Dilute and shoot: Analysis of drugs of abuse using selected reaction monitoring for quantification and full scan product ion spectra for identification

Journal of Analytical Toxicology

Volumn 36, Issue 2, 2012, Pages 106-111

  Fitzgerald, Robert L ^a,b   Griffin, Terrance L ^a   Yun, Yeo Min ^c   Godfrey, Richard A ^a   West, Robert ^d   Pesce, Amadeo J ^d   Herold, David A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Konkuk University   (South Korea)

^d Millennium Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; BENZOYLECGONINE; CODEINE; DEUTERIUM; HYDROCODONE; HYDROMORPHONE; METHAMPHETAMINE; MORPHINE; COCAINE; DRUG DERIVATIVE; ION;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG ABUSE; DRUG IDENTIFICATION; DRUG URINE LEVEL; HUMAN; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; SELECTED REACTION MONITORING; TANDEM MASS SPECTROMETRY; URINALYSIS; ISOLATION AND PURIFICATION; METHODOLOGY; REPRODUCIBILITY; SIGNAL NOISE RATIO; SUBSTANCE ABUSE; URINE;

CHROMATOGRAPHY, LIQUID; COCAINE; HUMANS; HYDROCODONE; HYDROMORPHONE; IONS; METHAMPHETAMINE; REPRODUCIBILITY OF RESULTS; SIGNAL-TO-NOISE RATIO; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

EID: 84862615124     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bkr024     Document Type: Article

References (19)

1. National Archives. Executive Orders. http://www.archives.gov/ federal-register/codification/executive-order/12564.html (accessed December 2010).
2. Mueller, C.A.; Weinmann, W.; Dresen, S.; Schreiber, A.; Gergov, M. Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching. Rapid Comm. Mass Spectrom. 2005, 19, 1332-1338.
3. Musshoff, F.; Trafkowski, J.; Kuepper, U.; Madea, B. An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites. J. Mass Spectrom. 2006, 41, 633-640.
4. Edinboro, L.E.; Backer, R.C.; Poklis, A. Direct analysis of opiates in urine by liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 2005, 29, 704-710.
5. Dams, R.; Murphy, C.M.; Lambert, W.E.; Huestis, M.A. Urine drug testing for opioids, cocaine, and metabolites by direct injection liquid chromatography/tandem mass spectrometry. Rapid Comm. Mass Spectrom. 2003, 17, 1665-1670.
6. Food and Drug Administration. FDA guidance 118. Guidance for Industry: Mass Spectrometry for Confirmation of the Identity of Animal Drug Residues. http://www.fda.gov/downloads/Animal Veterinary/GuidanceComplianceEnforcement/GuidanceforIndustry/ UCM052658.pdf (accessed December 2010).
7. Society of Forensic Toxicologists, Inc. and American Academy of Forensic Sciences. Forensic Toxicology Laboratory Guidelines 2006 version. http://www.soft-tox.org/files/Guidelines_2006_Final.pdf (accessed December 2010).
8. European Union decision 2002/657/EC 17.08.2002. Off. J. Eur. Commun. 2002, 221, 9-36.
9. World Anti-Doping Agency. Identification criteria for qualitative assays incorporating chromatography and mass spectrometry. http://www.wada-ama.org/rtecontent/document/criteria_1_2.pdf (accessed December 2010).
10. Lynch, K.L.; Breaud, A.R.; Vandenberghe, H.; Wu, A.H.B.; Clarke, W. Performance evaluation of three liquid chromatography mass spectrometry methods for broad spectrum drug screening. Clin. Chim. Acta 2010, 411, 1474-1481.
11. Annesley, T.M. Ion suppression in mass spectrometry. Clin. Chem. 2003, 49, 1041-1044.
12. Fitzgerald, R.L.; Rivera, J.D.; Herold, D.A. Broad spectrum drug identification directly from urine using liquid chromatography tandem mass spectrometry. Clin. Chem. 1999, 45, 1224-1234.
13. Dresen, S.; Ferreirós, N.; Gnann, H.; Zimmermann, R.; Weinmann, W. Detection and identification of 700 drugs by multi-target screening with a 3200 Q TRAPw LC-MS/MS system and library searching. Anal. Bioanal. Chem. 2010, 396, 2425-2434.
14. Sauvage, F.L.; Saint-Marcoux, F.; Duretz, B.; Deporte, D.; Lachatre, G.; Marquet, P. Screening of drugs and toxic compounds with liquid chromatography-linear ion trap tandem mass spectrometry. Clin. Chem. 2006, 52, 1735-1742.
15. Dowling, G.; Regan, L.; Tierney, J.; Nangle, M. A hybrid liquid chromatography- mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer. J. Chromatogr. A 2010, 1217, 6857-6866.
16. Wu, A.H.B.; Onigbinde, T.A.; Wong, S.S.; Johnson, K.G. Evaluation of full-scanning GC/ion trap MS analysis of NIDA drugs-of-abuse urine testing in urine. J. Anal. Toxicol. 1992, 16, 202-206.
17. Fitzgerald, R.L.; O'Neal, C.L.; Hart, B.J.; Poklis, A.; Herold, D.A. Comparison of an ion trap and a quadrapole mass spectrometer using diazepam as a model compound. J. Anal. Toxicol. 1997, 21, 445-450.
18. Marquet, P.; Saint-Marcouxa, F.; Gamble, T.N.; Leblanc, J.C.Y. Comparison of a preliminary procedure for the general unknown screening of drugs and toxic compounds using a quadrupole-linear ion-trap mass spectrometer with a liquid chromatography-mass spectrometry reference technique. J. Chromatogr. B 2003, 789, 9-18.
19. Todd, J.F.J. Introduction to practical aspects of ion trap mass spectrometry. In Practical Aspects of Ion Trap Mass Spectrometry, Vol. I., March, R.E.; Todd, J.F.J., Eds. CRC Press: New York, NY, 1995; pp 3-24.