High cholesterol levels are associated with coronary microvascular dysfunction

Journal of Cardiovascular Medicine

Volumn 13, Issue 7, 2012, Pages 439-442

  Mangiacapra, Fabio ^a   De Bruyne, Bernard ^a   Peace, Aaron J ^a   Melikian, Narbeh ^a   Wijns, William ^a   Barbato, Emanuele ^a  

^a OLV HOSPITAL   (Belgium)

Author keywords

coronary artery disease; coronary microvascular dysfunction; hypercholesterolemia; index of microvascular resistance

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; FEMALE; FRACTIONAL FLOW RESERVE; FUNCTIONAL ASSESSMENT; HUMAN; HYPERCHOLESTEROLEMIA; INDEX OF MICROVASCULAR RESISTANCE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MICROANGIOPATHY; PREDICTOR VARIABLE; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR RESISTANCE;

AGED; BIOLOGICAL MARKERS; CARDIAC CATHETERIZATION; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY CIRCULATION; FEMALE; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; TRIGLYCERIDES; VASCULAR RESISTANCE;

EID: 84862530317     PISSN: 15582027     EISSN: 15582035     Source Type: Journal    
DOI: 10.2459/JCM.0b013e328351725a     Document Type: Article

References (35)

1. Newman WP 3rd, Freedman DS, Voors AW, et al. Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bogalusa Heart Study. N Engl J Med 1986; 314:138-144. (Pubitemid 16183169)
2. Pitkanen OP, Raitakari OT, Niinikoski H, et al. Coronary flow reserve is impaired in young men with familial hypercholesterolemia. J Am Coll Cardiol 1996; 28:1705-1711. (Pubitemid 26426223)
3. Barbato E, Rubattu S, Bartunek J, et al. Human coronary atherosclerosis modulates cardiac natriuretic peptide release. Atherosclerosis 2009; 206:258-264.
4. Manfrini O, Pizzi C, Morgagni G, Fontana F, Bugiardini R. Effect of pravastatin on myocardial perfusion after percutaneous transluminal coronary angioplasty. Am J Cardiol 2004; 93:1391-1393. (Pubitemid 38692468)
5. Kaufmann PA, Gnecchi-Ruscone T, Schafers KP, Luscher TF, Camici PG. Low density lipoprotein cholesterol and coronary microvascular dysfunction in hypercholesterolemia. J Am Coll Cardiol 2000; 36:103-109. (Pubitemid 30466119)
6. Melikian N, Vercauteren S, Fearon WF, et al. Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis. EuroIntervention 2010; 5:939-945.
7. Bugiardini R. Women,non-specific chest pain, and normal or near-normal coronary angiograms are not synonymous with favourable outcome. Eur Heart J 2006; 27:1387.
8. Manfrini O, Bugiardini R. Barriers to clinical risk scores adoption. Eur Heart J 2007; 28:1045-1046. (Pubitemid 47343886)
9. Xhyheri B, Bugiardini R. Diagnosis and treatment of heart disease: are women different from men? Prog Cardiovasc Dis 2010; 53:227-236.
10. Barbato E, Piscione F, Bartunek J, et al. Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries. Circulation 2005; 111:288-294. (Pubitemid 40165334)
11. Barbato E. Role of adrenergic receptors in human coronary vasomotion. Heart 2009; 95:603-608.
12. Barbato E, De Bruyne B, MacCarthy P, et al. Functional assessment of coronary atherosclerosis in the catheterization laboratory: the key role of fractional flow reserve. Ital Heart J 2005; 6:549-556.
13. Fearon WF, Balsam LB, Farouque HM, et al. Novel index for invasively assessing the coronary microcirculation. Circulation 2003; 107:3129-3132. (Pubitemid 36793080)
14. Aarnoudse W, Fearon WF, Manoharan G, et al. Epicardial stenosis severity does not affect minimal microcirculatory resistance. Circulation 2004; 110:2137-2142. (Pubitemid 39372491)
15. Ng MK, Yeung AC, Fearon WF. Invasive assessment of the coronary microcirculation: superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve. Circulation 2006; 113:2054-2061.
16. Pijls NH, De Bruyne B, Peels K, et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med 1996; 334:1703-1708. (Pubitemid 26193622)
17. Barbato E, Bartunek J, Wyffels E, et al. Effects of intravenous dobutamine on coronary vasomotion in humans. J Am Coll Cardiol 2003; 42:1596-1601. (Pubitemid 37378439)
18. Barbato E, Bartunek J, Aarnoudse W, et al. Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses. Eur Heart J 2004; 25:2034-2039. (Pubitemid 39486023)
19. Cohen RA, Zitnay KM, Haudenschild CC, Cunningham LD. Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ Res 1988; 63:903-910. (Pubitemid 18269288)
20. Bugiardini R, Galvani M, Ferrini D, et al. Effects of iloprost, a stable prostacyclin analog, on exercise capacity and platelet aggregation in stable angina pectoris. Am J Cardiol 1986; 58:453-459. (Pubitemid 16052672)
21. Iaccarino G, Barbato E, Cipolletta E, et al. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. Eur Heart J 2005; 26:1752-1758. (Pubitemid 41219848)
22. Barbato E, Penicka M, Delrue L, et al. Thr164Ile Polymorphism of b2- adrenergic Receptor Negatively Modulates Cardiac Contractility: Implications for Prognosis in Patients with Idiopathic Dilated Cardiomyopathy. Heart 2007; 93:856-861. (Pubitemid 46998990)
23. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation 1993; 88:2541-2547. (Pubitemid 23360178)
24. Barbato E, Aarnoudse W, Aengevaeren WR, et al. Validation of coronary flow reserve measurements by thermodilution in clinical practice. Eur Heart J 2004; 25:219-223. (Pubitemid 38235158)
25. Kern MJ, Samady H. Current concepts of integrated coronary physiology in the catheterization laboratory. J Am Coll Cardiol 2010; 55:173-185.
26. De Bruyne B, Hersbach F, Pijls NH, et al. Abnormal epicardial coronary resistance in patients with diffuse atherosclerosis butnormal coronary angiography. Circulation 2001; 104:2401-2406. (Pubitemid 33108371)
27. Mangiacapra F, Barbato E. From SYNTAX to FAME, a paradigm shift in revascularization strategies: the key role of fractional flow reserve in guiding myocardial revascularization. J Cardiovasc Med (Hagerstown) 2011; 12:538-542.
28. Bugiardini R. Normal coronary arteries: clinical implications and further classification. Herz 2005; 30:3-7. (Pubitemid 40521551)
29. Pizzi C, Bugiardini R. Further insights into syndrome X. Heart 2010; 96:1865-1867.
30. Lembo G, Morisco C, Lanni F, et al. Systemic hypertension and coronary artery disease: the link. Am J Cardiol 1998; 82:2H-7H.
31. Cuisset T, Hamilos M, Melikian N, et al. Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation. J Am Coll Cardiol 2008; 51:1060-1065. (Pubitemid 351374771)
32. Mangiacapra F, Di Serafino L, Barbato E. The role of fractional flow reserve to guide stent implantation. Minerva Cardioangiol 2011; 59:39-48.
33. Peace A, De Bruyne B, Barbato E. The reconciliation of pressure and light: a clinical case of complementary use of fractional flow reserve and optical coherence tomography. J Cardiovasc Med (Hagerstown) 2011; 12:571-577.
34. Nissen SE, Nicholls SJ, Sipahi I, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 2006; 295:1556-1565.
35. Nissen SE, Tuzcu EM, Schoenhagen P, et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med 2005; 352:29-38. (Pubitemid 40075678)