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Volumn 43, Issue 1, 2012, Pages 355-363

Increased concentrations of both NMDA receptor co-agonists d-serine and glycine in global ischemia: A potential novel treatment target for perinatal asphyxia

Author keywords

d Serine; Glutamate; Ischemia; NMDA receptor; Perinatal asphyxia

Indexed keywords

DEXTRO SERINE; GLUCOSE; GLUTAMIC ACID; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXYGEN; SERINE;

EID: 84862753773     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1086-9     Document Type: Article
Times cited : (19)

References (42)
  • 1
    • 0025873453 scopus 로고
    • Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits
    • 2028499 10.1161/01.STR.22.5.666 1:CAS:528:DyaK3MXkvFShsL4%3D
    • AJ Baker MH Zornow MR Grafe MS Scheller SR Skilling DH Smullin AA Larson 1991 Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits Stroke 22 666 673 2028499 10.1161/01.STR.22.5.666 1:CAS:528:DyaK3MXkvFShsL4%3D
    • (1991) Stroke , vol.22 , pp. 666-673
    • Baker, A.J.1    Zornow, M.H.2    Grafe, M.R.3    Scheller, M.S.4    Skilling, S.R.5    Smullin, D.H.6    Larson, A.A.7
  • 2
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • DOI 10.1111/j.1471-4159.1984.tb05396.x
    • H Benveniste J Drejer A Schousboe NH Diemer 1984 Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis J Neurochem 43 1369 1374 6149259 10.1111/j.1471-4159.1984.tb05396.x 1:CAS:528:DyaL2cXmt1yjt7k%3D (Pubitemid 15205893)
    • (1984) Journal of Neurochemistry , vol.43 , Issue.5 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.H.4
  • 4
    • 55149085415 scopus 로고    scopus 로고
    • D-Serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brain
    • 18363840 10.1111/j.1582-4934.2008.00315.x 1:CAS:528:DC%2BD1cXhsVOgu73M
    • JM Billard 2008 d-Serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brain J Cell Mol Med 12 1872 1884 18363840 10.1111/j.1582-4934.2008.00315.x 1:CAS:528:DC%2BD1cXhsVOgu73M
    • (2008) J Cell Mol Med , vol.12 , pp. 1872-1884
    • Billard, J.M.1
  • 5
    • 0018372689 scopus 로고
    • Comparative aspects of the brain growth spurt
    • J Dobbing J Sands 1979 Comparative aspects of the brain growth spurt Early Hum Dev 3 79 83 118862 10.1016/0378-3782(79)90022-7 1:STN:280: DyaL3c7ht1GksA%3D%3D (Pubitemid 9141710)
    • (1979) Early Human Development , vol.3 , Issue.1 , pp. 79-83
    • Dobbing, J.1    Sands, J.2
  • 6
    • 0033596587 scopus 로고    scopus 로고
    • Deleterious brain cell membrane effects after NMDA receptor antagonist administration to newborn piglets
    • DOI 10.1016/S0006-8993(98)01178-0, PII S0006899398011780
    • KI Fritz F Groenendaal C Andersen ST Ohnishi OP Mishra M Delivoria-Papadopoulos 1999 Deleterious brain cell membrane effects after NMDA receptor antagonist administration to newborn piglets Brain Res 816 438 445 9878867 10.1016/S0006-8993(98)01178-0 1:CAS:528:DyaK1MXhsVagsQ%3D%3D (Pubitemid 29225392)
    • (1999) Brain Research , vol.816 , Issue.2 , pp. 438-445
    • Fritz, K.I.1    Groenendaal, F.2    Andersen, C.3    Ohnishi, S.T.4    Mishra, O.P.5    Delivoria-Papadopoulos, M.6
  • 8
    • 51349162646 scopus 로고    scopus 로고
    • Two mass-spectrometric techniques for quantifying serine enantiomers and glycine in cerebrospinal fluid: Potential confounders and age-dependent ranges
