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Volumn 11, Issue 1, 2012, Pages 5-14

Highly Active Antiretroviral Therapy for treatment of HIV/AIDS patients: Current status and future prospects and the Indian scenario

Author keywords

Drug targets; FDCs; HAART; HIV; Indian scenario; Viral reservoirs

Indexed keywords

1 ACETYL N [3 [4 (4 CARBAMOYLBENZYL) 1 PIPERIDINYL]PROPYL] N (3 CHLORO 4 METHYLPHENYL) 4 PIPERIDINECARBOXAMIDE; 2',3' DIDEHYDRO 2',3' DIDEOXY 2' FLUORO 5' O PHOSPHONOMETHYLADENOSINE; 8 [(4 AMINOBUTYL)(2 BENZIMIDAZOLYLMETHYL)AMINO] 1,2,3,4 TETRAHYDROQUINOLINE; ABACAVIR PLUS LAMIVUDINE; ABACAVIR PLUS LAMIVUDINE PLUS ZIDOVUDINE; AMDOXOVIR; APLAVIROC; APRICITABINE; CALANOLIDE A; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ELVITEGRAVIR; ELVUCITABINE; EMTRICITABINE; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ENFUVIRTIDE; FOSDEVIRINE; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; INTEGRASE INHIBITOR; LAMIVUDINE PLUS ZIDOVUDINE; MARAVIROC; MICROBICIDE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PF 232798; PROTEINASE INHIBITOR; RALTEGRAVIR; RDEA 806; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VICRIVIROC; ZIDOVUDINE;

EID: 84862796955     PISSN: 17301270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hivar.2012.02.003     Document Type: Review
Times cited : (40)

References (88)
  • 2
    • 0020532060 scopus 로고
    • Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)
    • R.C. Gallo, P.S. Sarin, E.P. Gelmann, M. Robert-Guroff, E. Richardson, V.S. Kalyanaraman, D. Mann, G.D. Sidhu, R.E. Stahl, S. Zolla-Pazner, J. Leibowitch, and M. Popovic Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS) Science 220 1983 865 867 (Pubitemid 13080156)
    • (1983) Science , vol.220 , Issue.4599 , pp. 865-867
    • Gallo, R.C.1    Sarin, P.S.2    Gelmann, E.P.3
  • 3
    • 0037249691 scopus 로고    scopus 로고
    • Long-term HIV/AIDS survival estimation in the highly active antiretroviral therapy era
    • DOI 10.1177/0272989X02239652
    • J.T. King Jr., A.C. Justice, M.S. Roberts, C.C. Chang, and J.S. Fusco Collaboration in HIV outcomes research - U.S. Program Team. Long-term HIV-AIDS survival estimation in the highly active antiretroviral therapy era Med. Decis. Making 23 2003 9 20 (Pubitemid 36133356)
    • (2003) Medical Decision Making , vol.23 , Issue.1 , pp. 9-20
    • King Jr., J.T.1    Justice, A.C.2    Roberts, M.S.3    Chang, C.-C.H.4    Fusco, J.S.5
  • 4
    • 0035882308 scopus 로고    scopus 로고
    • Initial virological and immunologic response to highly active antiretroviral therapy predicts long-term clinical outcome
    • DOI 10.1086/321900
    • C.M. Kitchen, S.G. Kitchen, J.A. Dubin, and M.S. Gottieb Initial virological and immunologic response to highly active antiretroviral therapy predicts long-term clinical outcome Clin. Infect. Dis. 33 2001 466 472 (Pubitemid 32709577)
    • (2001) Clinical Infectious Diseases , vol.33 , Issue.4 , pp. 466-472
    • Kitchen, C.M.1    Kitchen, S.G.2    Dubin, J.A.3    Gottlieb, M.S.4
  • 5
    • 0034977285 scopus 로고    scopus 로고
    • HAART is a cost-effective and improves outcomes
    • W.M. Valenti HAART is a cost-effective and improves outcomes AIDS Reader 11 2001 260 262
    • (2001) AIDS Reader , vol.11 , pp. 260-262
    • Valenti, W.M.1
  • 6
    • 0043069555 scopus 로고    scopus 로고
