Pharmacokinetics and cerebral distribution of glycine administered to rats

Amino Acids

Volumn 42, Issue 6, 2012, Pages 2129-2137

  Kawai, Nobuhiro ^a   Bannai, Makoto ^a   Seki, Shinobu ^a   Koizumi, Tomonori ^b   Shinkai, Kenji ^b   Nagao, Kenji ^a   Matsuzawa, Daisuke ^c   Takahashi, Michio ^a   Shimizu, Eiji ^c  

^a AJINOMOTO CO INC   (Japan)

^b Research Center   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

Blood CSF barrier; Brain uptake index; Glycine; NMDA receptor; Schizophrenia; Serine

Indexed keywords

CARBON 14; DRUG METABOLITE; GLYCINE; HISTONE H3; INULIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SERINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; BRAIN VENTRICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG TRANSPORT; ISOTOPE LABELING; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; WHOLE BODY AUTORADIOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; AUTORADIOGRAPHY; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; MALE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SERINE;

RATTUS;

EID: 84862756021     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-0950-y     Document Type: Article

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