    • 18606633 10.1373/clinchem.2007.100412 1:CAS:528:DC%2BD1cXhtVGqsbzM
    • SA Fuchs MG der Velden MM de Barse MW Roeleveld M Hendriks L Dorland LW Klomp R Berger TJ de Koning 2008 Two mass-spectrometric techniques for quantifying serine enantiomers and glycine in cerebrospinal fluid: potential confounders and age-dependent ranges Clin Chem 54 1443 1450 18606633 10.1373/clinchem.2007.100412 1:CAS:528:DC%2BD1cXhtVGqsbzM
    • (2008) Clin Chem , vol.54 , pp. 1443-1450
    • Fuchs, S.A.1    Der Velden, M.G.2    De Barse, M.M.3    Roeleveld, M.W.4    Hendriks, M.5    Dorland, L.6    Klomp, L.W.7    Berger, R.8    De Koning, T.J.9
  • 9
    • 0036402091 scopus 로고    scopus 로고
    • Effects of magnesium sulphate on amplitude-integrated continuous EEG in asphyxiated term neonates
    • DOI 10.1080/080352502760311575
    • F Groenendaal CM Rademaker MC Toet LS de Vries 2002 Effects of magnesium sulphate on amplitude-integrated continuous EEG in asphyxiated term neonates Acta Paediatr 91 1073 1077 12434893 10.1111/j.1651-2227.2002.tb00102.x 1:STN:280:DC%2BD38nnsVWgug%3D%3D (Pubitemid 35210153)
    • (2002) Acta Paediatrica, International Journal of Paediatrics , vol.91 , Issue.10 , pp. 1073-1077
    • Groenendaal, F.1    Rademaker, C.M.A.2    Toet, M.3    De Vries, L.S.4
  • 10
    • 18144446180 scopus 로고    scopus 로고
    • Excitatory amino acids and taurine levels in cerebrospinal fluid of hypoxic ischemic encephalopathy in newborn
    • DOI 10.1016/S0303-8467(99)00035-9, PII S0303846799000359
    • K Gucuyener Y Atalay YZ Aral A Hasanoglu C Turkyilmaz G Biberoglu 1999 Excitatory amino acids and taurine levels in cerebrospinal fluid of hypoxic ischemic encephalopathy in newborn Clin Neurol Neurosurg 101 171 174 10536902 10.1016/S0303-8467(99)00035-9 1:STN:280:DC%2BD3c%2FgsFaqtg%3D%3D (Pubitemid 29447581)
    • (1999) Clinical Neurology and Neurosurgery , vol.101 , Issue.3 , pp. 171-174
    • Gucuyener, K.1    Atalay, Y.2    Ziya Aral, Y.3    Hasanoglu, A.4    Turkyilmaz, C.5    Biberoglu, G.6
  • 11
    • 33846621575 scopus 로고    scopus 로고
    • The tripartite synapse: roles for gliotransmission in health and disease
    • DOI 10.1016/j.molmed.2006.12.005, PII S1471491406002851
    • MM Halassa T Fellin PG Haydon 2007 The tripartite synapse: roles for gliotransmission in health and disease Trends Mol Med 13 54 63 17207662 10.1016/j.molmed.2006.12.005 1:CAS:528:DC%2BD2sXhtlSnsr8%3D (Pubitemid 46186152)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.2 , pp. 54-63
    • Halassa, M.M.1    Fellin, T.2    Haydon, P.G.3
  • 12
    • 0027227598 scopus 로고
    • Glutamate uptake and glutamate content in primary cultures of mouse astrocytes during anoxia, substrate deprivation and simulated ischemia under normothermic and hypothermic conditions
    • DOI 10.1016/0006-8993(93)91289-5
    • R Huang A Shuaib L Hertz 1993 Glutamate uptake and glutamate content in primary cultures of mouse astrocytes during anoxia, substrate deprivation and simulated ischemia under normothermic and hypothermic conditions Brain Res 618 346 351 8104087 10.1016/0006-8993(93)91289-5 1:CAS:528:DyaK3sXlsFOnurk%3D (Pubitemid 23207980)
    • (1993) Brain Research , vol.618 , Issue.2 , pp. 346-351
    • Huang, R.1    Shuaib, A.2    Hertz, L.3
  • 13
    • 77957798517 scopus 로고    scopus 로고
