Discovery of human zinc deficiency: 50 years later

Journal of Trace Elements in Medicine and Biology

Volumn 26, Issue 2-3, 2012, Pages 66-69

  Prasad, Ananda S ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

A 20; IL 2; Immunity; TNF ; Zinc

Indexed keywords

DIIODOHYDROXYQUIN; GAMMA INTERFERON; INTERLEUKIN 2; IRON; PENICILLAMINE; PHYTIC ACID; THYMULIN; TRANSCRIPTION FACTOR; ZINC; ZINC ACETATE; ZINC SULFATE; ZINC TRANSPORTER;

ACRODERMATITIS ENTEROPATHICA; ACUTE DIARRHEA; ALCOHOL CONSUMPTION; ANEMIA; ARTICLE; CHRONIC INFLAMMATION; COMMON COLD; ENZYME ACTIVITY; GROWTH RETARDATION; HEPATOSPLENOMEGALY; HOOKWORM INFECTION; HUMAN; HYPOGONADISM; HYPOPITUITARISM; INFECTION; INNATE IMMUNITY; IRON DEFICIENCY; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SCHISTOSOMIASIS; SIGNAL TRANSDUCTION; TOTAL PARENTERAL NUTRITION; WILSON DISEASE; ZINC BLOOD LEVEL; ZINC DEFICIENCY; ZINC METABOLISM; ZINC URINE LEVEL;

FEMALE; HUMANS; IMMUNITY; INTERLEUKIN-2; MALE; TUMOR NECROSIS FACTOR-ALPHA; ZINC;

EID: 84862537820     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2012.04.004     Document Type: Article

References (35)