    • Toxicity of antiretroviral therapy and implications for drug development
    • A. Carr Toxicity of antiretroviral therapy and implications for drug development Nat. Rev. Drug Discov. 2 2003 624 634 (Pubitemid 37361766)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.8 , pp. 624-634
    • Carr, A.1
  • 9
    • 0021237243 scopus 로고
    • Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
    • M. Popovic, M.G. Sarngadharan, E. Read, and R.C. Gallo Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS Science 224 1984 497 500 (Pubitemid 14134740)
    • (1984) Science , vol.224 , Issue.4648 , pp. 497-500
    • Popovic, M.1    Sarngadharan, M.G.2    Read, E.3    Gallo, R.C.4
  • 10
    • 73549103358 scopus 로고    scopus 로고
    • The development of antiretroviral therapy and its impact on the global HIV-1/AIDS pandemic
    • S. Broder The development of antiretroviral therapy and its impact on the global HIV-1/AIDS pandemic Antiviral Res. 85 2010 1 18
    • (2010) Antiviral Res. , vol.85 , pp. 1-18
    • Broder, S.1
  • 11
    • 0001707601 scopus 로고
    • 3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
    • DOI 10.1073/pnas.82.20.7096
    • H. Mitsuya, K.J. Weinhold, P.A. Furman, St. M.H. Clair, S.N. Lehrman, R.C. Gallo, D. Bolognesi, D.W. Barry, and S. Broder 3′-Azido-3′- deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy- associated virus in vitro Proc. Natl. Acad. Sci. U.S.A.U. S. A. 82 1985 7096 7100 (Pubitemid 16209699)
    • (1985) Proceedings of the National Academy of Sciences of the United States of America , vol.82 , Issue.20 , pp. 7096-7100
    • Mitsuya, H.1    Weinhold, K.J.2    Furman, P.A.3
  • 13
    • 0023265911 scopus 로고
    • The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: A comparison with their parental 2',3'-dideoxyribonucleosides
    • J. Balzarini, G.J. Kang, M. Dalal, P. Herdewijn, E. De Clercq, S. Broder, and D.G. Johns The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2′,3′-didehydro-2′,3′-dideoxyribonucleosides: a comparison with their parental 2′,3′-dideoxyribonucleosides Mol. Pharmacol. 32 1987 162 167 (Pubitemid 17112329)
    • (1987) Molecular Pharmacology , vol.32 , Issue.1 , pp. 162-167
    • Balzarini, J.1    Kang, G.-J.2    Dalal, M.3
  • 17
    • 0028205185 scopus 로고
    • Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives
    • J. Balzarini Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives Pharm. World Soc. 16 1994 113 126 (Pubitemid 24142453)
    • (1994) Pharmacy World and Science , vol.16 , Issue.2 , pp. 113-126
    • Balzarini, J.1
  • 18
    • 0025122369 scopus 로고
    • Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2', 3'-dideoxyuridine-5'- triphosphate
    • Z. Hao, D.A. Cooney, D. Farquhar, C.F. Perno, K. Zhang, R. Masood, Y. Wilson, N.R. Hartman, J. Balzarini, and D.G. Johns DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2′,3′-dideoxyuridine-5′-triphosphate Mol. Pharmacol. 37 1990 157 163 (Pubitemid 20082978)
    • (1990) Molecular Pharmacology , vol.37 , Issue.2 , pp. 157-163
    • Hao, Z.1    Cooney, D.A.2    Farquhar, D.3    Perno, C.F.4    Zhang, K.5    Masood, R.6    Wilson, Y.7    Hartman, N.R.8    Balzarini, J.9    Johns, D.G.10
  • 21
    • 0027534937 scopus 로고
    • L-β-(2S,4S)- and L-α-(2S,4R)-dioxolanyl nucleosides as potential anti- HIV agents: Asymmetric synthesis and structure-activity relationships
