Functionalized mesoporous silica particles for application in drug delivery system

Mini-Reviews in Medicinal Chemistry

Volumn 12, Issue 8, 2012, Pages 775-788

  Pang, J ^a   Luan, Y ^a   Yang, X ^a   Jiang, Y ^a   Zhao, L ^a   Zong, Y ^a   Li, Z ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Biocompatibility; Drug delivery; Mesoporous silica particles; Modification

Indexed keywords

ATENOLOL; BIOMATERIAL; CAPTOPRIL; DOXORUBICIN; ERYTHROMYCIN; FLUORESCEIN; FLUORESCEIN ISOTHIOCYANATE; GENTAMICIN; HOE 33342; IBUPROFEN; MESOPOROUS SILICA PARTICLE; PACLITAXEL; POLYMER; RHODAMINE B; RIBOFLAVIN; SALICYLIC ACID; SILICON DIOXIDE; UNCLASSIFIED DRUG;

CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG TARGETING; HUMAN; MEDICAL RESEARCH; NONHUMAN; POLYMERIZATION; REVIEW;

ANIMALS; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; POROSITY; SILICON DIOXIDE;

EID: 84862625334     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955712801264855     Document Type: Review

References (115)

1. Ding, D.; Zhu, Z.; Li, R.; Li, X.; Wu, W.; Jiang, X.; Liu, B. Nanospheres-incorporated implantable hydrogel as a trans-tissue drug delivery system. Acs. Nano., 2011, 5, 2520-2534.
2. Gao, L.; Zhang, D.; Chen, M. Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J. Nanopart. Res., 2008, 10, 845-862.
3. Zhou, S.; Deng, X.; Yang, H. Biodegradable poly(e-caprolactone)- poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. Biomaterials, 2003, 24, 3563-3570.
4. Freiberg, S.; Zhu, X.X. Polymer microspheres for controlled drug release. Inter. J. Pharm., 2004, 282, 1-8.
5. Uhrich, K.E.; Cannizzaro, S.M.; Langer, R.S.; Shakesheff, K.M. Polymeric systems for controlled drug release. Chem. Rev,. 1999, 99, 3181-3198.
6. Vasir, J.K.; Tambwekar, K.; Garg, S. Bioadhesive microspheres as a controlled drug delivery system. Inter. J. Pharm., 2003, 255, 13-32.
7. Qu, F.; Zhu, G.; Lin, H.; Sun, J.; Zhang, D.; Li, S.; Qiu, S. Drug self-templated synthesis of ibuprofen/mesoporous silica for sustained release. Eur. J. Inorg. Chem., 2006, 19, 3943-3947.
8. Ma, R.; Shi, L. Polymeric micelles with tunable channels. Macromol. Biosci., 2010, 10, 1397-1405.
9. Malam, Y.; Loizidou, M.; Seifalian, A.M. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends. Pharmacol. Sci., 2009, 30, 592-599.
10. Labhasetwar, V.; Bonadio, J.; Goldstein, S.A.; Levy, R.J. Gene transfection using biodegradable nanospheres: results in tissue culture and a rat osteotomy model. Colloids. Surf. B., 1999, 16, 281-290.
11. Pang, J.; Luan, Y.; Li, F.; Cai, X.; Li, Z. Ionic liquid-assisted synthesis of silica particles and their application in drug release. Mater. Lett., 2010, 64, 2509-2512.
12. Slowing, I.I.; Vivero-Escoto, J.L.; Wu, C.W.; Lin, V.S.Y. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv. Drug Delivery Rev., 2008, 60, 1278-1288.
13. Maria, V.R.; Francisco, B.; Daniel, A. Mesoporous materials for drug delivery. Angew. Chem. Int. Ed., 2007, 46, 7548-7558.
14. Izquierdo-Barba, I.; Sousa, E.; Doadrio, J.C.; Doadrio, A.L.; Pariente, J.P.; Martinez, A.; Babonneau, F.; Vallet-Regi, M. Influence of mesoporous structure type on the controlled delivery of drugs: release of ibuprofen from MCM-48, SBA-15 and functionalized SBA-15. J. Sol-Gel Sci. Technol., 2009, 50, 421-429.
