Sustained cytoplasmic delivery and anti-viral effect of PLGA nanoparticles carrying a nucleic acid-hydrolyzing monoclonal antibody

Pharmaceutical Research

Volumn 29, Issue 4, 2012, Pages 932-942

  Joung, Yoon Ki ^a   Son, Sejin ^a,d   Jang, Ji Young ^b,c   Kwon, Myung Hee ^b   Park, Ki Dong ^a  

^a Ajou University   (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

Author keywords

Antiviral effect; Cytoplasmic delivery; Drug delivery; Monoclonal antibody; Nanoparticles

Indexed keywords

3D8 SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; ANTIVIRUS AGENT; NANOPARTICLE; POLYGLACTIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL TRANSPORT; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RELEASE; DRUG UPTAKE; FEMALE; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELL; HUMAN; HUMAN CELL; IMMUNOCHEMISTRY; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSOL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EMULSIONS; HCT116 CELLS; HELA CELLS; HUMANS; HYDROLYSIS; LACTIC ACID; MICE; NANOPARTICLES; NUCLEIC ACIDS; POLYGLYCOLIC ACID; RNA;

EID: 84862639235     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0633-0     Document Type: Article

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