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Volumn 41, Issue 2, 2012, Pages 220-226

Erythropoietin produced by the retina: Its role in physiology and diabetic retinopathy

Author keywords

Diabetic retinopathy; Erythropoietin; Erythropoietin receptor; Neurodegeneration; Neuroprotection; Retina

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2; JANUS KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84862639147     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-011-9579-6     Document Type: Review
Times cited : (42)

References (80)
  • 1
    • 0000909936 scopus 로고
    • Sur l'activite hemopoietique de serum au cours de la regeneration du sang.
    • P. Carnot, C. DeFlandre, Sur l'activite hemopoietique de serum au cours de la regeneration du sang. C. R. Acad. Sci. (Paris) 143, 384-386 (1906)
    • (1906) C. R. Acad. Sci. (Paris) , vol.143 , pp. 384-386
    • Carnot, P.1    Deflandre, C.2
  • 3
    • 0000499941 scopus 로고
    • Erythropoietin production by the in situ perfused kidney
    • J.W. Fisher, B.J. Birdwell, Erythropoietin production by the in situ perfused kidney. Acta Haematol. 26, 224-232 (1961)
    • (1961) Acta Haematol. , vol.26 , pp. 224-232
    • Fisher, J.W.1    Birdwell, B.J.2
  • 4
    • 0000182694 scopus 로고
    • Studies on the production of erythropoietin by isolated perfused organs
    • Z. Kuratowska, B. Lewartowski, E. Michalski, Studies on the production of erythropoietin by isolated perfused organs. Blood 18, 527-534 (1961)
    • (1961) Blood , vol.18 , pp. 527-534
    • Kuratowska, Z.1    Lewartowski, B.2    Michalski, E.3
  • 5
    • 0016239977 scopus 로고
    • In vitro production of erythropoietin by kidneys perfused with a serum free solution
    • A.J. Erslev, In vitro production of erythropoietin by kidneys perfused with a serum free solution. Blood 44, 77-85 (1974)
    • (1974) Blood , vol.44 , pp. 77-85
    • Erslev, A.J.1
  • 6
    • 0023868741 scopus 로고
    • Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization
    • S.T. Koury, M.S. Bondurant, M.J. Koury, Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71, 524-537 (1988)
    • (1988) Blood , vol.71 , pp. 524-537
    • Koury, S.T.1    Bondurant, M.S.2    Koury, M.J.3
  • 7
    • 0029819310 scopus 로고    scopus 로고
    • Erythropoietin production by interstitial cells of hypoxic monkey kidneys
    • J.W. Fisher, S. Koury, T. Ducey, S. Mendel, Erythropoietin (Epo) production by interstitial cells of hypoxic monkey kindeys. Br. J. Haematol. 95, 27-32 (1996) (Pubitemid 26340225)
    • (1996) British Journal of Haematology , vol.95 , Issue.1 , pp. 27-32
    • Fisher, J.W.1    Koury, S.2    Ducey, T.3    Mendel, S.4
  • 9
    • 0025912710 scopus 로고
    • Localization of cells producing erythropoietin in murine liver by in situ hybridization
    • S.T. Koury, M.C. Bondurant, M.J. Koury, G.L. Semenza, Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood 77, 2497-2503 (1991)
    • (1991) Blood , vol.77 , pp. 2497-2503
    • Koury, S.T.1    Bondurant, M.C.2    Koury, M.J.3    Semenza, G.L.4
  • 12
    • 0021978919 scopus 로고
    • Isolation and characterization of genomic and cDNA clones of human erythropoietin
    • DOI 10.1038/313806a0
    • K. Jacobs, C. Shoemaker, R. Rudersdorf, S.D. Neill, R.J. Kaufman, A. Mufson, A. Seehra, S.S. Jones, R. Hewick, E.F. Fritsch, M. Kawakita, T. Shimiza, T. Miyoke, Isolation and characterization of genomic cDNA clones of human erythropoietin. Nature 313, 806-810 (1985) (Pubitemid 15130833)