15. Xu, W.; Gao, Q.; Xu, Y.; Wu, D.; Sun, Y.; Shen, W.; Deng, F.; Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres. Powder Technol., 2009, 191, 13-20.
16. Rosenholm, J.M.; Linden, M. Wet-chemical analysis of surface concentration of accessible groups on different aminofunctionalized mesoporous SBA-15 silicas. Chem. Mater., 2007, 19, 5023-5034.
17. de Sousa, A.; Andrada Maria, D.; de Sousa, R.G.; de Sousa, E.M.B. Synthesis and characterization of mesoporous silica/poly(N- isopropylacrylamide) functional hybrid useful for drug delivery. J. Mater. Sci., 2010, 45, 1478-1486.
18. Kim, T.W.; Chung, P.W.; Slowing, I.I.; Tsunoda, M.; Yeung, E.S.; Lin, V.S.Y. Structurally ordered mesoporous carbon nanoparticles as transmembrane delivery vehicle in human cancer cells. Nano. Lett., 2008, 8, 3724-3727.
19. Kim, T.W.; Chung, P.W.; Lin, V.S.Y. Facile synthesis of monodisperse spherical MCM-48 mesoporous silica nanoparticles with controlled particle size. Chem. Mater., 2010, 22, 5093-5104.
20. Strømme, M.; Brohede, U.; Atluri, R.; Garcia-Bennett, A.E. Mesoporous silica-based nanomaterials for drug delivery: evaluation of structural properties associated with release rate. Wiley Interdiscipl. Rev. Nanomed. Nanobiotechnol., 2009, 1, 140-148.
21. Wang, S. Ordered mesoporous materials for drug delivery. Microporous Mesoporous Mater., 2009, 117, 1-9.
22. Barbe C., Bartlett J., Kong L., Finnie K., Lin H.Q., Larkin M., Calleja S., Bush A., Calleja G. Silica Particles: A Novel Drug- Delivery System. Adv. Mater., 2004, 16, 1959-1966.
23. Vallet-Regí, M.; Rámila, A.; Real, R.P.; Pérez-Pariente, J. A new property of MCM-41: drug delivery system. Chem. Mater., 2001, 13, 308-311.
24. Rosenholm, J.M.; Meinander, A.; Peuhu, E.; Niemi, R.; Eriksson, J.E.; Sahlgren, C.; Linde, M. Targeting of porous hybrid silica nanoparticles to cancer cells. Acs. Nano., 2009, 3, 197-206.
25. Kim, J.; Kim, H.S.; Lee, N.; Kim, T.; Kim, H.; Yu, T.; Song, I.C.; Moon, W.K.; Hyeon, T. Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angew. Chem. Int. Ed., 2008, 47, 8438-8441.
26. Zhu, Y.; Ikoma, T.; Hanagata, N.; Kaskel, S. Rattle-type Fe3O4@SiO2 hollow mesoporous spheres as carriers for drug delivery. Small, 2010, 6, 471-478.
27. Lee, J.E.; Lee, N.; Kim, H.; Kim, J.; Choi, S.H.; Kim, J.H.; Kim, T.; Song, I.C.; Park, S.P.; Moon, W.K.; Hyeon, T. Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery. J. Am. Chem. Soc., 2010, 132, 552-557.
28. Zhu, Y.; Fang, Y.; Kaskel, S. Folate-conjugated Fe3O4@SiO2 hollow mesoporous spheres for targeted anticancer drug delivery. J. Phys. Chem. C, 2010, 114, 16382-16588.
29. Huang, S.; Fan, Y.; Cheng, Z.; Kong, D.; Yang, P.; Quan, Z.; Zhang, C.; Lin, J. Magnetic mesoporous silica spheres for drug targeting and controlled release. J. Phys. Chem. C, 2009, 113, 1775-1784.
30. Wang, T.T.; Chai, Fang.; Wang, C.G.; Li, Lu.; Liu, H.Y.; Zhang, L.Y.; Su, Z.M.; Liao Y. Fluorescent hollow/rattle-type mesoporous Au@SiO2 nanocapsules for drug Delivery and fluorescence imaging of cancer cells., J. Colloid Interface Sci, 2011, 358, 109-115.
31. Qu, F.; Zhu, G.; Huang, S.; Li, S.; Sun, J.; Zhang, D.; Qiu, S. Controlled release of Captopril by regulating the pore size and morphology of ordered mesoporous silica. Microporous Mesoporous Mater., 2006, 92, 1-9.
