Mutation in cyclophilin B that causes hyperelastosis cutis in american quarter horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin b-protein interactions and affects collagen folding

Journal of Biological Chemistry

Volumn 287, Issue 26, 2012, Pages 22253-22265

  Ishikawa, Yoshihiro ^a,b   Vranka, Janice A ^a   Boudko, Sergei P ^a,b   Pokidysheva, Elena ^a,b   Mizuno, Kazunori ^a   Zientek, Keith ^a   Keene, Douglas R ^a   Rashmir Raven, Ann M ^d   Nagata, Kazuhiro ^c   Winand, Nena J ^e   Bächinger, Hans Peter ^a,b  

^a SHRINERS HOSPITAL FOR CHILDREN   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c KYOTO SANGYO UNIVERSITY   (Japan)

^d MICHIGAN STATE UNIVERSITY   (United States)

^e Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALRETICULIN; CATALYTIC DOMAINS; CIS-TRANS; COLLAGEN FIBRILS; COLLAGEN TRIPLE HELIX; CYCLOPHILIN; HYDROXYLASES; IN-VITRO; ISOMERASE ACTIVITY; MUTANT PROTEINS; PROTEIN COMPLEXES; RATE-LIMITING STEPS; ROUGH ENDOPLASMIC RETICULUMS; STRUCTURAL CHANGE; TYPE I COLLAGEN;

BIOCHEMISTRY; CATALYSIS; CELL CULTURE; CELL MEMBRANES; HYDROXYLATION; MAMMALS;

COLLAGEN;

CALRETICULIN; COLLAGEN; COLLAGEN TYPE 1; CYCLOPHILIN B; HYDROXYLYSINE; LYSYL HYDROXYLASE 1; PEPTIDYLPROLYL ISOMERASE; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ELASTOSIS; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GENE MUTATION; HORSE; HUMAN; HUMAN CELL; HYDROXYLATION; HYPELASTOSIS CUTIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

ANIMALS; ASTHENIA; CIRCULAR DICHROISM; CIS-TRANS-ISOMERASES; COLLAGEN; CYCLOPHILINS; ENDOPLASMIC RETICULUM, ROUGH; HORSES; KINETICS; MICE; MICE, TRANSGENIC; MOLECULAR CHAPERONES; MUTATION; PEPTIDYLPROLYL ISOMERASE; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SKIN DISEASES; SURFACE PLASMON RESONANCE;

EID: 84862691109     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.333336     Document Type: Article

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