    • (1985) Nature , vol.313 , Issue.6005 , pp. 806-810
    • Jacobs, K.1    Shoemaker, C.2    Rudersdorf, R.3
  • 13
    • 0037227316 scopus 로고    scopus 로고
    • Erythropoietin: Physiology and pharmacology update
    • J.W. Fisher, Erythropoietin: physiology and pharmacology update. Exp. Biol. Med. 228, 1-14 (2003) (Pubitemid 36077622)
    • (2003) Experimental Biology and Medicine , vol.228 , Issue.1 , pp. 1-14
    • Fisher, J.W.1
  • 14
    • 26444472438 scopus 로고    scopus 로고
    • Erythropoietin: A novel neuroprotective cytokine
    • DOI 10.1016/j.neuro.2005.01.016, PII S0161813X0500046X, First International Porto Pirgos Conference on Advances in Neuroscience
    • S. Bartesaghi, M. Marinovich, E. Corsini, C.L. Galli, B. Viviani, Erythropoietin: a novel neuroprotective cytokine. Neurotoxicology 26, 923-928 (2005) (Pubitemid 41427532)
    • (2005) NeuroToxicology , vol.26 , Issue.5 , pp. 923-928
    • Bartesaghi, S.1    Marinovich, M.2    Corsini, E.3    Galli, C.L.4    Viviani, B.5
  • 15
    • 78650065987 scopus 로고    scopus 로고
    • Landmark advances in the development of erythropoietin
    • J.W. Fisher, Landmark advances in the development of erythropoietin. Exp. Biol. Med. 235, 1398-1411 (2010)
    • (2010) Exp. Biol. Med. , vol.235 , pp. 1398-1411
    • Fisher, J.W.1
  • 16
    • 0030636320 scopus 로고    scopus 로고
    • Erythropoetin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
    • DOI 10.1016/S0306-4522(96)00306-5, PII S0306452296003065
    • E. Morishita, S. Masuda, M. Nagao, Y. Yasuda, R. Sasaki, Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76, 105-116 (1997) (Pubitemid 26407940)
    • (1997) Neuroscience , vol.76 , Issue.1 , pp. 105-116
    • Morishita, E.1    Masuda, S.2    Nagao, M.3    Yasuda, Y.4    Sasaki, R.5
  • 21
    • 0033561341 scopus 로고    scopus 로고
    • Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo
    • D. Ribatti, M. Presta, A. Vacca, R. Ria, R. Giuliani, P. Dell'Era, B. Nico, L. Roncali, F. Dammacco, Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Blood 93, 2627-2636 (1999) (Pubitemid 29181195)
    • (1999) Blood , vol.93 , Issue.8 , pp. 2627-2636
    • Ribatti, D.1    Presta, M.2    Vacca, A.3    Ria, R.4    Giuliani, R.5    Dell'Era, P.6    Nico, B.7    Roncali, L.8    Dammacco, F.9
  • 22
    • 4644310308 scopus 로고    scopus 로고
    • Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells
    • DOI 10.1182/blood-2004-02-0744
    • B. Bojana, B. Cokic, V.P. Cokie, X. Yu, B.B. Wiksler, A.N. Schechter, C.T. Noguchi, Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production in endothelial cells. Blood 104, 2073-2080 (2004) (Pubitemid 39297859)
    • (2004) Blood , vol.104 , Issue.7 , pp. 2073-2080
    • Beleslin-Cokic, B.B.1    Cokic, V.P.2    Yu, X.3    Weksler, B.B.4    Schechter, A.N.5    Noguchi, C.T.6
  • 23
    • 34047202482 scopus 로고    scopus 로고
    • EPO tecting the endothelium
    • DOI 10.1038/sj.bjp.0707162, PII 0707162
    • T.E. Peterson, Z.S. Katusic, EPO tecting the endothelium. Br. J. Pharmacol. 150, 823-825 (2007) (Pubitemid 46536626)
    • (2007) British Journal of Pharmacology , vol.150 , Issue.7 , pp. 823-825
    • Peterson, T.E.1    Katusic, Z.S.2
  • 26
    • 33846963814 scopus 로고    scopus 로고
    • Erythropoietin after a century of research: Younger than ever
