Evaluation of macrolide resistance and enhanced molecular typing of Treponema pallidum in patients with syphilis in taiwan: A prospective multicenter study

Journal of Clinical Microbiology

Volumn 50, Issue 7, 2012, Pages 2299-2304

  Wu, Hsiu ^a   Chang, Sui Yuan ^b,c   Lee, Nan Yao ^d   Huang, Wen Chi ^e   Wu, Bing Ru ^b,c   Yang, Chia Jui ^f   Liang, Shiou Haur ^g   Lee, Chen Hsiang ^e   Ko, Wen Chien ^d   Lin, Hsi Hsun ^g   Chen, Yen Hsu ^h   Liu, Wen Chun ^b   Su, Yi Ching ^b,c   Hsieh, Chia Yin ^b   Wu, Pei Ying ^b   Hung, Chien Ching ^b  

^a CENTER FOR DISEASE CONTROL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^f FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^g E DA HOSPITAL   (Taiwan)

^h KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; MACROLIDE; RNA 23S;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBODY TITER; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CD4 LYMPHOCYTE COUNT; CEREBROSPINAL FLUID; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE ARP; GENE SEQUENCE; GENETIC POLYMORPHISM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; MULTICENTER STUDY; NEUROSYPHILIS; OPEN READING FRAME; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYPHILIS; TAIWAN; TPR GENE; TREPONEMA PALLIDUM; UVEITIS; VITREOUS BODY;

ADULT; ANTI-BACTERIAL AGENTS; CLUSTER ANALYSIS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GENOTYPE; HIV INFECTIONS; HUMANS; MACROLIDES; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; OPEN READING FRAMES; POINT MUTATION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROSPECTIVE STUDIES; RNA, RIBOSOMAL, 23S; SYPHILIS; TAIWAN; TREPONEMA PALLIDUM;

EID: 84862747290     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00341-12     Document Type: Article

References (35)

