Cardiac autonomic modulation during methadone therapy among heroin users: A pilot study

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 37, Issue 1, 2012, Pages 188-193

  Chang, Li Ren ^a   Lin, Yu Hsuan ^a,b   Kuo, Terry B J ^b   Ho, Yen Cheng ^c   Chen, Shiuan Horng ^d   Wu Chang, Hung Chieh ^a   Liu, Chih Min ^a   Yang, Cheryl C H ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

Autonomic nervous system; Heart rate variability; Heroin; Methadone; Opioid

Indexed keywords

ALCOHOL; BARBITURIC ACID DERIVATIVE; CANNABIS; DIAMORPHINE; METHADONE; OPIATE; PSYCHEDELIC AGENT; TRANQUILIZER;

ADULT; ARTICLE; ASIAN; AUTONOMIC DYSFUNCTION; CARDIAC VAGAL DEPRESSION; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ELECTROCARDIOGRAM; FEMALE; HEART FUNCTION; HEART RATE VARIABILITY; HEROIN DEPENDENCE; HUMAN; MAJOR CLINICAL STUDY; MALE; METHADONE TREATMENT; MORNING DOSAGE; PARASYMPATHETIC TONE; PATIENT COMPLIANCE; PILOT STUDY; POWER SPECTRUM; RECURRENCE RISK; RR INTERVAL; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE;

ADULT; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HEROIN DEPENDENCE; HUMANS; MALE; MEDICATION ADHERENCE; METHADONE; PILOT PROJECTS; VAGUS NERVE;

EID: 84862777110     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.01.006     Document Type: Article

References (32)

