Structure and regulon of Campylobacter jejuni ferric uptake regulator fur define apo-Fur regulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 25, 2012, Pages 10047-10052

  Butcher, James ^a   Sarvan, Sabina ^a   Brunzelle, Joseph S ^b   Couture, Jean François ^a   Stintzi, Alain ^b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

DNA protein interactions; Gene regulation; Metal regulation; Structural characterization; Transcription factor

Indexed keywords

ENTEROCHELIN; FERRIC UPTAKE REGULATOR; HEME; LACTOFERRIN;

ARTICLE; BIOGENESIS; CAMPYLOBACTER JEJUNI; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; GENE ACTIVATION; GENE CONTROL; IN VIVO STUDY; IRON BINDING CAPACITY; IRON TRANSPORT; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; TRANSCRIPTOMICS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CAMPYLOBACTER JEJUNI; FERRIC COMPOUNDS; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTOME;

EID: 84862548944     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118321109     Document Type: Article

References (36)

1. Butcher J, Flint A, Stahl M, Stintzi A (2010) Campylobacter Fur and PerR regulons. Iron Uptake and Homeostasis in Microorganisms, eds Cornelis P, Andrews SC (Caister Academic, Norfolk, UK), pp 168-202.
2. Lee JW, Helmann JD (2007) Functional specialization within the Fur family of metalloregulators. Biometals 20:485-499.
3. McHugh JP, et al. (2003) Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. J Biol Chem 278:29478-29486.
4. Palyada K, Threadgill D, Stintzi A (2004) Iron acquisition and regulation in Campylobacter jejuni. J Bacteriol 186:4714-4729.
5. Gancz H, Censini S, Merrell DS (2006) Iron and pH homeostasis intersect at the level of Fur regulation in the gastric pathogen Helicobacter pylori. Infect Immun 74:602-614.
6. da Silva Neto JF, Braz VS, Italiani VC, Marques MV (2009) Fur controls iron homeostasis and oxidative stress defense in the oligotrophic á-proteobacterium Caulobacter crescentus. Nucleic Acids Res 37:4812-4825.
7. Jackson LA, et al. (2010) Transcriptional and functional analysis of the Neisseria gonorrhoeae Fur regulon. J Bacteriol 192(1):77-85.
8. Torres VJ, et al. (2010) Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia. Infect Immun 78: 1618-1628.
9. Ledala N, Sengupta M, Muthaiyan A, Wilkinson BJ, Jayaswal RK (2010) Transcriptomic response of Listeria monocytogenes to iron limitation and Fur mutation. Appl Environ Microbiol 76:406-416.
10. Carpenter BM, et al. (2009) A single nucleotide change affects Fur-dependent regulation of sodB in H. pylori. PLoS One 4:e5369.
11. Ouyang Z, Deka RK, Norgard MV (2011) BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathog 7:e1001272.
12. Friedman YE, O'Brian MR (2003) A novel DNA-binding site for the ferric uptake regulator (Fur) protein from Bradyrhizobium japonicum. J Biol Chem 278: 38395-38401.
13. Holmes K, et al. (2005) Campylobacter jejuni gene expression in response to iron limitation and the role of Fur. Microbiology 151:243-257.
14. Dian C, et al. (2011) The structure of the Helicobacter pylori ferric uptake regulator Fur reveals three functional metal binding sites. Mol Microbiol 79:1260-1275.
15. Sheikh MA, Taylor GL (2009) Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co-ordination. Mol Microbiol 72:1208-1220.
16. An YJ, et al. (2009) Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition. Nucleic Acids Res 37:3442-3451.
17. Jacquamet L, et al. (2009) Structural characterization of the active form of PerR: Insights into the metal-induced activation of PerR and Fur proteins for DNA binding. Mol Microbiol 73(1):20-31.
18. Traoré DA, et al. (2009) Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein. Nat Chem Biol 5(1):53-59.
19. Lucarelli D, et al. (2007) Crystal structure and function of the zinc uptake regulator FurB from Mycobacterium tuberculosis. J Biol Chem 282:9914-9922.
20. Pecqueur L, et al. (2006) Structural changes of Escherichia coli ferric uptake regulator during metal-dependent dimerization and activation explored by NMR and X-ray crystallography. J Biol Chem 281:21286-21295.
21. Traoré DA, et al. (2006) Crystal structure of the apo-PerR-Zn protein from Bacillus subtilis. Mol Microbiol 61:1211-1219.
22. Pohl E, et al. (2003) Architecture of a protein central to iron homeostasis: Crystal structure and spectroscopic analysis of the ferric uptake regulator. Mol Microbiol 47: 903-915.
23. Lewin AC, Doughty PA, Flegg L, Moore GR, Spiro S (2002) The ferric uptake regulator of Pseudomonas aeruginosa has no essential cysteine residues and does not contain a structural zinc ion. Microbiology 148:2449-2456.
24. Grabowska AD, et al. (2011) Campylobacter jejuni dsb gene expression is regulated by iron in a Fur-dependent manner and by a translational coupling mechanism. BMC Microbiol 11:166.
25. Kabsch W (1976) A solution for the best rotation to relate two sets of vectors. Acta Cryst A32:922-923.
26. Kabsch W, Kabsch H, Eisenberg D (1976) Packing in a new crystalline form of glutamine synthetase from Escherichia coli. J Mol Biol 100:283-291.
27. Vitale S, et al. (2009) A ZnS(4) structural zinc site in the Helicobacter pylori ferric uptake regulator. Biochemistry 48:5582-5591.
28. Danielli A, et al. (2006) In vivo dissection of the Helicobacter pylori Fur regulatory circuit by genome-wide location analysis. J Bacteriol 188:4654-4662.
29. Butcher BG, et al. (2011) Characterization of the Fur regulon in Pseudomonas syringae pv. tomato DC3000. J Bacteriol 193:4598-4611.
30. Hendrixson DR (2008) Regulation of flagellar gene expression and assembly. Campylobacter, eds Nachamkin I, Szymanski C, Blaser MJ (Am Soc Microbiol, Washington, DC), 3rd Ed, pp 545-559.
31. Smart JP, Cliff MJ, Kelly DJ (2009) A role for tungsten in the biology of Campylobacter jejuni: Tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter. Mol Microbiol 74:742-757.
32. Grass G, et al. (2005) The metal permease ZupT from Escherichia coli is a transporter with a broad substrate spectrum. J Bacteriol 187:1604-1611.
33. Miles S, Carpenter BM, Gancz H, Merrell DS (2010) Helicobacter pylori apo-Fur regulation appears unconserved across species. J Microbiol 48:378-386.
34. Danielli A, Scarlato V (2010) Regulatory circuits in Helicobacter pylori: Network motifs and regulators involved in metal-dependent responses. FEMS Microbiol Rev 34: 738-752.
35. Krzywinski M, et al. (2009) Circos: An information aesthetic for comparative genomics. Genome Res 19:1639-1645.
36. Tamura K, et al. (2011) MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28:2731-2739.