    • H.O. Kim, R.F. Schinazi, K. Shanmuganathan, L.S. Jeong, J.W. Beach, S. Nampalli, D.L. Cannon, and C.K. Chu L-β-(2S, 4S)- and L-α-(2S,4R)- Dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships J. Med. Chem. 36 1993 519 528 (Pubitemid 23097416)
    • (1993) Journal of Medicinal Chemistry , vol.36 , Issue.5 , pp. 519-528
    • Kim, H.O.1    Schinazi, R.F.2    Shanmuganathan, K.3    Jeong, L.S.4    Beach, J.W.5    Nampalli, S.6    Cannon, D.L.7    Chu, C.K.8
  • 22
    • 0028047132 scopus 로고
    • Antiviral activity of β-L(-)-2′,3′-dideoxy-5-fluoro- cytidine (L(-)ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro
    • T.S. Lin, M.Z. Luo, M.C. Liu, S.B. Pai, G.E. Dutschman, and Y.C. Cheng Antiviral activity of β-L(-)-2′,3′-dideoxy-5-fluoro-cytidine (L(-)ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro Biochem. Pharmacol. 47 1994 171 174
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 171-174
    • Lin, T.S.1    Luo, M.Z.2    Liu, M.C.3    Pai, S.B.4    Dutschman, G.E.5    Cheng, Y.C.6
  • 23
    • 26044432728 scopus 로고    scopus 로고
    • In vitro activity of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor (NRTI), against 215 HIV-1 isolates resistant to other NRTIs
    • R.C. Bethell, Y.S. Lie, and N.T. Parkin In vitro activity of SPD754, a new deoxycitidine nucleoside reverse transcriptase inhibitor (NRTI), against 215 HIV-1 isolates resistant to other NRTIs, Antiviral Chem. Chemother. 16 2005 295 302 (Pubitemid 41405996)
    • (2005) Antiviral Chemistry and Chemotherapy , vol.16 , Issue.5 , pp. 295-302
    • Bethell, R.C.1    Lie, Y.S.2    Parkin, N.T.3
  • 24
    • 31944441500 scopus 로고    scopus 로고
    • In vitro antiretroviral activity and in vitro toxicity profile of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus infection
    • DOI 10.1128/AAC.50.2.625-631.2006
    • Z. Gu, B. Allard, J.M. de Muys, J. Lippens, R.F. Rando, N. Nguyen-Ba, C. Ren, P. McKenna, D.L. Taylor, and R.C. Bethell In vitro antiretroviral activity and in vitro toxicity profile of SPD754, a new deoxycytidine nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus infection Antimicrob. Agents Chemother. 50 2006 625 631 (Pubitemid 43190975)
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , Issue.2 , pp. 625-631
    • Gu, Z.1    Allard, B.2    De Muys, J.M.3    Lippens, J.4    Rando, R.F.5    Nguyen-Ba, N.6    Ren, C.7    McKenna, P.8    Taylor, D.L.9    Bethell, R.C.10
  • 25
    • 33745869106 scopus 로고    scopus 로고
    • Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients
    • DOI 10.1097/01.aids.0000232233.41877.63, PII 0000203020060612000006
    • P. Cahn, I. Cassetti, R. Wood, P. Phanuphak, L. Shiveley, R.C. Bethell, and J. Sawyer Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naïve, HIV-infected patients AIDS 20 2006 1261 1268 (Pubitemid 44030374)
    • (2006) AIDS , vol.20 , Issue.9 , pp. 1261-1268
    • Cahn, P.1    Cassetti, I.2    Wood, R.3    Phanuphak, P.4    Shiveley, L.5    Bethell, R.C.6    Sawyer, J.7
  • 26
    • 65149105330 scopus 로고    scopus 로고
    • Safety profile of apricitabine, a novel NRTI, during 24-week dosing in experienced HIV-1 infected patients
    • Mexico City, Mexico, August 3-8 abstract no. TUAB0106
