New insights about the early diagnosis of fertility impairment in varicoceles: The DNA repair gene example

Medical Hypotheses

Volumn 78, Issue 4, 2012, Pages 536-538

  Guo, Sheng jie ^a   Sun, Zhi jian ^b   Li, Wei ^c  

^a SUN YAT SEN UNIVERSITY   (China)

^b No 202 Hospital of PLA   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CELL DNA; DEOXYRIBONUCLEOPROTEIN; METASTASIS ASSOCIATED PROTEIN 1; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROTECTION; DEACETYLATION; EARLY DIAGNOSIS; GENE EXPRESSION PROFILING; HEAT STRESS; HUMAN; MALE INFERTILITY; NONHUMAN; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SPERMATOCYTE; TESTIS INJURY; VARICOCELE;

APOPTOSIS; BIOLOGICAL MARKERS; GERM CELLS; HISTONE DEACETYLASES; HUMANS; INFERTILITY, MALE; MALE; MODELS, BIOLOGICAL; REPRESSOR PROTEINS; VARICOCELE;

EID: 84862779426     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.01.029     Document Type: Article

References (30)

1. Baazeem A., Belzile E., Ciampi A., Dohle G., Jarvi K., Salonia A., et al. Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur Urol 2011, 60:796-808.
2. Eisenberg M.L., Lipshultz L.I. Varicocele-induced infertility: newer insights into its pathophysiology. Indian J Urol 2011, 27:58-64.
3. Marmar J. Male factor infertility: innovations in varicocele surgery. Nat Rev Urol 2009, 6:470-471.
4. Gat Y., Zukerman Z., Chakraborty J., Gornish M. Varicocele, hypoxia and male infertility. Fluid Mechanics analysis of the impaired testicular venous drainage system. Hum Reprod 2005, 20:2614-2619.
5. Tetreau R., Julian P., Lyonnet D., Rouviere O. Intratesticular varicocele: an easy diagnosis but unclear physiopathologic characteristics. J Ultrasound Med 2007, 26:1767-1773.
6. Gat Y., Bachar G.N., Zukerman Z., Belenky A., Gorenish M. Physical examination may miss the diagnosis of bilateral varicocele: a comparative study of 4 diagnostic modalities. J Urol 2004, 172:1414-1417.
7. Al-Ali B.M., Marszalek M., Shamloul R., Pummer K., Trummer H. Clinical parameters and semen analysis in 716 Austrian patients with varicocele. Urology 2010, 75:1069-1073.
8. Paduch D.A., Niedzielski J. Semen analysis in young men with varicocele: preliminary study. J Urol 1996, 156:788-790.
9. Pakala S.B., Reddy S.D., Bui-Nguyen T.M., Rangparia S.S., Bommana A., Kumar R. MTA1 coregulator regulates LPS response via MyD88-dependent signaling. J Biol Chem 2010, 285:32787-32792.
10. Ghanta K.S., Pakala S.B., Reddy S.D., Li D.Q., Nair S.S., Kumar R. MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response. J Biol Chem 2011, 286:7132-7138.
11. Miura M., Sasagawa I., Suzuki Y., Nakada T., Fujii J. Apoptosis and expression of apoptosis-related genes in the mouse testis following heat exposure. Fertil Steril 2002, 77:787-793.
12. Li W., Zhang J., Liu X., Xu R., Zhang Y. Correlation of appearance of metastasis-associated protein1 Mta1 with spermatogenesis in developing mouse testis. Cell Tissue Res 2007, 329:351-362.
13. Absalan F., Movahedin M., Mowla S.J. Germ cell apoptosis induced by experimental cryptorchidism is mediated by molecular pathways in mouse testis. Andrologia 2010, 42:5-12.
14. Li W., Bao W., Ma J., Liu X., Xu R., Wang R.A., et al. Metastasis tumor antigen 1 is involved in the resistance to heat stress-induced testicular apoptosis. FEBS Lett 2008, 582:869-873.
15. Li W., Wu Z., Zhao J., Guo S., Li Z., Feng X., et al. Transient protection from heat-stress induced apoptotic stimulation by metastasis-associated protein 1 in pachytene spermatocytes. PLoS One 2011, 6:e26013.
16. Morgentaler A., Stahl B.C., Yin Y. Testis and temperature: an historical, clinical, and research perspective. J Androl 1999, 20:189-195.
17. Hikim A.P., Lue Y., Yamamoto C.M., Vera Y., Rodriguez S., Yen P.H., et al. Key apoptotic pathways for heat-induced programmed germ cell death in the testis. Endocrinology 2003, 144:3167-3175.
18. Bailey R.W., Aronow B., Harmony J.A., Griswold M.D. Heat shock-initiated apoptosis is accelerated and removal of damaged cells is delayed in the testis of clusterin/ApoJ knock-out mice. Biol Reprod 2002, 66:1042-1053.
19. Chowdhury A.K., Steinberger E. A quantitative study of the effect of heat on germinal epithelium of rat testes. Am J Anat 1964, 115:509-524.
20. Khan V.R., Brown I.R. The effect of hyperthermia on the induction of cell death in brain, testis, and thymus of the adult and developing rat. Cell Stress Chaperones 2002, 7:73-90.
21. Socher S.A., Yin Y., Dewolf W.C., Morgentaler A. Temperature-mediated germ cell loss in the testis is associated with altered expression of the cell-cycle regulator p53. J Urol 1997, 157:1986-1989.
22. Fujisawa M., Shirakawa T., Fujioka H., Gotoh A., Okada H., Arakawa S., et al. Adenovirus-mediated p53 gene transfer to rat testis impairs spermatogenesis. Arch Androl 2001, 46:223-231.
23. Mariotti A., Di Carlo L., Orlando G., Corradini M.L., Di Donato L., Pompa P., et al. Scrotal thermoregulatory model and assessment of the impairment of scrotal temperature control in varicocele. Ann Biomed Eng 2011, 39:664-673.
24. Stahl P., Schlegel P.N. Standardization and documentation of varicocele evaluation. Curr Opin Urol 2011, 21:500-505.
25. Rockett J.C., Mapp F.L., Garges J.B., Luft J.C., Mori C., Dix D.J. Effects of hyperthermia on spermatogenesis, apoptosis, gene expression, and fertility in adult male mice. Biol Reprod 2001, 65:229-239.
26. Ma L., Li W., Zhu H.P., Li Z., Sun Z.J., Liu X.P., et al. Localization and androgen regulation of metastasis-associated protein 1 in mouse epididymis. PLoS One 2010, 5:e15439.
27. Dai C., Gu W. P53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med 2010, 16:528-536.
28. Inoue Y., Iemura S., Natsume T., Miyazawa K., Imamura T. Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1. J Biol Chem 2011, 286:6311-6320.
29. Wang L.G., Liu X.M., Fang Y., Dai W., Chiao F.B., Puccio G.M., et al. De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc. Int J Oncol 2008, 33:375-380.
30. Manavathi B., Kumar R. Metastasis tumor antigens, an emerging family of multifaceted master coregulators. J Biol Chem 2007, 282:1529-1533.