Novel mechanical bioreactor for concomitant fluid shear stress and substrate strain

Journal of Biomechanics

Volumn 45, Issue 7, 2012, Pages 1323-1327

  Van Dyke, William S ^a   Sun, Xuanhao ^a   Richard, A Benjamin ^a   Nauman, Eric A ^a,b   Akkus, Ozan ^a,c  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Bioreactor; Fluid flow shear stress; Mechanotransduction; Multimodal mechanical loading; Substrate stretch

Indexed keywords

BONE CELLS; CELL IMAGING; CELLULAR ENVIRONMENT; DISPLACEMENT RATE; FLUID FLOW SHEAR STRESS; FLUID SHEAR STRESS; IN-VIVO; LOADING DEVICES; LOADING MODES; LOADING TYPES; MECHANICAL PERFORMANCE; MECHANICAL STIMULUS; MECHANOTRANSDUCTION; MULTI-MODAL; OUTPUT LEVELS; PHYSIOLOGICAL LEVELS; SUBSTRATE STRAIN;

BIOCONVERSION; BIOREACTORS; BONE; EXPERIMENTS; FLOW OF FLUIDS; LOADING; SHEAR STRESS;

SUBSTRATES;

ARTICLE; BIOREACTOR; BONE CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; FLUID FLOW; IN VIVO STUDY; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; PRIORITY JOURNAL; SHEAR STRESS; STATISTICAL ANALYSIS;

BIOMECHANICS; BIOREACTORS; EQUIPMENT DESIGN; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; OSTEOCYTES; RHEOLOGY; STRESS, MECHANICAL; TENSILE STRENGTH;

EID: 84862787627     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2012.02.002     Document Type: Article

References (26)

1. Aamodt A., Lund-Larsen J., Eine J., Andersen E., Benum P, Husby O.S. In vivo measurements show tensile axial strain in the proximal lateral aspect of the human femur. Journal of Orthopaedic Research 1997, 15:927-931.
2. Basso N, Heersche J.N.M. Characteristics of in vitro osteoblastic cell loading models. Bone 2002, 30:347-351.
3. Breen L.T., McHugh P.E., McCormack B.A., Muir G., Quinlan N.J., Heraty K.B, Murphy B.P. Development of a novel bioreactor to apply shear stress and tensile strain simultaneously to cell monolayers. Review of Scientific Instruments 2006, 77.
4. Brown T.D. Techniques for mechanical stimulation of cells in vitro: A review. Journal of Biomechanics 2000, 33:3-14.
5. Burr D.B., Milgrom C., Fyhrie D., Forwood M., Nyska M., Finestone A., Hoshaw S., Saiag E, Simkin A. In vivo measurement of human tibial strains during vigorous activity. Bone 1996, 18:405-410.
6. Chen J.-H., Liu C., You L, Simmons C.A. Boning up on wolff's law: Mechanical regulation of the cells that make and maintain bone. Journal of Biomechanics 2010, 43:108-118.
7. Dickerson D.A., Sander E.A, Nauman E.A. Modeling the mechanical consequences of vibratory loading in the vertebral body: Microscale effects. Biomechanics and Modeling in Mechanobiology 2008, 7:191-202.
8. Duncan R.L, Turner C.H. Mechanotransduction and the functional-response of bone to mechanical strain. Calcified Tissue International 1995, 57:344-358.
9. Frangos J.A., McIntire L.V, Eskin S.G. Shear-stress induced stimulation of mammalian-cell metabolism. Biotechnology and Bioengineering 1988, 32:1053-1060.
10. Han, Y.F., Cowin, S.C., Schaffler, M.B., Weinbaum, S., 2004. Mechanotransduction and strain amplification in osteocyte cell processes. Proceedings of the National Academy of Sciences of the United States of America 101, 16689-16694.
11. Nauman E.A., Chang W.C.W., Satcher R.L, Keaveny T.M. Microscale engineering applications in bone adaptation. Microscale Thermophysical Engineering 1998, 2:139-172.
12. Nauman E.A., Risic K.J., Keaveny T.M, Satcher R.L. Quantitative assessment of steady and pulsatile flow fields in a parallel plate flow chamber. Annals of Biomedical Engineering 1999, 27:194-199.
13. Nauman E.A., Satcher R.L., Keaveny T.M., Halloran B.P, Bikle D.D. Osteoblasts respond to pulsatile fluid flow with shortterm increases in pge(2) but no change in mineralization. Journal of Applied Physiology 2001, 90:1849-1854.
14. Neidlingerwilke C., Wilke H.J, Claes L. Cyclic stretching of human osteoblasts affects proliferation and metabolism - a new experimental-method and its application. Journal of Orthopaedic Research 1994, 12:70-78.
15. Owan I., Burr D.B., Turner C.H., Qiu J.Y., Tu Y., Onyia J.E, Duncan R.L. Mechanotransduction in bone: Osteoblasts are more responsive to fluid forces than mechanical strain. American Journal of Physiology-Cell Physiology 1997, 273:C810-C815.
16. Rawlinson S.C.F., Pitsillides A.A, Lanyon L.E. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. Bone 1996, 19:609-614.
17. Robling A., Duijvelaar K., Geevers J., Ohashi N, Turner C. Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force. Bone 2001, 29:105-113.
18. Robling A., Hinant F., Burr D, Turner C. Shorter, more frequent mechanical loading sessions enhance bone mass. Medicine & Science in Sports and Exercise 2002, 34:196-202.
19. Roelofsen J., KleinNulend J, Burger E.H. Mechanical stimulation by intermittent hydrostatic compression promotes bone-specific gene expression in vitro. Journal of Biomechanics 1995, 28:1493-1503.
20. Sorkin A.M., Dee K.C, Tate M.L.K. "Culture shock" From the bone cell's perspective: Emulating physiological conditions for mechanobiological investigations. American Journal of Physiology-Cell Physiology 2004, 287:C1527-C1536.
21. Tanaka S.M., Sun H.B., Roeder R.K., Burr D.B., Turner C.H, Yokota H. Osteoblast responses one hour after load-induced fluid flow in a three-dimensional porous matrix. Calcified Tissue International 2005, 76:261-271.
22. Turner C.H. Three rules for bone adaptation to mechanical stimuli. Bone 1998, 23:399-407.
23. Walker L.M., Publicover S.J., Preston M.R., Ahmed M, El Haj A.J. Calcium-channel activation and matrix protein upregulation in bone cells in response to mechanical strain. Journal of Cellular Biochemistry 2000, 79:648-661.
24. Weinbaum S., Cowin S.C, Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. Journal of Biomechanics 1994, 27:339-360.
25. You J., Yellowley C.E., Donahue H.J., Zhang Y., Chen Q, Jacobs C.R. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. Journal of Biomechanical Engineering-Transactions of the Asme 2000, 122:387-393.
26. You J.D., Cowin S.C., Schaffler M.B, Weinbaum S. A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix. Journal of Biomechanics 2001, 34:1375-1386.