The Vermont oxford neonatal encephalopathy registry: rationale, methods, and initial results

BMC Pediatrics

Volumn 12, Issue , 2012, Pages

  Pfister, Robert H ^a,b   Bingham, Peter ^a,b   Edwards, Erika M ^a,b   Horbar, Jeffrey D ^a,b   Kenny, Michael J ^a,b   Inder, Terrie ^b,c   Nelson, Karin B ^b,d,e   Raju, Tonse ^b,f   Soll, Roger F ^a,b  

^a UNIVERSITY OF VERMONT   (United States)

^b VERMONT OXFORD NETWORK   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^e CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^f EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Asphyxia; Cooling; HIE; Hypoxic ischemic encephalopathy; Neonatal encephalopathy; Neuroprotection; Registry; Therapeutic hypothermia

Indexed keywords

ANTICONVULSIVE AGENT; NEUROMUSCULAR BLOCKING AGENT; NITROUS OXIDE;

APGAR SCORE; ARTICLE; BLOOD GAS; BRAIN DISEASE; COMA; COMPUTER ASSISTED TOMOGRAPHY; DISEASE REGISTRY; ELECTROENCEPHALOGRAM; EXTRACORPOREAL OXYGENATION; HUMAN; INDUCED HYPOTHERMIA; MAJOR CLINICAL STUDY; NEUROLOGIC EXAMINATION; NEWBORN; NEWBORN DISEASE; NEWBORN ENCEPHALOPATHY; NUCLEAR MAGNETIC RESONANCE IMAGING; SEIZURE; STUPOR; SURVIVAL; VENTILATOR;

BRAIN DISEASES; HUMANS; HYPOTHERMIA, INDUCED; INFANT, NEWBORN; REGISTRIES; VERMONT;

EID: 84862531397     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/1471-2431-12-84     Document Type: Article

References (28)

1. Nelson KB, Leviton A. How much of neonatal encephalopathy is due to birth asphyxia?. Am J Dis Child 1991, 145(11):1325-1331.
2. Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O'Sullivan F, Burton PR, Pemberton PJ, Stanley FJ. Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ Clinical research ed 1998, 317(7172):1554-1558. 10.1136/bmj.317.7172.1554, 28733, 9836653.
3. Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O'Sullivan F, Burton PR, Pemberton PJ, Stanley FJ. Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ Clinical research ed 1998, 317(7172):1549-1553. 10.1136/bmj.317.7172.1549, 28732, 9836652.
4. Levene MI, Sands C, Grindulis H, Moore JR. Comparison of two methods of predicting outcome in perinatal asphyxia. Lancet 1986, 1(8472):67-69.
5. Ellenberg JH, Nelson KB. Cluster of perinatal events identifying infants at high risk for death or disability. J Pediatr 1988, 113(3):546-552. 10.1016/S0022-3476(88)80649-8, 3411402.
6. Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, Kapellou O, Levene M, Marlow N, Porter E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009, 361(14):1349-1358. 10.1056/NEJMoa0900854, 19797281.
7. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, Polin RA, Robertson CM, Thoresen M, Whitelaw A, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005, 365(9460):663-670.
8. Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane database of syst rev (Online) 2007, (4):CD003311.
9. Shankaran S, Laptook A, Wright LL, Ehrenkranz RA, Donovan EF, Fanaroff AA, Stark AR, Tyson JE, Poole K, Carlo WA, et al. Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants. Pediatrics 2002, 110(2 Pt 1):377-385.
10. Edwards AD, Azzopardi DV. Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child 2006, 91(2):F127-F131.
11. Kirpalani H, Barks J, Thorlund K, Guyatt G. Cooling for neonatal hypoxic ischemic encephalopathy: do we have the answer?. Pediatrics 2007, 120(5):1126-1130. 10.1542/peds.2006-2776, 17974750.
12. Blackmon LR, Stark AR. Hypothermia: a neuroprotective therapy for neonatal hypoxic-ischemic encephalopathy. Pediatrics 2006, 117(3):942-948. 10.1542/peds.2005-2950, 16510680.
13. Higgins RD, Raju TN, Perlman J, Azzopardi DV, Blackmon LR, Clark RH, Edwards AD, Ferriero DM, Gluckman PD, Gunn AJ, et al. Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop. J Pediatr 2006, 148(2):170-175. 10.1016/j.jpeds.2005.12.009, 16492424.
14. Gliklich RE, Dreyer NA. United States. Agency for Healthcare Research and Quality.: Registries for evaluating patient outcomes: a user's guide 2007, Dept. of Health and Human Services, Public Health Service, Agency for Healthcare Research and Quality, Rockville, MD: U.S.
15. Morales LS, Staiger D, Horbar JD, Carpenter J, Kenny M, Geppert J, Rogowski J. Mortality among very low-birthweight infants in hospitals serving minority populations. Am J Public Health 2005, 95(12):2206-2212. 10.2105/AJPH.2004.046730, 1449508, 16304133.
16. Stark AR. Levels of neonatal care. Pediatrics 2004, 114(5):1341-1347.
17. Dreyer NA, Garner S. Registries for robust evidence. Jama 2009, 302(7):790-791. 10.1001/jama.2009.1092, 19690313.
18. Edwards AD, Nelson KB. Neonatal encephalopathies. Time to reconsider the cause of encephalopathies. BMJ Clinical research ed 1998, 317(7172):1537-1538. 10.1136/bmj.317.7172.1537, 1114379, 9836647.
19. Volpe JJ. Neurology of the newborn 2008, Saunders/Elsevier, Philadelphia, 5.
20. Gunn AJ, Bennet L, Gunning MI, Gluckman PD, Gunn TR. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res 1999, 46(3):274-280. 10.1203/00006450-199909000-00005, 10473041.
21. Gunn AJ, Gunn TR, Gunning MI, Williams CE, Gluckman PD. Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep. Pediatrics 1998, 102(5):1098-1106. 10.1542/peds.102.5.1098, 9794940.
22. Ment LR, Bada HS, Barnes P, Grant PE, Hirtz D, Papile LA, Pinto-Martin J, Rivkin M, Slovis TL. Practice parameter: neuroimaging of the neonate: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2002, 58(12):1726-1738. 10.1212/WNL.58.12.1726, 12084869.
23. Draper ES, Kurinczuk JJ, Lamming CR, Clarke M, James D, Field D. A confidential enquiry into cases of neonatal encephalopathy. Arch Dis Child 2002, 87(3):F176-F180.
24. Gressens P, Rogido M, Paindaveine B, Sola A. The impact of neonatal intensive care practices on the developing brain. J Pediatr 2002, 140(6):646-653. 10.1067/mpd.2002.123214, 12072865.
25. Himmelmann K, Hagberg G, Beckung E, Hagberg B, Uvebrant P. The changing panorama of cerebral palsy in Sweden. IX. Prevalence and origin in the birth-year period 1995-1998. Acta Paediatr 2005, 94(3):287-294. 10.1111/j.1651-2227.2005.tb03071.x, 16028646.
26. The TOBY Register www.npeu.ox.ac.uk/tobyregister .
27. Azzopardi D, Strohm B, Edwards AD, Halliday H, Juszczak E, Levene M, Thoresen M, Whitelaw A, Brocklehurst P. Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial. Arch Dis Child 2009, 94(4):F260-F264.
28. Azzopardi D, Brocklehurst P, Edwards D, Halliday H, Levene M, Thoresen M, Whitelaw A. The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. BMC Pediatr 2008, 8:17. 10.1186/1471-2431-8-17, 2409316, 18447921.