-
1
-
-
77955930318
-
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
-
Abdool Karim Q, et al. 2010. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 329:1168-1174.
-
(2010)
Science
, vol.329
, pp. 1168-1174
-
-
Abdool Karim, Q.1
-
2
-
-
80053248640
-
First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy
-
doi:10.1371/journal.pone.0023243
-
Anton PA, et al. 2011. First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy. PLoS One 6:e23243. doi:10.1371/journal.pone.0023243.
-
(2011)
PLoS One
, vol.6
-
-
Anton, P.A.1
-
3
-
-
0029904239
-
Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus
-
Balzarini J, Brouwer WG, Dao DC, Osika EM, De Clercq E. 1996. Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus. Antimicrob. Agents Chemother. 40:1454-1466.
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 1454-1466
-
-
Balzarini, J.1
Brouwer, W.G.2
Dao, D.C.3
Osika, E.M.4
De Clercq, E.5
-
4
-
-
0034630305
-
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors
-
Balzarini J, De Clercq E, Carbonez A, Burt V, Kleim JP. 2000. Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors. AIDS Res. Hum. Retroviruses 16:517-528.
-
(2000)
AIDS Res. Hum. Retroviruses
, vol.16
, pp. 517-528
-
-
Balzarini, J.1
De Clercq, E.2
Carbonez, A.3
Burt, V.4
Kleim, J.P.5
-
5
-
-
0032500021
-
Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent
-
Balzarini J, et al. 1998. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS 12:1129-1138.
-
(1998)
AIDS
, vol.12
, pp. 1129-1138
-
-
Balzarini, J.1
-
6
-
-
0030997133
-
Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: Retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase
-
Borkow G, et al. 1997. Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. J. Virol. 71:3023-3030.
-
(1997)
J. Virol.
, vol.71
, pp. 3023-3030
-
-
Borkow, G.1
-
7
-
-
20944444788
-
Biologic and genetic characterization of a panel of 60 human immunodeficiency virus type 1 isolates, representing clades A, B, C, D, CRF01-AE, and CRF02-AG, for the development and assessment of candidate vaccines
-
Brown BK, et al. 2005. Biologic and genetic characterization of a panel of 60 human immunodeficiency virus type 1 isolates, representing clades A, B, C, D, CRF01-AE, and CRF02-AG, for the development and assessment of candidate vaccines. J. Virol. 79:6089-6101.
-
(2005)
J. Virol.
, vol.79
, pp. 6089-6101
-
-
Brown, B.K.1
-
8
-
-
18544400158
-
Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor of HIV type 1
-
Buckheit RW, Jr, et al. 1997. Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor of HIV type 1. AIDS Res. Hum. Retroviruses 13:789-796.
-
(1997)
AIDS Res. Hum. Retroviruses
, vol.13
, pp. 789-796
-
-
Buckheit Jr., R.W.1
-
9
-
-
8244226649
-
Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates
-
Buckheit RW, Jr, et al. 1997. Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates. Antimicrob. Agents Chemother. 41:831-837.
-
(1997)
Antimicrob. Agents Chemother.
, vol.41
, pp. 831-837
-
-
Buckheit Jr., R.W.1
-
10
-
-
77955050125
-
Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions
-
Damian F, Fabian J, Friend DR, Kiser PF. 2010. Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions. Int. J. Pharm. 396:1-10.
-
(2010)
Int. J. Pharm.
, vol.396
, pp. 1-10
-
-
Damian, F.1
Fabian, J.2
Friend, D.R.3
Kiser, P.F.4
-
11
-
-
0033856458
-
Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120
-
Derdeyn CA, et al. 2000. Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120. J. Virol. 74:8358-8367.
-
(2000)
J. Virol.
, vol.74
, pp. 8358-8367
-
-
Derdeyn, C.A.1
-
12
-
-
4644225675
-
In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission
-
Dezzutti CS, et al. 2004. In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission. Antimicrob. Agents Chemother. 48:3834-3844.
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 3834-3844
-
-
Dezzutti, C.S.1
-
13
-
-
41849087248
-
SAVVY vaginal gel (C31G) for prevention of HIV infection: A randomized controlled trial in Nigeria
-
doi:10.1371/journal.pone.0001474
-
Feldblum PJ, et al. 2008. SAVVY vaginal gel (C31G) for prevention of HIV infection: a randomized controlled trial in Nigeria. PLoS One 3:e1474. doi:10.1371/journal.pone.0001474.
-
(2008)
PLoS One
, vol.3
-
-
Feldblum, P.J.1
-
14
-
-
78149261870
-
Pharmaceutical development of microbicide drug products
-
Friend DR. 2010. Pharmaceutical development of microbicide drug products. Pharm. Dev. Technol. 15:562-581.
-
(2010)
Pharm. Dev. Technol.
, vol.15
, pp. 562-581
-
-
Friend, D.R.1
-
15
-
-
79551614982
-
Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections
-
Herold BC, Mesquita PM, Madan RP, Keller MJ. 2011. Female genital tract secretions and semen impact the development of microbicides for the prevention of HIV and other sexually transmitted infections. Am. J. Reprod. Immunol. 65:325-333.
-
(2011)
Am. J. Reprod. Immunol.
, vol.65
, pp. 325-333
-
-
Herold, B.C.1
Mesquita, P.M.2
Madan, R.P.3
Keller, M.J.4
-
16
-
-
77952530985
-
Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: Implications for future microbicide clinical trials
-
doi:10.1371/journal.pone.0008781.
