TcyR regulates l-cystine uptake via the TcyABC transporter in Streptococcus mutans

FEMS Microbiology Letters

Volumn 328, Issue 2, 2012, Pages 114-121

  Kim, Jennifer ^a   Senadheera, Dilani B ^a   Lévesque, Céline M ^a   Cvitkovitch, Dennis G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cystine; Streptococcus mutans; TcyABC; Transport

Indexed keywords

ABC TRANSPORTER; CYSTATHIONINE; CYSTINE; REGULATOR PROTEIN; S METHYLCYSTEINE; TCYABC TRANSPORTER; TCYR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIUM MUTANT; CONTROLLED STUDY; GENE EXPRESSION PROFILING; NONHUMAN; OPERON; PRIORITY JOURNAL; STREPTOCOCCUS MUTANS; TCYABC GENE; TRANSCRIPTION REGULATION; UPREGULATION;

ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BIOFILMS; CHROMOSOMES, BACTERIAL; CULTURE MEDIA; CYSTATHIONINE; CYSTEINE; CYSTINE; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; OPERON; PROTEIN TRANSPORT; STREPTOCOCCUS MUTANS; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

BACILLUS SUBTILIS; STREPTOCOCCUS MUTANS;

EID: 84862794226     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2011.02492.x     Document Type: Article

References (18)

1. Ajdic D, McShan WM, McLaughlin RE et al. (2002) Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. P Natl Acad Sci USA 99: 14434-14439.
2. Albanesi D, Mansilla MC, Schujman GE & de Mendoza D (2005) Bacillus subtilis cysteine synthetase is a global regulator of the expression of genes involved in sulfur assimilation. J Bacteriol 187: 7631-7638.
3. Burguiere P, Auger S, Hullo MF, Danchin A & Martin-Verstraete I (2004) Three different systems participate in L-cystine uptake in Bacillus subtilis. J Bacteriol 186: 4875-4884.
4. Burguiere P, Fert J, Guillouard I, Auger S, Danchin A & Martin-Verstraete I (2005) Regulation of the Bacillus subtilis ytmI operon, involved in sulfur metabolism. J Bacteriol 187: 6019-6030.
5. Carlsson J (1970) Nutritional requirements of Streptococcus mutans. Caries Res 4: 305-320.
6. Chapot-Chartier M-P, Nardi M, Chopin M-C, Chopin A & Gripon J-C (1993) Cloning and sequencing of pepC, a cysteine aminopeptidase gene from Lactococcus lactis subsp. cremoris AM2. Appl Environ Microbiol 59: 330-333.
7. Coppee J-Y, Auger S, Turlin E, Sekowska A, Le Caer J-P, Labas V, Vagner V, Danchin A & Martin-Verstraete I (2001) Sulfur-limitation-regulated proteins in Bacillus subtilis: a two-dimensional gel electrophoresis study. Microbiology 147: 1631-1640.
8. Cvitkovitch DG, Gutierrez JA & Bleiweiss AS (1997) Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans. J Bacteriol 179: 650-655.
9. Even S, Burguiere P, Auger S, Soutourina O, Danchin A & Martin-Verstraete I (2006) Global control of cysteine metabolism by CymR in Bacillus subtilis. J Bacteriol 188: 2184-2197.
10. Fernández M, Kleerebezem M, Kuipers OP, Siezen RJ & Kranenburg RV (2002) Regulation of the metC-cysK operon, involved in sulfur metabolism in Lactococcus lactis. J Bacteriol 184: 82-90.
11. Fujiwara S, Kobayashi S & Nakayam H (1978) Development of a minimal medium for Streptococcus mutans. Arch Oral Biol 23: 601-602.
12. Hanna MN, Ferguson RJ, Li YH & Cvitkovitch DG (2001) uvrA is an acid-inducible gene involved in the adaptive response to low pH in Streptococcus mutans. J Bacteriol 183: 5964-5973.
13. Kredich NM (1992) The molecular basis for positive regulation of cys promoters in Salmonella typhimurium and Escherichia coli. Mol Microbiol 6: 2747-2753.
14. Lau PCY, Sung CK, Lee JH, Morrison DA & Cvitkovitch DG (2002) PCR ligation mutagenesis in transformable streptococci: application and efficiency. J Microbiol Methods 49: 193-205.
15. Leichert LIO, Scharf C & Hecker M (2003) Global characterization of disulfide stress in Bacillus subtilis. J Bacteriol 185: 1967-1975.
16. Liu P-Q & Ferro-Luzzi Ames G (1998) In vitro disassembly and reassembly of an ABC transporter, the histidine permease. Biochemistry 95: 3495-3500.
17. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: 2002-2007.
18. Sperandio B, Gautier C, Pons N, Ehrlich DS, Renault P & Guedon E (2010) Three paralogous LysR-type transcriptional regulators control sulfur amino acid supply in Streptococcus mutans. J Bacteriol 192: 3464-3473.