Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment

Psychopharmacology

Volumn 221, Issue 2, 2012, Pages 329-339

  Bouet, Valentine ^a   Klomp, Anne ^b   Freret, Thomas ^a   Wylezinska Arridge, Marzena ^c   Lopez Tremoleda, Jordi ^c   Dauphin, François ^a   Boulouard, Michel ^a   Booij, Jan ^b   Gsell, Willy ^c   Reneman, Liesbeth ^b  

^a UNIVERSITÉ DE CAEN   (France)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

5 HT; Behavior; Brain development; Fluoxetine; phMRI

Indexed keywords

FLUOXETINE; SEROTONIN TRANSPORTER;

ADOLESCENT; ADULT ANIMAL; AGE DISTRIBUTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BINDING ASSAY; BOLD SIGNAL; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG RECEPTOR BINDING; EX VIVO STUDY; HYPOTHALAMUS; LOCOMOTION; LONG TERM CARE; MALE; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SEROTONINERGIC SYSTEM; TREATMENT DURATION; WORKING MEMORY;

ADMINISTRATION, ORAL; AGE FACTORS; ANIMALS; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; FLUOXETINE; HYPOTHALAMUS; INJECTIONS, INTRAPERITONEAL; MAGNETIC RESONANCE IMAGING; MALE; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS;

EID: 84862689211     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2580-1     Document Type: Article

References (43)

