Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation

Atherosclerosis

Volumn 222, Issue 1, 2012, Pages 84-91

  Joung, Hosouk ^a   Kwon, Jin Sook ^b   Kim, Ju Ryoung ^c   Shin, Sera ^a   Kang, Wanseok ^b   Ahn, Youngkeun ^b   Kook, Hyun ^a,b   Kee, Hae Jin ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c University School of Medicine   (United States)

Author keywords

Enhancer of polycomb1 (Epc1); Myocardin (Myocd); Neointimal formation; Serum response factor (SRF); Vascular smooth muscle cell differentiation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ENHANCER OF POLYCOMB 1; MYOCARDIN; PLATELET DERIVED GROWTH FACTOR; POLYCOMB GROUP PROTEIN; SERUM RESPONSE FACTOR; SMALL INTERFERING RNA; SMOOTH MUSCLE 22ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY INJURY; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE TARGETING; IMMUNOPRECIPITATION; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; SMOOTH MUSCLE FIBER; TRANSACTIVATION; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANGIOPLASTY, BALLOON; ANIMALS; CAROTID ARTERY INJURIES; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN-REGULATION; MICE; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; SERUM RESPONSE FACTOR; TRANS-ACTIVATORS; UP-REGULATION;

EID: 84862792430     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.02.015     Document Type: Article

References (30)

1. Regan C.P., Adam P.J., Madsen C.S., et al. Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury. J Clin Invest 2000, 106:1139-1147.
2. Rzucidlo E.M. Signaling pathways regulating vascular smooth muscle cell differentiation. Vascular 2009, 17(Suppl. 1):S15-S20.
3. Owens G.K., Kumar M.S., Wamhoff B.R. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004, 84:767-801.
4. Seki Y., Kai H., Shibata R., et al. Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury. Circ Res 2000, 87:12-18.
5. Wang Z., Wang D.Z., Pipes G.C., et al. Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad Sci U S A 2003, 100:7129-7134.
6. Kim J.R., Kee H.J., Kim J.Y., et al. Enhancer of polycomb1 acts on serum response factor to regulate skeletal muscle differentiation. J Biol Chem 2009, 284:16308-16316.
7. Kee H.J., Kook H. Kruppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy. J Mol Cell Cardiol 2009, 47:770-780.
8. Pauly R.R., Bilato C., Cheng L., et al. Vascular smooth muscle cell cultures. Methods Cell Biol 1997, 52:133-154.
9. Kee H.J., Kim J.R., Nam K.I., et al. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. J Biol Chem 2007, 282:7700-7709.
10. Oh T.K., Quan G.H., Kim H.Y., et al. Correction of anemia in uremic rats by intramuscular injection of lentivirus carrying an erythropoietin gene. Am J Nephrol 2006, 26:326-334.
11. Lim Y., Kwon J.S., Kim D.W., et al. Obovatol from Magnolia obovata inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1. Atherosclerosis 2010, 210:372-380.
12. Coward P., Wada H.G., Falk M.S., et al. Controlling signaling with a specifically designed Gi-coupled receptor. Proc Natl Acad Sci U S A 1998, 95:352-357.
13. Pintucci G., Yu P.J., Saponara F., et al. PDGF-BB induces vascular smooth muscle cell expression of high molecular weight FGF-2, which accumulates in the nucleus. J Cell Biochem 2005, 95:1292-1300.
14. Li L., Miano J.M., Cserjesi P., et al. SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis. Circ Res 1996, 78:188-195.
15. Feil S., Hofmann F., Feil R. SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis. Circ Res 2004, 94:863-865.
16. Miano J.M. Serum response factor: toggling between disparate programs of gene expression. J Mol Cell Cardiol 2003, 35:577-593.
17. Kumar M.S., Owens G.K. Combinatorial control of smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol 2003, 23:737-747.
18. Hauschka S.D. Myocardin. A novel potentiator of SRF-mediated transcription in cardiac muscle. Mol Cell 2001, 8:1-2.
19. Wang Z., Wang D.Z., Hockemeyer D., et al. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 2004, 428:185-189.
20. Yoshida T., Sinha S., Dandre F., et al. Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ Res 2003, 92:856-864.
21. Shin C.H., Liu Z.P., Passier R., et al. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell 2002, 110:725-735.
22. Balza R.O., Misra R.P. Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes. J Biol Chem 2006, 281:6498-6510.
23. Rzucidlo E.M., Martin K.A., Powell R.J. Regulation of vascular smooth muscle cell differentiation. J Vasc Surg 2007, 45(Suppl. A):A25-A32.
24. Wang D., Chang P.S., Wang Z., et al. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 2001, 105:851-862.
25. Schwartz R.S., Chu A., Edwards W.D., et al. A proliferation analysis of arterial neointimal hyperplasia: lessons for antiproliferative restenosis therapies. Int J Cardiol 1996, 53:71-80.
26. Dong L.H., Wen J.K., Miao S.B., et al. Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRbeta-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia. Cell Res 2010, 20:1252-1262.
27. Maillard L., Van Belle E., Smith R.C., et al. Percutaneous delivery of the gax gene inhibits vessel stenosis in a rabbit model of balloon angioplasty. Cardiovasc Res 1997, 35:536-546.
28. Taniyama Y., Tachibana K., Hiraoka K., et al. Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation 2002, 105:1233-1239.
29. Tanner F.C., Boehm M., Akyurek L.M., et al. Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation. Circulation 2000, 101:2022-2025.
30. Kocher O., Gabbiani F., Gabbiani G., et al. Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies. Lab Invest 1991, 65:459-470.