    • Evidence for the existence of secretory granule (dense-core vesicle)-based inositol 1,4,5-trisphosphate-dependent Ca2+ signaling system in astrocytes
    • 20700485 10.1371/journal.pone.0011973
    • YS Hur KD Kim SH Paek SH Yoo 2010 Evidence for the existence of secretory granule (dense-core vesicle)-based inositol 1,4,5-trisphosphate-dependent Ca2+ signaling system in astrocytes PLoS One 5 e11973 20700485 10.1371/journal.pone. 0011973
    • (2010) PLoS One , vol.5 , pp. 11973
    • Hur, Y.S.1    Kim, K.D.2    Paek, S.H.3    Yoo, S.H.4
  • 14
    • 0028353946 scopus 로고
    • Effects of hypothermic metabolic suppression on hippocampal glutamate concentrations after transient global cerebral ischemia
    • UM Illievich MH Zornow KT Choi MS Scheller MA Strnat 1994 Effects of hypothermic metabolic suppression on hippocampal glutamate concentrations after transient global cerebral ischemia Anesth Analg 78 905 911 8160988 10.1213/00000539-199405000-00012 1:CAS:528:DyaK2cXltVGrt7o%3D (Pubitemid 24138265)
    • (1994) Anesthesia and Analgesia , vol.78 , Issue.5 , pp. 905-911
    • Illievich, U.M.1    Zornow, M.H.2    Kyu Taek Choi3    Scheller, M.S.4    Strnat, M.A.P.5
  • 15
    • 12344252444 scopus 로고    scopus 로고
    • Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia
    • DOI 10.1038/sj.cr.7290225, PII 7290225
    • PA Jones GR May JA McLuckie A Iwashita J Sharkey 2004 Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia Cell Res 14 241 250 15225418 10.1038/sj.cr.7290225 1:CAS:528:DC%2BD2cXmt1Cgsbg%3D (Pubitemid 43231822)
    • (2004) Cell Research , vol.14 , Issue.3 , pp. 241-250
    • Jones, P.A.1    May, G.R.2    Mcluckie, J.A.3    Iwashita, A.4    Sharkey, J.5
  • 16
    • 6344276678 scopus 로고    scopus 로고
    • Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices
    • DOI 10.1124/jpet.104.070912
    • H Katsuki M Nonaka H Shirakawa T Kume A Akaike 2004 Endogenous d-serine is involved in induction of neuronal death by N-methyl-d-aspartate and simulated ischemia in rat cerebrocortical slices J Pharmacol Exp Ther 311 836 844 15240826 10.1124/jpet.104.070912 1:CAS:528:DC%2BD2cXptVKqsro%3D (Pubitemid 39391574)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.311 , Issue.2 , pp. 836-844
    • Katsuki, H.1    Nonaka, M.2    Shirakawa, H.3    Kume, T.4    Akaike, A.5
  • 17
    • 14744298742 scopus 로고    scopus 로고
    • 4 Million neonatal deaths: When? Where? Why?
    • DOI 10.1016/S0140-6736(05)71048-5
    • JE Lawn S Cousens J Zupan 2005 4 million neonatal deaths: when? Where? Why? Lancet 365 891 900 15752534 10.1016/S0140-6736(05)71048-5 (Pubitemid 40332168)
    • (2005) Lancet , vol.365 , Issue.9462 , pp. 891-900
    • Lawn, J.E.1    Cousens, S.2    Zupan, J.3
  • 19
    • 0036362935 scopus 로고    scopus 로고
    • NMDA receptor antagonists and glycine site NMDA antagonists
    • Madden K (2002) NMDA receptor antagonists and glycine site NMDA antagonists. Curr Med Res Opin 18 Suppl 2:s27-s31
    • (2002) Curr Med Res Opin , vol.18 , Issue.SUPPL 2
    • Madden, K.1
  • 20
    • 51349145743 scopus 로고    scopus 로고
    • Confocal imaging and tracking of the exocytotic routes for d-serine-mediated gliotransmission
    • 18615566 10.1002/glia.20696
    • M Martineau T Galli G Baux JP Mothet 2008 Confocal imaging and tracking of the exocytotic routes for d-serine-mediated gliotransmission Glia 56 1271 1284 18615566 10.1002/glia.20696