    • W. Jelkmann, Erythropoietin after a century of research: younger than ever. Eur. J. Haematol. 78, 183-205 (2007)
    • (2007) Eur. J. Haematol. , vol.78 , pp. 183-205
    • Jelkmann, W.1
  • 27
    • 39749184752 scopus 로고    scopus 로고
    • Control of erythropoietin gene expression and its use in medicine
    • W. Jelkmann, Control of erythropoietin gene expression and its use in medicine. Methods Enzymol. 435, 179-197 (2007)
    • (2007) Methods Enzymol. , vol.435 , pp. 179-197
    • Jelkmann, W.1
  • 28
    • 0031821059 scopus 로고
    • Proinflammatory cytokines lowering erythropoietin production
    • W. Jelkmann, Proinflammatory cytokines lowering erythropoietin production. J. Interferon. Cytokine. Res. 18, 555-559 (1992)
    • (1992) J. Interferon. Cytokine. Res. , vol.18 , pp. 555-559
    • Jelkmann, W.1
  • 29
    • 0028876304 scopus 로고
    • Erythropoietin activates three forms of MAP kinase in UT7 erythroleukemia cells
    • S. Gobert, V. Duprez, C. Lacombe, S. Gisselbrecht, P. Mayeux, Erythropoietin activates three forms of MAP kinase in UT7 erythroleukemia cells. Eur. J. Biochem. 234, 75-83 (1995)
    • (1995) Eur. J. Biochem. , vol.234 , pp. 75-83
    • Gobert, S.1    Duprez, V.2    Lacombe, C.3    Gisselbrecht, S.4    Mayeux, P.5
  • 30
    • 0028073675 scopus 로고
    • Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor
    • Y. Miura, O. Muira, J.N. Ihle, N. Aoki, Activation of the mitogen activated protein kinase pathway by the erythropoietin receptor. J. Biol. Chem. 269, 29962-29969 (1994) (Pubitemid 24365166)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.47 , pp. 29962-29969
    • Miura, Y.1    Miura, O.2    Ihle, J.N.3    Aoki, N.4
  • 32
    • 0029060110 scopus 로고
    • Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways
    • H. Wakao, N. Harada, T. Kitamura, A.L.F. Mui, A. Miyajima, Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO J. 14, 2527-2535 (1995)
    • (1995) EMBO J , vol.14 , pp. 2527-2535
    • Wakao, H.1    Harada, N.2    Kitamura, T.3    Mui, A.L.F.4    Miyajima, A.5
  • 33
    • 0029598817 scopus 로고
    • Erythropoietin induces the tyrosine phosphorylation, nuclear translocation, and DNA binding of STAT1 and STAT5 in erythroid cells
    • DOI 10.1074/jbc.270.52.31282
    • K. Penta, S.T. Sawyer, Erythropoietin induces the tyrosine phosphorylation nuclear translocation and DNA binding of STAT1 and STAT5 in erythroid cells. J. Biol. Chem. 270, 31282-31287 (1995) (Pubitemid 26012216)
    • (1995) Journal of Biological Chemistry , vol.270 , Issue.52 , pp. 31282-31287
    • Penta, K.1    Sawyer, S.T.2
  • 34
    • 0034529163 scopus 로고    scopus 로고
    • Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: Lack of specificity of Stat signals during red blood cell development
    • DOI 10.1089/107999000750053726
    • S.S. Watowich, A. Mikami, R.A. Busche, X. Xie, P.N. Pharr, G.D. Hongmore, P. Manduit, M. Sabbah, B. Druker, W. Vainchenker, S. Fisher, C. Lacombe, S. Gisselbreccht, Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of STAT signals during red blood cell development. J. Interferon. Cytokine. Res. 20, 1065-1070 (2000) (Pubitemid 32015245)
    • (2000) Journal of Interferon and Cytokine Research , vol.20 , Issue.12 , pp. 1065-1070
    • Watowich, S.S.1    Mikami, A.2    Busche, R.A.3    Xie, X.4    Pharr, P.N.5    Longmore, G.D.6
  • 35
    • 0028845212 scopus 로고
    • Cytokine receptor signaling