-
Keller MJ, et al. 2010. Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials. PLoS One 5:e8781. doi:10.1371/journal.pone.0008781.
-
(2010)
PLoS One
, vol.5
-
-
Keller, M.J.1
-
17
-
-
77958104207
-
PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): A phase 3, randomised, double-blind, parallel-group trial
-
McCormack S, et al. 2010. PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial. Lancet 376:1329-1337.
-
(2010)
Lancet
, vol.376
, pp. 1329-1337
-
-
McCormack, S.1
-
18
-
-
33750417135
-
Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides
-
Neurath AR, Strick N, Li YY. 2006. Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides. BMC Infect. Dis. 6:150.
-
(2006)
BMC Infect. Dis.
, vol.6
, pp. 150
-
-
Neurath, A.R.1
Strick, N.2
Li, Y.Y.3
-
19
-
-
22844446902
-
Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells
-
Njai HF, et al. 2005. Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells. Antivir. Ther. 10:255-262.
-
(2005)
Antivir. Ther.
, vol.10
, pp. 255-262
-
-
Njai, H.F.1
-
20
-
-
34248384307
-
Preclinical safety assessments of UC781 antihuman immunodeficiency virus topical microbicide formulations
-
Patton DL, et al. 2007. Preclinical safety assessments of UC781 antihuman immunodeficiency virus topical microbicide formulations. Antimicrob. Agents Chemother. 51:1608-1615.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 1608-1615
-
-
Patton, D.L.1
-
21
-
-
44349126694
-
SAVVY (C31G) gel for prevention of HIV infection in women: A phase 3, double-blind, randomized, placebo-controlled trial in Ghana
-
doi:10.1371/journal.pone.0001312
-
Peterson L, et al. 2007. SAVVY (C31G) gel for prevention of HIV infection in women: a phase 3, double-blind, randomized, placebo-controlled trial in Ghana. PLoS One 2:e1312. doi:10.1371/journal.pone.0001312.
-
(2007)
PLoS One
, vol.2
-
-
Peterson, L.1
-
22
-
-
0031954686
-
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1
-
Platt EJ, Wehrly K, Kuhmann SE, Chesebro B, Kabat D. 1998. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1. J. Virol. 72:2855-2864.
-
(1998)
J. Virol.
, vol.72
, pp. 2855-2864
-
-
Platt, E.J.1
Wehrly, K.2
Kuhmann, S.E.3
Chesebro, B.4
Kabat, D.5
-
23
-
-
33745158157
-
A simple method of estimating fifty per cent endpoints
-
Reed LJ, Muench H. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Hyg. 27:493-497.
-
(1938)
Am. J. Hyg.
, vol.27
, pp. 493-497
-
-
Reed, L.J.1
Muench, H.2
-
25
-
-
41149175595
-
A randomized six-day safety study of an antiretroviral microbicide candidate UC781, a non-nucleoside reverse transcriptase inhibitor
-
Schwartz JL, et al. 2008. A randomized six-day safety study of an antiretroviral microbicide candidate UC781, a non-nucleoside reverse transcriptase inhibitor. Sex. Transm. Dis. 35:414-419.
-
(2008)
Sex. Transm. Dis.
, vol.35
, pp. 414-419
-
-
Schwartz, J.L.1
-
26
-
-
57049091723
-
Efficacy of Carraguard for prevention of HIV infection in women in South Africa: A randomised, double-blind, placebo-controlled trial
-
Skoler-Karpoff S, et al. 2008. Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial. Lancet 372:1977-1987.
-
(2008)
Lancet
, vol.372
, pp. 1977-1987
-
-
Skoler-Karpoff, S.1
-
27
-
-
57349139455
-
Identification of gamma-retroviruses constitutively released from cell lines used for human immunodeficiency virus research
-
Takeuchi Y, McClure MO, Pizzato M. 2008. Identification of gamma-retroviruses constitutively released from cell lines used for human immunodeficiency virus research. J. Virol. 82:12585-12588.
-
(2008)
J. Virol.
, vol.82
, pp. 12585-12588
-
-
Takeuchi, Y.1
McClure, M.O.2
Pizzato, M.3
-
28
-
-
0037190597
-
Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: A randomised controlled trial
-
Van Damme L, et al. 2002. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet 360:971-977.
-
(2002)
Lancet
, vol.360
, pp. 971-977
-
-
Van Damme, L.1
-
29
-
-
0347992022
-
In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides
-
Van Herrewege Y, et al. 2004. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob. Agents Chemother. 48:337-339.
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 337-339
-
-
Van Herrewege, Y.1
-
30
-
-
48749094975
-
Comparative evaluation of virus transmission inhibition by dual-acting pyrimidinedione microbicides using the microbicide transmission and sterilization assay
-
Watson KM, Buckheit CE, Buckheit RW, Jr. 2008. Comparative evaluation of virus transmission inhibition by dual-acting pyrimidinedione microbicides using the microbicide transmission and sterilization assay. Antimicrob. Agents Chemother. 52:2787-2796.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 2787-2796
-
-
Watson, K.M.1
Buckheit, C.E.2
Buckheit Jr., R.W.3
-
31
-
-
0036090585
-
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
-
Wei X, et al. 2002. Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob. Agents Chemother. 46:1896-1905.
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 1896-1905
-
-
Wei, X.1
|