No significant association of aspirin use with cerebral microbleeds in the asymptomatic elderly

Journal of the Neurological Sciences

Volumn 319, Issue 1-2, 2012, Pages 56-58

  Kim, Chi Kyung ^a,b   Kwon, Hyuk Tae ^c   Kwon, Hyung Min ^d  

^a Seoul National University Hospital   (South Korea)

^b Biomedical Research Institute   (South Korea)

^c Seoul National University Hospital Healthcare System Gangnam Center   (South Korea)

^d Seoul National University Boramae Hospital   (South Korea)

Author keywords

Antiplatelet; Aspirin; Cerebral microbleeds; Hemorrhagic stroke; Intracerebral hemorrhage

Indexed keywords

ACETYLSALICYLIC ACID; WARFARIN;

AGED; ARTICLE; BRAIN HEMORRHAGE; CONTROLLED STUDY; ELDERLY CARE; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUESTIONNAIRE; RISK ASSESSMENT; STROKE; TRANSIENT ISCHEMIC ATTACK;

AGED; AGED, 80 AND OVER; ASPIRIN; FEMALE; HUMANS; INTRACRANIAL HEMORRHAGES; MALE; PLATELET AGGREGATION INHIBITORS; RISK FACTORS;

EID: 84862757760     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2012.05.017     Document Type: Article

References (17)

1. Greenberg SM, Eng JA, Ning M, Smith EE, Rosand J. Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke 2004;35: 1415-20. (Pubitemid 38697468)
2. Nishikawa T, Ueba T, Kajiwara M, Fujisawa I, Miyamatsu N, Yamashita K. Cerebral microbleeds predict first-ever symptomatic cerebrovascular events. Clin Neurol Neurosurg 2009;111:825-8.
3. Baigent C, Blackwell L, Collins R, Emberson J,Godwin J, Peto R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009;373:1849-60.
4. Gorelick PB, Weisman SM. Risk of hemorrhagic stroke with aspirin use: an update. Stroke 2005;36:1801-7. (Pubitemid 41098782)
5. Biffi A, Halpin A, Towfighi A, Gilson A, Busl K, Rost N, et al. Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy. Neurology 2010;75: 693-8.
6. Lovelock CE, Cordonnier C, Naka H, Al-Shahi Salman R, Sudlow CL, Sorimachi T, et al. Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: a systematic review of published and unpublished studies. Stroke 2010;41:1222-8.
7. Vernooij MW, Haag MD, van der Lugt A, Hofman A, Krestin GP, Stricker BH, et al. Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study. Arch Neurol 2009;66:714-20.
8. Ge L, Niu G, Han X, Gao Y, Wu Q, Wu H, et al. Aspirin treatment increases the risk of cerebral microbleeds. Can J Neurol Sci 2011;38:863-8.
9. Orken DN, Kenangil G, Uysal E, Forta H. Cerebral microbleeds in ischemic stroke patients on warfarin treatment. Stroke 2009;40:3638-40.
10. Nishikawa T, Ueba T, Kajiwara M, Miyamatsu N, Yamashita K. Cerebral microbleeds in patients with intracerebral hemorrhage are associated with previous cerebrovascular diseases and white matter hyperintensity, but not with regular use of antiplatelet agents. Neurol Med Chir (Tokyo) 2009;49:333-8.
11. Kwon HM, Kim BJ, Lee SH, Choi SH, Oh BH, Yoon BW. Metabolic syndrome as an independent risk factor of silent brain infarction in healthy people. Stroke 2006;37:466-70.
12. Kim CK, Lee SH, Kim BJ, Ryu WS, Yoon BW. Age-independent association of pulse pressure with cerebral white matter lesions in asymptomatic elderly individuals. J Hypertens 2011;29:325-9.
13. Kwon HM, Kim BJ, Park JH, Ryu WS, Kim CK, Lee SH, et al. Significant association of metabolic syndrome with silent brain infarction in elderly people. J Neurol 2009;256:1825-31.
14. Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 2001;56(4):537-9. (Pubitemid 32172884)
15. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 2008;70:1208-14. (Pubitemid 351482572)
16. Biffi A, Greenberg GM. Cerebral amyloid angiopathy: a systematic review. J Clin Neurol 2011;7:1-9.
17. Kato H, Izumiyama M, Izumiyama K, Takahashi A, Itoyama Y. Silent cerebral microbleeds on T2*-weighted MRI: correlation with stroke subtype, stroke recurrence, and leukoaraiosis. Stroke 2002;33:1536-40. (Pubitemid 34619953)