    • (2008) Glia , vol.56 , pp. 1271-1284
    • Martineau, M.1    Galli, T.2    Baux, G.3    Mothet, J.P.4
  • 21
    • 33646002696 scopus 로고    scopus 로고
    • Characterization of human d-amino acid oxidase
    • 16616139 10.1016/j.febslet.2006.03.045 1:CAS:528:DC%2BD28Xjs1aisrs%3D
    • G Molla S Sacchi M Bernasconi MS Pilone K Fukui L Pollegioni 2006 Characterization of human d-amino acid oxidase FEBS Lett 580 2358 2364 16616139 10.1016/j.febslet.2006.03.045 1:CAS:528:DC%2BD28Xjs1aisrs%3D
    • (2006) FEBS Lett , vol.580 , pp. 2358-2364
    • Molla, G.1    Sacchi, S.2    Bernasconi, M.3    Pilone, M.S.4    Fukui, K.5    Pollegioni, L.6
  • 25
    • 58149459159 scopus 로고    scopus 로고
    • Regulation of N-methyl-d-aspartate receptors by astrocytic d-serine
    • 18358625 10.1016/j.neuroscience.2008.01.071 1:CAS:528: DC%2BD1MXns1ygtw%3D%3D
    • SH Oliet JP Mothet 2009 Regulation of N-methyl-d-aspartate receptors by astrocytic d-serine Neuroscience 158 275 283 18358625 10.1016/j.neuroscience. 2008.01.071 1:CAS:528:DC%2BD1MXns1ygtw%3D%3D
    • (2009) Neuroscience , vol.158 , pp. 275-283
    • Oliet, S.H.1    Mothet, J.P.2
  • 26
    • 33646522699 scopus 로고    scopus 로고
    • Glia-derived d-serine controls NMDA receptor activity and synaptic memory
    • 16713567 10.1016/j.cell.2006.02.051 1:CAS:528:DC%2BD28XltlSkt7k%3D
    • A Panatier DT Theodosis JP Mothet B Touquet L Pollegioni DA Poulain SH Oliet 2006 Glia-derived d-serine controls NMDA receptor activity and synaptic memory Cell 125 775 784 16713567 10.1016/j.cell.2006.02.051 1:CAS:528: DC%2BD28XltlSkt7k%3D
    • (2006) Cell , vol.125 , pp. 775-784
    • Panatier, A.1    Theodosis, D.T.2    Mothet, J.P.3    Touquet, B.4    Pollegioni, L.5    Poulain, D.A.6    Oliet, S.H.7
  • 28
    • 0024842230 scopus 로고
    • Effect of a brief hypoxic/hypotensive episode on the in vivo release of cerebral cortical γ-aminobutyric acid and glycine
    • DOI 10.1016/0006-8993(89)91606-5
    • JW Phillis GA Walter 1989 Effect of a brief hypoxic/hypotensive episode on the in vivo release of cerebral cortical gamma-aminobutyric acid and glycine Brain Res 504 121 123 2598006 10.1016/0006-8993(89)91606-5 1:CAS:528: DyaK3cXntVKgsA%3D%3D (Pubitemid 20014048)
    • (1989) Brain Research , vol.504 , Issue.1 , pp. 121-123
    • Phillis, J.W.1    Walter, G.A.2
  • 29
    • 0029970149 scopus 로고    scopus 로고
    • Development of brain damage after neonatal hypoxia-ischemia: Excitatory amino acids and cysteine
    • DOI 10.1007/BF02069499
    • M Puka-Sundvall E Gilland E Bona A Lehmann M Sandberg H Hagberg 1996 Development of brain damage after neonatal hypoxia-ischemia: excitatory amino acids and cysteine Metab Brain Dis 11 109 123 8776714 10.1007/BF02069499 1:CAS:528:DyaK28Xktlemsbk%3D (Pubitemid 26177655)
    • (1996) Metabolic Brain Disease , vol.11 , Issue.2 , pp. 109-123
    • Puka-Sundvall, M.1    Gilland, E.2    Bona, E.3    Lehmann, A.4    Sandberg, M.5    Hagberg, H.6
  • 30
    • 0024602050 scopus 로고
    • School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term
    • DOI 10.1016/S0022-3476(89)80132-5
    • CM Robertson NN Finer MG Grace 1989 School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term J Pediatr 114 753 760 2469789 10.1016/S0022-3476(89)80132-5 1:STN:280:DyaL1M3jsF2htw%3D%3D (Pubitemid 19122969)
