Ototoxic effect of topical oxiconazole and terbinafine in rats

Journal of Otolaryngology - Head and Neck Surgery

Volumn 41, Issue 2, 2012, Pages 78-83

  Aydin, Emine ^a   Tasçtan, Eren ^a   Aydogčan, Filiz ^a   Karaca, Gökhan ^a   Sçafak, Mustafa Asim ^b  

^a ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b Medical Faculty   (Cyprus)

Author keywords

Auditory brainstem responses; Inner ear; Ototoxicity; Oxiconazole; Terbinafine

Indexed keywords

GENTA; GENTAMICIN; OXICONAZOLE; TERBINAFINE; TERBONILE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUDITORY STIMULATION; AUDITORY THRESHOLD; CONTROLLED STUDY; EARDRUM PERFORATION; ELECTRODE; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING; MALE; MIDDLE EAR; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; RAT;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIFUNGAL AGENTS; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FUNGI; IMIDAZOLES; MALE; NAPHTHALENES; OTITIS MEDIA; RATS; RATS, WISTAR; TRYPANOCIDAL AGENTS; TYMPANIC MEMBRANE;

EID: 84862527991     PISSN: 19160216     EISSN: None     Source Type: Journal    
DOI: 10.2310/7070.2011.110146     Document Type: Article

References (15)

1. Baylançiçek S, Serin GM, Ciprut A, et al. Ototoxic effect of topical ciclopirox as an antimycotic preparation. Otol Neurotol 2008;29: 910-3, doi:10.1097/MAO.0b013e318184f4a9.
2. Jadhav VJ, Pal M, Mishra GS. Etiological significance of Candida albicans in otitis externa. Mycopathologia 2003;156:313-5, doi:10.1023/B:MYCO. 0000003574.89032.99. (Pubitemid 37506813)
3. Munguia R, Daniel SJ. Ototopical antifungals and otomycosis: a review. Int J Pediatr Otorhinolaryngol 2008;72:453-9, doi:10.1016/ j.ijporl.2007.12.005.
4. Jackman A, Ward R, April M, et al. Topical antibiotic induced otomycosis. Int J Pediatr Otorhinolaryngol 2005;69:857-60, doi:10.1016/j.ijporl.2005.01. 022. (Pubitemid 40693238)
5. Tom LW. Ototoxicity of common topical antimycotic preparations. Laryngoscope 2000;110:509-16, doi:10.1097/00005537- 200004000-00003.
6. Oztürkcan S, Dündar R, Katilmis H, et al. The ototoxic effect of boric acid solutions applied into the middle ear of guinea pigs. Eur Arch Otorhinolaryngol 2009;266:663-7, doi:10.1007/s00405-008-0806-6.
7. Jerajani HR, Amladi ST, Bongale R, et al. Evaluation of clinical efficacy and safety of once daily topical administration of 1% oxiconazole cream and lotion in dermatophytosis: an open label, non comparative multicentre study. Indian J Dermatol Venereol Leprol 2000;66:188-92. (Pubitemid 33232081)
8. Vennewald I, Klemm E. Otomycosis: diagnosis and treatment. Clin Dermatol 2010;28:202-11, doi:10.1016/j.clindermatol.2009.12.003.
9. Fernandes NF, Geller SA, Fong TL. Terbinafine hepatotoxicity: case report and review of the literature. Am J Gastroenterol 1998;93: 459-60, doi:10.1111/j.1572-0241.1998.00459.x. (Pubitemid 29068357)
10. Karaarslan A, Arikan S, Ozcan M, et al. In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis. Mycoses 2004;47:284-7, doi:10.1111/j.1439- 0507.2004.00988.x.
11. Abdel-Rahman SM, Nahata MC. Oral terbinafine: a new antifungal agent. Ann Pharmacother 1997;31:445-56. (Pubitemid 27155250)
12. Marsh RR, Tom LW. Ototoxicity of antimycotics. Otolaryngol Head Neck Surg 1989;100:134-6. (Pubitemid 19080005)
13. Haynes DS, Rutka J, Hawke M, et al. Ototoxicity of ototopical drops-an update. Otolaryngol Clin North Am 2007;40:669-83, doi:10.1016/j.otc.2007.03.010. (Pubitemid 46830930)
14. Blakley BW, Hochman J, Wellman M, et al. Differences in ototoxicity across species. J Otolaryngol Head Neck Surg 2008;37: 700-3.
15. Spandow O, Anniko M, Møller AR. The round window as access route for agents injurious to the inner ear. Am J Otolaryngol 1988; 9:327-35, doi:10.1016/S0196-0709(88)80041-3. (Pubitemid 19030401)