Positive feedback and mutual antagonism combine to polarize crumbs in the drosophila follicle cell epithelium

Current Biology

Volumn 22, Issue 12, 2012, Pages 1116-1122

  Fletcher, Georgina C ^a   Lucas, Eliana P ^a   Brain, Ruth ^a   Tournier, Alexander ^a   Thompson, Barry J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRUMBS PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; MEMBRANE PROTEIN; PKC 3 PROTEIN; PKC-3 PROTEIN; PRIMER DNA; PROTEIN KINASE C;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL MEMBRANE; CELL POLARITY; COMPUTER SIMULATION; CYTOLOGY; DROSOPHILA; ELECTROKYMOGRAPHY; EPITHELIUM CELL; FEEDBACK SYSTEM; FEMALE; GENETICS; METABOLISM; OVARY FOLLICLE; PHOSPHORYLATION; PHYSIOLOGY; RNA INTERFERENCE; SITE DIRECTED MUTAGENESIS;

ANIMALS; CELL MEMBRANE; CELL POLARITY; COMPUTER SIMULATION; DNA PRIMERS; DROSOPHILA; DROSOPHILA PROTEINS; EPITHELIAL CELLS; FEEDBACK, PHYSIOLOGICAL; FEMALE; KYMOGRAPHY; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; OVARIAN FOLLICLE; PHOSPHORYLATION; PROTEIN KINASE C; RNA INTERFERENCE;

EID: 84862645361     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2012.04.020     Document Type: Article

References (35)

1. D. St Johnston, and J. Ahringer Cell polarity in eggs and epithelia: parallels and diversity Cell 141 2010 757 774
2. A. Wodarz, A. Ramrath, A. Grimm, and E. Knust Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts J. Cell Biol. 150 2000 1361 1374
3. M.M. Rolls, R. Albertson, H.P. Shih, C.Y. Lee, and C.Q. Doe Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia J. Cell Biol. 163 2003 1089 1098
4. A. Hutterer, J. Betschinger, M. Petronczki, and J.A. Knoblich Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis Dev. Cell 6 2004 845 854
5. Q. Wang, T.W. Hurd, and B. Margolis Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust J. Biol. Chem. 279 2004 30715 30721
6. O. Kempkens, E. Médina, G. Fernandez-Ballester, S. Ozüyaman, A. Le Bivic, L. Serrano, and E. Knust Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6 Eur. J. Cell Biol. 85 2006 753 767
7. S. Sotillos, M.T. Díaz-Meco, E. Caminero, J. Moscat, and S. Campuzano DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila J. Cell Biol. 166 2004 549 557
8. D. Bilder, M. Li, and N. Perrimon Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors Science 289 2000 113 116
9. D. Bilder, M. Schober, and N. Perrimon Integrated activity of PDZ protein complexes regulates epithelial polarity Nat. Cell Biol. 5 2003 53 58
10. G. Tanentzapf, and U. Tepass Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization Nat. Cell Biol. 5 2003 46 52
11. J. Betschinger, K. Mechtler, and J.A. Knoblich The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl Nature 422 2003 326 330
12. J. Betschinger, F. Eisenhaber, and J.A. Knoblich Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae Curr. Biol. 15 2005 276 282
13. F. Wirtz-Peitz, and J.A. Knoblich Lethal giant larvae take on a life of their own Trends Cell Biol. 16 2006 234 241
14. S.J. Altschuler, S.B. Angenent, Y. Wang, and L.F. Wu On the spontaneous emergence of cell polarity Nature 454 2008 886 889
15. A.C. Butty, N. Perrinjaquet, A. Petit, M. Jaquenoud, J.E. Segall, K. Hofmann, C. Zwahlen, and M. Peter A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization EMBO J. 21 2002 1565 1576
16. R. Wedlich-Soldner, S. Altschuler, L. Wu, and R. Li Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase Science 299 2003 1231 1235
17. S.X. Atwood, C. Chabu, R.R. Penkert, C.Q. Doe, and K.E. Prehoda Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC J. Cell Sci. 120 2007 3200 3206
18. K.P. Harris, and U. Tepass Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis J. Cell Biol. 183 2008 1129 1143
19. G. Joberty, C. Petersen, L. Gao, and I.G. Macara The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 Nat. Cell Biol. 2 2000 531 539
20. D. Lin, A.S. Edwards, J.P. Fawcett, G. Mbamalu, J.D. Scott, and T. Pawson A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity Nat. Cell Biol. 2 2000 540 547
21. H. Lu, and D. Bilder Endocytic control of epithelial polarity and proliferation in Drosophila Nat. Cell Biol. 7 2005 1232 1239
22. S. Kim, I. Gailite, B. Moussian, S. Luschnig, M. Goette, K. Fricke, M. Honemann-Capito, H. Grubmüller, and A. Wodarz Kinase-activity-independent functions of atypical protein kinase C in Drosophila J. Cell Sci. 122 2009 3759 3771
23. E. Morais-de-Sá, V. Mirouse, and D. St Johnston aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells Cell 141 2010 509 523
24. F. Pichaud, and C. Desplan Cell biology: a new view of photoreceptors Nature 416 2002 139 140
25. M. Pellikka, G. Tanentzapf, M. Pinto, C. Smith, C.J. McGlade, D.F. Ready, and U. Tepass Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis Nature 416 2002 143 149
26. C.L. Chen, K.M. Gajewski, F. Hamaratoglu, W. Bossuyt, L. Sansores-Garcia, C. Tao, and G. Halder The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila Proc. Natl. Acad. Sci. USA 107 2010 15810 15815
27. C. Ling, Y. Zheng, F. Yin, J. Yu, J. Huang, Y. Hong, S. Wu, and D. Pan The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded Proc. Natl. Acad. Sci. USA 107 2010 10532 10537
28. B.S. Robinson, J. Huang, Y. Hong, and K.H. Moberg Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded Curr. Biol. 20 2010 582 590
29. F. Hamaratoglu, M. Willecke, M. Kango-Singh, R. Nolo, E. Hyun, C. Tao, H. Jafar-Nejad, and G. Halder The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis Nat. Cell Biol. 8 2006 27 36
30. R. Baumgartner, I. Poernbacher, N. Buser, E. Hafen, and H. Stocker The WW domain protein Kibra acts upstream of Hippo in Drosophila Dev. Cell 18 2010 309 316
31. S.M. Pocha, T. Wassmer, C. Niehage, B. Hoflack, and E. Knust Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs Curr. Biol. 21 2011 1111 1117
32. B. Zhou, Y. Wu, and X. Lin Retromer regulates apical-basal polarity through recycling Crumbs Dev. Biol. 360 2011 87 95
33. J.F. Roeth, J.K. Sawyer, D.A. Wilner, and M. Peifer Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm PLoS ONE 4 2009 e7634
34. S.X. Atwood, and K.E. Prehoda aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division Curr. Biol. 19 2009 723 729
35. P.J. Plant, J.P. Fawcett, D.C. Lin, A.D. Holdorf, K. Binns, S. Kulkarni, and T. Pawson A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl Nat. Cell Biol. 5 2003 301 308