Ionotropic glutamate receptor mRNA editing in the prefrontal cortex: No alterations in schizophrenia or bipolar disorder

Journal of Psychiatry and Neuroscience

Volumn 37, Issue 4, 2012, Pages 267-272

  Lyddon, Rebecca ^a   Navarrett, Scott ^a,b   Dracheva, Stella ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 3; GLUTAMATE RECEPTOR 4; IONOTROPIC RECEPTOR; KAINIC ACID; MESSENGER RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; PREFRONTAL CORTEX; REAL TIME POLYMERASE CHAIN REACTION; RNA EDITING; SCHIZOPHRENIA; SUICIDE;

EID: 84862599144     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.110107     Document Type: Article

References (43)

1. Ure J, Baudry M, Perassolo M. Metabotropic glutamate receptors and epilepsy. J Neurol Sci 2006;247:1-9.
2. Zarate C, Machado-Vieira R, Henter I, et al. Glutamatergic modu lators: The future of treating mood disorders? Harv Rev Psychiatry 2010; 18:293-303.
3. Javitt DC. Glutamatergic theories of schizophrenia. Isr J Psychiatry Relat Sci 2010;47:4-16.
4. Cortese BM, Phan KL. The role of glutamate in anxiety and related disorders. CNS Spectr 2005;10:820-830.
5. Kawahara Y, Ito K, Sun H, et al. Glutamate receptors: RNA editing and death of motor neurons. Nature 2004;427:801.
6. Mitchell ND, Baker GB. An update on the role of glutamate in the pathophysiology of depression. Acta Psychiatr Scand 2010;122:192-210.
7. Mosbacher J, Schoepfer R, Monyer H, et al. A molecular determinant for submillisecond desensitization in glutamate receptors. Science 1994;266:1059-1062.
8. Koike M, Tsukada S, Tsuzuki K, et al. Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing. J Neurosci 2000;20:2166-2174.
9. Pei W, Huang Z, Wang C, et al. Flip and flop: a molecular deter -min ant for AMPA receptor channel opening. Biochemistry 2009;48: 3767-3777.
10. Gott, JM, Emeson, RB. Functions and mechanisms of RNA editing. Annu Rev Genet 2000:34;499-531.
11. Bass, BL. RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem 2002:71:817-846.
12. Brusa R, Zimmermann F, Koh DS, et al. Early-onset epilepsy and postnatal lethality associated with an editing-deficient Glur-B allele in mice. Science 1995;270:1677-1680.
13. Higuchi M, Maas S, Single FN, et al. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 2000;406:78-81.
14. Hideyama T, Yamashita T, Suzuki T, et al. Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. J Neurosci 2010;30:11917-11925.
15. Swanson, GT, Feldmeyer, D, Kaneda, M, et al. Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors. J Physiol 1996:492 (Pt 1):129-142.
16. Burnashev N, Zhou Z, Neher, et al. Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J Physiol 1995:485(Pt 2):403-418.
17. Köhler M, Burnashev N, Sakmann B, et al. Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron 1993;10:491-500.
18. Lomeli H, Mosbacher J, Melcher T, et al. Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science 1994; 266:1709-1713.
19. Morabito MV, Emeson RB. RNA editing as a therapeutic target for CNS disorders. Neuropsychopharmacology 2009;34:246.
20. Akbarian S, Smith MA, Jones EG. Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia. Brain Res 1995;699: 297-304.
21. Vollmar W, Gloger J, Berger E, et al. RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients. Neurobiol Dis 2004;15:371-379.
22. Vissel B, Royle GA, Christie BR, et al. The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 2001; 29: 217-227.
23. Gurevich I, Tamir H, Arango V, et al. Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 2002;34:349-356.
24. Niswender CM, Herrick-Davis K, Dilley GE, et al. RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsycho -pharmacology 2001;24:478-491.
25. Iwamoto K, Kato T. RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. Neurosci Lett 2003; 346:169-172.
26. Dracheva S, Patel N, Woo DA, et al. Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide. Mol Psychiatry 2008; 13:1001-1010.
27. Dracheva S, Elhakem SL, Marcus SM, et al. RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia. J Neurochem 2003;87:1402-1412.
28. Sodhi MS, Burnet PW, Makoff AJ, et al. RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia. Mol Psychiatry 2001; 6:373-379.
29. Wong K, Lyddon R, Dracheva S. TaqMan-based real-time quantitative PCR method for RNA editing analysis. Anal Biochem 2009; 390: 173-180.
30. Lance CE. Mallows' Cp statistics. In: Everitt BS, Howell DC, editors. Encyclopedia of statistics in behavioral science. Chichester: John Wiley & Sons; 2005. p. 1119-1120.
31. Wahlstedt H, Daniel C, Enstero M, et al. Large-scale mRNA sequencing determines global regulation of RNA editing during brain development. Genome Res 2009;19:978-986.
32. Greenberger S, Levanon EY, Paz-Yaacov N, et al. Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats. BMC Genomics 2010;11:608.
33. Barbon A, Fumagalli F, La VL, et al. Chronic phencyclidine administration reduces the expression and editing of specific glutamate receptors in rat prefrontal cortex. Exp Neurol 2007;208:54-62.
34. Pasqualetti M, Ori M, Castagna M, et al. Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain. Neuroscience 1999;92:601-611.
35. Liu S, Bubar MJ, Lanfranco MF, et al. Serotonin2C receptor localization in GABA neurons of the rat medial prefrontal cortex: implications for understanding the neurobiology of addiction. Neuroscience 2007;146:1677-1688.
36. Yang W, Wang Q, Kanes SJ, et al. Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy. Brain Res Mol Brain Res 2004;124:70-78.
37. Vitali P, Basyuk E, Le Meur E, et al. ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleo-lar RNAs. J Cell Biol 2005;169:745-753.
38. Barbon A, Popoli M, La Via L, et al. Regulation of editing and expression of glutamate alpha-amino-propionic-acid (AMPA)/ kainate receptors by antidepressant drugs. Biol Psychiatry 2006;59: 713-720.
39. Penn AC, Greger IH. Sculpting AMPA receptor formation and function by alternative RNA processing. RNA Biol 2009;6:517-521.
40. Dracheva S, McGurk SR, Haroutunian V. mRNA expression of AMPA receptors and AMPA receptor binding proteins in the cerebral cortex of elderly schizophrenics. J Neurosci Res 2005;79:868-878.
41. Paz JT, Bryant AS, Peng K, et al. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci 2011;14:1167-1173.
42. Sagata N, Iwaki A, Aramaki T, et al. Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function. Genes Brain Behav 2010;9:899-909.
43. Sawada J, Yamashita T, Aizawa H, et al. Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line. Neurosci Res 2009;64:251-258.