Potential clinical factors affecting hepatobiliary enhancement at Gd-EOB-DTPA-enhanced MR imaging

Magnetic Resonance Imaging

Volumn 30, Issue 5, 2012, Pages 689-693

  Higaki, Atsushi ^a   Tamada, Tsutomu ^a   Sone, Teruki ^a   Kanki, Akihiko ^a   Sato, Tomohiro ^a   Tanimoto, Daigo ^a   Higashi, Hiroki ^a   Ito, Katsuyoshi ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd EOB DTPA); Liver function; Magnetic resonance imaging

Indexed keywords

ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLINESTERASE; GADOXETIC ACID;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; ASCITES; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHOLINESTERASE BLOOD LEVEL; CHRONIC LIVER DISEASE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORRELATION COEFFICIENT; FEMALE; HEPATOBILIARY SYSTEM; HUMAN; IMAGE ANALYSIS; LIVER PARENCHYMA; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; PRIORITY JOURNAL; PROTHROMBIN TIME; SPLENOMEGALY;

ADULT; AGED; AGED, 80 AND OVER; ARTIFACTS; CONTRAST MEDIA; END STAGE LIVER DISEASE; FEMALE; GADOLINIUM DTPA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84862784761     PISSN: 0730725X     EISSN: 18735894     Source Type: Journal    
DOI: 10.1016/j.mri.2012.01.004     Document Type: Article

References (19)

1. Vogl T.J., Kümmel S., Hammerstingl R., et al. Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 1996, 200:59-67.
2. Reimer P., Rummeny E.J., Daldrup H.E., et al. Enhancement characteristics of liver metastases, hepatocellular carcinomas, and hemangiomas with Gd-EOB-DTPA: preliminary results with dynamic MR imaging. Eur Radiol 1997, 7:275-280.
3. Weinmann H.J., Schuhmann-Giampieri G., Schmitt-Willich H., Vogler H., Frenzel T., Gries H. A new lipophilic gadolinium chelate as a tissue-specific contrast medium for MRI. Magn Reson Med 1991, 22:233-237.
4. Schuhmann-Giampieri G., Schmitt-Willich H., Press W.R., Negishi C., Weinmann H.J., Speck U. Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system. Radiology 1992, 183:59-64.
5. Clément O., Mühler A., Vexler V., Berthezène Y., Brasch R.C. Gadolinium-ethoxybenzyl-DTPA, a new liver-specific magnetic resonance contrast agent. Kinetic and enhancement patterns in normal and cholestatic rats. Invest Radiol 1992, 27:612-619.
6. Giovagnoni A., Paci E. Liver. III: gadolinium-based hepatobiliary contrast agents (Gd-EOB-DTPA and Gd-BOPTA/Dimeg). Magn Reson Imaging Clin N Am 1996, 4:61-72.
7. Tschirch F.T., Struwe A., Petrowsky H., et al. Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma. Eur Radiol 2008, 18:1577-1586.
8. Ryeom H.K., Kim S.H., Kim J.Y., et al. Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA. Korean J Radiol 2004, 5:231-239.
9. Motosugi U., Ichikawa T., Sou H., et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement?. J Magn Reson Imaging 2009, 30:1042-1046.
10. Kim T., Murakami T., Hasuike Y., et al. Experimental hepatic dysfunction: evaluation by MRI with Gd-EOB-DTPA. J Magn Reson Imaging 1997, 7:683-688.
11. Leonhardt M., Keiser M., Oswald S., Kühn J., Jia J., Grube M., et al. Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos 2010, 38:1024-1028.
12. van Montfoort J.E., Stieger B., Meijer D.K., Weinmann H.J., Meier P.J., Fattinger K.E. Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther 1999, 290:153-157.
13. Narita M., Hatano E., Uemoto S., et al. Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma. J Gastroenterol 2009, 44:793-798.
14. Zhang W., He Y.J., Gan Z., et al. OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation. Clin Exp Pharmacol Physiol 2007, 34:1240-1244.
15. Hagenbuch B., Gui C. Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 2008, 38:778-801.
16. König J., Seithel A., Gradhand U., Fromm M.F. Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch Pharmacol 2006, 372:432-443.
17. Geier A., Dietrich C.G., Voigt S., et al. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology 2003, 38:345-354.
18. Geier A., Kim S.K., Gerloff T., et al. Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. J Hepatol 2002, 37:198-205.
19. Planchamp C., Montet X., Frossard J.L., et al. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Invest Radiol 2005, 40:187-194.