1. Azzato F, Ryan N, Fyfe J, Leslie ED. 2012. Molecular subtyping of Treponema pallidum during a local syphilis epidemic in men who have sex with men in Melbourne, Australia. J. Clin. Microbiol. 50:1895-1899.
2. Castro R, et al. 2009. Molecular subtyping of Treponema pallidum subsp. pallidum in Lisbon, Portugal. J. Clin. Microbiol. 47:2510-2512.
3. Centers for Disease Control. 2010. Statistics of communicable diseases and surveillance report, Taiwan CDC. Centers for Disease Control, Department of Health, Taipei. Taiwan. http://www.cdc.gov.tw/uploads/files/47d8b8ba-560e-486f- 8b3f-73e66a29f90b.pdf.
4. Centers for Disease Control and Prevention. 2010. Sexually transmitted disease surveillance 2010. Centers for Disease Control and Prevention, Atlanta, GA.
5. Centers for Disease Control and Prevention. 2004. Trends in primary and secondary syphilis and HIV infections in men who have sex with men-San Francisco and Los Angeles, California, 1998-2002. MMWR Morb. Mortal. Wkly. Rep. 53:575-578.
6. Reference deleted.
7. Cole MJ, Chisholm S, Palmer HM, Wallace LA, Ison CA. 2009. Molecular epidemiology of syphilis in Scotland. Sex. Transm. Infect. 85:447-451.
8. Cruz AR, et al. 2010. Secondary syphilis in Cali, Colombia: new concepts in disease pathogenesis. PLoS Negl. Trop. Dis. 4:e690. doi:10.1371/journal.pntd. 0000690.
9. Florindo C, et al. 2008. Molecular typing of Treponema pallidum clinical strains from Lisbon, Portugal. J. Clin. Microbiol. 46:3802-3803.
10. Gadkari DA, et al. 1998. HIV-1 DNA shedding in genital ulcers and its associated risk factors in Pune, India. J. Acquir. Immune Defic. Syndr Hum. Retrovirol. 18:277-281.
11. Gerbase A, Rowley J, Heymann D, Berkley S, Piot P. 1998. Global prevalence and incidence estimates of selected curable STDs. Sex. Transm. Infect. 74(Suppl 1):S12-S16.
12. Huang W-C, et al. 2011. Abstr. 51st Intersci. Conf. Antimicrob. Agents Chemother., abstr. L2-891.
13. Jin F, et al. 2005. Epidemic syphilis among homosexually active men in Sydney. Med. J. Aust. 183:179-183.
14. Katz KA, et al. 2010. Molecular epidemiology of syphilis-San Francisco, 2004-2007. Sex. Transm. Dis. 37:660-663.
15. Liu H, Rodes B, Chen CY, Steiner B. 2001. New tests for syphilis: rational design of a PCR method for detection of Treponema pallidum in clinical specimens using unique regions of the DNA polymerase I gene. J. Clin. Microbiol. 39:1941-1946.
16. Lukehart SA, et al. 2004. Macrolide resistance in Treponema pallidum in the United States and Ireland. N. Engl. J. Med. 351:154-158.
17. Marra CM, et al. 2006. Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum. J. Infect. Dis. 194:1771-1773.
18. Marra CM, et al. 2010. Enhanced molecular typing of Treponema pallidum: geographical distribution of strain types and association with neurosyphilis. J. Infect. Dis. 202:1380-1388.
19. Martin IE, Gu W, Yang Y, Tsang RS. 2009. Macrolide resistance and molecular types ofTreponema pallidum causing primary syphilis in Shanghai, China. Clin. Infect. Dis. 49:515-521.
20. Martin IE, et al. 2010. Molecular typing of Treponema pallidum strains in western Canada: predominance of 14d subtypes. Sex. Transm. Dis. 37:544-548.
21. Matejková P, et al. 2009. Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. J. Med. Microbiol. 58:832-836.
22. Mitchell SJ, et al. 2006. Azithromycin-resistant syphilis infection: San Francisco, California, 2000-2004. Clin. Infect. Dis. 42:337-345.
23. Molepo J, Pillay A, Weber B, Morse SA, Hoosen AA. 2007. Molecular typing of Treponema pallidum strains from patients with neurosyphilis in Pretoria, South Africa. Sex. Transm. Infect. 83:189-192.
24. Morshed MG, Jones HD. 2006. Treponema pallidum macrolide resistance in BC. CMAJ 174:349.
25. Peng RR, et al. 2012. Molecular typing of Treponema pallidum causing early syphilis in China: a cross-sectional study. Sex. Transm Dis. 39:42-45.
26. Pillay A, et al. 1998. Molecular subtyping of Treponema pallidum subspecies pallidum. Sex. Transm. Dis. 25:408-414.
27. Pillay A, et al. 2002. Molecular typing of Treponema pallidum in South Africa: cross-sectional studies. J. Clin. Microbiol. 40:256-258.
28. Pope V, et al. 2005. Molecular subtyping of Treponema pallidum from North and South Carolina. J. Clin. Microbiol. 43:3743-3746.
29. Sellati TJ, et al. 2000. Virulent Treponema pallidum, lipoprotein, and synthetic lipopeptides induce CCR5 on human monocytes and enhance their susceptibility to infection by human immunodeficiency virus type 1. J. Infect. Dis. 181:283-293.
30. Simms I, et al. 2005. The re-emergence of syphilis in the United Kingdom: the new epidemic phases. Sex. Transm. Dis. 32:220-226.
31. Sutton MY, et al. 2001. Molecular subtyping of Treponema pallidum in an Arizona County with increasing syphilis morbidity: use of specimens from ulcers and blood. J. Infect. Dis. 183:1601-1606.
32. Van Damme K, et al. 2009. Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar. Sex. Transm. Dis. 36:775-776.
33. Workowski KA, Berman SM. 2006. Sexually transmitted diseases treatment guidelines. MMWR Recomm. Rep. 55(RR-11):1-94.
34. Zetola NM, Klausner JD. 2007. Syphilis and HIV infection: an update. Clin. Infect. Dis. 44:1222-1228.
35. Zhou P, et al. 2010. Azithromycin treatment failure among primary and secondary syphilis patients in Shanghai. Sex. Transm. Dis. 37:726-729.