    • S. Cox, S. Moore, J. Southby, and A. Alsumbe Safety profile of apricitabine, a novel NRTI, during 24-week dosing in experienced HIV-1 infected patients XVII International AIDS Conference Mexico City, Mexico, August 3-8 2008 abstract no. TUAB0106
    • (2008) XVII International AIDS Conference
    • Cox, S.1    Moore, S.2    Southby, J.3    Alsumbe, A.4
  • 27
    • 34547229756 scopus 로고    scopus 로고
    • The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naïve HIV-1-infected patients
    • DOI 10.1310/hct0803-164
    • I. Cassetti, J.V.R. Madruga, J.M.A.H. Suleiman, A. Etzel, L.J. Zhong, A.K. Cheng, and J. Enejosa The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naïve HIV-1-infected patients HIV Clin. Trials 8 2007 164 172 (Pubitemid 47121761)
    • (2007) HIV Clinical Trials , vol.8 , Issue.3 , pp. 164-172
    • Cassetti, I.1    Madruga, J.V.R.2    Suleiman, J.M.A.H.3    Etzel, A.4    Zhong, L.5    Cheng, A.K.6    Enejosa, J.7
  • 31
    • 12144265244 scopus 로고    scopus 로고
    • Non-nucleoside reverse transcriptase inhibitors (NNRTIs): Past, present and future
    • E. De Clercq Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present and future Chem. Biodivers. 1 2004 44 64
    • (2004) Chem. Biodivers. , vol.1 , pp. 44-64
    • De Clercq, E.1
  • 34
    • 15444370583 scopus 로고    scopus 로고
    • New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections
    • DOI 10.1016/j.coph.2004.07.005, PII S1471489204001304
    • R. Pauwels New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections Curr. Opin. Pharmacol. 4 2004 437 446 (Pubitemid 40533003)
    • (2004) Current Opinion in Pharmacology , vol.4 , Issue.5 , pp. 437-446
    • Pauwels, R.1
  • 36
    • 0009505878 scopus 로고    scopus 로고
    • R165335-TMC125, a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) with nanomolar activity against NNRTI resistant HIV strains
    • Toronto, Canada, September 17-20 abstract no. 1840
    • K. Andries, M.-p. de Bethune, M.J. Kukla, H. Azijn, P.J. Lewi, P.A.J. Janssen, and R. Pauwels R165335-TMC125, a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) with nanomolar activity against NNRTI resistant HIV strains 40th Interscience Conference on Antimicrobial Agents and Chemotherapy Toronto, Canada, September 17-20 2000 abstract no. 1840
    • (2000) 40th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Andries, K.1    Bethune2    Kukla, M.J.3    Azijn, H.4    Lewi, P.J.5    Janssen, P.A.J.6    Pauwels, R.7
  • 38
    • 2942565660 scopus 로고    scopus 로고
    • Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors
    • DOI 10.1016/j.biocel.2004.02.026, PII S1357272504000937, Molecular Biology of HIV
    • R.A. Domaoal, and L.M. Demeter Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors Int. J. Biochem. Cell Biol. 36 2004 1735 1751 (Pubitemid 38750243)
    • (2004) International Journal of Biochemistry and Cell Biology , vol.36 , Issue.9 , pp. 1735-1751
    • Domaoal, R.A.1    Demeter, L.M.2
  • 45
    • 46749104685 scopus 로고    scopus 로고
    • Improving non-nucleoside reverse transcriptase inhibitors for first-line treatment of HIV infection: The development pipeline and recent clinical data
    • Z.K. Sweeney, and K. Klumpp Improving non-nucleoside reverse transcriptase inhibitors for first-line treatment of HIV infection: the development pipeline and recent clinical data Curr. Opin. Drug Discov. Devel. 11 2008 458 470 (Pubitemid 351950841)
