Microencapsulation-Based Cell Therapy

Biotechnology: Second Edition

Volumn 10, Issue , 2008, Pages 547-571

  Zimmermann, Ulrich ^a   Cramer, Hubert ^a   Jork, Anette ^a   Thürmer, Frank ^a   Zimmermann, Heiko ^b   Fuhr, Günter ^b   Hasse, Christian ^c   Rothmund, Matthias ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ENGINEERING;

CELL THERAPY;

BIOTECHNOLOGY;

EID: 84862733838     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527620937.ch19     Document Type: Chapter

References (123)

1. AEBISCHER, P., WINN, S.R., TRESCO, P.A., JAEGER, C.B., GREENE, L.A.(1991), Transplantation of polymer encapsulated neurotransmitter secreting cells: effect of the encapsulation technique, J.Biomech.Eng.113, 178-183.
2. ARFORS, K.E., LEY, K.(1993), Sulfated polysaccharides in inflammation, J.Lab.Clin.Med.121, 201-202.
3. ARNOLD, L.J., DAGAN, A., KAPLAN, N.O.(1983), Poly (L-lysine) as an antineoplastic agent and tumorspecific drug carrier, in: Targeted Drugs Vol.2 (GOLDBERG, E.P., Ed.), pp.89-112.New York: John Wiley & Sons.
4. BESSIS, M.(1973), Living Blood Cells and their Ultrastructure.Berlin, Heidelberg, New York: Springer-Verlag.
5. BEUNINK, I., BAUMGäRTL, H., ZIMELKA, W., REHM, H.-J.(1989), Determination of oxygen gradients in single Ca-alginate beads by means of oxygenmicroelectrodes, Experientia 45, 1041-1047.
6. BRANDENBERGER, H., WIDMER, F.(1998), A new multinozzle encapsulation/immobilization system to produce uniform beads of alginate, J.Biotechnol.63, 73-80.
7. BRODELIUS, P., VANDAMME, E.J.(1987), Immobilized cell systems, in: Biotechnogy Vol.7a (REHM, H.-J., REED, G., Eds.), pp.405-164.Weinheim: Verlag Chemie.
8. BüCHNER, K.H., ZIMMERMANN, I.J.(1982), Water relations of immobilized giant algal cells, Planta 154, 318-325.
9. CALAFIORE, R., BASTA, G., LUCA, G., BOSELLI, C., BUFALARI, A.et al.(1999), Transplantation of pancreatic islets contained in minimal volume microcapsules in diabetic high mammalians, Ann.N.Y.Acad.Sci.875, 219-232.
10. CASANOVA, D., SARFATI, E., DE FRANCISCO, A., AMADO, J.A., ARIAS, M., DUBOST, C.(1991), Secondary hyperparathyroidism: diagnosis of site of recurrence, World J.Surg.15, 546-550.
11. CHANG, T.M.S.(1997), Artificial cells, in: Encyclopedia of Human Biology 2nd Edn.(DULBECCO, R., Ed.), pp.457-463.San Diego, CA: Academic Press.
12. CHICHEPORTICHE, D., REACH, G.(1988), In vitro kinetics of insulin release by microencapsulated rat islets: effect of the size of the microcapsules, Diabetologia 31, 54-57.
13. CLAYTON, H.A., LONDON, N.J.M., COLLOBY, P.S., BELL, P.R.F., JAMES, R.F.L.(1991), The effect of capsule composition on the biocompatibility of alginate-poly-L-lysine capsules, J.Microencapsul.8, 221-233.
14. CLAYTON, H.A., JAMES, R.F.L., LONDON, N.J.M.(1993), Islet microencapsulation: a review, Acta Diabetologica 30, 181-189.
15. COCHRUM, K., JEMTRUD, S., DORIAN, R.(1995), Successful xenografts in mice with microencapsulated rat and dog islets, Transplant.Proc.27, 3297-3301.
16. COLE, D.R., WATERFALL, M., MCINTYRE, M., BAIRD, J.D.(1992), Microencapsulated islet grafts in the BB/E rat: a possible role for cytokines in graft failure, Diabetologia 35, 231-237.
