Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins

Biochemical and Biophysical Research Communications

Volumn 417, Issue 4, 2012, Pages 1235-1241

  Murakami, Hidekazu ^a   Wang, Yetao ^a   Hasuwa, Hidetoshi ^a   Maeda, Yusuke ^a   Kinoshita, Taroh ^a   Murakami, Yoshiko ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Glycosylphosphatidylinositol anchor; Lipid raft; Lipid remodeling; Pgap3; T cell signal; Thy 1

Indexed keywords

FATTY ACID; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; MEMBRANE PROTEIN; PGAP2 PROTEIN; PGAP3 PROTEIN; SATURATED FATTY ACID; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL INTERACTION; CELL SURFACE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; GOLGI COMPLEX; GROWTH RETARDATION; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LIMB; LIPID RAFT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WILD TYPE;

ANIMALS; ANTIGENS; ANTIGENS, THY-1; CARBOXYLIC ESTER HYDROLASES; CD4-POSITIVE T-LYMPHOCYTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FATTY ACIDS; FEMALE; GLYCOSYLPHOSPHATIDYLINOSITOLS; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE MICRODOMAINS; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL;

MUS;

EID: 84862776850     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.116     Document Type: Article

References (22)

1. Paulick M.G., Bertozzi C.R. The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Biochemistry 2008, 47:6991-7000.
2. Tanaka S., Maeda Y., Tashima Y., Kinoshita T. Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. J. Biol. Chem. 2004, 279:14256-14263.
3. Fujita M., Maeda Y., Ra M., Yamaguchi Y., Taguchi R., Kinoshita T. GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. Cell 2009, 139:352-365.
4. Kinoshita T., Fujita M., Maeda Y. Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress. J. Biochem. 2008, 144:287-294.
5. Fujita M., Kinoshita T. Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins. FEBS Lett. 2010, 584:1670-1677.
6. Tarutani M., Itami S., Okabe M., Ikawa M., Tezuka T., Yoshikawa K., Kinoshita T., Takeda J. Tissue specific knock-out of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc. Natl. Acad. Sci. USA 1997, 94:7400-7405.
7. Sakai K., Miyazaki J. A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem. Biophys. Res. Commun. 1997, 237:318-324.
8. Maeda Y., Tashima Y., Houjou T., Fujita M., Yoko-o T., Jigami Y., Taguchi R., Kinoshita T. Fatty acid remodeling of GPI-anchored proteins is required for their raft association. Mol. Biol. Cell 2007, 18:1497-1506.
9. Stromnes I.M., Goverman J.M. Active induction of experimental allergic encephalomyelitis. Nat. Protoc. 2006, 1:1810-1819.
10. Tanimura N., Nagafuku M., Minaki Y., Umeda Y., Hayashi F., Sakakura J., Kato A., Liddicoat D.R., Ogata M., Hamaoka T., Kosugi A. Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activation. J. Cell Biol. 2003, 160:125-135.
11. Vacchio M.S., Ryan J.J., Hodes R.J. Characterization of the ligand(s) responsible for negative selection of V beta 11- and V beta 12-expressing T cells: effects of a new Mls determinant. J. Exp. Med. 1990, 172:807-813.
12. Rajendran L., Simons K. Lipid rafts and membrane dynamics. J. Cell Sci. 2005, 118:1099-1102.
13. Simons K., Toomre D. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 2000, 1:31-39.
14. Jones D.R., Varela-Nieto I. The role of glycosyl-phosphatidylinositol in signal transduction. Int. J. Biochem. Cell Biol. 1998, 30:313-326.
15. Robinson P.J. Signal transduction via GPI-anchored membrane proteins. Adv. Exp. Med. Biol. 1997, 419:365-370.
16. Hazenbos W.L., Murakami Y., Nishimura J., Takeda J., Kinoshita T. Enhanced responses of glycosylphosphatidylinositol anchor-deficient T lymphocytes. J. Immunol. 2004, 173:3810-3815.
17. Stanford W.L., Haque S., Alexander R., Liu X., Latour A.M., Snodgrass H.R., Koller B.H., Flood P.M. Altered proliferative response by lymphocytes of Ly-6A (Sca-1) null mice. J. Exp. Med. 1997, 186:705-717.
18. -/- mice show augmented TCR signaling and impaired differentiation. Curr. Biol. 1997, 7:705-708.
19. Leyton L., Quest A.F., Bron C. Thy-1/CD3 coengagement promotes TCR signaling and enhances particularly tyrosine phosphorylation of the raft molecule LAT. Mol. Immunol. 1999, 36:755-768.
20. Johnson R., Lancki D.W., Fitch F.W. Accessory molecules involved in antigen-mediated cytolysis and lymphokine production by cytotoxic T lymphocyte subsets. I: Identification of functions for the T cell surface molecules Ly-6C and Thy-1. J. Immunol. 1993, 151:2986-2999.
21. Leyton L., Schneider P., Labra C.V., Ruegg C., Hetz C.A., Quest A.F., Bron C. Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites. Curr. Biol. 2001, 11:1028-1038.
22. Haeryfar S.M., Al-Alwan M.M., Mader J.S., Rowden G., West K.A., Hoskin D.W. Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hit. J. Immunol. 2003, 171:69-77.