32. Li, X.; Zhang, L.; Dong, X.; Liang, J.; Shi, J. Preparation of mesoporous calcium doped silica spheres with narrow size dispersion and their drug loading and degradation behavior. Microporous Mesoporous Mater., 2007, 102, 151-158.
33. Charnay, C.; Bégu, S.; Tourné-Péteilh, C.; Nicole, L.; Lerner, D.A.; Devoisselle, J.M. Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property. Eur. J. Pharm. Biopharm., 2004, 57, 533-540.
34. Zhu, Y.; Shi, J.; Li, Y.; Chen, H.; Shen, W.; Dong, X. Storage and release of ibuprofen drug molecules in hollow mesoporous silica spheres with modified pore surface. Microporous Mesoporous Mater., 2005, 85, 75-81.
35. Zhao, W.; Chen, H.; Li, Y.; Li, L.; Lang, M.; Shi, J. Uniform rattletype hollow magnetic mesoporous spheres as drug delivery carriers and their sustained-release property. Adv. Funct. Mater., 2008, 18, 2780-2788.
36. Depan, D.; Saikia, L.; Singh, R.P. Ultrasound-triggered release of ibuprofen from a chitosan-mesoporous silica composite - a novel approach for controlled drug release. Macromol. Symp., 2010, 287, 80-88.
37. Zhu, Y.; Shi, J.; Shen, W.; Dong, X.; Feng, J.; Ruan, M.; Li, Y. Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core-shell structure. Angew. Chem. Int. Ed., 2005, 44, 5083-5087.
38. Gao, Q.; Xu, Y.; Wu, D.; Sun, Y.; Li, X. pH-responsive drug release from polymer-coated mesoporous silica spheres. J. Phys. Chem. C, 2009, 113, 12753-12758.
39. Wu, C.; Wang, X.; Zhao, L.; Gao, Y.; Ma, R.; An, Y.; Shi, L. Facile strategy for synthesis of silica/polymer hybrid hollow nanoparticles with channels. Langmuir, 2010, 26, 18503-18507.
40. Kim, H.; Kim, S.; Park, C.; Lee, H.; Park, H.J.; Kim, C. Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers. Adv. Mater., 2010, 22, 4280-4283.
41. Bernardos, A.; Mondragon, L.; Aznar, E.; Marcos, M.D.; Martinez-Manez, R.; Sancenon, F.; Soto, J.; Barat, J.M.; Perez-Paya, E.; Guillem, C.; Amoros, P. Enzyme-responsive intracellular controlled release using nanometric silica mesoporous supports capped with "saccharides". Acs. Nano., 2010, 4, 6353-6368.
42. Lai, C.Y.; Trewyn, B.G.; Jeftinija, D.M.; Jeftinija, K.; Xu, S.; Jeftinija, S.; Lin, V.S.Y. A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. J. Amer. Chem. Soc., 2003, 125, 4451-4459.
43. Aznar, E.; Marcos, M.D.; Martinez-Manez, R.; Sancenon, F.; Soto, J.; Amoros, P.; Guillem, C. pH- and photo-switched release of guest molecules from mesoporous silica supports. J. Am. Chem. Soc., 2009, 131, 6833-6843.
44. Gan, Q.; Lu, X.; Yuan, Y.; Qian, J.; Zhou, H.; Lu, X.; Shi, J.; Liu, C. A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica. Biomaterials, 2011, 32, 1932-1942.
45. Bernardos, A.; Aznar, E.; Coll, C.; Martínez-Mañez, R.; Barat, J.M.; Marcos, M.D.; Sancenón, F.; Benito, A.; Soto, J. Controlled release of vitamin B2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings. J. Controlled Release, 2008, 131, 181-189.
46. Climent, E.; Martinez-Manez, R.; Sancenon, F.; Marcos, M.D.; Soto, J.; Maquieira, A.; Amoros, P. Controlled delivery using oligonucleotide-capped mesoporous silica nanoparticles. Angew. Chem. Int. Ed., 2010, 49, 7281-7283.
47. Sun, J.T.; Hong, C.Y.; Pan, C.Y. Fabrication of PDEAEMA-coated mesoporous silica nanoparticles and pH-responsive controlled release. J. Phys. Chem. C, 2010, 114, 12481-12486.