17. COLTON, C.K., AVGOUSTINIATOS, E.S.(1991), Bioengineering in development of the hybrid artificial pancreas, J.Biomech.Eng.113, 152-170.
18. CURTIS, A., WILKINSON, C.(1999), New depths in cell behavior: reactions of cells to nanotopography, Biochem Soc.Symp.65, 15-26.
19. DE VOS, P., WOLTERS, G.H., FRITSCHY, W.M., VAN SCHILFGAARDE, R.(1993), Obstacles in the application of microencapsulation in islet transplantation, Int.J.Artif.Organs 16, 205-212.
20. DE VOS, P., DE HAAN, B.J., WOLTERS, G.H.I., VAN SCHILFGAARDE, R.(1996), Factors influencing the adequacy of microencapsulation of rat pancreatic islets, Transplantation 62, 888-893.
21. DE VOS, P., DE HAAN, B.I., VAN SCHILFGAARDE, R.(1997a), Effect of the alginate composition on the biocompatibility of alginate-polylysine microcapsules, Biomaterials 18, 273-278.
22. DE VOS, P., DE HAAN, B.I., WOLTERS, G.H.X., STRUBBE, J.H., VAN SCHILFGAARDE, R.(1997b), Im proved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets, Diabetologia 40, 262-270.
23. DE VOS, P., VAN STRAATEN, J.F.M., NIEUWENHUIZEN, A.G., DE GROOT, M., PLOEG, R.J.et al.(1999), Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth? Diabetes 48, 1381-1388.
24. DULIEU, C., PONCELET, D., NEUFELD, R.J.(1999), Encapsulation and immobilization techniques, in: Cell Encapsulation Technoloy and Therapeutics (KüHTREIBER, W.M., LANZA, R.P., CHICK, W.L., Eds.), pp.3-17.Boston, MA: Birkhäuser.
25. ESCH, M., SUKHORUKOV, V.L., KüRSCHNER, M., ZIMMERMANN, U.(1999), Dielectric properties of alginate beads and bound water relaxation studied by electrorotation, Biopolymers 50, 227-237.
26. ESPEVIK, T., OTTERLEI, M., SKJàK-BRÆEK, G, RYAN, L., WRIGHT, S.D., SUNDAN, A.(1993), The involvement of CD14 in stimulation of cytokine production by uronic acid polymers, Eur.J.Immunol.23, 255-261.
27. FAN, M.Y., LUM, Z.P., Fu, X.-W, LEVESQUE, L., TAI, LT., SUN, A.M.(1990), Reversal of diabetes in BB rats by transplantation of encapsulated pancreatic islets, Diabetes 39, 519-522.
28. FRIEDRICH, U., STACHOWICZ, N., SIMM, A., FUHR, G., LUCAS, K., ZIMMERMANN, U.(1998), High efficiency electrotransfection with aluminum electrodes using microsecond controlled pulses, Bioelectrochem.Bioenerg.47, 103-111.
29. FRITSCHY, W.M., WOLTERS, G.H.J., VAN SCHILFGAARDE, R.(1991), Effect of alginate-polylysine-alginate microencapsulation on in vitro insulin release from rat pancreatic islets, Diabetes 40, 37-43.
30. FUHR, G., RICHTER, E., ZIMMERMANN, H., HITZLER, H., NIEHUS, H., HAGEDORN, R.(1998), Cell traces -footprints of individual cells during locomotion and adhesion, Biol.Chem.379, 1161-1173.
31. GâSEROD, O., SANNES, A., SKJAK-BRÆEK, G.(1999), Microcapsules of alginate-chitosan.II.A study of capsule stability and permeability, Biomaterials 20, 773-783.
32. GEISEN, K., DEUTSCHLäNDER, H., GORBACH, S., KLENKE, C., ZIMMERMANN, U.(1990), Function of barium alginate-microencapsulated xenogenic islets in different diabetic mouse models, in: Frontiers in Diabetes Research.Lessons from Animal Diabetes III (SHAFRIR, E., Ed.), II.8., pp.142-148.
33. GENTILE, F.T., DOHERTY, E.J., REIN, D.H., SHOICHET, M.S., WINN, S.H.(1995), Polymer science for macroencapsulation of cells for central nervous system transplantation, Reactive Polymers 25, 207-227.
