Increased susceptibility to kidney injury by transfer of genomic segment from SHR onto Dahl S genetic background

Physiological Genomics

Volumn 44, Issue 12, 2012, Pages 629-637

  Regner, Kevin R ^c   Harmon, Ashlyn C ^a   Williams, Jan M ^a   Stelloh, Cary ^c   Johnson, Ashley C ^a   Kyle, Patrick B ^b   Lerch Gaggl, Alexandra ^c   White, Sarah M ^c   Garrett, Michael R ^a,b  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Animal model; Chronic kidney disease; Proteinuria; Renal injury; Renal vessels

Indexed keywords

SODIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CHROMOSOME 11; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; DISEASE COURSE; DISEASE PREDISPOSITION; DNA MODIFICATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; GENOMICS; GLOMERULOSCLEROSIS; IMMUNOCOMPETENT CELL; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; KIDNEY INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEINURIA; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; GENETIC LINKAGE; GENETIC PREDISPOSITION TO DISEASE; KIDNEY; KIDNEY DISEASES; PROTEINURIA; RATS; RATS, INBRED DAHL; RATS, INBRED SHR; SURVIVAL RATE;

EID: 84862628928     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00015.2012     Document Type: Article

References (35)

1. Bergman S, Key BO, Kirk KA, Warnock DG, Rostant SG. Kidney disease in the first-degree relatives of African-Americans with hypertensive end-stage renal disease. Am J Kidney Dis 27: 341-346, 1996.
2. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet 12: 44-51, 1996.
3. Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van Lente F, Levey AS. Prevalence of chronic kidney disease in the United States. Jama 298: 2038-2047, 2007.
4. Dahl LK, Heine M, Tassinari L. Effects of chronic excess salt ingestion: evidence that genetic factors play an important role in the susceptibility to experimental hypertension. J Exp Med 115: 1173-1190, 1962.
5. Dahl LK, Heine M, Tassinari L. Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature 194: 480-482, 1962.
6. Ferguson R, Grim CE, Opgenorth TJ. A familial risk of chronic renal failure among blacks on dialysis? J Clin Epidemiol 41: 1189-1196, 1988.
7. Freedman BI, Spray BJ, Tuttle AB, Buckalew VM Jr. The familial risk of end-stage renal disease in African Americans. Am J Kidney Dis 21: 387-393, 1993.
8. Garrett MR, Dene H, Rapp JP. Time-course genetic analysis of albu-minuria in Dahl salt-sensitive rats on low-salt diet. J Am Soc Nephrol 14: 1175-1187, 2003.
9. Garrett MR, Gunning WT, Radecki T, Richard A. Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. Physiol Genomics 30: 322-334, 2007.
10. Garrett MR, Joe B, Yerga-Woolwine S. Genetic linkage of urinary albumin excretion in Dahl salt-sensitive rats: influence of dietary salt and confirmation using congenic strains. Physiol Genomics 25: 39-49, 2006.
11. Hampton JA, Bernardo DA, Khan NA, Lacher DA, Rapp JP, Gohara AF, Goldblatt PJ. Morphometric evaluation of the renal arterial system of Dahl salt-sensitive and salt-resistant rats on a high salt diet. Lab Invest 60: 839-846, 1989.
12. Hemmelgarn BR, Manns BJ, Lloyd A, James MT, Klarenbach S, Quinn RR, Wiebe N, Tonelli M. Relation between kidney function, proteinuria, and adverse outcomes. JAMA 303: 423-429, 2010.
13. Hsu CY, Ordonez JD, Chertow GM, Fan D, McCulloch CE, Go AS. The risk of acute renal failure in patients with chronic kidney disease. Kidney Int 74: 101-107, 2008.
14. Kriegel AJ, Liu Y, Cohen B, Usa K, Liu Y, Liang M. MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis. Physiol Genomics 44: 259-267, 2012.
15. Lerman LO, Chade AR. Angiogenesis in the kidney: a new therapeutic target? Curr Opin Nephrol Hypertens 18: 160-165, 2009.
