.8
Rooney, J.F.9
Haas, D.W.10
Mellors, J.W.11
Havlir, D.V.12
-
82
-
-
43549094732
-
Class-sparing regimens for initial treatment of HIV-1 infection
-
DOI 10.1056/NEJMoa074609
-
S.A Riddler, R. Haubrich, A.G. DiRienzo, L. Peeples, W.G. Powderly, K.L. Klingman, K.W. Garren, T. George, J.F. Rooney, B. Brizz, U.G. Lalloo, R.L. Murphy, S. Swindells, D. Havlir, and J.W. Mellors Class-sparing regimens for initial treatment of HIV-1 infection N. Engl. J. Med. 358 2008 2095 2106 (Pubitemid 351679596)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.20
, pp. 2095-2106
-
-
Riddler, S.A.1
Haubrich, R.2
DiRienzo, A.G.3
Peeples, L.4
Powderly, W.G.5
Klingman, K.L.6
Garren, K.W.7
George, T.8
Rooney, J.F.9
Brizz, B.10
Lalloo, U.G.11
Murphy, R.L.12
Swindells, S.13
Havlir, D.14
Mellors, J.W.15
-
83
-
-
61849099349
-
Simplification strategies to reduce antiretroviral drug exposure: Progress and prospects
-
J.E. McKinnon, J.W. Mellors, and S. Swindells Simplification strategies to reduce antiretroviral drug exposure: progress and prospects Antivir. Ther. 14 2009 1 12
-
(2009)
Antivir. Ther.
, vol.14
, pp. 1-12
-
-
McKinnon, J.E.1
Mellors, J.W.2
Swindells, S.3
-
84
-
-
73549119700
-
The evolution of HIV treatment guidelines: Current state-of-the art of ART
-
A.R. Zolopa The evolution of HIV treatment guidelines: current state-of-the art of ART Antiviral Res. 85 2010 241 244
-
(2010)
Antiviral Res.
, vol.85
, pp. 241-244
-
-
Zolopa, A.R.1
-
85
-
-
56649085112
-
Novel targets for HIV therapy
-
W.C. Greene, Z. Debyser, Y. Ikeda, E.O. Freed, E. Stephens, W. Yonemoto, R.W. Buckheit, J.A. Este, and T. Cihlar Novel targets for HIV therapy Antiviral Res. 80 2008 251 265
-
(2008)
Antiviral Res.
, vol.80
, pp. 251-265
-
-
Greene, W.C.1
Debyser, Z.2
Ikeda, Y.3
Freed, E.O.4
Stephens, E.5
Yonemoto, W.6
Buckheit, R.W.7
Este, J.A.8
Cihlar, T.9
-
86
-
-
65249105408
-
Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
-
Y. Levy, C. Lacabaratz, L. Weiss, J.P. Viard, C. Goujard, J.D. Lelievre, F. Boue, J.M. Molina, C. Rouzioux, V. Avettand-Fenoel, T. Croughs, S. Beq, R. Thiebaut, G. Chene, M. Morre, and J.F. Delfraissy Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment J. Clin. Invest. 119 2009 997 1007
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 997-1007
-
-
Levy, Y.1
Lacabaratz, C.2
Weiss, L.3
Viard, J.P.4
Goujard, C.5
Lelievre, J.D.6
Boue, F.7
Molina, J.M.8
Rouzioux, C.9
Avettand-Fenoel, V.10
Croughs, T.11
Beq, S.12
Thiebaut, R.13
Chene, G.14
Morre, M.15
Delfraissy, J.F.16
-
87
-
-
73549099755
-
Development of topical microbicides to prevent the sexual transmission of HIV
-
R.W. Buckheit, K.M. Watson, K. Moorrow, and A.S. Ham Development of topical microbicides to prevent the sexual transmission of HIV Antiviral Res. 85 2010 142 158
-
(2010)
Antiviral Res.
, vol.85
, pp. 142-158
-
-
Buckheit, R.W.1
Watson, K.M.2
Moorrow, K.3
Ham, A.S.4
-
88
-
-
0028219733
-
Challenges for the development of female-controlled vaginal microbicides
-
C.J. Elias, and L.L. Heise Challenges for the development of female-controlled vaginal microbicides AIDS 8 1994 1 10
-
(1994)
AIDS
, vol.8
, pp. 1-10
-
-
Elias, C.J.1
Heise, L.L.2
|