48. Rosenholm, J.M.; Lindén, M. Towards establishing structureactivity relationships for mesoporous silica in drug delivery applications. J. Controlled Release, 2008, 128, 157-164.
49. Xue, J.M., Shi, M. PLGA/mesoporous silica hybrid structure for controlled drug release. J. Controlled Release, 2004, 98, 209-217.
50. Fagundes, L.B.; Sousa, T.G.F.; Sousa, A.; Silva, V.V.; Sous, E.M.B. SBA-15-collagen hybrid material for drug delivery applications. J. Non-Cryst. Solids, 2006, 352, 3496-3501.
51. Juan C. Doadrio, Edesia M. B. Sousa, Isabel Izquierdo-Barba, Antonio L. Doadrio, Joaquin Perez-Pariente and Maria Vallet-Regi. Functionalization of mesoporous materials with long alkyl chains as a strategy for controlling drug delivery pattern. J. Mater. Chem., 2006, 16, 462-466.
52. Lay, C.L.; Liu, H.Q.; Wu, D.; Liu, Y. Poly(ethylene glycol)-grafthollow silica vesicles for drug delivery. Chem. Eur. J., 2010, 16, 3001-3004.
53. Du, L.; Liao, S.; Khatib, H.A.; Stoddart, J.F.; Zink, J.I. Controlledaccess hollow mechanized silica nanocontainers. J. Am. Chem. Soc., 2009, 131, 15136-15142.
54. Radin, S.; El-Bassyounia, G.; J. Vresilovic, E.; Schepers, E.; Ducheyne, P. In vivo tissue response to resorbable silica xerogels ascontrolled-release materials. Biomaterials,2005, 26, 1043-1052.
55. Vallhov, H.; Gabrielsson, S.; Strømme, M.; Scheynius, A.; Garcia-Bennett, A. E. Mesoporous Silica Particles Induce Size Dependent Effects on Human Dendritic Cells. Nanoletters, 2007, 7, 3576-3582.
56. Hudson, S. P.; Padera, R. F.; Langer, R.; Kohane, D. S. The biocompatibility of mesoporous silicates. Biomaterials, 2008, 29, 4045-4055.
57. Liu, T.; Li, L.; Teng, X.; Huang, X.; Liu, H.; Dong, Chen.; Ren, J.; He, J.; Tang, F. Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice. Biomaterials., 2011, 32, 1657-1668.
58. Slowing, I.; Trewyn, B.G.; Lin, V.S.Y. Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells. J. Am. Chem. Soc., 2006, 128, 14792-14793.
59. Rosenholm, J.M.; Duchanoy, A.; Lindén, M. Hyperbranching surface polymerization as a tool for preferential functionalization of the outer surface of mesoporous silica. Chem. Mater., 2008, 20, 1126-1133.
60. Rosenholm, J.M.; Lindén, M. Wet-chemical analysis of surface concentration of accessible groups on different aminofunctionalized mesoporous SBA-15 silicas. Chem. Mater., 2007, 19, 5023-5034.
61. Babonneau, F.; Yeung, L.; Steunou, N.; Gervais, C. Solid state NMR characterisation of encapsulated molecules in mesoporous silica. J. Sol-Gel Sci. Technol., 2004, 31, 219-223.
62. Li, J.; Miao, X.; Hao, Y.; Zhao, J.; Sun, X.; Wang, L. Synthesis, amino-functionalization of mesoporous silica and its adsorption of Cr (VI). J Colloid Interface Sci., 2008, 318, 309-314.
63. Heidari, A.; Younesi, H.; Mehraban, Z. Removal of Ni(II), Cd(II), and Pb(II) from a ternary aqueous solution by amino functionalized mesoporous and nano mesoporous silica. Chem. Eng. J., 2009, 153, 70-79.
64. Bardi, G.; Malvindi, M.A.; Gherardini, L.; Costa, M.; Pompa, P.P.; Cingolani, R.; Pizzorusso, T. The biocompatibility of amino functionalized CdSe/ZnS quantum-dot-Doped SiO2 nanoparticles with primary neural cells and their gene carrying performance. Biomaterials, 2010, 31, 6555-6566.
