Downregulation of fetuin-B and zinc-α2-glycoprotein is linked to impaired fatty acid metabolism in liver cells

Cellular Physiology and Biochemistry

Volumn 30, Issue 2, 2012, Pages 295-306

  Choi, Jung Won ^a   Liu, Hao ^a   Mukherjee, Rajib ^a   Yun, Jong Won ^a  

^a Daegu University   (South Korea)

Author keywords

Fetuin B; High fat diet; Obesity prone and resistant rats; Plasma proteome; RNA interference; Zinc 2 glycoprotein

Indexed keywords

ALPHA2 GLYCOPROTEIN; FETUIN A; FETUIN B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ZINC ALPHA2 GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; FATTY ACID METABOLISM; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; LIPID DIET; LIPOGENESIS; LIVER CELL; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RAT;

RATTUS;

EID: 84862727052     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000339065     Document Type: Article

References (47)

1. Choi JW, Wang X, Joo JI, Kim DH, Oh TS, Choi DK, Yun JW: Plasma proteome analysis in diet-induced obesity-prone and obesity-resistant rats. Proteomics 2010;10:4386-4400.
2. Kim DH, Choi JW, Joo JI, Wang X, Choi DK, Oh TS, Yun JW: Changes in expression of skeletal muscle proteins between obesity-prone and obesity-resistant rats induced by a high-fat diet. J Proteome Res 2011;10:1281-1292.
3. Joo JI, Oh TS, Kim DH, Choi DK, Wang X, Choi JW, Yun JW: Differential expression of adipose tissue proteins between obesity-susceptible and-resistant rats fed a high-fat diet. Proteomics 2011;11:1429-1448.
4. Wang X, Choi JW, Joo JI, Kim DH, Oh TS, Choi DK, Yun JW: Differential expression of liver proteins between obesity-prone and obesity-resistant rats in response to a high-fat diet. Br J Nutr 2011;106:612-626.
5. Choi JW, Liu H, Choi DK, Oh TS, Mukherjee R, Yun JW: Profiling of gender-specific rat plasma proteins associated with susceptibility or resistance to diet-induced obesity. J Proteomics 2012;75:1386-1400.
6. Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP: Fetuin-B, a second member of the fetuin family in mammals. Biochem J 2000;350 Pt 2:589-597.
7. Denecke B, Graber S, Schafer C, Heiss A, Woltje M, Jahnen-Dechent W: Tissue distribution and activity testing suggest a similar but not identical function of fetuin-Band fetuin-A. Biochem J 2003;376:135-145.
8. Pedersen KO: Ultracentrifugal and electrophoretic studies on fetuin. J Phys Colloid Chem 1947;51:164-171.
9. Mathews ST, Singh GP, Ranalletta M, Cintron VJ, Qiang X, Goustin AS, Jen KL, Charron MJ, Jahnen-Dechent W Grunberger G: Improved insulin sensitivity and resistance to weight gain in mice null for the ahsg gene. Diabetes 2002;51:2450-2458.
10. Reinehr T, Roth CL: Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab 2008;93:4479-4485.
11. Ix JH, Shlipak MG, Brandenburg VM, Ali S, Ketteler M, Whooley MA: Association between human Fetuin-A and the metabolic syndrome: Data from the heart and soul study. Circulation 2006;113:1760-1767.
12. Fiore CE, Celotta G, Politi GG, Di Pino L, Castelli Z, Mangiafico RA, Signorelli SS, Pennisi P: Association of high alpha2-heremans-schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass. Atherosclerosis 2007;195:110-115.
13. Weikert C, Stefan N, Schulze MB, Pischon T, Berger K, Joost HG, Haring HU, Boeing H, Fritsche A: Plasma Fetuin-A levels and the risk of myocardial infarction and ischemic stroke. Circulation 2008;118:2555-2562.
14. Ix JH, Wassel CL, Kanaya AM, Vittinghoff E, Johnson KC, Koster A, Cauley JA, Harris TB, Cummings SR, Shlipak MG: Fetuin-A and incident diabetes mellitus in older persons. JAMA 2008;300:182-188.
15. Mori K, Emoto M, Yokoyama H, Araki T, Teramura M, Koyama H, Shoji T, Inaba M, Nishizawa Y: Association of serum Fetuin-A with insulin resistance in type 2 diabetic and nondiabetic subjects. Diabetes Care 2006;29:468.
16. Gunduz FO, Yildirmak ST, Temizel M, Faki Y, Cakmak M, Durmuscan M, Sezgin F: Serum visfatin and Fetuin-A levels and glycemic control in patients with obese type 2 diabetes mellitus. Diabetes Metab J 2011;35:523-528.
17. Yilmaz MI, Saglam M, Qureshi AR, Carrero JJ, Caglar K, Eyileten T, Sonmez A, Cakir E, Oguz Y, Vural A, Yenicesu M, Stenvinkel P, Lindholm B, Axelsson J: Endothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin. Nephrol Dial Transplant 2008;23:1621-1627.
18. Tada T, Ohkubo I, Niwa M, Sasaki M, Tateyama H, Eimoto T: Immunohistochemical localization of zn-alpha 2-glycoprotein in normal human tissues. J Histochem Cytochem 1991;39:1221-1226.
19. Bing C, Bao Y, Jenkins J, Sanders P, Manieri M, Cinti S, Tisdale MJ, Trayhurn P: Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci USA 2004;101:2500-2505.