    • J.N. Ihle, Cytokine receptor signaling. Nature 377, 591-594 (1995)
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 36
    • 0028785893 scopus 로고
    • Tyrosine 343 in the erythropoietinreceptor positively regulates erythropoietin-induced cell proliferation and STAT5 activation
    • J.E. Damen, H. Wakao, A. Miyajima, J. Krosl, R.K. Humphries, R.L. Cutler, G. Krystal, Tyrosine 343 in the erythropoietinreceptor positively regulates erythropoietin-induced cell proliferation and STAT5 activation. EMBO J. 14, 5557-5568 (1995)
    • (1995) EMBO J , vol.14 , pp. 5557-5568
    • Damen, J.E.1    Wakao, H.2    Miyajima, A.3    Krosl, J.4    Humphries, R.K.5    Cutler, R.L.6    Krystal, G.7
  • 37
    • 0028979693 scopus 로고
    • Interaction of the erythropoietin and stem-cell-factor receptors
    • H. Wu, U. Klingmuller, P. Besmer, H.F. Lodish, Interaction of the erythropoietin and stem-cell-factor receptors. Nature 377, 242-246 (1995)
    • (1995) Nature , vol.377 , pp. 242-246
    • Wu, H.1    Klingmuller, U.2    Besmer, P.3    Lodish, H.F.4
  • 40
    • 53549097076 scopus 로고    scopus 로고
    • Erythropoietin-mediated tissue protection: Reducing collateral damage from the primary injury response
    • M. Brines, A. Cerami, Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response. J. Intern. Med. 264, 405-432 (2008)
    • (2008) J. Intern. Med. , vol.264 , pp. 405-432
    • Brines, M.1    Cerami, A.2
  • 41
    • 4644318784 scopus 로고    scopus 로고
    • Erythropoietin and the hypoxic brain
    • DOI 10.1242/jeb.01049
    • H.H. Marti, Erythropoietin and the hypoxic brain. J. Exp. Biol. 207, 3233-3242 (2004) (Pubitemid 39275297)
    • (2004) Journal of Experimental Biology , vol.207 , Issue.18 , pp. 3233-3242
    • Marti, H.H.1
  • 42
    • 33845327176 scopus 로고    scopus 로고
    • Erythropoietin is expressed in the human retina and it is highly elevated in the vitreous fluid of patients with diabetic macular edema
    • DOI 10.2337/dc06-0556
    • C. Hernández, A. Fonollosa, M. García-Ramírez et al., Erythropoietin is expressed in the human retina and it is highly elevated in the vitreous fluid of patients with diabetic macular edema. Diabetes Care 29, 2028-2033 (2006) (Pubitemid 44871182)
    • (2006) Diabetes Care , vol.29 , Issue.9 , pp. 2028-2033
    • Hernandez, C.1    Fonollosa, A.2    Garcia-Ramirez, M.3    Higuera, M.4    Catalan, R.5    Miralles, A.6    Garcia-Arumi, J.7    Simo, R.8
  • 43
    • 48649089571 scopus 로고    scopus 로고
    • Expression of erythropoietin and its receptor in the human retina: A comparative study of diabetic and nondiabetic subjects
    • M. García-Ramírez, C. Hernández, R. Simó, Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and nondiabetic subjects. Diabetes Care 31, 1189-1194 (2008)
    • (2008) Diabetes Care , vol.31 , pp. 1189-1194
    • García-Ramírez, M.1    Hernández, C.2    Simó, R.3
  • 44
    • 13844299502 scopus 로고    scopus 로고
    • Effects of erythropoietin on brain function
    • W. Jelkmann, Effects of erythropoietin on brain function. Curr. Pharm. Biotechnol. 6, 65-79 (2005) (Pubitemid 40246754)
    • (2005) Current Pharmaceutical Biotechnology , vol.6 , Issue.1 , pp. 65-79
    • Jelkmann, W.1
  • 45
    • 0037069780 scopus 로고    scopus 로고
    • Erythropoietin - An endogenous retinal survival factor
    • DOI 10.1056/NEJMcibr022629