34. GOOSEN, M.F.A.(1993), Fundamentals of Animal Cell Encapsulation and Immobilization.Boca Raton, FL: CRC Press.
35. GOOSEN, M.F.A.(1999), Mass transfer in immobilized cell systems, in: Cell Encapsulation Technology and Therapeutics (KüHTREIBER, W.M., LANZA, R.P., CHICK, W L., Eds.), pp.18-28.Boston, MA: Birkhäuser.
36. GOTFREDSEN, C.F., STEWART, M.G., O'SHEA, G.M., VOSE, J.R., HORN, T., MOODY, A.J.(1990), The fate of transplanted encapsulated islets in spontaneously diabetic BB/Wor rats, Diabetes Res.15, 157-163.
37. GRöHN, P., KLöCK, G., SCHMITT, I., ZIMMERMANN, I.J., HORCHER, A.et al.(1994), Large-scale production of Ba2+ alginate-coated islets of Langerhans for immunoisolation, Exp.Clin.Endocrinol.102, 380-387.
38. 2+alginate microcarriers for the culture of anchorage-dependent mammalian cells, BioTechniques 22, 970-975.
39. HAMA, A.T., SAGEN, J.(1993), Reduced pain-related behavior by adrenal medullary transplants in rats with experimental painful peripheral neuropathy, Pain 52, 223-231.
40. HARTMEIER, W.(1986), Immobilisierte Biokatalysatoren.Berlin, Heidelberg, New York, Tokyo: Springer-Verlag.
41. HASSE, G., KLöCK, G., ZIELKE, A., SCHLOSSER, A., BARTH, P.et al.(1996), Transplantation of parathyroid tissue in experimental hypoparathyroidism: in vitro and in vivo function of parathyroid tissue microencapsulated with a novel amitogenic alginate, Int.J.Artif.Organs 19, 735-741.
42. HASSE, G., KLöCK, G., SCHLOSSER, A., ZIMMERMANN, U., ROTHMUND, M.(1997a), Parathyroid allotransplantation without immunosuppression, The Lancet 350, 1296-1297.
43. HASSE, G., ZIELKE, A., KLöCK, G., BARTH, P., SCHLOSSER, A.et al.(1997b), First successful xenotransplantation of microencapsulated human parathyroid tissue in experimental hypoparathyroidism: long-term function without immunosuppression, J.Microencapsulation 14, 617-626.
44. HASSE, G., ZIELKE, A., KLöCK, G., SCHLOSSER, A., BARTH, P.et al.(1998), Amitogenic alginates: key to first clinical application of microencapsulation technology, World J.Surg.22, 659-665.
45. HASSE, G., ZIELKE, A., ZIMMERMANN, U., ROTHMUND, M.(1999), Transplantation of microencapsulated parathyroid tissue: clinical background, methods, and current status of research, in: Cell Encapsulation Technology and Therapeutics (KüHTREIBER, W.M., LANZA, R.P., CHICK, W.L., Eds.), pp.240-251.Boston, MA: Birkhäuser.
46. HEINZEN, G.(1999), Zellverkapselung bei 1000 Volt, BioTec 4, 50-51.
47. 19F-labeled alginate gels: production, biocompatibility, stability, and long-term monitoring of functional integrity, Mat.-wiss.Werkstofftech.30, 783-792.
48. HUNKELER, D., SUN, A.M., KORBUTT, S., RAJOTTE, R.V., GILL, R.G.et al.(1999), Bioartificial organs and acceptable risk, Nature Biotechnol.17, 1045.
49. ITO, Y.(1999), Surface micropatterning to regulate cell functions, Biomaterials 20, 2333-2342.
50. JAHR, T.G., RYAN, L., SUNDAN, A., LICHENSTEIN, H.S., SKJâK-BRÆEK, G.et al.(1997), Induction of tumor necrosis factor production from monocytes stimulated with mannuronic acid polymers and involvement of lipopolysaccharide-binding protein, CD14, and bactericidal/permeability-increasing factor, Infect.Immun.65, 89-94.