20. Dahlman I, Kaaman M, Olsson T, Tan GD, Bickerton AS, Wahlen K, Andersson J, Nordstrom EA, Blomqvist L, Sjogren A, Forsgren M, Attersand A, Arner P: A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab 2005;90:5834-5840.
21. Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, Wilding J, Trayhurn P, Bing C: The adipokine zinc-alpha2-glycoprotein (zag) is downregulated with fat mass expansion in obesity. Clin Endocrinol (Oxf) 2010; 72:334-341.
22. Gong FY, Zhang SJ, Deng JY, Zhu HJ, Pan H, Li NS, Shi YF: Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue. Int J Obes (Lond) 2009;33:1023-1030.
23. Russell ST, Tisdale MJ: Studies on the anti-obesity activity of zinc-alpha2-glycoprotein in the rat. Int J Obes (Lond) 2011;35:658-665.
24. Russell ST, Tisdale MJ: Studies on the antiobesity effect of zinc-alpha2-glycoprotein in the ob/ob mouse. Int J Obes (Lond) 2011;35:345-354.
25. Rolli V, Radosavljevic M, Astier V, Macquin C, Castan-Laurell I, Visentin V, Guigne C, Carpene C, Valet P, Gilfillan S, Bahram S: Lipolysis is altered in mhc class i zinc-alpha(2)-glycoprotein deficient mice. FEBS Lett 2007;581:394-400.
26. Selva DM, Lecube A, Hernandez C, Baena JA, Fort JM, Simo R: Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance. J Clin Endocrinol Metab 2009;94:4499-4507.
27. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
28. Choi JW, Hwang HS, Kim DH, Joo JI, Yun JW: Proteomic analysis of liver proteins in rats fed with a high-fat diet in response to capsaicin treatments. Biotechnol Bioproc E 2010;15:534-544.
29. Kim SW, Hwang HJ, Cho EJ, Oh JY, Baek YM, Choi JW, Yun JW: Time-dependent plasma protein changes in streptozotocin-induced diabetic rats before and after fungal polysaccharide treatments. J Proteome Res 2006;5:2966-2976.
30. Oh TS, Kwon EY, Choi JW, Choi MS, Yun JW: Time-dependent hepatic proteome analysis in lean and diet-induced obese mice. J Microbiol Biotechnol 2011;21:1211-1227.
31. Voorhoeve PM, Agami R: Knockdown stands up. Trends Biotechnol 2003;21:2-4.
32. Wise EM, Jr., Ball EG: Malic enzyme and lipogenesis. Proc Natl Acad Sci USA 1964;52:1255-1263.
33. Wada F, Maruyama E, Shibayama K, Sakamoto Y: Physiological role of malic enzymes in the liver. J Biochem 1968;63:805-807.
34. Kim TS, Leahy P, Freake HC: Promoter usage determines tissue specific responsiveness of the rat acetyl-coa carboxylase gene. Biochem Biophys Res Commun 1996;225:647-653.
35. Barber MC, Price NT, Travers MT: Structure and regulation of acetyl-coa carboxylase genes of metazoa. Biochim Biophys Acta 2005;1733:1-28.
36. Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ: The subcellular localization of acetyl-coa carboxylase 2. Proc Natl Acad Sci USA 2000;97:1444-1449.
37. Takekoshi K, Fukuhara M, Quin Z, Nissato S, Isobe K, Kawakami Y, Ohmori H: Long-term exercise stimulates adenosine monophosphate-activated protein kinase activity and subunit expression in rat visceral adipose tissue and liver. Metabolism 2006;55:1122-1128.
38. Ix JH, Sharma K: Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: The roles of fetuin-A, adiponectin, and ampk. J Am Soc Nephrol 2010;21:406-412.
39. Hennige AM, Staiger H, Wicke C, Machicao F, Fritsche A, Haring HU, Stefan N: Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One 2008;3:el765.
40. Jenkins NT, McKenzie JA, Hagberg JM, Witkowski S: Plasma Fetuin-A concentrations in young and older highland low-active men. Metabolism 2011;60:265-271.
41. Xu Y, Xu M, Bi Y, Song A, Huang Y, Liu Y, Wu Y, Chen Y, Wang W, Li X, Ning G: Serum Fetuin-A is correlated with metabolic syndrome in middle-aged and elderly Chinese. Atherosclerosis 2011;216:180-186.
42. Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Krober SM, Machicao F, Fritsche A, Haring HU: Alpha2-heremans-schmid glycoprotein/Fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care 2006;29:853-857.
43. Marrades MP, Martinez JA, Moreno-Aliaga MJ: Zag, a lipid mobilizing adipokine, is downregulated in human obesity. J Physiol Biochem 2008;64:61-66.
44. Yeung DC, Lam KS, Wang Y, Tso AW, Xu A: Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects. J Clin Endocrinol Metab 2009;94:2531-2536.
45. Russell ST, Zimmerman TP, Domin BA, Tisdale MJ: Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein. Biochim Biophys Acta 2004;1636:59-68.
46. Eckardt K, Schober A, Platzbecker B, Mracek T, Bing C, Trayhurn P, Eckel J: The adipokine zinc-alpha2-glycoprotein activates amp kinase in human primary skeletal muscle cells. Arch Physiol Biochem 2011;117:88-93.
47. Gong FY, Deng JY, Zhu HJ, Pan H, Wang LJ, Yang HB: Fatty acid synthase and hormone-sensitive lipase expression in liver are involved in zinc-alpha2-glycoprotein-induced body fat loss in obese mice. Chin Med Sci J 2010;25:169-175.