    • (2008) Current Opinion in Drug Discovery and Development , vol.11 , Issue.4 , pp. 458-470
    • Sweeney, Z.K.1    Klumpp, K.2
  • 46
  • 47
    • 14944344464 scopus 로고    scopus 로고
    • New approaches toward anti-HIV chemotherapy
    • DOI 10.1021/jm040158k
    • E. De Clercq New approaches towards anti-HIV chemotherapy J. Med. Chem. 48 2005 1297 1313 (Pubitemid 40364540)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.5 , pp. 1297-1313
    • De Clercq, E.1
  • 48
    • 34548239620 scopus 로고    scopus 로고
    • Darunavir (TMC114): A new HIV-1 protease inhibitor
    • DOI 10.1517/14656566.8.12.1951
    • J.M. Molina, and A. Hill Darunavir (TMC114): a new HIV-1 protease inhibitor Expert Opin. Pharmacother. 8 2007 1951 1964 (Pubitemid 47316150)
    • (2007) Expert Opinion on Pharmacotherapy , vol.8 , Issue.12 , pp. 1951-1964
    • Molina, J.-M.1    Hill, A.2
  • 49
    • 30444449824 scopus 로고    scopus 로고
    • Tipranavir
    • DOI 10.1358/dot.2005.41.11.937960
    • Z. Temesgen, F. Cainelli, and S. Vento Tipranavir Drugs Today 41 2005 711 720 (Pubitemid 43074781)
    • (2005) Drugs of Today , vol.41 , Issue.11 , pp. 711-720
    • Temesgen, Z.1    Cainelli, F.2    Vento, S.3
  • 51
    • 0029840569 scopus 로고    scopus 로고
    • Ritonavir
    • A.P. Lea, and D. Faulds Ritonavir Drugs 52 1996 541 546
    • (1996) Drugs , vol.52 , pp. 541-546
    • Lea, A.P.1    Faulds, D.2
  • 52
    • 0033401920 scopus 로고    scopus 로고
    • Indinavir. A review of its use in the management of HIV infection
    • G.L. Plosker, and S. Noble Indinavir: a review of its use in the management of HIV infection Drugs 58 1999 1165 1203 (Pubitemid 30055050)
    • (1999) Drugs , vol.58 , Issue.6 , pp. 1165-1203
    • Plosker, G.L.1    Noble, S.2
  • 54
    • 0031804689 scopus 로고    scopus 로고
    • Amprenavir
    • J.C. Adkins, and D. Faulds Amprenavir Drugs 55 1998 837 842
    • (1998) Drugs , vol.55 , pp. 837-842
    • Adkins, J.C.1    Faulds, D.2
  • 55
    • 0035160110 scopus 로고    scopus 로고
    • Lopinavir-ritonavir: A new protease inhibitor
    • E.M. Mangum, and K.K. Graham Lopinavir-ritonavir: a new protease inhibitor Pharmacotherapy 21 2001 1352 1363
    • (2001) Pharmacotherapy , vol.21 , pp. 1352-1363
    • Mangum, E.M.1    Graham, K.K.2
  • 56
    • 4544227361 scopus 로고    scopus 로고
    • Fosamprenavir: Advancing HIV protease inhibitor treatment options
    • DOI 10.1517/14656566.5.9.1995
    • S. Becker, and L. Thornton Fosamprenavir: advancing HIV protease inhibitor treatment options Expert Opin. Pharmacother. 5 2004 1995 2005 (Pubitemid 39236600)
    • (2004) Expert Opinion on Pharmacotherapy , vol.5 , Issue.9 , pp. 1995-2005
    • Becker, S.1    Thornton, L.2
  • 59
    • 0027692502 scopus 로고
    • A synthetic peptide from HIV-1 gp41is a potent inhibitor of virus-mediated cell-cell fusion
    • C. Wild, T. Greenwell, and T. Matthews A synthetic peptide from HIV-1 gp41is a potent inhibitor of virus-mediated cell-cell fusion AIDS Res. Hum. Retroviruses 9 1993 1051 1053
    • (1993) AIDS Res. Hum. Retroviruses , vol.9 , pp. 1051-1053
    • Wild, C.1    Greenwell, T.2    Matthews, T.3
  • 60
    • 0037126834 scopus 로고    scopus 로고
    • Design of a protein surface antagonist based on α-helix mimicry: Inhibition of gp41 assembly and viral fusion
