Prognostic value of chromogranin A in severe sepsis: Data from the FINNSEPSIS study

Intensive Care Medicine

Volumn 38, Issue 5, 2012, Pages 820-829

  Røsjø, Helge ^a,b   Nygard, Stale ^b,c   Kaukonen, Kirsi Maija ^d   Karlsson, Sari ^e   Stridsberg, Mats ^f   Ruokonen, Esko ^g   Pettilä, Ville ^d   Omland, Torbjørn ^a,b  

^a AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e NORTH KARELIA CENTRAL HOSPITAL   (Finland)

^f UPPSALA UNIVERSITY   (Sweden)

^g KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Chromogranin A SAPS II score; Mortality; Prognosis; Sepsis

Indexed keywords

CHROMOGRANIN A;

ADRENERGIC ACTIVITY; ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HEART FUNCTION; HOSPITALIZATION; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; SEPSIS; SURVIVOR;

AGED; BIOLOGICAL MARKERS; CARDIOVASCULAR SYSTEM; CHROMOGRANIN A; FEMALE; FINLAND; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SEPSIS; SEVERITY OF ILLNESS INDEX;

EID: 84862549733     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-012-2546-8     Document Type: Article

References (40)

1. Schuetz P, Christ-Crain M, Muller B (2007) Biomarkers to improve diagnostic and prognostic accuracy in systemic infections. Curr Opin Crit Care 13:578-585
2. Røsjø H, Varpula M, Hagve TA, Karlsson S, Ruokonen E, Pettilä V, Omland T, FINNSEPSIS Study Group (2011) Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome. Intensive Care Med 37:77-85
3. Karlsson S, Heikkinen M, Pettilä V, Alila S, Väisänen S, Pulkki K, Kolho E, Ruokonen E, Finnsepsis Study Group (2010) Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study. Crit Care 14:R205
4. Groves AC, Griffiths J, Leung F, Meek RN (1973) Plasma catecholamines in patients with serious postoperative infection. Ann Surg 178:102-107
5. Fernandes Junior CJ, Iervolino M, Neves RA, Sampaio EL, Knobel E (1994) Interstitial myocarditis in sepsis. Am J Cardiol 74:958
6. Taupenot L, Harper KL, O'Connor DT (2003) The chromogranin-secretogranin family. N Engl J Med 348:1134-1149
7. Takiyyuddin MA, Cervenka JH, Sullivan PA, Pandian MR, Parmer RJ, Barbosa JA, O'Connor DT (1990) Is physiologic sympathoadrenal catecholamine release exocytotic in humans? Circulation 81:185-195
8. Cryer PE, Wortsman J, Shah SD, Nowak RM, Deftos LJ (1991) Plasma chromogranin A as a marker of sympathochromaffin activity in humans. Am J Physiol 260:E243-E246
9. Dimsdale JE, O'Connor DT, Ziegler M, Mills P (1992) Chromogranin A correlates with norepinephrine release rate. Life Sci 51:519-525
10. Pieroni M, Corti A, Tota B, Curnis F, Angelone T, Colombo B, Cerra MC, Bellocci F, Crea F, Maseri A (2007) Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function. Eur Heart J 28:1117-1127
11. Røsjø H, Husberg C, Dahl MB, Stridsberg M, Sjaastad I, Finsen AV, Carlson CR, Øie E, Omland T, Christensen G (2010) Chromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardium. Circ Heart Fail 3:503-511
12. Bartolomucci A, Possenti R, Mahata SK, Fischer-Colbrie R, Loh YP, Salton SR (2011) The extended granin family: structure, function, and biomedical implications. Endocr Rev 32:755-797
13. Mazza R, Imbrogno S, Tota B (2010) The interplay between chromogranin A-derived peptides and cardiac natriuretic peptides in cardioprotection against catecholamine-evoked stress. Regul Pept 165:86-94
14. Omland T, Dickstein K, Syversen U (2003) Association between plasma chromogranin A concentration and long-term mortality after myocardial infarction. Am J Med 114:25-30
15. Estensen ME, Hognestad A, Syversen U, Squire I, Ng L, Kjekshus J, Dickstein K, Omland T (2006) Prognostic value of plasma chromogranin A levels in patients with complicated myocardial infarction. Am Heart J 152(927):e1-e6
16. Jansson AM, Røsjø H, Omland T, Karlsson T, Hartford M, Flyvbjerg A, Caidahl K (2009) Prognostic value of circulating chromogranin A levels in acute coronary syndromes. Eur Heart J 30:25-32
17. Dieplinger B, Gegenhuber A, Struck J, Poelz W, Langsteger W, Haltmayer M, Mueller T (2009) Chromogranin A and C-terminal endothelin-1 precursor fragment add independent prognostic information to amino-terminal proBNP in patients with acute destabilized heart failure. Clin Chim Acta 400:91-96
