Development of a method for the determination of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine of nonsmokers and smokers using liquid chromatography/tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 63, Issue , 2012, Pages 17-22

  Hou, Hongwei ^a   Zhang, Xiaotao ^a,b   Tian, Yongfeng ^a   Tang, Gangling ^a   Liu, Yulan ^b   Hu, Qingyuan ^a  

^a ZHENGZHOU TOBACCO RESEARCH INSTITUTE OF CNTC   (China)

^b HENAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Biomarker; LC MS MS; MIP; NNAL; Urine

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL;

ARTICLE; CHEMICAL CARCINOGENESIS; CIGARETTE SMOKING; CONTROLLED STUDY; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE LEVEL; VALIDATION PROCESS;

BIOLOGICAL MARKERS; BIOTRANSFORMATION; CARCINOGENS; CASE-CONTROL STUDIES; CHINA; CHROMATOGRAPHY, LIQUID; HUMANS; LIMIT OF DETECTION; NITROSAMINES; PYRIDINES; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SMOKING; TANDEM MASS SPECTROMETRY; TARS; TIME FACTORS;

EID: 84862791860     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.01.028     Document Type: Article

References (24)

1. Vineis P., Alavanja M., Buffler P., Fontham E., Franceschi S., Gao Y.T., Gupta P.C., Hackshaw A., Matos E., Samet J., Sitas F., Smith J., Stayner L., Straif K., Thun M.J., Wichmann H.E., Wu A.H., Zaridze D., Peto R., Doll R., Tobacco and cancer: recent epidemiological evidence J. Natl. Cancer Inst. 2004, 96. 10.1093/jnci/djh1014.
2. Yuan J.M., Koh W.P., Murphy S.E., Fan Y.H., Wang R.W., Carmella S.G., Han S.M., Wickham K., Gao Y.T., Yu M.C., Hecht S.S. Urinary levels of tobacco-specific nitrosamine metabolites in Relation to lung cancer development in two prospective cohorts of cigarette smokers. Cancer Res. 2009, 69:2990-2995.
3. Hecht S.S. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem. Res. Toxicol. 1998, 11:559-603.
4. Hoffmann D., Rivenson A., Amin S., Hecht S.S. Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats. J. Cancer Res. Clin. Oncol. 1984, 108:81-86.
5. Eisner M.D., Jacob P., Benowitz N.L., Balmes J., Blanc P.D. Longer term exposure to secondhand smoke and health outcomes in COPD: impact of urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Nicotine Tob. Res. 2009, 11:945-953.
6. Ashley D.L., O'Connor R.J., Bernert J.T., Watson C.H., Polzin G.M., Jain R.B., Hammond D., Hatsukami D.K., Giovino G.A., Cummings K.M., McNeill A., Shahab L., King B., Fong G.T., Zhang L.Q., Xia Y., Yan X.Z., McCraw J.M. Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers. Cancer Epidemiol. Biomarkers Prev. 2010, 19:1389-1398.
7. Hatsukami D.K., Benowitz N.L., Rennard S.I., Oncken C., Hecht S.S. Biomarkers to assess the utility of potential reduced exposure tobacco products. Nicotine Tob. Res. 2006, 8:600-622.
8. Hecht S.S. Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. Carcinogenesis 2002, 23:907-922.
9. Shah K.A., Halquist M.S., Thomas Karnes H. A modified method for the determination of tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine by solid phase extraction using a molecularly imprinted polymer and liquid chromatography tandem mass spectrometry. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009, 877:1575-1582.
10. Xia Y., Bernert J.T. Quantitation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine by LC tandem mass spectrometry. Epidemiology 2008, 19:S230.
11. Xia Y., McGuffey J.E., Bhattacharyya S., Sellergren B., Yilmaz E., Wang L.Q., Bernert J.T. Analysis of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine by extraction on a molecularly imprinted polymer column and liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. Anal. Chem. 2005, 77:7639-7645.
12. Yang Y.Y., Nie H.G., Li C.C., Bai Y., Li N., Liao J., Liu H.W. On-line concentration and determination of tobacco-specific N-nitrosamines by cation-selective exhaustive injection-sweeping-micellar electrokinetic chromatography. Talanta 2010, 82:1797-1801.
13. Bhat S.H., Gelhaus S.L., Mesaros C., Vachani A., Blair I.A. A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine. Rapid Commun. Mass Spectrom. 2011, 25:115-121.
14. Shah K.A., Peoples M.C., Halquist M.S., Rutan S.C., Thomas Karnes H. Microfluidic direct injection method for analysis of urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) using molecularly imprinted polymers coupled on-line with LC-MS/MS. J. Pharm. Biomed. Anal. 2011, 54:368-378.
15. Jacob P., Havel C., Lee D.H., Yu L.S., Eisner M.D., Benowitz N.L. Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry. Anal. Chem. 2008, 80:8115-8121.
16. Food and Drug Administration (FDA), Guidance for Industry-Bioanalytical Method Validation. (accessed 17.04.09). http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070107.pdf.
17. Kavvadias D., Scherer G., Urban M., Cheung F., Errington G., Shepperd J., McEwan M. Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009, 877:1185-1192.
18. Xiong W., Hou H.W., Jiang X.Y., Tang G.L., Hu Q.Y. Simultaneous determination of four tobacco-specific N-nitrosamines in mainstream smoke for Chinese virginia cigarettes by liquid chromatography-tandem mass spectrometry and validation under ISO and Canadian intense machine smoking regimes. Anal. Chim. Acta 2010, 674:71-78.
19. H.W. Hou, W. Xiong, D.K. Song, G.L. Tang, Q.Y. Hu, LC-MS-MS measurements of urinary creatinine and the application of creatinine normalization techniques on cotinine in smokers urine, J. Automated Methods Manag. Chem., submitted for publication.
20. Goniewicz M.L., Havel C.M., Peng M.W., Jacob P., Dempsey D., Yu L., Zielinska-Danch W., Koszowski B., Czogala J., Sobczak A., Benowitz N.L. Elimination kinetics of the tobacco-specific biomarker and lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Cancer Epidemiol. Biomarkers Prev. 2009, 18:3421-3425.
21. Shepperd C.J., Eldridge A.C., Errington G., Dixon M. A study to evaluate the effect on mouth level exposure and biomarkers of exposure estimates of cigarette smoke exposure following a forced switch to a lower ISO tar yield cigarette. Regul. Toxicol. Pharmacol. 2011, 10.1016/j.yrtph.2011.1005.1011.
22. Mendes P., Liang Q.W., Frost-Pineda K., Munjal S., Walk R.A., Roethig H.J. The relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the US. Regul. Toxicol. Pharmacol. 2009, 55:17-27.
23. Adam T., McAughey J., Mocker C., McGrath C., Zimmermann R. Influence of filter ventilation on the chemical composition of cigarette mainstream smoke. Anal. Chim. Acta 2010, 657:36-44.
24. Purkis S.W., Troude V., Duputié G., Tessier C. Limitations in the characterisation of cigarette products using different machine smoking regimes. Regul. Toxicol. Pharmacol. 2010, 58:501-515.