1. Andersen SL, Navalta CP (2004) Altering the course of neuro-development: a framework for understanding the enduring effects of psychotropic drugs. Int J Dev Neurosci 22:423-440
2. Bachrach LK (2004) Bare-bones fact-children are not small adults. N Eng J Med 351:924-946
3. Beasley CM, Koke SC, Nilsson ME, Gonzales JS (2000) Adverse events and treatment discontinuations in clinical trials of fluoxetine in major depressive disorder. An updated meta-analysis. Clin Ther 22:1319-1330
4. Bhagwagar Z, Cowen PJ (2008) 'It's not over when it's over', persistent neurobiological abnormalities in recovered depressed patients. Psychol Med 38:307-313
5. 123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease. Synapse 39:101-108
6. Bouet V, Freret T, Ankri S, Bezault M, Renolleau S, Boulouard M, Jacotot E, Chauvier D, Schumann-Bard P (2010) Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat. Behav Brain Res 212:56-63
7. Bourdeaux R, Desor D, Lehr PR, Younos C, Capolaghi B (1998) Effects of fluoxetine and norfluoxetine on 5-hydroxytryptamine metabolism in blood platelets and brain after administration to rats. J Pharm Pharmacol 50:1387-1392
8. Caccia S, Cappi M, Fracasso C, Garattini S (1990) Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat. Psychopharmacology 100:509-514
9. Canli T, Lesch KP (2007) Long story short, the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 10:1103-1109
10. Castro JE, Varea E, Márquez C, Cordero MI, Poirier G, Sandi C (2010) Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat. PLoS One 5:e8618
11. Couillard-Despres S,Wuertinger C, KandasamyM, Caioni M, Stadler K, Aigner R, Bogdahn U, Aigner L (2009) Ageing abolishes the effects of fluoxetine on neurogenesis. Mol Psychiatry 14:856-864
12. Downey D, Juhasz G, McKie S, Davies KE, Thomas EJ, Chase D, Elliott R, Deakin JW, Anderson IM, Williams SR (2010) Short-long functional polymorphism of serotonin transporter gene modulates the acute citalopram challenge phMRI response. Poster ISMRM
13. Engelbregt MJ, Houdijk ME, Popp-Snijders C, Delemarre-van de Waal HA (2000) The effects of intra-uterine growth retardation and postnatal undernutrition on onset of puberty in male and female rats. Pediatr Res 48:803-807
14. Griebel G, Cohen C, Perrault G, Sanger DJ (1999) Behavioral effects of acute and chronic fluoxetine in Wistar-Kyoto rats. Physiol Behav 67:315-320
15. Hatzidimitriou G, McCann UD, Ricaurte GA (1999) Altered serotonin innervations patterns in the forebrain of monkeys treated with (±) 3,4-methylenedioxymethamphetamine seven years previously, factors influencing abnormal recovery. J Neurosci 19:5096-5107
16. Heils A, Mossner R, Lesch KP (1997) The human serotonin transporter gene polymorphism-basic research and clinical implications. J Neural Transm 104:1005-1014
17. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D et al (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624
18. Homberg JR, Olivier JD, Blom T, Arentsen T, van BC, Schipper P, Korte-Bouws G, van LG, Reneman L (2011) Fluoxetine exerts age-dependent effects on behavior and amygdala neuroplasticity in the rat. PLoS ONE 6:e16646
19. Iñiguez SD, Warren BL, Bolaños-Guzmán CA (2010) Short- and long-term functional consequences of fluoxetine exposure during adolescence in male rats. Biol Psychiatry 67:1057-1066
20. Kapornai K, Vetró A (2008) Depression in children. Curr Opin Psychiatry 21:1-7
21. LaRoche RB, Morgan RE (2007) Adolescent fluoxetine exposure produces enduring, sex-specific alterations of visual discrimination and attention in rats. Neurotoxicol Teratol 29:96-107
22. Lesch KP, Aulakh CS, Wolozin BL, Tolliver TJ, Hill JL, Murphy DL (1993) Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Brain Res Mol Brain Res 17:31-35
23. Lifschytz T, Shalom G, Lerer B, Newman ME (2006) Sex-dependent effects of fluoxetine andtriiodothyronine in the forced swim test in rats. Eur Neuropsychopharmacol 16:115-121
24. McKie S, Del-Ben C, Elliott R, Williams S, del Vai N, Anderson I, Deakin JF (2005) Neuronal effects of acute citalopram detected by pharmaco MRI. Psychopharmacology 180:680-686
25. Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Rüther E, Huether G (2000) Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood. Brain Res Dev Brain Res 119:251-257
26. Navailles S, Hof PR, Schmauss C (2008) Antidepressant drug-induced stimulation of mouse hippocampal neurogenesis is age-dependent and altered by early life stress. J Comp Neurol 509:372-381
27. Olfson M, Marcus SC, Shaffer D (2006) Antidepressant drug therapy and suicide in severely depressed children and adults: A case-control study. Arch Gen Psychiatry 63:865-872
28. Pellow S, Chopin P, File SE, Briley M (1985) Validation of open-closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149-167
29. Piñeyro G, Blier P, Dennis T, de Montigny C (1994) Desensitization of the neuronal 5-HT carrier following its long-term blockade. J Neurosci 14:3036-3047
30. Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730-732
31. Preece MA, Taylor MJ, Raley J, Blamire A, Sharp T, Sibson NR (2009) Evidence that increased 5-HT release evokes regionspecific effects on blood-oxygenation level-dependent functional magnetic resonance imaging responses in the rat brain. Neuroscience 159:751-759
32. Reneman L, Booij J, Lavalaye J, de Bruin K, de Wolff FA, Koopmans RP, Stoof JC, den Heeten GJ (1999) Comparative in vivo study of iodine-123-labeled beta-CIT and nor-beta-CIT binding to serotonin transporters in rat brain. Synapse 34:77-80
33. Rijks LJ, Booij J, Doornbos T, Boer GJ, Ronken E, de Bruin K, Vermeulen RJ, Janssen AG, van Royen EA (1996) In vitro and in vivo characterization of newly developed iodinated 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazine derivatives in rats, limited value as dopamine transporter SPECT ligands. Synapse 23:201-207
34. Schwarz AJ, Gozzi A, Reese T, Bifone A (2007) In vivo mapping of functional connectivity in neurotransmitter systems using pharmacological MRI. Neuroimage 34:1627-1636
35. Shishkina GT, Kalinina TS, Dygalo NN (2007) Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Neuroscience 150:404-412
36. Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417-463
37. Strupp JP (1996) Stimulate: A GUI based fMRI analysis software package. Neuroimage 3:S607
38. Swaab DF, Boer K (2001) Functional teratogenic effects of chemicals on the developing brain. In: Levene MI et al (eds) Fetal and neonatal neurology and neurosurgery, 3rd edn. Churchill Living-stone, London, pp 251-265
39. Tordera RM, Monge A, Del Río J, Lasheras B (2002) Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. Eur J Pharmacol 442:63-71
40. Wegerer V, Moll GH, Bagli M, Rothenberger A, Ruther E, Huether G (1999) Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life. J Child Adolesc Psychopharmacol 9:13-24
41. Whitaker-Azmitia PM, Azmitia EC (1989) Stimulation of astroglial serotonin receptors produces culture media which regulates growth of serotonergic neurons. Brain Res 497:80-85
42. Whitaker-Azmitia PM, Druse M, Walker P, Lauder JM (1996) Serotonin as a developmental signal. Behav Brain Res 73:19-29
43. Zito JM, Tobi H, de Jong-van den Berg LT, Fegert JM, Safer DJ, Janhsen K, Hansen DG, Gardner JF, Glaeske G (2006) Antidepressant prevalence for youths: a multi-national comparison. Pharmacoepidemiol Drug Saf 15:793-798