18. Karlsson S, Varpula M, Ruokonen E, Pettilä V, Parviainen I, Ala-Kokko TI, Kolho E, Rintala EM (2007) Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study. Intensive Care Med 33:435-443
19. Le Gall JR, Lemeshow S, Saulnier F (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957-2963
20. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707-710
21. Varpula M, Pulkki K, Karlsson S, Ruokonen E, Pettilä V (2007) Predictive value of N-terminal probrain natriuretic peptide in severe sepsis and septic shock. Crit Care Med 35:1277-1283
22. Stridsberg M, Eriksson B, Ö berg K, Janson ET (2003) A comparison between three commercial kits for chromogranin A measurements. J Endocrinol 177:337-341
23. Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31-41
24. Nguyen HB, Kuan WS, Batech M, Shrikhande P, Mahadevan M, Li CH, Ray S, Dengel A, The ATLAS (Asia Network to Regulate Sepsis care) Investigators (2011) Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item: a multi-national evaluation. Crit Care 15:R229
25. DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837-845
26. Pencina MJ, D'Agostino RB Sr, Steyerberg EW (2011) Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med 30:11-21
27. Zhang D, Lavaux T, Voegeli AC, Lavigne T, Castelain V, Meyer N, Sapin R, Aunis D, Metz-Boutigue MH, Schneider F (2008) Prognostic value of chromogranin A at admission in critically ill patients: a cohort study in a medical intensive care unit. Clin Chem 54:1497-1503
28. Dieplinger B, Gegenhuber A, Kaar G, Poelz W, Haltmayer M, Mueller T (2010) Prognostic value of established and novel biomarkers in patients with shortness of breath attending an emergency department. Clin Biochem 43:714-719
29. Dieplinger B, Gegenhuber A, Haltmayer M, Mueller T (2009) Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath. Heart 95:1508-1513
30. Leinhardt DJ, Arnold J, Shipley KA, Mughal MM, Little RA, Irving MH (1993) Plasma NE concentrations do not accurately reflect sympathetic nervous system activity in human sepsis. Am J Physiol 265:E284-E288
31. Dimsdale JE, Ziegler MG (1991) What do plasma and urinary measures of catecholamines tell us about human response to stressors? Circulation 83:II36-II42
32. O'Connor DT, Pandlan MR, Carlton E, Cervenka JH, Hslao RJ (1989) Rapid radioimmunoassay of circulating chromogranin A: in vitro stability, exploration of the neuroendocrine character of neoplasia, and assessment of the effects of organ failure. Clin Chem 35:1631-1637
33. Røsjø H, Masson S, Latini R, Flyvbjerg A, Milani V, LaRovere MT, Revera M, Mezzani A, Tognoni G, Tavazzi L, Omland T, GISSI-HF Investigators (2010) Prognostic value of chromogranin A in chronic heart failure: data from the GISSI-Heart Failure trial. Eur J Heart Fail 12:549-556
34. Portela-Gomes GM, Stridsberg M (2002) Chromogranin A in the human gastrointestinal tract: an immunocytochemical study with region-specific antibodies. J Histochem Cytochem 50:1487-1492
35. Lugardon K, Raffner R, Goumon Y, Corti A, Delmas A, Bulet P, Aunis D, Metz-Boutigue MH (2000) Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A. J Biol Chem 275:10745-10753
36. Bendel S, Karlsson S, Pettilä V, Loisa P, Varpula M, Ruokonen E (2008) Free cortisol in sepsis and septic shock. Anesth Analg 106:1813-1819
37. Karlsson S, Pettilä V, Tenhunen J, Lund V, Hovilehto S, Ruokonen E (2008) Vascular endothelial growth factor in severe sepsis and septic shock. Anesth Analg 106:1820-1826
38. Karlsson S, Pettilä V, Tenhunen J, Laru-Sompa R, Hynninen M, Ruokonen E (2008) HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis. Intensive Care Med 34:1046-1053
39. Koch A, Voigt S, Kruschinski C, Sanson E, Dückers H, Horn A, Yagmur E, Zimmermann H, Trautwein C, Tacke F (2011) Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Crit Care 15:R63
40. Fung MM, Salem RM, Mehtani P, Thomas B, Lu CF, Perez B, Rao F, Stridsberg M, Ziegler MG, Mahata SK, O'Connor DT (2010) Direct vasoactive effects of the chromogranin A (CHGA) peptide catestatin in humans in vivo. Clin Exp Hypertens 32:278-287