Hedyotis diffusa Willd extract inhibits HT-29 cell proliferation via cell cycle arrest

Experimental and Therapeutic Medicine

Volumn 4, Issue 2, 2012, Pages 307-310

  Lin, Minghe ^a,b   Lin, Jiumao ^b,d   Wei, Lihui ^b   Xu, Wei ^c   Hong, Zhenfeng ^b   Cai, Qiaoyan ^b,d   Peng, Jun ^b,d   Zhu, Dezeng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Academy of Integrative Medicine Biomedical Research Center   (China)

^c Department of Pharmacology ^*  (China)

^d FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Cell cycle; Chinese herbal medicine; Colorectal cancer; Hedyotis diffusa willd; Proliferation

Indexed keywords

ALCOHOL; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLINE; HEDYOTIS DIFFUSA EXTRACT; MESSENGER RNA; PROTEIN P21;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLON CARCINOMA; CONTROLLED STUDY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; S PHASE CELL CYCLE CHECKPOINT;

EID: 84862688328     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.599     Document Type: Article

References (22)

1. Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348, 2001.
2. Nurse P: Ordering S phase and M phase in the cell cycle. Cell 79: 547-550, 1994.
3. Chen Y, Robles AI, Martinez LA, Liu F, Gimenez-Conti IB and Conti CJ: Expression of G1 cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors in androgen-induced prostate proliferation in castrated rats. Cell Growth Differ 7: 1571-1578, 1996.
4. Graña X and Reddy EP: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11: 211-219, 1995.
5. Zhong W, Peng J, He H, Wu D, Han Z, Bi X and Dai Q: Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia. Clin Invest Med 31: E8-E15, 2008.
6. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816, 1993.
7. Gustin DM and Brenner DE: Chemoprevention of colon cancer: current status and future prospects. Cancer Metast Rev 21: 323-348, 2002.
8. Gorlick R and Bertino JR: Drug resistance in colon cancer. Semin Oncol 26: 606-611, 1999.
9. Longley DB, Allen WL and Johnston PG: Drug resistance, predictive markers and pharmacogenomics in colorectal cancer. Biochim Biophys Acta 1766: 184-196, 2006.
10. Boose G and Stopper H: Genotoxicity of several clinically used topoisomerase II inhibitors. Toxicol Lett 116: 7-16, 2000.
11. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
12. Kelloff GJ: Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res 78: 199-334, 2000.
13. Tyagi AK, Singh RP, Agarwal C, Chan DC and Agarwal C: Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest, and apoptosis. Clin Cancer Res 8: 3512-3519, 2002.
14. Newman DJ, Cragg GM and Snader KM: The influence of natural products upon drug discovery. Nat Prod Rep 17: 215-234, 2000.
15. Jeune MA, Kumi-Diaka J and Brown J: Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. J Med Food 8: 469-475, 2005.
16. Sausville EA: Versipelostatin: unfolding an unsweetened death. J Natl Cancer Inst 96: 1266-1267, 2004.
17. Won HJ, Han CH, Kim YH, Kwon HJ, Kim BW, Choi JS and Kim KH: Induction of apoptosis in human acute leukemia Jurkat T cells by Albizzia julibrissin extract is mediated via mitochondria-dependent caspase-3 activation. J Ethnopharmacol 106: 383-389, 2006.
18. Song LR: Zhonghuabencao. Vol 61. Shanghai Science and Technology Press, Shanghai, pp433, 1999.
19. Yang JJ, Hsu HY, Ho YH and Lin CC: Comparative study on the immunocompetent activity of three different kinds of Peh-Hue-Juwa-Chi-Cao, Hedyotis diffusa, H. corymbosa and Mollugo pentaphylla after sublethal whole body X-irradiation. Phytother Res 11: 428-432, 1997.
20. Li R, Zhao HR and Lin YM: Anti-tumor effect and protective effect on chemotherapeutic damage of water soluble extracts from Hedyotis diffusa. J Chin Pharm Sci 11: 54-58, 2002.
21. Lin JM, Chen YQ, Wei LH, Chen XZ, Xu W, Hong ZF, Sferra TJ, and Peng, J.: Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. Int J Oncol 37: 1331-1338, 2010.
22. Lin JM, Wei LH, Xu W, Hong ZF, Liu XX and Peng J: Effect of Hedyotis Diffusa Willd extract on tumor angiogenesis. Mol Med Rep 4: 1283-1288, 2011.