Genomic and clinical analysis of fusion gene amplification in rhabdomyosarcoma: A report from the Children's Oncology Group

Genes Chromosomes and Cancer

Volumn 51, Issue 7, 2012, Pages 662-674

  Duan, Fenghai ^a   Smith, Lynette M ^b   Gustafson, Donna M ^c   Zhang, Chune ^c   Dunlevy, Mandy J ^d   Gastier Foster, Julie M ^d,e   Barr, Frederic G ^c,f  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NATIONWIDE CHILDREN S HOSPITAL   (United States)

^e THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTION FACTOR PAX7;

AMPLICON; ARTICLE; CANCER PROGNOSIS; CHILD; CHILDHOOD CANCER; CHROMOSOME 13Q; CHROMOSOME 1P; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; OPEN READING FRAME; PRESCHOOL CHILD; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SCHOOL CHILD;

CHILD; CHILD, PRESCHOOL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; KAPLAN-MEIER ESTIMATE; MALE; MULTIVARIATE ANALYSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS, FUSION; PAIRED BOX TRANSCRIPTION FACTORS; PAX7 TRANSCRIPTION FACTOR; RHABDOMYOSARCOMA, ALVEOLAR;

EID: 84862790800     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.21953     Document Type: Article

References (22)

1. Barr FG, Womer R. 2009. Rhabdomyosarcoma. In: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG, editors. Oncology of Infancy and Childhood. Philadelphia: Saunders, pp. 743-828.
2. Barr FG, Galili N, Holick J, Biegel JA, Rovera G, Emanuel BS. 1993. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. Nat Genet 3: 113-117.
3. Barr FG, Nauta LE, Davis RJ, Schafer BW, Nycum LM, Biegel JA. 1996. In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma. Hum Mol Genet 5: 15-21.
4. Barr FG, Smith LM, Lynch JC, Strzelecki D, Parham DM, Qualman SJ, Breitfeld PP. 2006. Examination of gene fusion status in archival samples of alveolar rhabdomyosarcoma entered on the Intergroup Rhabdomyosarcoma Study-III trial: A report from the Children's Oncology Group. J Mol Diagn 8: 202-208.
5. Barr FG, Duan F, Smith LM, Gustafson D, Pitts M, Hammond S, Gastier-Foster JM. 2009. Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: A report from the Children's Oncology Group. Genes Chromosomes Cancer 48: 661-672.
6. Bridge JA, Liu J, Qualman SJ, Suijkerbuijk R, Wenger G, Zhang J, Wan X, Baker KS, Sorensen P, Barr FG. 2002. Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. Genes Chromosomes Cancer 33: 310-321.
7. Davis RJ, Barr FG. 1997. Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma. Proc Natl Acad Sci USA 94: 8047-8051.
8. Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJd, Emanuel BS, Rovera G, Barr FG. 1993. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat Genet 5: 230-235.
9. Gordon AT, Brinkschmidt C, Anderson J, Coleman N, Dockhorn-Dworniczak B, Pritchard-Jones K, Shipley J. 2000. A novel and consistent amplicon at 13q31 associated with alveolar rhabdomyosarcoma. Genes Chromosomes Cancer 28: 220-226.
10. Mansouri A. 1998. The role of Pax3 and Pax7 in development and cancer. Crit Rev Oncog 9: 141-149.
11. Matsumura T, Yamaguchi T, Seki K, Shimoda T, Wada T, Yamashita T, Hasegawa T. 2008. Advantage of FISH analysis using FKHR probes for an adjunct to diagnosis of rhabdomyosarcomas. Virchows Arch 452: 251-258.
12. Moller E, Isaksson M, Mandahl N, Mertens F, Panagopoulos I. 2007. Comparison of the proximal promoter regions of the PAX3 and PAX7 genes. Cancer Genet Cytogenet 178: 114-119.
13. Newton WA, Jr., Gehan EA, Webber BL, Marsden HB, van Unnik AJ, Hamoudi AB, Tsokos MG, Shimada H, Harms D, Schmidt D, Ninfo V, Cavazzana AO, Gonzalez-Crussi F, Parham DM, Reiman HM, Asmar L, Beltangady MS, Sachs NE, Triche RJ, Maurer HM. 1995. Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification-an Intergroup Rhabdomyosarcoma Study. Cancer 76: 1073-1085.
14. Pandita A, Zielenska M, Thorner P, Bayani J, Godbout R, Greenberg M, Squire JA. 1999. Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma. Neoplasia 1: 262-275.
15. Parham DM, Ellison DA. 2006. Rhabdomyosarcomas in adults and children: an update. Arch Pathol Lab Med 130: 1454-1465.
16. Qiao Y, Ogawa S, Hangaishi A, Yuji K, Izutsu K, Kunisato A, Imai Y, Wang L, Hosoya N, Nannya Y, Sato Y, Maki K, Mitani K, Hirai H. 2003. Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis. Leukemia 17: 1112-1120.
17. Reichek JL, Duan F, Smith LM, Gustafson DM, O' Connor RS, Zhang C, Pitts MJ, Gastier-Foster JM, Barr FG. 2011. Genomic and clinical analysis of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Clin Cancer Res 17: 1463-1473.
18. Sorensen PH, Lynch JC, Qualman SJ, Tirabosco R, Lim JF, Maurer HM, Bridge JA, Crist WM, Triche TJ, Barr FG. 2002. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: A report from the Children's Oncology Group. J Clin Oncol 20: 2672-2679.
19. Weber-Hall S, McManus A, Anderson J, Nojima T, Abe S, Pritchard-Jones K, Shipley J. 1996. Novel formation and amplification of the PAX7-FKHR fusion gene in a case of alveolar rhabdomyosarcoma. Genes Chromosomes Cancer 17: 7-13.
20. Xia SJ, Barr FG. 2004. Analysis of the transforming and growth suppressive activities of the PAX3-FKHR oncoprotein. Oncogene 23: 6864-6871.
21. Xia SJ, Rajput P, Strzelecki DM, Barr FG. 2007. Analysis of genetic events that modulate the oncogenic and growth suppressive activities of the PAX3-FKHR fusion oncoprotein. Lab Invest 87: 318-325.
22. Xia SJ, Holder DD, Pawel BR, Zhang C, Barr FG. 2009. High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts. Am J Pathol 175: 2600-2608.