    • S.P. Becerra, J. Amaral, Erythropoietin: an endogenous retinal survival factor. N. Engl. J. Med. 347, 1968-1970 (2002) (Pubitemid 35429930)
    • (2002) New England Journal of Medicine , vol.347 , Issue.24 , pp. 1968-1970
    • Becerra, S.P.1    Amaral, J.2
  • 46
    • 70349445409 scopus 로고    scopus 로고
    • Neuroprotection of photoreceptors by direct delivery of erythropoietin to the retina of the retinal degeneration slow mouse
    • T.S. Rex, T.Y. Wong, K. Kodali, S. Merry, Neuroprotection of photoreceptors by direct delivery of erythropoietin to the retina of the retinal degeneration slow mouse. Exp. Eye Res. 89, 735-740 (2009)
    • (2009) Exp. Eye Res. , vol.89 , pp. 735-740
    • Rex, T.S.1    Wong, T.Y.2    Kodali, K.3    Merry, S.4
  • 47
    • 75749093639 scopus 로고    scopus 로고
    • ERK- and Akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD
    • J. Shen, Y. Wu, J.Y. Xu, S.H. Sinclair, M. Yanoff, G. Xu, W. Li, G.T. Xu, ERK- and Akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD. Invest. Ophthalmol. Vis. Sci. 5, 35-46 (2010)
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.5 , pp. 35-46
    • Shen, J.1    Wu, Y.2    Xu, J.Y.3    Sinclair, S.H.4    Yanoff, M.5    Xu, G.6    Li, W.7    Xu, G.T.8
  • 49
    • 33646705396 scopus 로고    scopus 로고
    • Erythropoietin prevents the increase in blood-brain barrier permeability during pentylentetrazol induced seizures
    • DOI 10.1016/j.lfs.2005.10.027, PII S0024320505011343
    • G. Uzum, A. Sarper Diler, N. Bahcekapili, Y. Ziya Ziylan, Erythropoietin prevents the increase in blood-brain barrier permeability during pentylenetetrazol induced seizures. Life. Sci. 78, 2571-2576 (2006) (Pubitemid 44313776)
    • (2006) Life Sciences , vol.78 , Issue.22 , pp. 2571-2576
    • Uzum, G.1    Sarper Diler, A.2    Bahcekapili, N.3    Ziya Ziylan, Y.4
  • 57
    • 65949093935 scopus 로고    scopus 로고
    • Vitreous levels of erythropoietin in patients with macular oedema secondary to retinal vein occlusions: A comparative study with diabetic macular oedema
    • J. García-Arumí, A. Fonollosa, C. Macià, C. Hernandez, V. Martinez-Castillo, A. Boixadera, M.A. Zapata, R. Simo, Vitreous levels of erythropoietin in patients with macular oedema secondary to retinal vein occlusions: a comparative study with diabetic macular oedema. Eye 23, 1066-1071 (2009)
    • (2009) Eye , vol.23 , pp. 1066-1071
    • García-Arumí, J.1    Fonollosa, A.2    MacIà, C.3    Hernandez, C.4    Martinez-Castillo, V.5    Boixadera, A.6    Zapata, M.A.7    Simo, R.8
  • 59
    • 0035525338 scopus 로고    scopus 로고
    • Effects of glucose on growth, metabolism and EPO expresión in recombinant CHO cell cultures
    • X.M. Sun, Y.X. Zhang, Effects of glucose on growth, metabolism and EPO expresión in recombinant CHO cell cultures. Sheng. Wu. Gong. Cheng. Xue. Bao. 17, 698-702 (2001)
    • (2001) Sheng. Wu. Gong. Cheng. Xue. Bao. , vol.17 , pp. 698-702
    • Sun, X.M.1    Zhang, Y.X.2
  • 60
    • 0037058888 scopus 로고    scopus 로고
    • Glycosylation of erythropoietin affects receptor binding kinetics: Role of electrostatic interactions
    • DOI 10.1021/bi0265022
    • R.J. Darling, U. Kuchibhotla, W. Glaesner, R. Micanovic, D.R. Witcher, J.M. Beals, Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostática interactions. Biochemistry 41, 14524-14531 (2002) (Pubitemid 35440264)
    • (2002) Biochemistry , vol.41 , Issue.49 , pp. 14524-14531
