A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells

Biochemical and Biophysical Research Communications

Volumn 423, Issue 1, 2012, Pages 152-157

  Yamawaki, Hideyuki ^a   Kameshima, Satoshi ^a   Usui, Tatsuya ^a   Okada, Muneyoshi ^a   Hara, Yukio ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Adipocytokine; CGMP; CMKLR1; ENOS; HUVECs; IL 1; Inflammation; L NAME; NF B; Nitric oxide; NO; Signal transduction; SNP; TNF ; Vascular endothelial cell; VCAM 1

Indexed keywords

ADIPOCYTOKINE; CHEMERIN; CYCLIC AMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITROPRUSSIDE SODIUM; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AORTA; ARTICLE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; VASCULAR ENDOTHELIUM;

ADIPOKINES; ANIMALS; CELL ADHESION; CHEMOKINES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; MALE; MONOCYTES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

RATTUS;

EID: 84862675951     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.103     Document Type: Article

References (16)

1. Bozaoglu K., Bolton K., McMillan J., Zimmet P., Jowett J., Collier G., Walder K., Segal D. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology 2007, 148:4687-4694.
2. Goralski K.B., McCarthy T.C., Hanniman E.A., Zabel B.A., Butcher E.C., Parlee S.D., Muruganandan S., Sinal C.J. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J. Biol. Chem. 2007, 282:28175-28188.
3. Roh S.G., Song S.H., Choi K.C., Katoh K., Wittamer V., Parmentier M., Sasaki S. Chemerin - a new adipokine that modulates adipogenesis via its own receptor. Biochem. Biophys. Res. Commun. 2007, 362:1013-1018.
4. Wittamer V., Franssen J.D., Vulcano M., Mirjolet J.F., Le Poul E., Migeotte I., Brezillon S., Tyldesley R., Blanpain C., Detheux M., Mantovani A., Sozzani S., Vassart G., Parmentier M., Communi D. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J. Exp. Med. 2003, 198:977-985.
5. Zabel B.A., Allen S.J., Kulig P., Allen J.A., Cichy J., Handel T.M., Butcher E.C. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J. Biol. Chem. 2005, 280:34661-34666.
6. Samson M., Edinger A.L., Stordeur P., Rucker J., Verhasselt V., Sharron M., Govaerts C., Mollereau C., Vassart G., Doms R.W., Parmentier M. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Eur. J. Immunol. 1998, 28:1689-1700.
7. Du X.Y., Leung L.L. Proteolytic regulatory mechanism of chemerin bioactivity. Acta Biochim. Biophys. Sin. (Shanghai) 2009, 41:973-979.
8. Takahashi M., Takahashi Y., Takahashi K., Zolotaryov F.N., Hong K.S., Kitazawa R., Iida K., Okimura Y., Kaji H., Kitazawa S., Kasuga M., Chihara K. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett. 2008, 582:573-578.
9. Sell H., Laurencikiene J., Taube A., Eckardt K., Cramer A., Horrighs A., Arner P., Eckel J. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes 2009, 58:2731-2740.
10. Kaur J., Adya R., Tan B.K., Chen J., Randeva H.S. Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. Biochem. Biophys. Res. Commun. 2010, 391:1762-1768.
11. Yamawaki H., Pan S., Lee R.T., Berk B.C. Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells. J. Clin. Invest. 2005, 115:733-738.
12. Yamawaki H., Iwai N. Cytotoxicity of water-soluble fullerene in vascular endothelial cells. Am. J. Physiol. Cell Physiol. 2006, 290:C1495-1502.
13. Yamawaki H., Hara Y. Glyoxal causes inflammatory injury in human vascular endothelial cells. Biochem. Biophys. Res. Commun. 2008, 369:1155-1159.
14. Yamawaki H., Hara N., Okada M., Hara Y. Visfatin causes endothelium-dependent relaxation in isolated blood vessels. Biochem. Biophys. Res. Commun. 2009, 383:503-508.
15. Yamawaki H., Tsubaki N., Mukohda M., Okada M., Hara Y. Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels. Biochem. Biophys. Res. Commun. 2010, 393:668-672.
16. Sell H., Divoux A., Poitou C., Basdevant A., Bouillot J.L., Bedossa P., Tordjman J., Eckel J., Clement K. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J. Clin. Endocrinol. Metab. 2010, 95:2892-2896.