Local gene expression changes after UV-irradiation of human skin

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Weinkauf, Benjamin ^a   Rukwied, Roman ^a   Quiding, Hans ^b   Dahllund, Leif ^b   Johansson, Patrick ^b   Schmelz, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMIN; BRADYKININ RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CHEMOKINE RECEPTOR CCR2; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; PROSTAGLANDIN E SYNTHASE; PROTEIN TYROSINE KINASE A; SODIUM CHANNEL NAV1.7; SORTILIN; VANILLOID RECEPTOR 1;

ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOWN REGULATION; ERYTHEMA; GENE EXPRESSION; HEAT SENSATION; HUMAN; HYPERALGESIA; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN SENSITIZATION; STIMULUS RESPONSE; ULTRAVIOLET C RADIATION; ULTRAVIOLET IRRADIATION; UPREGULATION;

ADULT; AXONS; DOWN-REGULATION; ERYTHEMA; GENE EXPRESSION; HUMANS; HYPERALGESIA; INFLAMMATION MEDIATORS; ION CHANNELS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; PAIN MEASUREMENT; PAIN THRESHOLD; SKIN; ULTRAVIOLET RAYS;

EID: 84862673593     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039411     Document Type: Article

References (35)

1. Gillardon F, Eschenfelder C, Rush RA, Zimmerman M, (1995) Increase in Neuronal Jun Immunoreactivity and Epidermal NGF Levels Following UV Exposure of Rat Skin. Neuroreport 6: 1322-1324.
2. Benrath J, Eschenfelder C, Zimmerman M, Gillardon F, (1995) Calcitonin gene-related peptide, substance P and nitric oxide are involved in cutaneous inflammation following ultraviolet irradiation. Eur J Pharmacol 293: 87-96.
3. Bishop T, Marchand F, Young AR, Lewin GR, McMahon SB, (2010) Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation. Pain 150: 524-532.
4. Bishop T, Hewson DW, Yip PK, Fahey MS, Dawbarn D, et al. (2007) Characterisation of ultraviolet-B-induced inflammation as a model of hyperalgesia in the rat. Pain 131: 70-82.
5. Rukwied R, Dusch M, Schley M, Forsch E, Schmelz M, (2008) Nociceptor sensitization to mechanical and thermal stimuli in pig skin in vivo. Eur J Pain 12: 242-250.
6. Hoffmann RT, Schmelz M, (1999) Time course of UVA- and UVB-induced inflammation and hyperalgesia in human skin. Eur J Pain 3: 131-139.
7. Seifert F, Jungfer I, Schmelz M, Maihofner C, (2008) Representation of UV-B-induced thermal and mechanical hyperalgesia in the human brain: A functional MRI study. Hum Brain Mapp 29: 1327-1342.
8. Maihofner C, Ringler R, Herrndobler F, Koppert W, (2007) Brain imaging of analgesic and antihyperalgesic effects of cyclooxygenase inhibition in an experimental human pain model: a functional MRI study. Eur J Neurosci 26: 1344-1356.
9. Eisenbarth H, Rukwied R, Petersen M, Schmelz M, (2004) Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin. Pain 110: 197-204.
10. Bishop T, Ballard A, Holmes H, Young AR, McMahon SB, (2009) Ultraviolet-B induced inflammation of human skin: characterisation and comparison with traditional models of hyperalgesia. Eur J Pain 13: 524-532.
11. Bickel A, Dorfs S, Schmelz M, Forster C, Uhl W, et al. (1998) Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. Pain 76: 317-325.
12. Chizh BA, O'donnell MB, Napolitano A, Wang J, Brooke AC, et al. (2007) The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans. Pain 132: 132-141.
13. Clydesdale GJ, Dandie GW, Muller HK, (2001) Ultraviolet light induced injury: immunological and inflammatory effects. Immunol Cell Biol 79: 547-568.
14. Rukwied R, Mayer A, Kluschina O, Obreja O, Schley M, et al. (2010) NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin. Pain 148: 407-413.
15. Schmelz M, Michael K, Weidner C, Schmidt R, Torebjörk HE, et al. (2000) Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport 11: 645-648.
16. Koppert W, Brueckl V, Weidner C, Schmelz M, (2004) Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine. Eur J Pain 8: 237-244.
17. Kohlloffel LU, Koltzenburg M, Handwerker HO, (1991) A novel technique for the evaluation of mechanical pain and hyperalgesia. Pain 46: 81-87.
18. Dawes JM, Calvo M, Perkins JR, Paterson KJ, Kiesewetter H, et al. (2011) CXCL5 Mediates UVB Irradiation-Induced Pain. Sci Transl Med 3: 90ra60.
19. Rhodes LE, Gledhill K, Masoodi M, Haylett AK, Brownrigg M, et al. (2009) The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases. FASEB J 23: 3947-3956.
20. Perkins MN, Kelly D, (1993) Induction of bradykinin B1 receptors in vivo in a model of ultra-violet irradiation-induced thermal hyperalgesia in the rat. Br J Pharmacol 110: 1441-1444.
21. Petho G, Derow A, Reeh PW, (2001) Bradykinin-induced nociceptor sensitization to heat is mediated by cyclooxygenase products in isolated rat skin. Eur J Neurosci 14: 210-218.
22. Sycha T, Anzenhofer S, Lehr S, Schmetterer L, Chizh B, et al. (2005) Rofecoxib attenuates both primary and secondary inflammatory hyperalgesia: a randomized, double blinded, placebo controlled crossover trial in the UV-B pain model. Pain 113: 316-322.
23. Qin X, Wan Y, Wang X, (2005) CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. J Neurosci Res 82: 51-62.
24. Wang XM, Hamza M, Wu TX, Dionne RA, (2009) Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: Correlation to clinical pain. Pain 142: 275-283.
25. Lewin GR, Mendell LM, (1993) Nerve growth factor and nociception. Trends Neurosci 16: 353-359.
26. Obreja O, Kluschina O, Mayer A, Hirth M, Schley M, et al. (2011) NGF enhances electrically induced pain, but not axon reflex sweating. Pain.
27. Tron VA, Coughlin MD, Jang DE, Stanisz J, Sauder DN, (1990) Expression and modulation of nerve growth factor in murine keratinocytes (PAM 212). J Clin Invest 85: 1085-1089.
28. Stefanato CM, Yaar M, Bhawan J, Phillips TJ, Kosmadaki MG, et al. (2003) Modulations of nerve growth factor and Bcl-2 in ultraviolet-irradiated human epidermis. J Cutan Pathol 30: 351-357.
29. Bull HA, Leslie TA, Chopra S, Dowd PM, (1998) Expression of nerve growth factor receptors in cutaneous inflammation. Br J Dermatol 139: 776-783.
30. Donnelly CJ, Fainzilber M, Twiss JL, (2010) Subcellular communication through RNA transport and localized protein synthesis. Traffic 11: 1498-1505.
31. Cattaneo A, (2010) Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain. Curr Opin Mol Ther 12: 94-106.
32. Zhao P, Barr TP, Hou Q, Dib-Hajj SD, Black JA, et al. (2008) Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain. Pain 139: 90-105.
33. Kohlloffel LU, Koltzenburg M, Handwerker HO, (1991) A novel technique for the evaluation of mechanical pain and hyperalgesia. Pain 46: 81-87.
34. Rukwied R, Chizh BA, Lorenz U, Obreja O, Margarit S, et al. (2007) Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2. J Pain 8: 443-451.
35. Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, et al. (2006) Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 10: 77-88.