    • Darling, R.J.1    Kuchibhotla, U.2    Glaesner, W.3    Micanovic, R.4    Witcher, D.R.5    Beals, J.M.6
  • 61
    • 33644867127 scopus 로고    scopus 로고
    • Cellular trafficking and degradation of erythropoietin and Novel Erythropoiesis Stimulating Protein (NESP)
    • DOI 10.1074/jbc.M510493200
    • A.W. Gross, H.F. Lodish, Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating proteína (NESP). J. Biol. Chem. 281, 2024-2032 (2006) (Pubitemid 43845790)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.4 , pp. 2024-2032
    • Gross, A.W.1    Lodish, H.F.2
  • 64
    • 31544460689 scopus 로고    scopus 로고
    • Intravitreal administration of erythropoietin and preservation of retinal ganglion cells in an experimental rat model of glaucoma
    • DOI 10.1080/02713680500320729, PII MT2214K14LU4U5M2
    • J.C. Tsai, L. Wu, B. Worgul, M. Forbes, J. Cao, Intravitreal administration of erythropoietin and preservation of retinal ganglion cells in an experimental rat model of glaucoma. Curr. Eye Res. 30, 1025-1031 (2005) (Pubitemid 43154696)
    • (2005) Current Eye Research , vol.30 , Issue.11 , pp. 1025-1031
    • Tsai, J.C.1    Wu, L.2    Worgul, B.3    Forbes, M.4    Cao, J.5
  • 65
    • 13244249727 scopus 로고    scopus 로고
    • Neuronal death in primary retinal cultures is related to nitric oxide production, and is inhibited by erythropoietin in a glucose-sensitive manner
    • DOI 10.1111/j.1471-4159.2004.02876.x
    • C.J. Layton, J.P. Wood, G. Chidlow, N.N. Osborne, Neuronal death in primary retinal cultures is related to nitric oxide production, and is inhibited by erythropoietin in a glucose-sensitive manner. J. Neurochem. 92, 487-493 (2005) (Pubitemid 40189452)
    • (2005) Journal of Neurochemistry , vol.92 , Issue.3 , pp. 487-493
    • Layton, C.J.1    Wood, J.P.M.2    Chidlow, G.3    Osborne, N.N.4
  • 69
    • 79960705253 scopus 로고    scopus 로고
    • Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions: Essential role of JAK2/PI3K signaling
    • M. Garcia-Ramírez, C. Hernández, M. Ruiz-Meana, M. Villarroel, L. Corraliza, D. García-Dorado, R. Simó, Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions: essential role of JAK2/PI3K signaling. Cell. Signal. 23, 1596-1602 (2011)
    • (2011) Cell. Signal. , vol.23 , pp. 1596-1602
    • Garcia-Ramírez, M.1    Hernández, C.2    Ruiz-Meana, M.3    Villarroel, M.4    Corraliza, L.5    García-Dorado, D.6    Simó, R.7
  • 70
    • 22144458380 scopus 로고    scopus 로고
    • Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells
    • DOI 10.1016/j.bbrc.2005.06.072, PII S0006291X05013173
    • N. Sekiguchi, T. Inoguchi, K. Kobayashi, N. Sonoda, H. Nawata, Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells. Biochem. Biophys. Res. Commun. 334, 218-222 (2005) (Pubitemid 40978528)
    • (2005) Biochemical and Biophysical Research Communications , vol.334 , Issue.1 , pp. 218-222
    • Sekiguchi, N.1    Inoguchi, T.2    Kobayashi, K.3    Sonoda, N.4    Nawata, H.5
  • 71
    • 33644535467 scopus 로고    scopus 로고
    • Epo protects SOD2-deficient mouse astrocytes from damage by oxidative stress
    • J. Liu, P. Narasimhan, Y.S. Song, T. Nishi, F. Yu, Y.S. Lee, P.H. Chan, Epo protects SOD2-deficient mouse astrocytes from damage by oxidative stress. Glia 53, 360-365 (2006)
    • (2006) Glia , vol.53 , pp. 360-365
    • Liu, J.1    Narasimhan, P.2    Song, Y.S.3    Nishi, T.4    Yu, F.5    Lee, Y.S.6    Chan, P.H.7