1. Barutcu I., Esen A.M., Kaya D., Turkmen M., Karakaya O., Melek M., et al. Cigarette smoking and heart rate variability: dynamic influence of parasympathetic and sympathetic maneuvers. Ann Noninvasive Electrocardiol 2005, 10:324-329.
2. Bau P.F., Moraes R.S., Bau C.H., Ferlin E.L., Rosito G.A., Fuchs F.D. Acute ingestion of alcohol and cardiac autonomic modulation in healthy volunteers. Alcohol 2011, 45:123-129.
3. Cami J., Farre M. Drug addiction. N Engl J Med 2003, 349:975-986.
4. Chugh S.S., Socoteanu C., Reinier K., Waltz J., Jui J., Gunson K. A community-based evaluation of sudden death associated with therapeutic levels of methadone. Am J Med 2008, 121:66-71.
5. Clausen T., Anchersen K., Waal H. Mortality prior to, during and after opioid maintenance treatment (OMT): a national prospective cross-registry study. Drug Alcohol Depend 2008, 94:151-157.
6. Darke S., Ward J., Hall W., Heather N., Wodak A. The Opiate Treatment Index (OTI) Researcher's Manual. National Drug and Alcohol Research Centre Technical Report Number 11 1991, National Drug and Alcohol Research Centre, Sydney.
7. Darke S., Hall W., Wodak A., Heather N., Ward J. Development and validation of a multi-dimensional instrument for assessing outcome of treatment among opiate users: the Opiate Treatment Index. Br J Addict 1992, 87:733-742.
8. Darke S., Duflou J., Torok M. The comparative toxicology and major organ pathology of fatal methadone and heroin toxicity cases. Drug Alcohol Depend 2010, 106:1-6.
9. Degenhardt L., Randall D., Hall W., Law M., Butler T., Burns L. Mortality among clients of a state-wide opioid pharmacotherapy program over 20years: risk factors and lives saved. Drug Alcohol Depend 2009, 105:9-15.
10. Dettmeyer R., Friedrich K., Schmidt P., Madea B. Heroin-associated myocardial damages-conventional and immunohistochemical investigations. Forensic Sci Int 2009, 187:42-46.
11. Eap C.B., Buclin T., Baumann P. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet 2002, 41:1153-1193.
12. Gossop M., Marsden J., Stewart D. Remission of psychiatric symptoms among drug misusers after drug dependence treatment. J Nerv Ment Dis 2006, 194:826-832.
13. Handelsman L., Cochrane K.J., Aronson M.J., Ness R., Rubinstein K.J., Kanof P.D. Two new rating scales for opiate withdrawal. Am J Drug Alcohol Abuse 1987, 13:293-308.
14. Jansson L.M., Dipietro J., Elko A. Fetal response to maternal methadone administration. Am J Obstet Gynecol 2005, 193:611-617.
15. Jansson L.M., Dipietro J.A., Elko A., Velez M. Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates. J Matern Fetal Neonatal Med 2007, 20:677-685.
16. Jansson L.M., Dipietro J.A., Velez M., Elko A., Knauer H., Kivlighan K.T. Maternal methadone dosing schedule and fetal neurobehaviour. J Matern Fetal Neonatal Med 2009, 22:29-35.
17. Jeanne M., Logier R., De Jonckheere J., Tavernier B. Heart rate variability during total intravenous anesthesia: effects of nociception and analgesia. Auton Neurosci 2009, 147:91-96.
18. Kosten T.R., O'Connor P.G. Management of drug and alcohol withdrawal. N Engl J Med 2003, 348:1786-1795.
19. Krantz M.J., Martin J., Stimmel B., Mehta D., Haigney M.C. QTc interval screening in methadone treatment. Ann Intern Med 2009, 150:387-395.
20. Kuo T.B.J., Chan S.H.H. Continuous, on-line, real-time spectral analysis of systemic arterial pressure signals. Am J Physiol 1993, 264:H2208-H2213.
21. Kuo T.B.J., Lin T., Yang C.C.H., Li C.L., Chen C.F., Chou P. Effect of aging on gender differences in neural control of heart rate. Am J Physiol 1999, 277:H2233-H2239.
22. Manzano B.M., Vanderlei L.C., Ramos E.M., Ramos D. Acute effects of smoking on autonomic modulation: analysis by Poincare plot. Arq Bras Cardiol 2011, 96:154-160.
23. McLellan A.T., Lewis D.C., O'Brien C.P., Kleber H.D. Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. JAMA 2000, 284:1689-1695.
24. Michaloudis D., Kochiadakis G., Georgopoulou G., Fraidakis O., Chlouverakis G., Petrou A., et al. The influence of premedication on heart rate variability. Anaesthesia 1998, 53:446-453.
25. Panel N.C.D. Effective medical treatment of opiate addiction. National Consensus Development Panel on Effective Medical Treatment of Opiate Addiction. JAMA 1998, 280:1936-1943.
26. Peles E., Bodner G., Kreek M.J., Rados V., Adelson M. Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients: a cross-sectional study. Addiction 2007, 102:289-300.
27. Ramirez-Cacho W.A., Flores S., Schrader R.M., McKay J., Rayburn W.F. Effect of chronic maternal methadone therapy on intrapartum fetal heart rate patterns. J Soc Gynecol Investig 2006, 13:108-111.
28. Ravndal E., Amundsen E.J. Mortality among drug users after discharge from inpatient treatment: an 8-year prospective study. Drug Alcohol Depend 2010, 108:65-69.
29. Routsi C., Kolias S., Kaskarellis I., Politis P., Zervou M., Filippatos G., et al. Acute cardiomyopathy and cardiogenic pulmonary edema after inhaled heroin use. Acta Anaesthesiol Scand 2007, 51:262-264.
30. Senbanjo R., Wolff K., Marshall E.J., Strang J. Persistence of heroin use despite methadone treatment: poor coping self-efficacy predicts continued heroin use. Drug Alcohol Rev 2009, 28:608-615.
31. Tagliaro F., De Battisti Z., Smith F.P., Marigo M. Death from heroin overdose: findings from hair analysis. Lancet 1998, 351:1923-1925.
32. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996, 93:1043-1065.