Roles of vimentin and 14-3-3 zeta/delta in the inhibitory effects of heparin on PC-3M cell proliferation and B16-F10-luc-G5 cells metastasis

Acta Pharmacologica Sinica

Volumn 33, Issue 6, 2012, Pages 798-808

  Pan, Yan ^a   Zhong, Li Jun ^a   Zhou, Hong ^a   Wang, Xin ^a   Chen, Kui ^a   Yang, Hao Peng ^a   Xiaokaiti, Yilixiati ^a   Maimaiti, Aikebaier ^a   Jiang, Ling ^a   Li, Xue Jun ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

v integrin; 14 3 3 zeta delta; cell growth; heparin; proteome; vimentin

Indexed keywords

14 3 3 ZETA/DELTA PROTEIN; ALPHA5 INTEGRIN; BROXURIDINE; HEPARIN; KI 67 ANTIGEN; MESSENGER RNA; PROTEIN 14 3 3; PROTEOME; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENERGY METABOLISM; ERYTHROCYTE; HEMATOCRIT; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; LUNG PARENCHYMA; MOUSE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIMARY TUMOR; PROSTATE CANCER; PROTEIN EXPRESSION; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

14-3-3 PROTEINS; ANIMALS; ANTICOAGULANTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CADHERINS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPARIN; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASMS; PROSTATE; PROSTATIC NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA; VIMENTIN;

EID: 84862532711     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.42     Document Type: Article

References (26)

1. Mandal AK, Lyden TW, Saklayen MG. Heparin lowers blood pressure biological and clinical perspectives. Kidney Int 1995; 47: 1017-24.
2. Neison RM, Cecconi O, Roberts G, Aruffo A, Linhard RJ, Bcvilaqua MP. Heparin oligosaccharides bind L- and P-selection and inhibit acute inflammation. Blood 1993; 82: 3253-61.
3. Li HL, Ye KH, Zhang HW, Luo YR, Ren XD, Xiong AH, et al. Effect of heparin on apoptosis in human nasopharyngeal carcinoma CNE2 cells. Cell Res 2001; 4: 311-5.
4. Lebeau B, Chastang C, Brechot JM, Capron F, Dautzenberg B, Delaisements C, et al. Subcutaneous heparin treatment increases survival in small cell lung cancer. Cancer 1994; 1: 38-45.
5. Altinbas M, Coskun HS, Er O, Ozkan M, Eser B, Unal A, et al. A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer. J Thromb Haemost 2004; 8: 1266-71.
6. Niers TM, Klerk CP, DiNisio M, Van Noorden CJ, Büller HR, Reitsma PH, et al. Mechanisms of heparin induced anti-cancer activity in experimental cancer models. Crit Rev Oncol Hematol 2007; 3: 195-207.
7. Pan Y, Iwata F, Wang D, Muraguchi M, Ooga K, Ohmoto Y, et al. Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva. Biochim Biophys Acta 2009; 1: 49-56.
8. Boeryd B. Effect of heparin and plasminogen inhibitor (EACA) in brief and prolonged treatment on intravenously injected tumor cells. Acta Pathol Microbiol Scand 1966; 68: 347-54.
9. Hagmar B, Boeryd B. Disseminating effect of heparin on experimental tumor metastases. Pathol Eur 1969; 4: 274-82.
10. Maat B. Extrapulmonary colony formation after intravenous injection of tumor cells into heparin-treated animals. Br J Cancer 1978; 3: 369-76.
11. Ramakrishnan S, Grebe R, Singh M, Schmid-Schönbein H. Evaluation of hemorheological risk factor profile in plasmacytoma patients. Clin Hemorheol Microcirc 1999; 20: 11-9.
12. Rickles FR, Falanga A. Molecular basis for the relationship between thrombosis and cancer. Thromb Res 2001; 6: V215-24.
13. Mousa SA, Petersen LJ. Anti-cancer properties of low-molecularweight heparin: preclinical evidence. Thromb Haemost 2009; 102: 258-67.
14. Casu B, Vlodavsky I, Sanderson RD. Non-anticoagulant heparins and inhibition of cancer. Pathophysiol Haemost Thromb 2008; 36: 195-203.
15. Erduran E, Tekelioglu Y, Gedik Y, Bektas I, Hacisalihoglu S. In vitro determination of the apoptotic effect of heparin on lymphoblasts using DNA analysis and measurements of Fas and Bcl-2 proteins by flow cytometry. Pediatr Hematol Oncol 2004; 5: 383-91.
16. Pan Y, Lei TL, Teng B, Liu JH, Zhang JZ, An Y, et al. Role of vimentin in inhibitory effects of low molecular weight heparin on PC-3M adhesion to and migration through endothelium. J Pharmacol Exp Ther 2011; 339: 82-92.
17. Tzivion G, Luo ZJ, Avruch J. Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo. J Biol Chem 2000; 275: 29772-8.
18. Satoh J, Yamamura T, Arima K. The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes. Am J Pathol 2004; 165: 577-92.
19. Yang X, Cao W, Zhang L, Zhang W, Zhang X, Lin H. Targeting 14-3- 3zeta in cancer therapy. Cancer Gene Ther 2012; 19: 153-9.
20. Neal CL, Yu D. 14-3-3. as a prognostic marker and therapeutic target for cancer. Expert Opin Ther Targets 2010; 14: 1343-1354
21. Maxwell SA, Cherry EM, Bayless KJ. Akt, 14-3-3., and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma. Leuk Lymphoma 2011; 52: 849-64.
22. Shirahata A, Sakata M, Sakuraba K, Goto T, Mizukami H, Saito M, et al. Vimentin methylation as a marker for advanced colorectal carcinoma. Anticancer Res 2009; 29: 279-81.
23. Vora HH, Patel NA, Rajvik KN, Mehta SV, Brahmbhatt BV, Shah MJ, et al. Cytokeratin and vimentin expression in breast cancer. Int J Biol Markers 2009; 23: 38-46.
24. Tsuruta D, Jones JC. The vimentin cytoskeleton regulates focal contact size and adhesion of endothelial cells subjected to shear stress. J Cell Sci 2003; 116: 4977-84.
25. Zhang X, Fournier MV, Ware JL, Bissell MJ, Yacoub A, Zehner ZE. Inhibition of vimentin or beta1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo. Mol Cancer Ther 2009; 3: 499-508.
26. Bhattacharya R, Gonzalez AM, Debiase PJ, Trejo HE, Goldman RD, Flitney FW, et al. Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength. J Cell Sci 2009; 122: 1390-400.