On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: Role of adenosine A1 receptor

Journal of Thoracic and Cardiovascular Surgery

Volumn 144, Issue 1, 2012, Pages

  Abd Elfattah, Anwar Saad ^a   Ding, Mai ^b   Jessen, Michael E ^c   Wechsler, Andrew S ^d  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

^b St John Medical Center   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d DREXEL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 (2 HYDROXY 3 NONYL)ADENINE; ADENOSINE A1 RECEPTOR; ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITROBENZYLTHIOINOSINE; PROXYPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CLAMPING; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HEART FUNCTION; HEART PERFORMANCE; HEART PROTECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REPERFUSION INJURY;

EID: 84862632575     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2011.09.073     Document Type: Article

References (24)

1. Braunwald E, Kloner RA. Myocardial reperfusion: a double-edged sword? J Clin Invest. 1985;76:1713-9.
2. Mangano DT, Miao Y, Tudor IC, Dietzel C, Investigators of the Multicenter Study of Perioperative Ischemia (McSPI) Research Group; Ischemia Research and Education Foundation (IREF). Post-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine. J Am Coll Cardiol. 2006;48:206-14.
3. Abd-Elfattah A, Higgins R, Latifi R, Merrell R. Targeting post-ischemic reperfusion injury: scientific dream and clinical reality. New Surg. 2001;1:41-51.
4. Liu GS, Thornton J, Van Winkle DM, Stanley AW, Olsson RA, Downey JM. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation. 1991;84:350-6.
5. Schultz R, Rose J, Post H, Heusch G. Involvement of endogenous adenosine in ischemic preconditioning in swine. Pflugers Arch. 1995;430:273-82.
6. McCully JD, Uematsu M, Parker RA, Levitsky S. Adenosine-enhanced ischemic preconditioning provides enhanced postischemic recovery and limitation of infarct size in the rabbit heart. J Thorac Cardiovasc Surg. 1998;116:154-62.
7. Mentzer RM Jr, Rahko PS, Molina-Viamonte V, Canver CC, Chopra PS, Love RB, Cook TD, Hegge JO, Lasley RD. Safety, tolerance, and efficacy of adenosine as an additive to blood cardioplegia in humans during coronary artery bypass surgery. Am J Cardiol. 1997;79(12A):38-43.
8. Mentzer RM Jr, Birjiniuk V, Khuri S, Lowe JE, Rahko PS, Weisel RD, et al. Adenosine myocardial protection: preliminary results of a phase II clinical trial. Ann Surg. 1999;229:643-9.
9. Kloner RA, Forman MB, Gibbons RJ, Ross AM, Alexander RW, Stone GW. Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the AMISTAD-2 trial. Eur Heart J. 2006;27: 2400-5.
10. Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW, AMISTAD-II Investigators. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol. 2005;45:1775-80.
11. Abd-Elfattah AS, Jessen ME, Lekven J, Doherty NE III, Brunsting LA, Wechsler AS. Myocardial reperfusion injury: role of myocardial hypoxanthine and xanthine in free radical-mediated reperfusion injury. Circulation. 1988; 78(5 Pt 2):III224-35.
12. Abd-Elfattah AS, Jessen ME, Lekven J, Wechsler AS. Differential cardioprotection with selective inhibitors of adenosine metabolism and transport: role of purine release in ischemic and reperfusion injury. Mol Cell Biochem. 1998;180: 179-91.
13. Abd-Elfattah AS, Ding M, Wechsler AS. Intermittent aortic cross clamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): is it preconditioning? J Thorac Cardiovasc Surg. 1995; 110:328-39.
14. Abd-Elfattah AS, Hoehner J, Wechsler AS. Identification of nucleoside transport binding sites in the human myocardium. Mol Cell Biochem. 1998;180:105-10.
15. Grube K, Rüdebusch J, Xu Z, Böckenholt T, Methner C, Müller T, et al. Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes. Basic Res Cardiol. 2011;106:385-96.
16. Dobson JG Jr, Schrader J. Role of extracellular and intracellular adenosine in the attenuation of catecholamine evoked responses in guinea pig heart. J Mol Cell Cardiol. 1984;16:813-22.
17. Poelchen W, Sieler D, Wirkner K, Illes P. Co-transmitter function of ATP in central catecholaminergic neurons of the rat. Neuroscience. 2001;102:593-602.
18. Burnstock G. Purine cotransmission. Exp Physiol. 2009;94:20-4.
19. Xi J, McIntosh R, Shen X, Lee S, Chanoit G, Criswell H, et al. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 2009;47:684-90.
20. Urmaliya VB, Pouton CW, Ledent C, Short JL, White PJ. Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart. J Cardiovasc Pharmacol. 2010;56:379-88.
21. Zhan E, McIntosh VJ, Lasley RD. Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol. 2011;301:H1183-9.
22. Xia Y, Khatchikian G, Zweier JL. Adenosine deaminase inhibition prevents free radical mediated injury in the postischemic heart. J Biol Chem. 1996;271: 10096-102.
23. Walsh RS, Abd-Elfattah AS, Daly JJF, Wechsler AS, Downey J. Selective blockade of nucleoside transport channels prevents preconditioning of rabbit myocardium. Surg Forum. 1993;XLIV:234-6.
24. Zughaib ME, Abd-Elfattah AS, Jeroudi MO, Sun JZ, Sekili S, Tang XL, et al. Augmentation of endogenous adenosine attenuates myocardial "stunning" independently of coronary flow or hemodynamic effects. Circulation. 1993;88(5 Pt 1):2359-69.