    • DOI 10.1002/1521-3773(20020118)41:2<278::AID-ANIE278>3.0.CO;2-A
    • J.T. Ernst, O. Kutzki, A.K. Debnath, S. Jiang, H. Lu, and A.D. Hamilton Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion Angew. Chem. Int. Ed. 41 2002 278 281 (Pubitemid 34118069)
    • (2002) Angewandte Chemie - International Edition , vol.41 , Issue.2 , pp. 278-281
    • Ernst, J.T.1    Kutzki, O.2    Debnath, A.K.3    Jiang, S.4    Lu, H.5    Hamilton, A.D.6
  • 64
    • 23044515844 scopus 로고    scopus 로고
    • Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist
    • DOI 10.1128/AAC.49.8.3474-3482.2005
    • K. Takashima, H. Miyake, N. Kanzaki, Y. Tagawa, X. Wang, Y. Sugihara, Y. Iizawz, and M. Baba Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist Antimicrob. Agents Chemother. 49 2005 3474 3482 (Pubitemid 41060598)
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , Issue.8 , pp. 3474-3482
    • Takashima, K.1    Miyake, H.2    Kanzaki, N.3    Tagawa, Y.4    Wang, X.5    Sugihara, Y.6    Iizawa, Y.7    Baba, M.8
  • 66
    • 29744465528 scopus 로고    scopus 로고
    • Human immunodeficiency virus (HIV) entry inhibitors (CCR5 specific blockers) in development: Are they the next novel therapies?
    • DOI 10.1310/979L-39QP-NC9G-WFTF
    • V. Idemyor Human immunodeficiency virus (HIV) entry inhibitors (CCR5 specific blockers) in development: are they the next novel therapies? HIV Clin. Trials 6 2005 272 277 (Pubitemid 43025158)
    • (2005) HIV Clinical Trials , vol.6 , Issue.5 , pp. 272-277
    • Idemyor, V.1
  • 68
    • 0035968306 scopus 로고    scopus 로고
    • HIV integrase, a brief overview from chemistry to therapeutics
    • R. Craigie HIV integrase, a brief overview from chemistry to therapeutics J. Biol. Chem. 276 2001 23213 23216
    • (2001) J. Biol. Chem. , vol.276 , pp. 23213-23216
    • Craigie, R.1
  • 70
    • 0033619146 scopus 로고    scopus 로고
    • The AIDS epidemic - Considerations for the 21st century
    • DOI 10.1056/NEJM199909303411406
    • A.S. Fauci The AIDS epidemic. Considerations for the 21st century N. Engl. J. Med. 341 1999 1046 1050 (Pubitemid 29451801)
    • (1999) New England Journal of Medicine , vol.341 , Issue.14 , pp. 1046-1050
    • Fauci, A.S.1
  • 71
    • 0032491030 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection [1]
    • DOI 10.1056/NEJM199808063390612
    • S.H. Michaels, R. Clark, and P. Kissinger Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection N. Engl. J. Med. 339 1998 405 406 (Pubitemid 28363808)
    • (1998) New England Journal of Medicine , vol.339 , Issue.6 , pp. 405-406
    • Michaels, S.H.1    Clark, R.2    Kissinger, P.3
  • 72
    • 0033040536 scopus 로고    scopus 로고
    • Estimating AIDS-free survival in a severely immunosuppressed asymptomatic HIV-infected population in the era of antiretroviral triple combination therapy
    • P.P. Sendi, H.C. Bucher, B.A. Craig, and M. Pfluger Estimating AIDS-free survival in a severely immunosuppressed asymptomatic HIV-infected population in the era of antiretroviral triple combination therapy. Swiss HIV Cohort Study J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 20 1999 376 381 (Pubitemid 29143032)
    • (1999) Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology , vol.20 , Issue.4 , pp. 376-381
    • Sendi, P.P.1    Bucher, H.C.2    Craig, B.A.3    Pfluger, D.4    Battegay, M.5