    • (1989) Journal of Pediatrics , vol.114 , Issue.5 , pp. 753-760
    • Robertson, C.M.T.1    Finer, N.N.2    Grace, M.G.A.3
  • 31
    • 0032857114 scopus 로고    scopus 로고
    • Glycine and other neurotransmitter amino acids in cerebrospinal fluid in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy
    • DOI 10.1080/08035259950168225
    • A Roldan J Figueras-Aloy R Deulofeu R Jimenez 1999 Glycine and other neurotransmitter amino acids in cerebrospinal fluid in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy Acta Paediatr 88 1137 1141 10565463 10.1111/j.1651-2227.1999.tb01002.x 1:STN:280:DC%2BD3c%2FivFWqsQ%3D%3D (Pubitemid 29489173)
    • (1999) Acta Paediatrica, International Journal of Paediatrics , vol.88 , Issue.10 , pp. 1137-1141
    • Roldan, A.1    Figueras-Aloy, J.2    Deulofeu, R.3    Jimenez, R.4
  • 32
    • 35548957889 scopus 로고    scopus 로고
    • Astrocyte metabolism and signaling during brain ischemia
    • DOI 10.1038/nn2004, PII NN2004
    • DJ Rossi JD Brady C Mohr 2007 Astrocyte metabolism and signaling during brain ischemia Nat Neurosci 10 1377 1386 17965658 10.1038/nn2004 1:CAS:528:DC%2BD2sXht1ajsbnE (Pubitemid 350014689)
    • (2007) Nature Neuroscience , vol.10 , Issue.11 , pp. 1377-1386
    • Rossi, D.J.1    Brady, J.D.2    Mohr, C.3
  • 33
    • 0035693680 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death
    • DOI 10.1385/MN:24:1-3:107
    • R Sattler M Tymianski 2001 Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death Mol Neurobiol 24 107 129 11831548 10.1385/MN:24:1-3:107 1:CAS:528:DC%2BD38XnsVaqug%3D%3D (Pubitemid 34066681)
    • (2001) Molecular Neurobiology , vol.24 , Issue.1-3 , pp. 107-129
    • Sattler, R.1    Tymianski, M.2
  • 34
    • 77952267258 scopus 로고    scopus 로고
    • State of the science: Hypoxic ischemic encephalopathy and hypothermic intervention for neonates
    • 20386369
    • LD Selway 2010 State of the science: hypoxic ischemic encephalopathy and hypothermic intervention for neonates Adv Neonatal Care 10 60 66 20386369
    • (2010) Adv Neonatal Care , vol.10 , pp. 60-66
    • Selway, L.D.1
  • 35
    • 0025765904 scopus 로고
    • Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants
    • 1713544 10.1016/0378-3782(91)90191-5 1:STN:280:DyaK3MzhslWgsg%3D%3D
    • S Shankaran E Woldt T Koepke MP Bedard R Nandyal 1991 Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants Early Hum Dev 25 135 148 1713544 10.1016/0378-3782(91)90191-5 1:STN:280:DyaK3MzhslWgsg%3D%3D
    • (1991) Early Hum Dev , vol.25 , pp. 135-148
    • Shankaran, S.1    Woldt, E.2    Koepke, T.3    Bedard, M.P.4    Nandyal, R.5
  • 36
    • 26844461474 scopus 로고    scopus 로고
    • D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices
    • DOI 10.1523/JNEUROSCI.3190-05.2005
    • M Shleper E Kartvelishvily H Wolosker 2005 d-Serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices J Neurosci 25 9413 9417 16221850 10.1523/JNEUROSCI.3190-05.2005 1:CAS:528:DC%2BD2MXhtFGmu7rF (Pubitemid 41464754)
    • (2005) Journal of Neuroscience , vol.25 , Issue.41 , pp. 9413-9417
    • Shleper, M.1    Kartvelishvily, E.2    Wolosker, H.3
  • 37
    • 0025968104 scopus 로고
    • The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex
    • 1677460 10.1016/0304-3940(91)90827-G 1:CAS:528:DyaK3MXltVKktr4%3D