16. Lorenz JN, Gruenstein E. A simple, nonradioactive method for evaluating single-nephron filtration rate using FITC-inulin. Am J Physiol Renal Physiol 276: F172-F177, 1999.
17. Matsuyama M, Ogiu T, Kontani K, Yamada C, Kawai M, Hiai H, Nakamura T, Shimizu F, Toyokawa T, Kinoshita Y. Genetic regulation of the development of glomerular sclerotic lesions in the BUF/Mna rat. Nephron 54: 334-337, 1990.
18. Mittalhenkle A, Stehman-Breen CO, Shlipak MG, Fried LF, Katz R, Young BA, Seliger S, Gillen D, Newman AB, Psaty BM, Siscovick D. Cardiovascular risk factors and incident acute renal failure in older adults: the Cardiovascular Health Study. Clin J Am Soc Nephrol 3: 450-456, 2008.
19. Mori T, O'Connor PM, Abe M, Cowley AW. Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk. Hypertension 49: 1336-1341, 2007.
20. Murayama S, Yagyu S, Higo K, Ye C, Mizuno T, Oyabu A, Ito M, Morita H, Maeda K, Serikawa T, Matsuyama M. A genetic locus susceptible to the overt proteinuria in BUF/Mna rat. Mamm Genome 9: 886-888, 1998.
21. Packard M, Saad Y, Gunning WT, Gupta S, Shapiro J, Garrett MR. Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains. Am J Physiol Renal Physiol 296: F839-F846, 2009.
22. Polichnowski AJ, Lu L, Cowley AW. Renal injury in angiotensin II+L-NAME-induced hypertensive rats is independent of elevated blood pressure. Am J Physiol Renal Physiol 300: F1008-F1016, 2011.
23. Regner KR, Roman RJ. Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. Curr Opin Nephrol Hypertens 21: 33-38, 2012.
24. Regner KR, Zuk A, Van Why SK, Shames BD, Ryan RP, Falck JR, Manthati VL, McMullen ME, Ledbetter SR, Roman RJ. Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury. Kidney Int 75: 511-517, 2009.
25. Schulz A, Litfin A, Kossmehl P, Kreutz R. Genetic dissection of increased urinary albumin excretion in the Munich Wistar Frömter rat. J Am Soc Nephrol 13: 2706-2714, 2002.
26. Schulz A, Standke D, Kovacevic L, Mostler M, Kossmehl P, Stoll M, Kreutz R. A major gene locus links early onset albuminuria with renal interstitial fibrosis in the MWF rat with polygenetic albuminuria. J Am Soc Nephrol 14: 3081-3089, 2003.
27. Shiozawa M, Provoost AP, van Dokkum RP, Majewski RR, Jacob HJ. Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. J Am Soc Nephrol 11: 2068-2078, 2000.
28. Solberg Woods LC, Stelloh C, Regner KR, Schwabe T, Eisenhauer J, Garrett MR. Heterogeneous stock rats: a new model to study the genetics of renal phenotypes. Am J Physiol Renal Physiol 298: F1484-F1491, 2010.
29. Spray BJ, Atassi NG, Tuttle AB, Freedman BI. Familial risk, age at onset, and cause of end-stage renal disease in white Americans. J Am Soc Nephrol 5: 1806-1810, 1995.
30. Stella P, Cusi D, Duzzi L, Bianchi G. Relations between hypertension and glomerulosclerosis in first-generation hybrid rats of the Milan strains. Child Nephrol Urol 11: 6-9, 1991.
31. Sterzel RB, Luft FC, Gao Y, Schnermann J, Briggs JP, Ganten D, Waldherr R, Schnabel E, Kriz W. Renal disease and the development of hypertension in salt-sensitive Dahl rats. Kidney Int 33: 1119-1129, 1988.
32. Stevens LA, Greene T, Levey AS. Surrogate end points for clinical trials of kidney disease progression. Clin J Am Soc Nephrol 1: 874-884, 2006.
33. Tylicki L, Rutkowski B, Horl WH. Multifactorial determination of hypertensive nephroangiosclerosis. Kidney Blood Press Res 25: 341-353, 2002.
34. USRDS. United States Renal Data System 2003 Annual Data Report. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Disease, 2005.
35. Waikar SS, Liu KD, Chertow GM. Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol 3: 844-861, 2008.