1. Raulin J. Chemical studies on vegetation. Ann Sci Nat 1869, 11:93-99. [in French].
2. Todd W.R., Elvehjem C.A., Hart E.B. Zinc in the nutrition of the rat. Am J Physiol 1933, 107:146-156.
3. O'Dell B.L., Savage J.E. Effect of phytic acid on zinc bioavailability. Proc Soc Exp Biol Med 1960, 103:304-306.
4. Prasad A.S., Halsted J.A., Nadimi M. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism, and geophagia. Am J Med 1961, 31:532-546.
5. Prasad A.S., Miale A., Farid Z., Schulert A., Sandstead H.H. Zinc metabolism in patients with the syndrome of iron deficiency anemia; hypogonadism and dwarfism. J Lab Clin Med 1963, 61:537-549.
6. Sandstead H.H., Prasad A.S., Schulert A.R., Farid Z., Miale A., Bassily S., et al. Human zinc deficiency, endocrine manifestations and response to treatment. Am J Clin Nutr 1967, 20:422-442.
7. Halsted J.A., Ronaghy H.A., Abadi P., Haghshenass, Amirhakimi G.H., Barakat R.M., et al. Zinc deficiency in man: the Shiraz experiment. Am J Med 1972, 53:277-284.
8. MacMahon R.A., Parker M.L., McKinnon M. Zinc treatment in malabsorption. Med J Aust 1968, 2:210-212.
9. Hambidge K.M., Hambidge C., Jacobs M., Brown J.D. Low levels of zinc in hair, anorexia, poor growth and hypogeusia in children. Pediatr Res 1972, 6:868-874.
10. Barnes P.M., Moynahan E.J. Zinc deficiency in acrodermatitis enteropathica. Proc R Soc Med 1973, 66:327-329.
11. Wang K., Zhou B., Kuo Y.M., Zemansky J., Gitschier J. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet 2002, 71:66-73.
12. Kay R.G., Tasman-Jones C. Zinc deficiency and intravenous feeding. Lancet 1975, 2:605-606.
13. Okada A., Takagi Y., Itakura T., Satani M., Manabe H. Skin lesions during intravenous hyperalimentation. Zinc deficiency. Surgery 1976, 80:629-635.
14. Arakawa T., Tamara T., Igarashi Y. Zinc deficiency in two infants during parenteral alimentation for diarrhea. Am J Clin Nutr 1976, 29:197-204.
15. Prasad A.S., Rabbani P., Abbasi A., Bowersox E., Spivey-Fox M.R. Experimental zinc deficiency in humans. Ann Intern Med 1978, 89:483-490.
16. Prasad A.S. Biochemistry of zinc 1993, Plenum Press, New York.
17. Shankar A.H., Prasad A.S. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998, 68(Suppl.):447-463.
18. Prasad A.S., Meftah S., Abdallah J., Kaplan J., Brewer G.J., Bach J.F., et al. Serum thymulin in human zinc deficiency. J Clin Invest 1988, 82:1202-1210.
19. Beck F.W.J., Prasad A.S., Kaplan J., Fitzgerald J.T., Brewer G.J. Changes in cytokine production and T cell subpopulations in experimentally induced zinc deficient humans. Am J Physiol Endocrinol Metab 1997, 272:1002-1007.
20. Prasad A.S., Oberleas D., Wolf P.L., Horwitz J.P. Studies on zinc deficiency: changes in trace elements and enzyme activities in tissues of zinc-deficient rats. J Clin Invest 1967, 46:549-557.
21. Prasad A.S., Oberleas D. Thymidine kinase activity and incorporation of thymidine into DNA in zinc-deficient tissue. J Lab Clin Med 1974, 83:634-639.
22. Prasad A.S., Bao B., Beck F.W.J., Sarkar F.H. Zinc activates NF-kB in HUT-78 cells. J Lab Clin Med 2001, 138:250-255.
23. Prasad A.S., Bin B., Beck F.W.J., Sarkar F.H. Zinc enhances the expression of IL-2 and IL-2 receptors in HUT-78 cells via NF-kB activation. J Lab Clin Med 2002, 140(4):272-289.
24. Prasad A.S., Bao B., Beck F.W.J., Kucuk O., Sarkar F.H. Antioxidant effect of zinc in humans. Free Radic Biol Med 2004, 37:1182-1190.
25. Prasad A.S., Bao B., Beck F.W.J., Sarkar F.H. Zinc-suppressed inflammatory cytokines by induction of A20-medated inhibition of nuclear factor-κB. Nutrition 2011, 27:816-823.
26. Bao B., Prasad A.S., Beck F.W.J., Bao G.W., Singh T., Ali S., et al. Intracellular free zinc up-regulates IFN-γ and T-bet essential for Th1 differentiation in Con-A stimulated HUT-78 cells. Biosci Biotechnol Res Commun 2011, 407:703-707.
27. Fukada T., Kambe T. Molecular and genetic features of zinc transporters in physiology and pathogenesis. Metallomics 2011, 3:662-674.
28. Haase H., Rink L. Zinc signaling. Zinc in human health 2011, 94-117. IOS Press. L. Rink (Ed.).
29. Prasad A.S., Beck F.W.J., Bao B., Fitzgerald J.T., Snell D.C., Steinberg J.D., et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin 2007, 85:837-844.
30. Bao B., Prasad A.S., Beck F.W.J., Fitzgerald J.T., Snell D., Bao G.W., et al. Zinc decreases C-reactive protein, lipid peroxidation, and implication of zinc as an atheroprotective agent. Am J Clin Nutr 2010, 91:1634-1641.
31. Bao B., Prasad A., Beck F.W.J., Snell D., Suneja A., Sarkar F.H., et al. Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients. Transl Res 2008, 152:67-80.
32. Fischer Walker C.L., Lamberti L., Roth D., Black R.E. Zinc and infectious diseases. Zinc in human health 2011, 234-253. IOS Press. L. Rink (Ed.).
33. Prasad A.S., Beck F.W.J., Bao B., Snell D., Fitzgerald T. Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecule in patients with common cold treated with zinc acetate. J Infect Dis 2008, 197:795-802.
34. Brewer G.J. Practical recommendations and new therapies for Wilson's disease. Drugs 1995, 2:240-249.
35. AREDS Report No.13 Association of mortality with ocular disorders and an intervention of high dose antioxidants and zinc in the age-related eye disease study. Arch Ophthalmol 2004, 122:716-726.