51. JORK, A., THüRMER, F., CRAMER, H., ZIMMERMANN, G., GESSNER, P.et al.(2000), Biocompatible alginate from freshly collected Laminaria pallida for implantation, Appl.Microbiol.Biotechnol.53, 224-229.
52. Ju, L.K., ARMIGER, W.B.(1992), Use of perfluorocarbon emulsions in cell culture, BioTechniques 12, 258-263.
53. JUNKER, B.H., WANG, D.I.G, HATTON, T.A.(1990), Oxygen transfer enhancement in aqueous/perfluorocarbon fermentation systems: II.Theoretical analysis, Biotechnol.Bioeng.35, 586-597.
54. KAPLAN, J.H., ELLIS-DAVIES, G.G.R.(1988), Photolabile chelators for the rapid photorelease of divalent cations, Proc.Natl.Acad.Sci.USA 85, 6571-6575.
55. KING, K.(1994), Changes in the functional properties and molecular weight of sodium alginate following γ irradiation, Food Hydrocolloids 8, 83-96.
56. KIRKMAN, R.L.(1989), Of swine and men: organ physiology in different species, in: Xenograft 25 (HARDY, M.A., Ed.), pp.125-132.Amsterdam: Elsevier.
57. KLöCK, G., SIEBERS, U., PFEFFERMANN, A., SCHMITT, J., HOUBEN, R.et al.(1993), Immunisolation transplantierter Langerhansscher Inseln: Mikrokapseln mit definierter molekularer Ausschlußgrenze, Immun.Infekt.21, 183-184.
58. KLöCK, G., FRANK, H., HOUBEN, R., ZEKORN, T., HORCHER, A.et al.(1994), Production of purified alginates suitable for use in immunoisolated transplantation, Appl.Microbiol.Biotechnol.40, 638-643.
59. KLöCK, G., PFEFFERMANN, A., RYSER, G, GRöHN, P., KUTTLER, B.et al.(1997), Biocompatibility of mannuronic acid-rich alginates, Biomaterials 18, 707-713.
60. KRESTOW, M., LUM, Z.P., TAI, I.T., SUN, A.(1991), Xenotransplantation of microencapsulated fetal rat islets, Transplantation 51, 651-655.
61. KüHTREIBER, W.M., LANZA, R.P., CHICK, W.L.(1999), Cell Encapsulation Technology and Therapeutics.Boston, MA: Birkhäuser.
62. KULSENG, B., SKJâK-BRÆK, G., RYAN, L., ANDERSSON, A., KING, A.et al.(1999), Transplantation of alginate microcapsules, Transplantation 67, 978-984.
63. LANZA, R.P., HAYES, J.L., CHICK, W.L.(1996), Encapsulated cell technology, Nature Biotechnol.14, 1107-1111.
64. LANZA, R.P., ECKER, D.M., KüHTREIBER, W.M., MARSH, J.P., RINGELING, J., CHICK, W.L.(1999), Transplantation of islets using microencapsulation: studies in diabetic rodents and dogs, J.Mol.Med.77, 206-210.
65. LIM, F., SUN, A.M.(1980), Microencapsulated islets as bioartificial endocrine pancreas, Science 210, 908-910.
66. MARTINSEN, A., SKJàK-BRÆEK, G., SMIDSROD, O.(1989), Alginate as immobilization material: I.Correlation between chemical and physical properties of alginate gel beads, Biotechnol.Bioeng.33, 79-89.
67. MARTINSEN, A., STORRO, I., SKJàK-BRÆK, G.(1992), Alginate as immobilization material: III.Diffusional properties, Biotechnol.Bioeng.39, 186-194.
68. MATTIASSON, B.(1982), Immobilization methods, in: Immobilized Cells and Organelles Vol.I (MATTIASSON, B., Ed.), pp.3-26.Boca Raton, FL: CRC Press.
69. MAZAHERI, R., ATKISON, P., STILLER, C., DUPRé, J., VOSE, J.et al.(1991), Transplantation of encapsulated allogeneic islets into diabetic BB/W rats.Effects of immunosuppression, Transplantation 51, 750-754.
70. MCHUGH, D.J.(1987), Production, properties and uses of alginates, in: Production and Utilization of Products from Commercial Seaweeds (MCHUGH, D.J., Ed.), pp.58-115.Rome: Food and Agriculture Organization of the United Nations.