  • 73
    • 73549088708 scopus 로고    scopus 로고
    • Molecular basis of Human Immunodeficiency Virus drug resistance: An update
    • L. Menendez-Arias Molecular basis of Human Immunodeficiency Virus drug resistance: an update Antiviral Res. 85 2010 210 231
    • (2010) Antiviral Res. , vol.85 , pp. 210-231
    • Menendez-Arias, L.1
  • 75
    • 0034010539 scopus 로고    scopus 로고
    • Adherence to HIV combination therapy
    • DOI 10.1016/S0277-9536(99)00468-2, PII S0277953699004682
    • M.A. Chesney, M. Morin, and L. Sherr Adherence to HIV combination therapy Soc. Sci. Med. 50 2000 1599 1605 (Pubitemid 30129133)
    • (2000) Social Science and Medicine , vol.50 , Issue.11 , pp. 1599-1605
    • Chesney, M.A.1    Morin, M.2    Sherr, L.3
  • 76
    • 0030832598 scopus 로고    scopus 로고
    • Potential factors affecting adherence with HIV therapy
    • DOI 10.1097/00002030-199714000-00002
    • S. Mehta, R.D. Moore, and N.M. Graham Potential factors affecting adherence with HIV therapy AIDS 11 1997 1665 1670 (Pubitemid 27470267)
    • (1997) AIDS , vol.11 , Issue.14 , pp. 1665-1670
    • Mehta, S.1    Moore, R.D.2    Graham, N.M.H.3
  • 77
    • 0030889653 scopus 로고    scopus 로고
    • Compliance with treatment regimens in chronic asymptomatic diseases
    • DOI 10.1016/S0002-9343(97)00467-1, PII S0002934397004676
    • N.H. Miller Compliance with treatment regimens in chronic asymptomatic diseases Am. J. Med. 102 1997 43 49 (Pubitemid 27147947)
    • (1997) American Journal of Medicine , vol.102 , Issue.A , pp. 43-49
    • Miller, N.H.1
  • 80
    • 73549105254 scopus 로고    scopus 로고
    • Sexual transmission of HIV
    • J. Fox, and S. Fidler Sexual transmission of HIV Antivirol Res. 85 2010 276 285
    • (2010) Antivirol Res. , vol.85 , pp. 276-285
    • Fox, J.1    Fidler, S.2
  • 83
    • 61849099349 scopus 로고    scopus 로고
    • Simplification strategies to reduce antiretroviral drug exposure: Progress and prospects
    • J.E. McKinnon, J.W. Mellors, and S. Swindells Simplification strategies to reduce antiretroviral drug exposure: progress and prospects Antivir. Ther. 14 2009 1 12
    • (2009) Antivir. Ther. , vol.14 , pp. 1-12
    • McKinnon, J.E.1    Mellors, J.W.2    Swindells, S.3
  • 84
    • 73549119700 scopus 로고    scopus 로고
    • The evolution of HIV treatment guidelines: Current state-of-the art of ART
    • A.R. Zolopa The evolution of HIV treatment guidelines: current state-of-the art of ART Antiviral Res. 85 2010 241 244
    • (2010) Antiviral Res. , vol.85 , pp. 241-244
    • Zolopa, A.R.1
  • 87
    • 73549099755 scopus 로고    scopus 로고
    • Development of topical microbicides to prevent the sexual transmission of HIV
    • R.W. Buckheit, K.M. Watson, K. Moorrow, and A.S. Ham Development of topical microbicides to prevent the sexual transmission of HIV Antiviral Res. 85 2010 142 158
    • (2010) Antiviral Res. , vol.85 , pp. 142-158
    • Buckheit, R.W.1    Watson, K.M.2    Moorrow, K.3    Ham, A.S.4
  • 88
    • 0028219733 scopus 로고
    • Challenges for the development of female-controlled vaginal microbicides
    • C.J. Elias, and L.L. Heise Challenges for the development of female-controlled vaginal microbicides AIDS 8 1994 1 10
    • (1994) AIDS , vol.8 , pp. 1-10
    • Elias, C.J.1    Heise, L.L.2


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