65. Ritter, H.; Bruhwiler, D. Accessibility of amino groups in postsynthetically modified mesoporous silica. J. Phys. Chem. C., 2009, 113, 10667-10674.
66. Wei, K.; Shu, L.; Guo, W.; Wu, Y.; Zeng, X. Synthesis of aminofunctionalized hexagonal mesoporous silica for adsorption of Pb2. Chin. J. Chem., 2011, 29, 143-146.
67. Yoshitake, H. Highly-controlled synthesis of organic layers on mesoporous silica: their structure and application to toxic ion adsorptions. New J. Chem., 2005, 29, 1107-1117.
68. Suzuki, T.M.; Nakamura, T.; Fukumoto, K.; Yamamoto, M.; Akimoto, Y.; Yano, K. Direct synthesis of amino-functionalized monodispersed mesoporous silica spheres and their catalytic activity for nitroaldol condensation. J. Mol. Catal. A: Chem., 2008, 280, 224-232.
69. Kao, H.M.; Liao, C.H.; Palani, A.; Liao, Y.C. One-pot synthesis of ordered and stable cubic mesoporous silica SBA-1 functionalized with amino functional groups. Microporous Mesoporous Mater., 2008, 113, 212-223.
70. Zeng, W.; Qian, X.F.; Yin, J.; Zhu, Z.K. The drug delivery system of MCM-41 materials via co-condensation synthesis. Mater. Chem. Phys., 2006, 97, 437-441.
71. Wang, X.; Lin, K.S.K.; Chan, J.C.C.; Cheng, S. Direct synthesis and catalytic applications of ordered large pore aminopropylfunctionalized SBA-15 mesoporous materials. J. Phys. Chem. B, 2005, 109, 1763-1769.
72. Sujandi Prasetyanto, E.A.; Park, S.E. Synthesis of short-channeled amino-functionalized SBA-15 and its beneficial applications in base-catalyzed reactions. Appl. Catal. A General, 2008, 350, 244-251.
73. Du, X.; He, J. Hierarchically mesoporous silica nanoparticles: extraction, amino-functionalization, and their multipurpose potentials. Langmuir, 2011, 27, 2972-2979.
74. Kim, H.J.; Moon, J.H.; Park, J.W. A Hyperbranched Poly(ethyleneimine) Grown on Surfaces. J. Colloid Interface Sci., 2000, 227, 247-249.
75. Hicks, J.C.; Drese, J.H.; Fauth, D.J.; Gray, M.L.; Qi, G.; Jones, C.W. Designing adsorbents for CO2 capture from flue gashyperbranched aminosilicas capable of capturing CO2 reversibly. J. Am. Chem. Soc., 2008, 130, 2902-2903.
76. Kim, C.O.; Cho, S.J.; Park, J.W. Hyperbranching polymerization of aziridine on silica solid substrates leading to a surface of highly dense reactive amine groups. J. Colloid Interface Sci., 2003, 260, 374-378.
77. Rosenholm, J.M.; Peuhu, E.; Eriksson, J.E.; Sahlgren, C.; Linden, M. Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems. Nano. Lett., 2009, 9, 3308-3311.
78. Patel, K.; Angelos, S.; Dichtel, W.R.; Coskun, A.; Yang, Y.W.; Zink, J.I.; Stoddart, J.F. Enzyme-responsive snap-top covered silica nanocontainers. J. Am. Chem. Soc., 2008, 130, 2382-2383.
79. Vivero-Escoto, J.L.; Slowing, I.I.; Wu, C.W.; Lin, V.S.Y. Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere. J. Am. Chem. Soc., 2009, 131, 3462-3463.
80. Zhu, C.L.; Lu, C.H.; Song, X.Y.; Yang, H.H.; Wang, X.R. Bioresponsive controlled release using mesoporous silica nanoparticles capped with aptamer-based molecular gate. J. Am. Chem. Soc., 2011, 133, 1278-1281.
81. Giri, S.; Trewyn, B.G.; Stellmaker, M.P.; Lin, V.S.Y. Stimuliresponsive controlled-release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles. Angew. Chem. Int. Ed., 2005, 44, 5038-5044.