71. MESSIAEN, J., CAMBIER, P., VAN CUTSEM, P.(1997), Polyamines and pectins, Plant Physiol.113, 387-395.
72. NEWGARD, C.B.(1994), Cellular engineering and gene therapy strategies for insulin replacement in diabetes, Diabetes 43, 341-350.
73. 19F-MRI in vivo determination of the partial oxygen pressure in perfluorocarbon-loaded alginate capsules implanted into the peritoneal cavity and different tissues, Magn.Reson.Med.42, 1039-1047.
74. O'SHEA, G.M., SUN, A.M.(1986), Encapsulation of rat islets of Langerhans prolongs xenograft survival in diabetic mice, Diabetes 35, 943-946.
75. O'SHEA, G.M., GOOSEN, M.F.A., SUN, A.M.(1984), Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane, Biochim.Biophys.Acta 804, 133-136.
76. OTTERLEI, M., OSTGAARD, K., SKJAK-BRÆCK, G., SMIDSROD, O., SOON-SHIONG, P., ESPEVIK, T.(1991), Induction of cytokine production from human monocytes stimulated with alginate, J.Immunother.10, 286-291.
77. OTTERLEI, M., SUNDAN, A., SKJâK-BRÆK, G., RYAN, L., SMIDSROD, O., ESPEVIK, T.(1993), Similar mechanisms of action of defined polysaccharides and lipopolysaccharides: characterization of binding and tumor necrosis factor alpha induction, Infect Immun.61, 1917-1925.
78. PARADIS, K., LANGFORD, G., LONG, Z., HENEINE, W., SANDSTROM, P.et al.(1999), Search for crossspecies transmission of porcine endogenous retrovirus in patients treated with living pig tissue, Science 285, 1236-1241.
79. PARKER, W., SAADI, S., LIN, S.S., HOLZKNECHT, Z.E., BUSTOS, M.(1996), Transplantation of discordant xenografts: a challenge revisited, Immunology Today 17, 373-378.
80. PATIENCE, C., TAKEUCHI, Y., WEISS, R.A.(1997), Infection of human cells by an endogenous retrovirus of pigs, Nature Med.3, 282-286.
81. PFEFFERMANN, A., KLöCK, G., GRöHN, P, KUTTLER, B., HAHN, H.J., ZIMMERMANN, U.(1996), Evaluation of assay procedures for the assessment of the biocompatibility of alginate implants, Cell.Eng.4, 167-173.
82. PILWAT, G., WASHAUSEN, P., KLEIN, J., ZIMMERMANN, U.(1980), Immobilization of human red blood cells, Z.Naturforsch.35c, 352-356.
83. PLUMB, R.C., BRIDGMAN, W.B.(1972), Ascent of sap in trees, Science 176, 1129-1131.
84. PLüSS, R., HEINZEN, C., KOCH, M., WIDMER, F.(1997), Immobilisierte Biokatalysatoren, BioWorld 2, 16-19.
85. RICORDI, C., Socci, C., DAVALLI, A.M., STAUDACHER, C., BARO, P.et al.(1990), Isolation of the elusive pig islet, Surgery 107, 688-694.
86. ROSENGARD, A.M., CARY, N., HORSLEY, J., BELCHER, C., LANGFORD, G.et al.(1995), Endothelial expression of human decay accelerating factor in transgenic pig tissue: a potential approach for human complement inactivation in discordant xenografts, Transplant.Proc.27, 326-327.
87. ROTHE, H., FEHSEL, K., KOLB, H.(1990), Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats, Diabetologia 33, 573-575.
88. SCHNABL, H., YOUNGMAN, R.J., ZIMMERMANN, U.(1983), Maintenance of plant cell membrane integrity and function by the immobilization of protoplasts in alginate matrices, Planta 158, 392-397.
89. SCHNABL, H., ZIMMERMANN, U.(1989), Immobilization of plant protoplasts, in: Biotechnology in Agriculture and Forestry, Vol.8, Plant Protoplasts and Genetic Engineering I.(BAJAJ, Y.P.S., Ed.), pp.63-96.Berlin, Heidelberg: Springer-Verlag.