  • 72
    • 38849205803 scopus 로고    scopus 로고
    • Erythropoietin: When liability becomes asset in neurovascular repair
    • DOI 10.1172/JCI34643
    • M.B. Grant, M.E. Boulton, A.V. Ljubimov, Erythropoietin: when liability becomes asset in neurovascular repair. J. Clin. Invest. 118, 467-470 (2008) (Pubitemid 351206536)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.2 , pp. 467-470
    • Grant, M.B.1    Boulton, M.E.2    Ljubimov, A.V.3
  • 73
    • 79961116472 scopus 로고    scopus 로고
    • Erythropoietin receptor positive circulating progenitor cells and endothelial progenitor cells in patients with different stages of diabetic retinopathy
    • L.M. Hu, X. Lei, B. Ma, Y. Zhang, Y. Yan, Y.L. Wu, G.Z. Xu, W. Ye, L. Wang, G.X. Xu, G.T. Xu, L. Wei-Ye, Erythropoietin receptor positive circulating progenitor cells and endothelial progenitor cells in patients with different stages of diabetic retinopathy. Chin. Med. Sci. 26, 69-76 (2011)
    • (2011) Chin. Med. Sci. , vol.26 , pp. 69-76
    • Hu, L.M.1    Lei, X.2    Ma, B.3    Zhang, Y.4    Yan, Y.5    Wu, Y.L.6    Xu, G.Z.7    Ye, W.8    Wang, L.9    Xu, G.X.10    Xu, G.T.11    Wei-Ye, L.12
  • 75
    • 80755152818 scopus 로고    scopus 로고
    • Intervention with an erythropoietin- derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy
    • C.M. McVivar, R. Hamilton, L.M. Colhoun, T.A. Gardiner, M. Brines, A. Cerami, A.W. Stitt, Intervention with an erythropoietin- derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy. Diabetes 60, 2995-3005 (2011)
    • (2011) Diabetes , vol.60 , pp. 2995-3005
    • McVivar, C.M.1    Hamilton, R.2    Colhoun, L.M.3    Gardiner, T.A.4    Brines, M.5    Cerami, A.6    Stitt, A.W.7
  • 76
    • 77953173751 scopus 로고    scopus 로고
    • New techniques for drug delivery to the posterior eye segment
    • E. Eljarrat-Binstock, J. Pe'er, A.J. Domb, New techniques for drug delivery to the posterior eye segment. Pharm. Res. 27, 530-543 (2010)
    • (2010) Pharm. Res. , vol.27 , pp. 530-543
    • Eljarrat-Binstock, E.1    Pe'er, J.2    Domb, A.J.3
  • 77
    • 65249098513 scopus 로고    scopus 로고
    • Experimental and clinical evidence for brimonidine as an optic nerve and retinal neuroprotective agent: An evidence-based review
    • M. Saylor, L.K. McLoon, A.R. Harrison, M.S. Lee, Experimental and clinical evidence for brimonidine as an optic nerve and retinal neuroprotective agent: an evidence-based review. Arch. Ophthalmol. 127, 402-406 (2009)
    • (2009) Arch. Ophthalmol. , vol.127 , pp. 402-406
    • Saylor, M.1    McLoon, L.K.2    Harrison, A.R.3    Lee, M.S.4
  • 79
    • 53449088505 scopus 로고    scopus 로고
    • Alpha 2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity
    • C.J. Dong, Y. Guo, P. Agey, L. Wheeler, W.A. Hare, Alpha 2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity. Invest. Ophthalmol. Vis. Sci. 49, 4515-4522 (2008)
    • (2008) Invest. Ophthalmol. Vis. Sci. , vol.49 , pp. 4515-4522
    • Dong, C.J.1    Guo, Y.2    Agey, P.3    Wheeler, L.4    Hare, W.A.5
  • 80
    • 50449090755 scopus 로고    scopus 로고
    • Targeting intraocular neovascularization and edema- one drop at a time
    • L.P. Aiello, Targeting intraocular neovascularization and edema- one drop at a time. N. Engl. J. Med. 359, 967-969 (2008)
    • (2008) N. Engl. J. Med. , vol.359 , pp. 967-969
    • Aiello, L.P.1


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