82. Aznar, E.; Coll, C.; Marcos, M.D.; Martinez-Manez, R.; Sancenon, F.; Soto, J.; Amoros, P.; Cano, J.; Ruiz, E. Borate-driven gatelike scaffolding using mesoporous materials functionalised with saccharides. Chem. Eur. J., 2009, 15, 6877-6888.
83. Mal, N. K.; Fujiwara, M.; Tanaka, Y. Photocontrolled reversible release of guest molecules from coumarinmodified mesoporous silica. Nature, 2003, 421, 350-353.
84. Casasu, R.; Marcos, M.D.; Martinez-Manez, R.; Ros-Lis, J.V.; Soto, J.; Villaescusa, L.A.; Amoros, P.; Beltran, D.; Guillem, C.; Latorre, J. Toward the Development of Ionically Controlled Nanoscopic Molecular Gates. J. Am. Chem. Soc. 2004, 126, 8612-8613.
85. Lee, J.; Lee, J.; Kim, S.; Kim, C.; Lee, S.; Min, B.; Shin, Y.; Kim, C. Sugar-Induced Release of Guests from Silica Nanocontainer with Cyclodextrin Gatekeepers. Bull. Korean Chem. Soc. 2011, 32, 1357-1360.
86. Liu, R.; Zhang, Y.; Zhao, X.; Agarwal, A.; Mueller, L.J.; Feng, P. pH- Responsive Nanogated Ensemble Based on Gold-Capped Mesoporous Silica through an Acid-Labile Acetal Linker. J. Am. Chem. Soc. 2010, 132, 1500-1501.
87. Liu, R.; Zhang, Y.; Feng, P. Multiresponsive Supramolecular Nanogated Ensembles. J. Am. Chem. Soc. 2009, 131, 15128-15129.
88. Zhu, Y.; Shi, J.; Chen, H.; Shen, W.; Dong, X. A facile method to synthesize novel hollow mesoporous silica spheres and advanced storage property. Microporous Mesoporous Mater., 2005, 84, 218-222.
89. Huang, S.; Yang, P.; Cheng, Z.; Li, C.; Fan, Y.; Kong, D.; Lin, J. Synthesis and characterization of magnetic FexOy@SBA-15 composites with different morphologies for controlled drug release and targeting. J. Phys. Chem. C, 2008, 112, 7130-7137.
90. Gai, S.; Yang, P.; Li, C.; Wang, W.; Dai, Y.; Niu, N.; Lin J. Synthesis of magnetic, up-conversion luminescent, and mesoporous core-shell-structured nanocomposites as drug carriers. Adv. Funct. Mater., 2010, 20, 1-7.
91. Gu, J.; Fan, W.; Shimojima, A.; Okubo, T. Organic-inorganic mesoporous nanocarriers integrated with biogenic ligands. Small, 2007, 3, 1740-1744.
92. Liu, J.; Yang, Q.; Zhang, L.; Yang, H.; Gao, J.; Li, C. Organic inorganic hybrid hollow nanospheres with microwindows on the shell. Chem. Mater., 2008, 20, 4268-4275.
93. Ho, J.; Huang, Y.; Danquah, M.K.; Wang, H.; Forde, G.M. Synthesis of biodegradable polymer-mesoporous silica composite microspheres for DNA prime-protein boost vaccination. Eur. J. Pharm. Sci., 2010, 39, 412-420.
94. Ji, X.; Hampsey, J.; Hu, Q.; He, J.; Yang, Z.; Lu, Y. Mesoporous silica-reinforced polymer nanocomposites. Chem. Mater., 2003, 15, 3656-3662.
95. Anandhakumar, S.; Debapriya, M.; Nagaraja, V.; Raichur, A.M. Polyelectrolyte microcapsules for sustained delivery of watersoluble drugs. Mater. Sci. Eng. C, 2011, 31, 342-349.
96. Tan, J.P.K.; Wang, Q.; Tam, K.C. Control of burst release from nanogels via layer by layer assembly. J. Controlled Release, 2008, 128, 248-254.
97. Zhu, Y.; Shi, J. A mesoporous core-shell structure for pH- controlled storage and release of water-soluble drug. Microporous Mesoporous Mater., 2007, 103, 243-249.
98. Wang, Y.; Bansal, V.; Zelikin, AN.; Caruso, F. Templated synthesis of single-component polymer capsules and their application in drug delivery. Nano. Letters., 2008, 8, 1741-1745.