    • RE Simpson GA Walter JW Phillis 1991 The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex Neurosci Lett 124 83 86 1677460 10.1016/0304-3940(91)90827-G 1:CAS:528:DyaK3MXltVKktr4%3D
    • (1991) Neurosci Lett , vol.124 , pp. 83-86
    • Simpson, R.E.1    Walter, G.A.2    Phillis, J.W.3
  • 38
    • 25444532514 scopus 로고    scopus 로고
    • Dual substrate and reaction specificity in mouse serine racemase: Identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the β-eliminase activity
    • DOI 10.1021/bi051201o
    • K Strisovsky J Jiraskova A Mikulova L Rulisek J Konvalinka 2005 Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity Biochemistry 44 13091 13100 16185077 10.1021/bi051201o 1:CAS:528:DC%2BD2MXpsleqs70%3D (Pubitemid 41377289)
    • (2005) Biochemistry , vol.44 , Issue.39 , pp. 13091-13100
    • Strisovsky, K.1    Jiraskova, J.2    Mikulova, A.3    Rulisek, L.4    Konvalinka, J.5
  • 39
    • 0026632948 scopus 로고
    • Changes in extracellular glutamate concentration produced in the rat striatum by repeated ischemia
    • 1353276 10.1161/01.STR.23.8.1125 1:CAS:528:DyaK38XmsV2msr0%3D
    • Y Ueda TP Obrenovitch SY Lok GS Sarna L Symon 1992 Changes in extracellular glutamate concentration produced in the rat striatum by repeated ischemia Stroke 23 1125 1130 1353276 10.1161/01.STR.23.8.1125 1:CAS:528:DyaK38XmsV2msr0%3D
    • (1992) Stroke , vol.23 , pp. 1125-1130
    • Ueda, Y.1    Obrenovitch, T.P.2    Lok, S.Y.3    Sarna, G.S.4    Symon, L.5
  • 40
    • 1842708964 scopus 로고    scopus 로고
    • Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia
    • 15066209 1:CAS:528:DC%2BD2cXjtFKgsL0%3D
    • LZ Wang XZ Zhu 2004 Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia Acta Pharmacol Sin 25 436 441 15066209 1:CAS:528:DC%2BD2cXjtFKgsL0%3D
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 436-441
    • Wang, L.Z.1    Zhu, X.Z.2
  • 41
    • 30944467472 scopus 로고    scopus 로고
    • Effect of the glycine antagonist gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI substudy
    • DOI 10.1159/000090208
    • S Warach D Kaufman D Chiu T Devlin M Luby A Rashid L Clayton M Kaste KR Lees R Sacco M Fisher 2006 Effect of the glycine antagonist gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: the GAIN MRI substudy Cerebrovasc Dis 21 106 111 16340185 10.1159/000090208 1:CAS:528:DC%2BD28Xjs1Whug%3D%3D (Pubitemid 43110319)
    • (2006) Cerebrovascular Diseases , vol.21 , Issue.1-2 , pp. 106-111
    • Warach, S.1    Kaufman, D.2    Chiu, D.3    Devlin, T.4    Luby, M.5    Rashid, A.6    Clayton, L.7    Kaste, M.8    Lees, K.R.9    Sacco, R.10    Fisher, M.11
  • 42
    • 0033539510 scopus 로고    scopus 로고
    • Serine racemase: A glial enzyme synthesizing d-serine to regulate glutamate-N-methyl-d-aspartate neurotransmission
    • 10557334 10.1073/pnas.96.23.13409 1:CAS:528:DyaK1MXns1Gmtb0%3D
    • H Wolosker S Blackshaw SH Snyder 1999 Serine racemase: a glial enzyme synthesizing d-serine to regulate glutamate-N-methyl-d-aspartate neurotransmission Proc Natl Acad Sci USA 96 13409 13414 10557334 10.1073/pnas.96.23.13409 1:CAS:528:DyaK1MXns1Gmtb0%3D
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13409-13414
    • Wolosker, H.1    Blackshaw, S.2    Snyder, S.H.3


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