90. SCUDIERO, D.A., SHOEMAKER, R.H., PAULL, K.D., MONKS, A., TIERNEY, S.et al.(1988), Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines, Cancer Res.48, 4827-1833.
91. SEEBACH, J.D., YAMADA, K., MCMORROW, I.S., SACHS, D.H., DERSIMONIAN, H.(1996), Xenogeneic human anti-pig cytotoxicity mediated by activated natural killer cells, Xenotransplantation 3, 188-197.
92. SIEBERS, U., ZEKORN, T., HORCHER, A., HERING, B., BRETZEL, R.G.et al.(1992), In vitro testing of rat and porcine islets microencapsulated in barium alginate beads, Transplant.Proc.24, 950-951.
93. SIEBERS, U., HORCHER, A., BRETZEL, R.G., KLOCK, G., ZIMMERMANN, U.(1993), Transplantation of free and microencapsulated islets in rats: evidence for the requirement of an increased islet mass for transplantation into the peritoneal site, Int.J.Artif.Organs 16, 35-38.
94. SKJâK-BRÆEK, G., MURANO, E., PAOLETTI, S.(1989), Alginate as immobilization material.II: Determination of polyphenol contaminants by fluorescence spectroscopy, and evaluation of methods for their removal, Biotechnol.Bioeng.33, 90-94.
95. SMIDSROD, O., SKJâK-BRÆEK, G.(1990), Alginate as immobilization matrix for cells, Trends Biotechnol.8, 71-78.
96. SOON-SHIONG, P., OTTERLEI, M., SKJâK-BR-K, G., SMIDSROD, O., HEINTZ, R.et al.(1991), An immunologie basis for the fibrotic reaction to implanted microcapsules, Transplant.Proc.23, 758-759.
97. SOON-SHIONG, P., FELDMAN, E., NELSON, R., KOMTEBEDDE, J., SMIDSROD, O.et al.(1992), Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets, Transplantation 54, 769-774.
98. SULTZBAUGH, K.J., SPEAKER, T.J.(1996), A method to attach lectins to the surface of spermine alginate microcapsules based on the avidin biotin interaction, J.Microencapsul.13, 363-375.
99. SUN, Y., MA, X., ZHOU, D., VACEK, I., SUN, A.M.(1996), Normalization of diabetes in spontaneously diabetic cynomolgus monkeys by xenografts of microencapsulated porcine islets without immunosuppression, J.Clin.Invest.98, 1417-1422.
100. 2+, Biotechnol.Techniques 2, 115-120.
101. ULRICHS, K., BOSSE, M., HEISER, A., ECKSTEIN, V., WACKER, H.H.et al.(1995), Histomorphological characteristics of the porcine pancreas as a basis for the isolation of islets of Langerhans, Xenotransplantation 2, 176-187.
102. VAN HAEFTEN, T.W.(1989), Clinical significance of insulin antibodies in insulin-treated diabetic patients, Diabetes Care 12, 641-648.
103. VAN SCHILFGAARDE, R., DE VOS, P.(1999), Factors influencing the properties and performance of microcapsules for immunoprotection of pancreatic islets, J.Mol.Med.77, 199-205.
104. VANSTEENKISTE, S.O., DAVIES, M.C., ROBERTS, C.J., TENDLER, S.J.B., WILLIAMS, P.M.(1998), Scanning probe miscroscopy of biomedical interfaces, Prog.Surf.Sci.57, 95-136.
105. WANG, T.G.(1999), Polymer membranes for cell encapsulation, in: Cell Encapsulation Technology and Therapeutics (KüHTREIBER, W M., LANZA, R.P., CHICK, W L., Eds.), pp.29-39.Boston, MA: Birkhäuser.
106. WARNOCK, G.L., RAJOTTE, R.V.(1988), Critical mass of purified islets that induce normoglycemia after implantation into dogs, Diabetes 37, 467-470.
107. WEBER, C., COSTANZO, M., KREKUN, S., D'AGATI, V.(1993), Causes of destruction of microencapsulated islet grafts: Characteristics of a "double-wall" poly-L-lysine-alginate microcapsule, Diabetes, Nutrition, Metabolism 1, 167-171.
