Inhibition of claudin-11 and occludin expression in rat sertoli cells by mono-(2-ethylhexyl) phthalate through p44/42 mitogen-activated protein kinase pathway

Journal of Andrology

Volumn 33, Issue 3, 2012, Pages 368-374

  Chiba, Koji ^a   Kondo, Yutaka ^b   Yamaguchi, Kohei ^a   Miyake, Hideaki ^a   Fujisawa, Masato ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HYOGO CANCER CENTER   (Japan)

Author keywords

MEHP; P44 42 MAPK; Tight junction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTISPERMATOGENIC AGENT; CLAUDIN 11; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OCCLUDIN; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PROTEIN P42; PROTEIN P44; PROTEIN ZO1; RNA;

ANIMAL CELL; ARTICLE; CELL LYSATE; DOWN REGULATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; INCUBATION TEMPERATURE; INCUBATION TIME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERTOLI CELL; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TESTIS; TIGHT JUNCTION; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; CLAUDINS; DIETHYLHEXYL PHTHALATE; MALE; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SERTOLI CELLS; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TIGHT JUNCTIONS;

EID: 84862561866     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.111.013664     Document Type: Article

References (26)

1. Boekelheide K, Johnson KJ, Richburg JH. Sertoli cell toxicants. In: Skinner MK, Griswold MD, eds. Sertoli Cell Biology. San Diego, CA: Elsevier Academic Press; 2005:345-382.
2. Cavicchia JC, Sacerdote FL, Ortiz L. The human blood-testis barrier in impaired spermatogenesis. Ultrastruct Pathol. 1996;20:211-218.
3. Cheng CY, Wong EW, Lie PP, Li MW, Su L, Siu ER, Yan HH, Mannu J, Mathur PP, Bonanomi M, Silvestrini B, Mruk DD. Environmental toxicants and male reproductive function. Spermatogenesis. 2011;1:2-13.
4. Fiorini C, Tilloy-Ellul A, Chevalier S, Charuel C, Pointis G. Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants. Reprod Toxicol. 2004;18:413-421.
5. Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol. 1994;127:1617-1626.
6. Giammona CJ, Sawhney P, Chandrasekaran Y, Richburg JH. Death receptor response in rodent testis after mono-(2-ethylhexyl) phthalate exposure. Toxicol Appl Pharmacol. 2002;185:119-127.
7. Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie SE, Danias J, Bronstein JM, Kachar B, Lazzarini RA. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell. 1999;99:649-659.
8. Hellani A, Ji J, Mauduit C, Deschildre C, Tabone E, Benahmed M. Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis. Endocrinology. 2000;141:3012-3019.
9. Ishikawa T, Kondo Y, Goda K, Fujisawa M. Overexpression of endothelial nitric oxide synthase in transgenic mice accelerates testicular germ cell apoptosis induced by experimental cryptorchidism. J Androl. 2005;26:281-288.
10. Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999;147:1351-1363.
11. Kaitu'u-Lino TJ, Sluka P, Foo CF, Stanton PG. Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro. Reproduction. 2007;133:1169-1179.
12. Kanzaki M, Morris PL. Identification and regulation of testicular interferon-gamma (IFNgamma) receptor subunits: IFNgamma enhances interferon regulatory factor-1 and interleukin-1beta converting enzyme expression. Endocrinology. 1998;139:2636-2644.
13. Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P, Golub M, Henderson R, Hinberg I, Little R, Seed J, Shea K, Tabacova S, Tyl R, Williams P, Zacharewski T. NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod Toxicol. 2002;16:529-653.
14. Lee NP, Cheng CY. Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/ 3',5'-cyclic guanosine monophosphate/protein kinase G signaling pathway: an in vitro study. Endocrinology. 2003;144:3114-3129.
15. Li MW, Mruk DD, Lee WM, Cheng CY. Disruption of the bloodtestis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics? Int J Biochem Cell Biol. 2009;41:2302-2314.
16. McCabe MJ, Tarulli GA, Meachem SJ, Robertson DM, Smooker PM, Stanton PG. Gonadotropins regulate rat testicular tight junctions in vivo. Endocrinology. 2010;151:2911-2922.
17. Moroi S, Saitou M, Fujimoto K, Sakakibara A, Furuse M, Yoshida O, Tsukita S. Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes. Am J Physiol. 1998;274:C1708-C1717.
18. Richburg JH, Nanez A, Williams LR, Embree ME, Boekelheide K. Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a nonfunctional form of Fas ligand. Endocrinology. 2000;141:787-793.
19. Russell LD, Peterson RN. Sertoli cell junctions: morphological and functional correlates. Int Rev Cytol. 1985;94:177-211.
20. Saitou M, Furuse M, Sasaki H, Schulzke JD, Fromm M, Takano H, Noda T, Tsukita S. Complex phenotype of mice lacking occludin, a component of tight junction strands.Mol Biol Cell. 2000;11:4131-4142.
21. Sobarzo CM, Lustig L, Ponzio R, Suescun MO, Denduchis B. Effects of di(2-ethylhexyl) phthalate on gap and tight junction protein expression in the testis of prepubertal rats. Microsc Res Tech. 2009;72:868-877.
22. Yamaguchi K, Ishikawa T, Kondo Y, Fujisawa M. Cisplatin regulates Sertoli cell expression of transferrin and interleukins. Mol Cell Endocrinol. 2008;283:68-75.
23. Yao PL, Lin YC, Richburg JH. Mono-(2-ethylhexyl) phthalateinduced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2. Biol Reprod. 2010;82:516-527.
24. Zhang YH, Lin L, Liu ZW, Jiang XZ, Chen BH. Disruption effects of monophthalate exposures on inter-Sertoli tight junction in a two-compartment culture model. Environ Toxicol. 2008;23:302-308.
25. Zhang XS, Zhang ZH, Jin X, Wei P, Hu XQ, Chen M, Lu CL, Lue YH, Hu ZY, Sinha Hikim AP, Swerdloff RS, Wang C, Liu YX. Dedifferentiation of adult monkey Sertoli cells through activation of extracellularly regulated kinase 1/2 induced by heat treatment. Endocrinology. 2006;147:1237-1245.
26. Zini A, Abitbol J, Schulsinger D, Goldstein M, Schlegel PN. Restoration of spermatogenesis after scrotal replacement of experimentally cryptorchid rat testis: assessment of germ cell apoptosis and eNOS expression. Urology. 1999;53:223-227.