Validity of triple- and dual-tracer techniques to estimate glucose appearance

American Journal of Physiology - Endocrinology and Metabolism

Volumn 302, Issue 12, 2012, Pages

  Haidar, A ^a,b   Elleri, D ^a   Allen, J M ^a   Harris, J ^a   Kumareswaran, K ^a   Nodale, M ^a   Acerini, C L ^a   Wilinska, M E ^a   Jackson, N ^c   Umpleby, A M ^c   Evans, M L ^a   Dunger, D B ^a   Hovorka, R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Dual tracer technique; Glucose flux; Glucose tracer; Meal tolerance test; Radziuk mari model; Triple tracer technique

Indexed keywords

[1,2,3,4,5,6,6 2 H 7]GLUCOSE; [6,6 2 H 2 ]GLUCOSE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; NEUTRAL INSULIN; TRACER; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; DISEASE DURATION; DRUG DOSE TITRATION; DUAL TRACER TECHNIQUE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; HUMAN; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; ISOTOPE TRACING; MASS FRAGMENTOGRAPHY; MEASUREMENT ERROR; POSTPRANDIAL GLUCOSE APPEARANCE; PRIORITY JOURNAL; TRIPLE TRACER TECHNIQUE; VALIDATION STUDY;

ADOLESCENT; ALGORITHMS; AREA UNDER CURVE; BLOOD GLUCOSE; CARBON RADIOISOTOPES; DATA INTERPRETATION, STATISTICAL; DEUTERIUM; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; INTESTINAL ABSORPTION; ISOTOPE LABELING; LEAST-SQUARES ANALYSIS; MALE; RADIOACTIVE TRACERS; RADIOISOTOPE DILUTION TECHNIQUE; REPRODUCIBILITY OF RESULTS; STOCHASTIC PROCESSES; YOUNG ADULT;

EID: 84862513986     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00581.2011     Document Type: Article

References (35)

1. Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, Rizza R, Cobelli C. Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol Endocrinol Metab 284: E55-E69, 2003.
2. Chase HP, Saib SZ, MacKenzie T, Hansen MM, Garg SK. Postprandial glucose excursions following four methods of bolus insulin administration in subjects with type 1 diabetes. Diabetic Med 19: 317-321, 2002.
3. Cobelli C, Mari A, Ferrannini E. Non-steady state: error analysis of Steele's model and developments for glucose kinetics. Am J Physiol Endocrinol Metab 252: E679-E689, 1987.
4. Congdon P. Bayesian Statistical Modelling. Chichester, UK; Hoboken, NJ: Wiley & Sons, 2006.
5. El-Khatib FH, Russell SJ, Nathan DM, Sutherlin RG, Damiano ER. A Bihormonal closed-loop artificial pancreas for type 1 diabetes. Sci Transl Med 2: 27ra27, 2010.
6. Elleri D, Allen JM, Harris J, Haidar A, Kumareswaran K, Leelarthna L, Nodale M, Wilinska ME, Weston J, Acerini CL, Jackson N, Umpleby AM, Evans ML, Dunger DB, Hovorka R. Glucose appearance of large evening meals with low and high glycaemic loads in type 1 diabetes. Diabetologia 54, Suppl 1: S54, 2011.
7. Ferrannini E, Bjorkman O, Reichard GA Jr, Pilo A, Olsson M, Wahren J, DeFronzo RA. The disposal of an oral glucose load in healthy subjects A quantitative study. Diabetes 34: 580-588, 1985.
8. Gilks WR, Richardson S, Spiegelhalter DJ. Markov Chain Monte Carlo in Practice. Boca Raton, FL: Chapman & Hall, 1998.
9. Haidar A, Potocka E, Boulet B, Umpleby AM, Hovorka R. Estimating postprandial glucose fluxes using hierarchical Bayes modelling. Computer Methods Programs Biomed. 2012 Feb 22 [Epub ahead of print] PMID: 22364961.
10. Hovorka R. Closed-loop insulin delivery: from bench to clinical practice. Nat Rev Endocrinol 7: 385-395, 2011.
11. Hovorka R, Allen JM, Elleri D, Chassin LJ, Harris J, Xing D, Kollman C, Hovorka T, Larsen AM, Nodale M, De Palma A, Wilinska ME, Acerini CL, Dunger DB. Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial. Lancet 375: 743-751, 2010.
12. Hovorka R, Jayatillake H, Rogatsky E, Tomuta V, Hovorka T, Stein DT. Calculating glucose fluxes during meal tolerance test: a new computational approach. Am J Physiol Endocrinol Metab 293: E610-E619, 2007.
13. Hovorka R, Kumareswaran K, Harris J, Allen JM, Elleri D, Xing D, Kollman C, Nodale M, Murphy HR, Dunger DB, Amiel SA, Heller SR, Wilinska ME, Evans ML. Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies. BMJ 342: d1855, 2011.
14. Hovorka R, Shojaee-Moradie F, Carroll PV, Chassin LJ, Gowrie IJ, Jackson NC, Tudor RS, Umpleby AM, Jones RH. Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT. Am J Physiol Endocrinol Metab 282: E992-E1007, 2002.
15. Kalderon B, Korman SH, Gutman A, Lapidot A. Glucose recycling and production in glycogenosis type I and III: stable isotope technique study. Am J Physiol Endocrinol Metab 257: E346-E353, 1989.
16. 13C]glucose in rats. J Biol Chem 264: 12994-13004, 1989.
17. Lunn DJ, Thomas A, Best N, Spiegelhalter D. WinBUGS-a Bayesian modelling framework: concepts, structure, and extensibility. Stat Comput 10: 325-337, 2000.
18. Mari A. Estimation of the rate of appearance in the nonsteady state with a two-compartment model. Am J Physiol Endocrinol Metab 263: E400- E415, 1992.
19. Pennant ME, Bluck LJ, Marcovecchio ML, Salgin B, Hovorka R, Dunger DB. Insulin administration and rate of glucose appearance in people with type 1 diabetes. Diabetes Care 31: 2183-2187, 2008.
20. Potocka E, Hovorka R, Baughman RA, Umpleby M, Diaz MLM, Chen R, Boss AH, Richardson PC. AFRESA (TM) suppresses endogenous glucose production earlier than a rapid-acting analog (Lispro) and inhaled exubera. Diabetes 58, Suppl 1: A61, 2009.
21. Rabasa-Lhoret R, Burelle Y, Ducros F, Bourque J, Lavoie C, Massicotte D, Peronnet F, Chiasson JL. Use of an alpha-glucosidase inhibitor to maintain glucose homoeostasis during postprandial exercise in intensively treated Type 1 diabetic subjects. Diabetes Med 18: 739-744, 2001.
22. Radziuk J, McDonald TJ, Rubenstein D, Dupre J. Initial splanchnic extraction of ingested glucose in normal man. Metabolism 27: 657-669, 1978.
23. Rosenblatt J, Chinkes D, Wolfe M, Wolfe RR. Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects. Am J Physiol Endocrinol Metab 263: E584-E596, 1992.
24. Scavone G, Manto A, Pitocco D, Gagliardi L, Caputo S, Mancini L, Zaccardi F, Ghirlanda G. Effect of carbohydrate counting and medical nutritional therapy on glycaemic control in Type 1 diabetic subjects: a pilot study. Diabetic Med 27: 477-479, 2010.
25. Schernthaner G, Wein W, Shnawa N, Bates PC, Birkett Preprandial MA. Postprandial insulin lispro-a comparative crossover trial in patients with Type 1 diabetes. Diabetic Med 21: 279-284, 2004.
26. Shojaee-Moradie F, Jackson NC, Jones RH, Mallet AI, Hovorka R, Umpleby AM. Quantitative measurement of 3-O-methyl-D-glucose by gas chromatography mass spectrometry as a measure of glucose transport in vivo. J Mass Spectrom 31: 961-966, 1996.
27. Spiegelhalter D, Thomas A. Graphical modeling for complex stochastic systems: the BUGS project. IEEE Intelligent Syst Appl 13: 14-15, 1998.
28. Spiegelhalter D, Thomas A, Best N, Lunn D. WinBugs User Manual. Cambridge, UK: Medical Research Council Biostatistics Unit, 2003.
29. Steele R, Bjerknes C, Rathgeb I, Altszuler N. Glucose uptake and production during the oral glucose tolerance test. Diabetes 17: 415-421, 1968.
30. Thorburn A, Litchfield A, Fabris S, Proietto J. Abnormal transient rise in hepatic glucose production after oral glucose in non-insulin-dependent diabetic subjects. Diabetes Res Clin Pract 28: 127-135, 1995.
31. Tikhonov AN, Goncharsky A, Stepanov VV, Yagola AG. Numerical Methods for the Solution of Ill-Posed Problems. Dordrecht; Boston, MA: Kluwer Academic, 1995.
32. Toffolo G, Basu R, Dalla Man C, Rizza R, Cobelli C. Assessment of postprandial glucose metabolism: conventional dual- vs. triple-tracer method. Am J Physiol Endocrinol Metab 291: E800-E806, 2006.
33. Weinzimer SA, Steil GM, Swan KL, Dziura J, Kurtz N, Tamborlane WV. Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas. Diabetes Care 31: 934-939, 2008.
34. Wilinska ME, Chassin LJ, Acerini CL, Allen JM, Dunger DB, Hov-orka R. Simulation environment to evaluate closed-loop insulin delivery systems in type 1 diabetes. J Diabet Sci Technol 4: 132-144, 2010.
35. Wolfe R. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York: Wiley-Liss, 1992.