108. WEBER, C.J., KAPP, J.A., HAGLER, M.K., SAFLEY, S., CHRYSSOCHOOS, J.T.et al.(1999), Long-term survival of poly-L-lysine-alginate microencapsulated islet xenografts in spontaneously diabetic NOD mice, in: Cell Encapsulation Technology and Therapeutics (KüHTREIBER, W M., LANZA, R.P., CHICK, W L., Eds.), pp.117-137.Boston, MA: Birkhäuser.
109. WIJSMAN, J., ATKISON, P., MAZAHERI, R., GARCIA, B., PAUL, T.et al.(1992), Histological and immunopathological analysis of recovered encapsulated allogeneic islets from transplanted diabetic BB/W rats, Transplantation 54, 588-592.
110. Xu, K., HERCULES, D.M., LACIK, I., WANG, T.G.(1998), Atomic force microscopy used for the surface characterization of microcapsule immunoisolation devices, J.Biomed.Mat.Res.41, 461-467.
111. ZEKORN, T., SIEBERS, U., BRETZEL, R.G., HELLER, S., MEDER, U.et al.(1991), Impact of the perfluorochemical FC43 on function of isolated islets, Horm.metab.Res.23, 302-303.
112. ZEKORN, T.D.G, HORCHER, A., SIEBERS, U., SCHNETTLER, R., KLöCK, G.et al.(1992a), Barium-cross-linked alginate beads: A simple, onestep method for successful immunoisolated transplantation of islets of Langerhans, Acta Diabetol.29, 99-106.
113. ZEKORN, T., SIEBERS, U., HORCHER, A., SCHNETTLER, R., ZIMMERMANN, U.et al.(1992b), Alginate coating of islets of Langerhans: in vitro studies on a new method for microencapsulation for immunoisolated transplantation, Acta Diabetol.29, 41-45.
114. ZEKORN, T.D.C, BRETZEL, R.G.(1999), Immunoprotection of islets of Langerhans by microencapsulation in barium alginate beads, in: Cell Encapsulation Technology and Therapeutics (KüHTREIBER, W M., LANZA, R.P., CHICK, W.L., Eds.) pp.90-96.Boston, MA: Birkhäuser.
115. ZHOU, D., SUN, Y.L., VACEK, I., MA, P., SUN, A.M.(1994), Normalization of diabetes in cynomolgus monkeys by xenotransplantation of microencap sulated porcine islets, Transplant.Proc.26, 1091.
116. ZIMMERMANN, H., FUHR, G.(1999), Zellspuren -neue Ansätze zur Diagnostik und Oberflächenanalyse, BlOforum 22, 708-710.
117. ZIMMERMANN, H., HAGEDORN, R., RICHTER, E., FUHR, G.(1999), Topography of cell traces studied by atomic force microscopy, Eur.Biophys.J.28, 516-525.
118. ZIMMERMANN, U., NEIL, G.A.(1996), Electromanipulation of Cells.Boca Raton, FL: CRC-Press.
119. ZIMMERMANN, U., STEUDLE, E.(1978), Physical aspects of water relations, Adv.Bot.Res.6, 45-117.
120. ZIMMERMANN, U., KLöCK, G., FEDERLIN, K., HANNIG, K., KOWALSKI, M.et al.(1992), Production of mitogen-contamination free alginates with variable ratios of mannuronic acid to guluronic acid by free flow electrophoresis, Electrophoresis 13, 269-274.
121. ZIMMERMANN, U., ZHU, J.J., MEINZER, F.C., GOLDSTEIN G., SCHNEIDER, H.et al.(1994), High molecular weight organic compounds in the xylem sap of mangroves: implications for longdistance water transport, Bot.Acta 107, 218-229.
122. ZIMMERMANN, U., HASSE, C., ROTHMUND, M., KüHTREIBER, W.(1999), Biocompatible encapsulation materials: fundamentals and application, in: Cell Encapsulation Technology and Therapeutics (KüHTREIBER, W.M., LANZA, R.P., CHICK, W.L., Eds.), pp.40-52.Boston, MA: Birkhäuser.
123. 2+-alginate beads, Artificial Cells, Blood Substitutes, and Immobilization Biotechnology 28, 129-146.