Increased expression of hypoxia-inducible factor-1α and connective tissue growth factor accompanied by fibrosis in the rat testis of varicocele;Expresión aumentada del factor inducible por hipoxia 1α y del factor de crecimiento del tejido conectivo acompañando a fibrosis en testículos de ratas con varicocele

Actas Urologicas Espanolas

Volumn 36, Issue 5, 2012, Pages 282-288

  Paick, J S ^a   Park, K ^a   Kim, S W ^a   Park, J W ^a   Kim, J J ^b   Kim, M S ^c   Park, J Y ^b  

^a Seoul National University   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Gachon University College of Medicine   (South Korea)

Author keywords

Alpha subunit; Connective tissue growth factor; Fibrosis; Hypoxia inducible factor 1; Varicocele

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ANIMAL; ARTICLE; BIOSYNTHESIS; FIBROSIS; MALE; METABOLISM; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; TESTIS; VARICOCELE;

ANIMALS; CONNECTIVE TISSUE GROWTH FACTOR; FIBROSIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; RATS; RATS, SPRAGUE-DAWLEY; TESTIS; VARICOCELE;

EID: 84862776871     PISSN: 02104806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acuro.2011.07.022     Document Type: Article

References (20)

1. a ed. 1997 Mosby St. Louis 336 359
2. D.A. Paduch, and S.J. Skoog Current management of adolescent varicocele Rev Urol 3 2001 120 133
3. S. Agarwal Vascular morphology in testes of infertile males with varicocele Indian J Med Res 94 1991 228 231
4. C.K. Naughton, A.K. Nangia, and A. Agarwal Varicocele and male infertility: Part II: Pathophysiology of varicoceles in male infertility Hum Reprod Update 7 2001 473 481 (Pubitemid 32827547)
5. A.T.K. Cockett, H. Takihara, M. Iwamura, and K. Koshiba Pathophysiology of Clinical Varicoceles in Infertile Men Int J Urol 5 1998 113 115 (Pubitemid 28197302)
6. P.C. Fretz, and J.I. Sandlow Varicocele: current concepts in pathophysiology, diagnosis, and treatment Urol Clin North Am 29 2002 921 937 (Pubitemid 36015333)
7. F. Kilinc, F. Kayaselcuk, C.E.M. Aygun, S. Guvel, T. Egilmez, and H. Ozkardes Experimental varicocele induces hypoxia inducible factor-1alpha, vascular endothelial growth factor expression and angiogenesis in the rat testis J Urol 172 2004 1188 1191 (Pubitemid 39096497)
8. J.D. Lee, S.Y. Jeng, and T.H. Lee Increased expression of hypoxia-inducible factor-1[alpha] in the internal spermatic vein of patients with varicocele J Urol 175 2006 1045 1048
9. D.F. Higgins, M.P. Biju, Y. Akai, A. Wutz, R.S. Johnson, and V.H. Haase Hypoxic induction of CTGF is directly mediated by HIF-1 Am J Physiol Renal Physiol 287 2004 F1223 F1232
10. K.H. Hong, S.A. Yoo, S.S. Kang, J.J. Choi, W.U. Kim, and C.S. Cho Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts Clin Exp Immunol 146 2006 362 370
11. Y. Shi, and O. Tokunaga Chlamydia pneumoniae and multiple infections in the aorta contribute to atherosclerosis Pathol Int 52 2002 755 763 (Pubitemid 35478098)
12. V. Paradis, D. Dargere, M. Vidaud, Gouville A-Cd, S. Huet, and V. Martinez Expression of connective tissue growth factor in experimental rat and human liver fibrosis Hepatology 30 1999 968 976 (Pubitemid 29458286)
13. D. Raleigh, L. O'Donnell, G.J. Southwick, D.M. De Kretser, and R.I. McLachlan Stereological analysis of the human testis after vasectomy indicates impairment of spermatogenic efficiency with increasing obstructive interval Fertil Steril 81 2004 1595 1603 (Pubitemid 38749005)
14. T.T. Turner, C.E. Jones, and M.S. Roddy Experimental varicocele does not affect the blood-testis barrier, epididymal electrolyte concentrations, or testicular blood gas concentrations Biol Reprod 36 1987 926 932
15. H. Ozturk, B. Tander, A. Aydin, Z. Okumus, and S. Cetinkursun The effects of chemical sympathectomy on testicular injury in varicocele BJU Int 87 2001 232 234 (Pubitemid 32142534)
16. J.W. Park, Y.S. Chun, and M.S. Kim Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools J Pharmacol Sci 94 2004 221 232
17. R.E. Gilbert, A. Akdeniz, S. Weitz, W.R. Usinger, C. Molineaux, and S.E. Jones Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy Diabetes Care 26 2003 2632 2636 (Pubitemid 37052112)
18. B.L. Riser, P. Cortes, M. Denichilo, P.V. Deshmukh, P.S. Chahal, and A.K. Mohammed Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary report Kidney Int 64 2003 451 458 (Pubitemid 36871916)
19. C.M. Wiener, G. Booth, and G.L. Semenza In vivo expression of mRNAs encoding hypoxia-inducible factor 1 Biochem Biophys Res Commun 225 1996 485 488 (Pubitemid 26355627)
20. T. Shimo, S. Kubota, S. Kondo, T. Nakanishi, A. Sasaki, and H. Mese Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line Cancer Lett 174 2001 57 64 (Pubitemid 33001308)