99. Díez-Pascual, A.M.; Wong, J.E. Effect of layer-by-layer confinement of polypeptides and polysaccharides onto thermoresponsive microgels: A comparative study. J. Colloid Interface Sci., 2010, 347, 79-89.
100. Kumar, K.N.A.; Ray, S.B.; Nagaraja, V.; Raichur, A.M. Encapsulation and release of rifampicin using poly(vinyl pyrrolidone)-poly(methacrylic acid) polyelectrolyte capsules. Mater. Sci. Eng. C, 2009, 29, 2508-2513.
101. Johnston, A.P.R.; Cortez, C.; Angelatos, A.S.; Caruso, F. Layer-bylayer engineered capsules and their applications. Curr. Opin. Colloid Interface Sci., 2006, 11, 203-209.
102. Wang, Y.; Angelatos, A.S.; Caruso, F. Template synthesis of nanostructured materials via layer-by-layer assembly. Chem. Mater., 2008, 20, 848-858.
103. Yu, A.; Wang, Y.; Barlow, E.; Caruso, F. Mesoporous silica particles as templates for preparing enzyme-loaded biocompatible microcapsules. Adv. Mater., 2005, 17, 1737-1741.
104. Wang, Y.; Caruso, F. Mesoporous silica spheres as supports for enzyme immobilization and encapsulation. Chem. Mater., 2005, 17, 953-961.
105. Yu, A.; Gentle, I.R.; Lu, G.Q. Biocompatible polypeptide microcapsules via templating mesoporous silica spheres. J. Colloid Interface Sci., 2009, 333, 341-345.
106. Radu, D.R.; Lai, C.Y.; Jeftinija, K.; Rowe, E.W.; Jeftinija, S.; Lin, V.S.Y. A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent. J. Am. Chem. Soc., 2004, 126, 13216-13217.
107. Zhu, S.G.; Xiang, J.J.; Li, X.L.; Shen, S.R.; Lu, H.B.; Zhou, J.; Xiong, W.; Zhang, B.C.; Nie, X.M.; Zhou, M.; Tang, K.; Li, G.Y. Poly(L-lysine)-modified silica nanoparticles for the delivery of antisense oligonucleotides. Biotechnol. Appl. Biochem., 2004, 39, 179-187.
108. Kneuer, C.; Sameti, M.; Bakowsky, U.; Schiestel, T.; Schirra, H.; Schmidt, H.; Lehr, C.M. A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjugate Chem., 2000, 11, 926-932.
109. Choi, M.; Kleitz, F.; Liu, D.; Lee, H.Y.; Ahn, W.S.; Ryoo, R. Controlled polymerization in mesoporous silica toward the design of organic inorganic composite nanoporous materials. J. Am. Chem. Soc., 2005, 127, 1924-1932.
110. Liu, R.; Liao, P.; Liu, J.; Feng, P. Responsive polymer-coated mesoporous silica as a pH-sensitive nanocarrier for controlled release. Langmuir, 2011, 27, 3095-3099.
111. Wu, J.; Sailor, M.J. Chitosan hydrogel-capped porous SiO2 as a pH responsive nano-valve for triggered release of insulin. Adv. Funct. Mater., 2009, 19, 733-741.
112. Kim, T.W.; Slowing, I.I.; Chung, P.W.; Lin, V.S.Y. Ordered mesoporous polymer-silica hybrid nanoparticles as vehicles for the intracellular controlled release of macromolecules. Acs. Nano., 2011, 5, 360-366.
113. Zhu, S., Chen, C.; Chen, Z.; Liu, X.; Li, Y.; Shi, Y.; Zhang, D. Thermo-responsive polymer-functionalized mesoporous carbon for controlled drug release. Mater. Chem. Phys., 2011, 126, 357-363.
114. Wan, X.; Wang, D.; Liu, S. Fluorescent pH-sensing organic/inorganic hybrid mesoporous silica nanoparticles with tunable redox-responsive release capability. Langmuir, 2010, 26, 15574-15579.
115. You, Y.Z.; Kalebaila, K.K.; Brock, S.L.; Oupicky, D. Temperaturecontrolled uptake and release in PNIPAM-modified porous silica nanoparticles. Chem. Mater., 2008, 20, 3354-3359.