RNA-seq analysis reveals different dynamics of differentiation of human dermis- and adipose-derived stromal stem cells

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Jääger, Kersti ^a,b   Islam, Saiful ^c   Zajac, Pawel ^c   Linnarsson, Sten ^c   Neuman, Toomas ^a,d  

^a TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

^b Cellin Technologies LLC   (Estonia)

^c KAROLINSKA INSTITUTE   (Sweden)

^d Protobios LLC   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CALVASCULIN; COLLAGEN TYPE 1; FIBRONECTIN; FIBULIN; GAMMA GLUTAMYLTRANSFERASE; POLYCOMB GROUP PROTEIN; RNA; THYMIDINE KINASE 1; TROPOMYOSIN; VASCULOTROPIN; WNT PROTEIN;

ADIPOCYTE; ADIPOSE DERIVED STEM CELL; ARTICLE; CARTILAGE CELL; CAV1 GENE; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL POPULATION; CELL TYPE; COL1A1 GENE; COL1A2 GENE; DNM1 GENE; EFEMP1 GENE; FN1 GENE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GGT5 GENE; GREM1 GENE; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; OSTEOBLAST; RNA SEQUENCE; S100A4 GENE; SEQUENCE ANALYSIS; SKIN FIBROBLAST; TK1 GENE; TPM2 GENE; VEGF GENE; ZRANB1 GENE;

ADIPOGENESIS; ADIPOSE TISSUE; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; DERMIS; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MESENCHYMAL STROMAL CELLS; ORGAN SPECIFICITY; OSTEOGENESIS; SEQUENCE ANALYSIS, RNA; TRANSCRIPTOME;

EID: 84862517576     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038833     Document Type: Article

References (32)

1. Toma JG, Akhavan M, Fernandes KJ, Barnabe-heider F, Sadikot A, et al. (2001) Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 3: 778-784.
2. Sabatini F, Petecchia L, Tavian M, Jodon de Villeroché V, Rossi G a, et al. (2005) Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities. Lab Invest 85: 962-971.
3. da Silva Meirelles L, Chagastelles PC, Nardi NB, (2006) Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119: 2204-2213.
4. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, et al. (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7: 211-228.
5. Zuk PA, Zhu M, Ashjian P, Ugarte D, A D, et al. (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13: 4279-4295.
6. Gimble J, Guilak F, (2003) Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy 5: 362-369.
7. Krampera M, Marconi S, Pasini A, Galiè M, Rigotti G, et al. (2007) Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus. Bone 40: 382-390.
8. Bae S, Ahn JH, Park CW, Son HK, Kim K-S, et al. (2009) Gene and microRNA expression signatures of human mesenchymal stromal cells in comparison to fibroblasts. Cell Tissue Res 335: 565-573.
9. Wagner W, Wein F, Seckinger A, Frankhauser M, Wirkner U, et al. (2005) Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 33: 1402-1416.
10. Lorenz K, Sicker M, Schmelzer E, Rupf T, Salvetter J, et al. (2008) Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp Dermatol 17: 925-932.
11. Haniffa MA, Wang X-nong, Holtick U, Rae M, Isaacs JD, et al. (2007) Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol 179: 1595-1604.
12. Hanson SE, Kim J, Johnson BHQ, Bradley B, Breunig MJ, et al. (2010) Characterization of mesenchymal stem cells from human vocal fold fibroblasts. Laryngoscope 120: 546-551.
13. Blasi A, Martino C, Balducci L, Saldarelli M, Soleti A, et al. (2011) Dermal fibroblasts display similar phenotypic and differentiation capacity to fat-derived mesenchymal stem cells, but differ in anti-inflammatory and angiogenic potential. Vascular cell 3: 5.
14. Jääger K, Neuman T, (2011) Human dermal fibroblasts exhibit delayed adipogenic differentiation compared with mesenchymal stem cells. Stem Cells Dev 20: 1327-1336.
15. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, et al. (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317.
16. Islam S, Kjällquist U, Moliner A, Zajac P, Fan J-B, et al. (2011) Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq. Genome Res 21: 1160-1167.
17. Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, et al. (2007) Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J 26: 1637-1648.
18. Chun J-S, Oh H, Yang S, Park M, (2008) Wnt signaling in cartilage development and degeneration. BMB Rep 41: 485-494.
19. Hennig T, Lorenz H, Thiel A, Goetzke K, Dickhut A, et al. (2007) Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. J Cell Physiol 211: 682-691.
20. Kuklick L, Brendel C, Ritter M, Kim T, Hartmann O, et al. (2002) Gene expression profile of human mesenchymal stem cells in comparison to skin fibroblasts employing cDNA microarray analysis of 9600 genes. Blood 100: 167b-167b.
21. Abeyta MJ, Clark AT, Rodriguez RT, Bodnar MS, Pera RAR, et al. (2004) Unique gene expression signatures of independently-derived human embryonic stem cell lines. Hum Mol Genet 13: 601-608.
22. Skottman H, Mikkola M, Lundin K, Olsson C, Strömberg A-M, et al. (2005) Gene expression signatures of seven individual human embryonic stem cell lines. Stem Cells 23: 1343-1356.
23. Tsai M-S, Hwang S-M, Chen K-D, Lee Y-S, Hsu L-W, et al. (2007) Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow. Stem Cells 25: 2511-2523.
24. Kim K, Doi A, Wen B, Ng K, Zhao R, et al. (2010) Epigenetic memory in induced pluripotent stem cells. Nature 467: 285-290.
25. Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, et al. (2010) Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol 28: 848-855.
26. Scheideler M, Elabd C, Zaragosi L-E, Chiellini C, Hackl H, et al. (2008) Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis. BMC Genomics 9: 340.
27. Song L, Tuan RS, (2004) Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J 18: 980-982.
28. Woodbury D, Reynolds K, Black IB, (2002) Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci Res 69: 908-917.
29. Song L, Webb NE, Song Y, Tuan RS, (2006) Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency. Stem Cells 24: 1707-1718.
30. Lin T-M, Chang H-W, Wang K-H, Kao A-P, Chang C-C, et al. (2007) Isolation and identification of mesenchymal stem cells from human lipoma tissue. Biochem Biophys Res Commun 361: 883-889.
31. Yamamoto N, Akamatsu H, Hasegawa S, Yamada T, Nakata S, et al. (2007) Isolation of multipotent stem cells from mouse adipose tissue. J Dermatol Sci 48: 43-52.
32. Takashima A, (2001) Establishment of fibroblast cultures. In: Wiley Online Library, Curr Protoc Cell Biol Chapter 2: Unit 2.1.